Management of Behçet's syndrome.

Abstract:

PURPOSE OF REVIEW:Current trends in the management of Behçet's syndrome will be reviewed in this article. RECENT FINDINGS:Biologic agents have gained increasing importance over the years in the management of Behçet's syndrome. Long-term results of observational studies have shown that anti-tumor necrosis factor agents may be effective in Behçet's syndrome patients with refractory eye involvement. Case series reporting about use of anti-tumor necrosis factor agents in vascular and gastrointestinal involvement have also shown good results. Caution is required for infectious complications with these agents. Apremilast is an immunomodulatory agent that works through phosphodiesterase 4 inhibition. A randomized controlled trial has shown that it is effective for the management of oral and genital ulcers and is generally well tolerated. SUMMARY:The outcome of Behçet's syndrome with major organ involvement has improved with more effective management strategies, especially with the use of biologic agents in severe cases. Controlled trials are needed to guide physicians in making treatment decisions.

journal_name

Curr Opin Rheumatol

authors

Ozguler Y,Hatemi G

doi

10.1097/BOR.0000000000000231

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

45-50

issue

1

eissn

1040-8711

issn

1531-6963

journal_volume

28

pub_type

杂志文章,评审
  • Novel screening tools for latent tuberculosis: time to leave an old friend?

    abstract:PURPOSE OF REVIEW:Therapeutic inhibition of tumour necrosis factor-alpha strongly increases the risk of reactivation in latent tuberculosis infection. Recent blood tests based on antigen-specific T cell response and measuring production of interferon-gamma, so called interferon-gamma release assays (IGRAs), are promisi...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0b013e328329c6cb

    authors: Villiger PM,Zellweger JP,Möller B

    更新日期:2009-05-01 00:00:00

  • Mimics of axial spondyloarthritis.

    abstract:PURPOSE OF REVIEW:Axial spondyloarthritis (AxSpA) is a distinct clinical entity with characteristic clinical and radiographic features; however, a multitude of other metabolic, infectious and inflammatory disorders mimic it both clinically and radiographically. RECENT FINDINGS:We present in this review article recent ...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000613

    authors: Merjanah S,Igoe A,Magrey M

    更新日期:2019-07-01 00:00:00

  • Interaction of proteinase 3 with its associated partners: implications in the pathogenesis of Wegener's granulomatosis.

    abstract:PURPOSE OF REVIEW:This review focuses on proteinase 3 (PR3), the preferred target of antineutrophil cytoplasmic antibodies (ANCAs) in Wegener's granulomatosis. Deciphering the molecular associations that PR3 can make with its cognate partners might help to understand its pathophysiological significance in Wegener's gra...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0b013e3283331594

    authors: Witko-Sarsat V,Reuter N,Mouthon L

    更新日期:2010-01-01 00:00:00

  • Cardiovascular involvement in myositis.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to provide an update on cardiovascular involvement in idiopathic inflammatory myopathy (IIM). Studies from the past 18 months are identified and reviewed. Finally, the clinical impact of these findings is discussed. RECENT FINDINGS:Epidemiological studies have revealed a...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000442

    authors: Diederichsen LP

    更新日期:2017-11-01 00:00:00

  • Role of viruses in systemic lupus erythematosus and Sjögren syndrome.

    abstract::Systemic lupus erythematosus and Sjögren syndrome remain elusive in the description of their underlying etiologic causes and pathogenic mechanisms. Although underlying genetic predisposition appears to contribute to both diseases based on twin and other genetic studies, additional factors must play a role. Over the de...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/00002281-200109000-00005

    authors: James JA,Harley JB,Scofield RH

    更新日期:2001-09-01 00:00:00

  • Relationship between joint shape and the development of osteoarthritis.

    abstract:PURPOSE OF REVIEW:To present an updated summary of the relationship between joint shape and the development of osteoarthritis, with a particular focus on osteoarthritis of the hip. RECENT FINDINGS:Osteoarthritis of the hip is highly heritable, with a genetic contribution estimated at 60%. Among the genes that have bee...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0b013e32833d20ae

    authors: Baker-LePain JC,Lane NE

    更新日期:2010-09-01 00:00:00

  • Biologics in the treatment of Sjogren's syndrome, systemic lupus erythematosus, and lupus nephritis.

    abstract:PURPOSE OF REVIEW:It is an understatement to say that drug approvals in systemic lupus erythematosus (SLE), lupus nephritis, and Sjogren's syndrome have lagged far behind those in other autoimmune diseases, such as rheumatoid arthritis and psoriatic arthritis. Reasons for this are multiple and include the molecular and...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章

    doi:10.1097/BOR.0000000000000754

    authors: Narain S,Berman N,Furie R

    更新日期:2020-11-01 00:00:00

  • Rheumatic manifestations of neoplasia.

