Abstract:
:Nitric oxide (NO) and prostaglandin E2 (PGE2) are two pleiotropic inflammatory mediators overproduced in arthritis-affected joints. The inducible isoform of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are found both in the synovial tissue and in the cartilage. Their expression is regulated by catabolic cytokines, such as interleukin-1beta and tumor necrosis factor-alpha. These inflammatory mediators play a profound role in the pathogenic processes that arise in the pannus of rheumatoid arthritis and also interfere with cartilage homeostasis in osteoarthritis. Several drugs, including nonsteroidal anti-inflammatory drugs, immunosuppressive agents, and tetracyclines, attenuate the activity of NO and PGE2. These pleiotropic mediators are targets for pharmacologic intervention and gene therapy.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Amin AR,Attur M,Abramson SBdoi
10.1097/00002281-199905000-00009keywords:
subject
Has Abstractpub_date
1999-05-01 00:00:00pages
202-9issue
3eissn
1040-8711issn
1531-6963journal_volume
11pub_type
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journal_title:Current opinion in rheumatology
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abstract:PURPOSE OF REVIEW:Many patients with psoriatic arthritis (PsA) have additional medical problems that can have an impact on morbidity and mortality. The goal of this review is to summarize the available evidence to date on the association of medical comorbidities with PsA and the implications these comorbidities have on...
journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
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abstract:PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the ...
journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
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doi:10.1097/00002281-199110000-00006
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abstract:PURPOSE OF REVIEW:This review provides an update on recent findings with regards to the genetics of hyperuricemia and gout, including recent data from genome-wide association studies (GWAS). RECENT FINDINGS:Five GWAS around the same time reported that genetic variants of SLC2A9/GLUT9 were associated with lower serum u...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32833645e8
更新日期:2010-03-01 00:00:00
abstract::The concept suggesting the involvement of the proinflammatory cytokine tumor necrosis factor (TNF)-alpha in the pathogenesis of rheumatoid arthritis (RA) has been demonstrated by several clinical trials targeting TNF-alpha. In addition to reduction of pain and swelling, a dramatic effect of TNF blocking therapies on t...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200105000-00010
更新日期:2001-05-01 00:00:00
abstract::New information on the treatment of juvenile rheumatoid arthritis emphasizes more aggressive control of arthritis, particularly the use of methotrexate, both in low- and higher-dose regimens. Information concerning drug toxicity, including that of the nonsteroidal anti-inflammatory drugs, second-line agents, and metho...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199305050-00011
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000218947.42730.dd
更新日期:2006-05-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:Current trends in the management of Behçet's syndrome will be reviewed in this article. RECENT FINDINGS:Biologic agents have gained increasing importance over the years in the management of Behçet's syndrome. Long-term results of observational studies have shown that anti-tumor necrosis factor agents...
journal_title:Current opinion in rheumatology
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更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the emergence, clinical features, pathogenesis, and treatment of acute chikungunya (CHIK) fever and chronic CHIK arthritis. RECENT FINDINGS:Since 2004, CHIK, an arboviral infection, has spread throughout the world, infecting millions of people. The illness occurs in two phases: an acute vir...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000486
更新日期:2018-05-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328329c6cb
更新日期:2009-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To review recent evidence on cutaneous manifestations of lupus, with a focus on evidence for pediatric patients. RECENT FINDINGS:Cutaneous manifestations of SLE are common and may precede signs or symptoms of systemic disease. Early recognition and initiation of therapy improves quality of life by re...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Clinical use of immune checkpoint inhibitor (ICI) therapy has revolutionized the therapeutic landscape of cancer. By activating the immune system using monoclonal anti-CTLA-4 and PD(L)-1 antibodies, remission can be induced in previously terminal cancers. However, these breakthroughs come at a price. ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000672
更新日期:2020-01-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200201000-00003
更新日期:2002-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Systemic sclerosis, or scleroderma, is a systemic autoimmune disease manifest by vascular damage and fibrosis within the skin and visceral organs. Whereas scleroderma is a heterogenous disorder in terms of disease symptoms and clinical course, scleroderma-specific autoantibody profiles associate stron...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200311000-00016
更新日期:2003-11-01 00:00:00
abstract:PURPOSE OF REVIEW:A severe decrease of CD4 T cells predisposes humans to opportunistic infections. In adults, HIV is certainly the most common cause of CD4 lymphocytopenia, but other causes, such as infections, autoimmune diseases, immunosuppressive therapy, lymphoma and idiopathic forms need to be considered. This rev...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2006-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Juvenile systemic sclerosis has a variety of clinical manifestations, sometimes different from the adult form. Early recognition, proper classification and treatment may improve the long-term outcome. RECENT FINDINGS:A large multicenter study coordinated by the Pediatric Rheumatology European Society...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3282f01625
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journal_title:Current opinion in rheumatology
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更新日期:2015-07-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
abstract::In primary hyperparathyroidism (PHPT), asymptomatic bone disease can be detected by bone densitometry. The bone mineral density is about 10% lower than normal control values, especially in the cortical radius. Without parathyroidectomy, bone mineral density is frequently stable, but a few patients, mostly postmenopaus...
journal_title:Current opinion in rheumatology
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更新日期:2000-07-01 00:00:00
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journal_title:Current opinion in rheumatology
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更新日期:2017-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2002-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent interest in gout has led to development of new drugs for acute gout and long-term urate-lowering, as well as interest in improving the use of older drugs. The patients' comorbidities and concomitant medications may contribute to the risk of adverse drug reactions with anti-gout therapies. This ...
journal_title:Current opinion in rheumatology
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更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To review developments in the literature concerning work disability in the rheumatic diseases. RECENT FINDINGS:There have been three sets of studies to emerge in the last year. In the first, several studies analyze alternative research methods to document work disability. The second set uses qualitat...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2007-03-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2005-07-01 00:00:00
abstract::Autoantibodies in systemic lupus erythematosus (SLE) are targeted predominantly to intracellular nucleoprotein particles. Following analysis of the quantitative and qualitative properties of the humoral immune response as well as identification of the major particles recognized as antigens, current studies are address...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199509000-00004
更新日期:1995-09-01 00:00:00
abstract::Ankylosing spondylitis and IgA nephropathy share some immunologic features, eg, elevated serum IgA and IgA-immune complex levels. These entities are frequently found as being associated. IgA and IgA immune complex catabolism involves asialoglycoprotein receptors and specific IgA Fc receptors (FcalphaR or CD89) on tiss...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199907000-00007
更新日期:1999-07-01 00:00:00