Abstract:
PURPOSE OF REVIEW:Current trends in the management of Behçet's syndrome will be reviewed in this article. RECENT FINDINGS:Biologic agents have gained increasing importance over the years in the management of Behçet's syndrome. Long-term results of observational studies have shown that anti-tumor necrosis factor agents may be effective in Behçet's syndrome patients with refractory eye involvement. Case series reporting about use of anti-tumor necrosis factor agents in vascular and gastrointestinal involvement have also shown good results. Caution is required for infectious complications with these agents. Apremilast is an immunomodulatory agent that works through phosphodiesterase 4 inhibition. A randomized controlled trial has shown that it is effective for the management of oral and genital ulcers and is generally well tolerated. SUMMARY:The outcome of Behçet's syndrome with major organ involvement has improved with more effective management strategies, especially with the use of biologic agents in severe cases. Controlled trials are needed to guide physicians in making treatment decisions.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Ozguler Y,Hatemi Gdoi
10.1097/BOR.0000000000000231subject
Has Abstractpub_date
2016-01-01 00:00:00pages
45-50issue
1eissn
1040-8711issn
1531-6963journal_volume
28pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Therapeutic inhibition of tumour necrosis factor-alpha strongly increases the risk of reactivation in latent tuberculosis infection. Recent blood tests based on antigen-specific T cell response and measuring production of interferon-gamma, so called interferon-gamma release assays (IGRAs), are promisi...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328329c6cb
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abstract:PURPOSE OF REVIEW:Axial spondyloarthritis (AxSpA) is a distinct clinical entity with characteristic clinical and radiographic features; however, a multitude of other metabolic, infectious and inflammatory disorders mimic it both clinically and radiographically. RECENT FINDINGS:We present in this review article recent ...
journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3283331594
更新日期:2010-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to provide an update on cardiovascular involvement in idiopathic inflammatory myopathy (IIM). Studies from the past 18 months are identified and reviewed. Finally, the clinical impact of these findings is discussed. RECENT FINDINGS:Epidemiological studies have revealed a...
journal_title:Current opinion in rheumatology
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doi:10.1097/BOR.0000000000000442
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200109000-00005
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journal_title:Current opinion in rheumatology
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doi:10.1097/BOR.0b013e32833d20ae
更新日期:2010-09-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章
doi:10.1097/BOR.0000000000000754
更新日期:2020-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2019-09-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000011
更新日期:2014-01-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000124
更新日期:2015-01-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3283588de4
更新日期:2012-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000324
更新日期:2016-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199701000-00005
更新日期:1997-01-01 00:00:00
abstract::In 1990, there were signs of a renewed interest in clinical studies about several aspects of osteoarthritis. The work-up of classic data and the use of new information from epidemiologic surveys as well as careful radiographic monitoring of selected groups of patients have brought us broader views on the general cours...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199108000-00017
更新日期:1991-08-01 00:00:00
abstract:PURPOSE OF REVIEW:This review focuses on recent progress in the understanding of various aspects of renal transport of urate. RECENT FINDINGS:Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to the transport of urate have been identified. The mo...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328032781a
更新日期:2007-03-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000353
更新日期:2017-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Regeneration of damaged articular cartilage remains one of the most challenging problems in orthopedic surgery. Distinct surgical procedures were developed for the repair of focal cartilage defects and this review will focus on recent aspects of cell-based healing approaches that aim to achieve restor...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3282a95e4c
更新日期:2007-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To review studies that clarify the rheumatic manifestations of autoimmune hepatitis, elucidate shared pathogenic pathways, and encourage innovative site-specific therapies. RECENT FINDINGS:Autoimmune hepatitis has clinical manifestations, serological markers, pathogenic mechanisms, genetic predisposi...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328010c56b
更新日期:2007-01-01 00:00:00
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journal_title:Current opinion in rheumatology
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doi:10.1097/BOR.0000000000000162
更新日期:2015-05-01 00:00:00
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journal_title:Current opinion in rheumatology
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更新日期:2016-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2016-07-01 00:00:00
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journal_title:Current opinion in rheumatology
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更新日期:1993-09-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3282fcc345
更新日期:2008-07-01 00:00:00
abstract::Osteoarthritis is the most common form of arthritis in adults and its incidence increases with age. More than 50% of people aged 65 and older have radiographic changes of knee osteoarthritis. Calcium crystals, including calcium pyrophosphate dihydrate and basic calcium phosphate crystals, are also common in the elderl...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:Myositis, or idiopathic inflammatory myopathy, is an overarching concept that includes dermatomyositis, polymyositis, immune-mediated necrotizing myopathy and the antisynthetase syndrome. Glucocorticoids are still considered the mainstay of treatment of myositis but some patients require add-on immuno...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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更新日期:2017-11-01 00:00:00
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journal_title:Current opinion in rheumatology
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更新日期:2002-01-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00