    abstract::Neoplasia can be associated with a wide range of rheumatologic manifestations. Literature over the last 12 months has reviewed metastasis of solid tumors to the joint and hypertrophic pulmonary osteoarthropathy. Vasculitis has been reported as a paraneoplastic syndrome associated with both hematologic and solid malign...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:

    authors: Brooks PM

    更新日期:1992-02-01 00:00:00

  • Update on the treatment and outcome of systemic lupus erythematous in children.

    abstract:PURPOSE OF REVIEW:Provide an update of studies published in last 2 years on the outcomes and therapies in childhood-onset systemic lupus erythematous (cSLE). RECENT FINDINGS:Additional evidence has been provided about the benefits of universal hydroxychloroquine in SLE patients, although antimalarial maculopathy may b...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000621

    authors: Rodriguez-Smith J,Brunner HI

    更新日期:2019-09-01 00:00:00

  • T-cell aging in rheumatoid arthritis.

    abstract:PURPOSE OF REVIEW:With progressive age, the immune system and the propensity for abnormal immunity change fundamentally. Individuals greater than 50 years of age are not only more susceptible to infection and cancer, but also at higher risk for chronic inflammation and immune-mediated tissue damage. The process of immu...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000011

    authors: Weyand CM,Yang Z,Goronzy JJ

    更新日期:2014-01-01 00:00:00

  • Genetics of vasculitis.

    abstract:PURPOSE OF REVIEW:We aim to give an overview of the recent progress in the knowledge of the genetic component of vasculitides. RECENT FINDINGS:Using a state-of-the-art imputation method to analyse the major histocompatibility complex (MHC) region, Ombrello and colleagues narrowed down the association between human leu...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000124

    authors: Carmona FD,Martín J,González-Gay MA

    更新日期:2015-01-01 00:00:00

  • Interstitial lung disease: is interstitial lung disease the same as scleroderma lung disease?

    abstract:PURPOSE OF REVIEW:Pulmonary fibrosis is a devastating disease that affects millions of people worldwide. Among the most common forms of lung fibrosis are idiopathic pulmonary fibrosis (IPF) and scleroderma-related interstitial lung disease (SSc-ILD). Despite a wealth of literature regarding each of these diseases, stud...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0b013e3283588de4

    authors: Murray LA,Rubinowitz A,Herzog EL

    更新日期:2012-11-01 00:00:00

  • Emerging biomarkers in systemic sclerosis.

    abstract:PURPOSE OF REVIEW:The severity of each organ involvement, natural course, and response to therapies are extremely heterogeneous among patients with systemic sclerosis (SSc). The discovery and validation of biomarkers can help identify disease risk, improve early diagnosis and prognosis, better design clinical trials an...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000324

    authors: Manetti M

    更新日期:2016-11-01 00:00:00

  • New developments in the treatment of Wegener's granulomatosis, polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome.

    abstract::With the opportunity for long-term follow-up, it has been appreciated that disease severity may vary considerably in patients with Wegener's granulomatosis, polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome. Although combined therapy with cyclophosphamide and glucocorticoids continues to be th...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/00002281-199701000-00005

    authors: Langford CA,Sneller MC

    更新日期:1997-01-01 00:00:00

  • Clinical features of osteoarthritis, diffuse idiopathic skeletal hyperostosis, and hypermobility syndromes.

    abstract::In 1990, there were signs of a renewed interest in clinical studies about several aspects of osteoarthritis. The work-up of classic data and the use of new information from epidemiologic surveys as well as careful radiographic monitoring of selected groups of patients have brought us broader views on the general cours...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/00002281-199108000-00017

    authors: Peyron JG

    更新日期:1991-08-01 00:00:00

  • New insights into renal transport of urate.

    abstract:PURPOSE OF REVIEW:This review focuses on recent progress in the understanding of various aspects of renal transport of urate. RECENT FINDINGS:Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to the transport of urate have been identified. The mo...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0b013e328032781a

    authors: Anzai N,Kanai Y,Endou H

    更新日期:2007-03-01 00:00:00

  • Role of low-grade inflammation in osteoarthritis.

    abstract:PURPOSE OF REVIEW:Inflammatory changes in joint tissues can be detected by modern imaging techniques in osteoarthritis patients, but may be clinically subtle compared with many other types of arthritis. These changes associate with disease progression and clinical severity, and many inflammatory mediators may have biom...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000353

    authors: Scanzello CR

    更新日期:2017-01-01 00:00:00

  • Cell-based cartilage repair: illusion or solution for osteoarthritis.

    abstract:PURPOSE OF REVIEW:Regeneration of damaged articular cartilage remains one of the most challenging problems in orthopedic surgery. Distinct surgical procedures were developed for the repair of focal cartilage defects and this review will focus on recent aspects of cell-based healing approaches that aim to achieve restor...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0b013e3282a95e4c

    authors: Richter W

    更新日期:2007-09-01 00:00:00

  • Autoimmune liver disease and rheumatic manifestations.

