Clinical trials: types, design, and end-points.

Abstract:

:Although the pathogenesis of systemic sclerosis is poorly understood, an increasing number of high quality clinical research trials are attempting to modify the overall disease outcome. Survival has improved, largely through therapies focused on single organs. Candidate outcome measures have been tested and a consensus template for trial design has evolved. The complexity of process in systemic sclerosis renders unlikely that an agent of focused mechanism of therapeutic effect will alter all cardinal features of illness.

journal_name

Curr Opin Rheumatol

authors

Seibold JR

doi

10.1097/00002281-200111000-00011

keywords:

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

512-5

issue

6

eissn

1040-8711

issn

1531-6963

journal_volume

13

pub_type

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