    abstract:PURPOSE OF REVIEW:To review studies that clarify the rheumatic manifestations of autoimmune hepatitis, elucidate shared pathogenic pathways, and encourage innovative site-specific therapies. RECENT FINDINGS:Autoimmune hepatitis has clinical manifestations, serological markers, pathogenic mechanisms, genetic predisposi...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0b013e328010c56b

    authors: Czaja AJ

    更新日期:2007-01-01 00:00:00

  • Biologic basis of osteoarthritis: state of the evidence.

    abstract:PURPOSE OF REVIEW:Evidence accumulated since 2010 indicates that human osteoarthritis should now be reclassified as a systemic musculoskeletal disease rather than a focal disorder of synovial joints. RECENT FINDINGS:Inflammation was seen as the key component promoting synovitis as well as progression of cartilage and ...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000162

    authors: Malemud CJ

    更新日期:2015-05-01 00:00:00

  • Spectrum of immune-mediated necrotizing myopathies and their treatments.

    abstract:PURPOSE OF REVIEW:This review aims to describe the spectrum of clinical, histological, and serological features in patients with immune-mediated necrotizing myopathies (IMNMs). RECENT FINDINGS:Autoantibodies recognizing the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) define tw...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000335

    authors: Pinal-Fernandez I,Mammen AL

    更新日期:2016-11-01 00:00:00

  • The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies.

    abstract:PURPOSE OF REVIEW:The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental compo...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000299

    authors: Asquith M,Rosenbaum JT

    更新日期:2016-07-01 00:00:00

  • Antiphospholipid antibodies in systemic lupus erythematosus and Sjögren's syndrome.

    abstract::The spectrum of clinical descriptions and clinicopathologic studies on patients with primary and secondary forms of antiphospholipid antibody syndrome continues to widen. Some differences exist for patients with lupus compared with those with Sjogren's syndrome. Some new thoughts regarding pathogenetic mechanisms and ...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/00002281-199305050-00007

    authors: McCarty-Farid GA

    更新日期:1993-09-01 00:00:00

  • Do antitumor necrosis factor agents increase the risk of postoperative orthopedic infections?

    abstract:PURPOSE OF REVIEW:Patients with rheumatoid arthritis and other inflammatory arthritides treated with tumor necrosis factor inhibitors frequently undergo orthopedic procedures. These patients may be at risk for serious postoperative infections as antitumor necrosis factor agents may be associated with impaired immunity ...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0b013e3282fcc345

    authors: Pappas DA,Giles JT

    更新日期:2008-07-01 00:00:00

  • Calcium crystals in osteoarthritis.

    abstract::Osteoarthritis is the most common form of arthritis in adults and its incidence increases with age. More than 50% of people aged 65 and older have radiographic changes of knee osteoarthritis. Calcium crystals, including calcium pyrophosphate dihydrate and basic calcium phosphate crystals, are also common in the elderl...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/00002281-200205000-00018

    authors: Jaovisidha K,Rosenthal AK

    更新日期:2002-05-01 00:00:00

  • Up-to-date treatment and management of myositis.

    abstract:PURPOSE OF REVIEW:Myositis, or idiopathic inflammatory myopathy, is an overarching concept that includes dermatomyositis, polymyositis, immune-mediated necrotizing myopathy and the antisynthetase syndrome. Glucocorticoids are still considered the mainstay of treatment of myositis but some patients require add-on immuno...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章

    doi:10.1097/BOR.0000000000000745

    authors: Pipitone N,Salvarani C

    更新日期:2020-11-01 00:00:00

  • Which nonautoimmune myopathies are most frequently misdiagnosed as myositis?

    abstract:PURPOSE OF REVIEW:To discuss the spectrum of nonautoimmune myopathies that may be misdiagnosed as autoimmune myopathy. RECENT FINDINGS:Inherited myopathies, such as dysferlinopathy, calpainopathy, and facioscapulohumeral dystrophy may be misdiagnosed as autoimmune myopathy, especially when they have inflammatory muscl...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000441

    authors: Mammen AL

    更新日期:2017-11-01 00:00:00

  • Churg-Strauss syndrome: update on recent developments.

    abstract::Churg-Strauss syndrome (CSS) is a form of primary vasculitis characterized by allergy and angiitis. In the organ systems involved (lung, heart, peripheral nervous system, and so forth), eosinophilic infiltration can be found. Eosinophilia and normochromic normocytic anemia are leading laboratory findings together with...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/00002281-200201000-00003

    authors: Gross WL

    更新日期:2002-01-01 00:00:00

  • Parasitic worms and inflammatory disease.

    abstract:PURPOSE OF REVIEW:Parasitic worms have evolved strategies to manipulate the host immune system, some of which may lead to a reduction in inflammation. Characterisation of the ways in which these organisms mediate an anti-inflammatory response and identification of parasite-derived molecules involved in immune modulatio...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0b013e3283535937

    authors: Cooke A

    更新日期:2012-07-01 00:00:00

  • Epidemiology of systemic lupus erythematosus: an update.

    abstract:PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the ...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审

    doi:10.1097/BOR.0000000000000480

    authors: Stojan G,Petri M

    更新日期:2018-03-01 00:00:00