Immunodeficient states and associated rheumatic manifestations.

abstract：:The results of twin and family studies clearly implicate an important role for genetic factors in the etiology of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, the complex nature of these diseases has hampered progress in defining the genetic determinants. Recent advances in molecular gene...

journal_title：Current opinion in rheumatology

authors： Criswell LA,Amos CI

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review focuses on the most significant recent findings regarding selective estrogen receptor modulators (SERMs) and selective androgen receptor modulators (SARMs). SERMs, which interact with estrogen receptor-alpha and estrogen receptor-beta in multiple tissues, continue to generate clinic...

journal_title：Current opinion in rheumatology

authors： Clarke BL,Khosla S

更新日期：2009-07-01 00:00:00

abstract：:Connective tissue diseases (CTDs) frequently present with one or only a few symptoms, which does not allow prompt diagnosis. Raynaud's phenomenon is one of those symptoms. However, only a minority of patients who present with Raynaud's phenomenon develop a CTD. Prognostic factors for the future development of CTD in s...

journal_title：Current opinion in rheumatology

authors： Kallenberg CG

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To investigate the association between systemic sclerosis (SSc) to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) carriage. We utilized the database of Clalit Health Services, the largest healthcare organization in Israel and performed a cross-sectional study. RECENT FINDINGS:The study i...

journal_title：Current opinion in rheumatology

authors： Tiosano S,Cohen AD,Amital H

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent developments in the nosology of primary systemic vasculitis are placed in the context of an historical overview. The ongoing attempts to develop criteria for classification and diagnosis are discussed. RECENT FINDINGS:Giant cell arteritis has supplanted temporal arteritis as the preferred term...

journal_title：Current opinion in rheumatology

authors： Jennette JC,Falk RJ

更新日期：2007-01-01 00:00:00

abstract：:A polymyositis syndrome has been described as a rare complication in patients who develop chronic graft-versus-host disease after allogeneic bone marrow transplantation. Chronic graft-versus-host disease is a cellular immune-mediated donor bone marrow versus patient rejection reaction, which may also lead to an autoim...

journal_title：Current opinion in rheumatology

authors： Parker PM,Openshaw H,Forman SJ

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an increasing interest in improving the understanding of pathophysiology, outcome measures, and therapies of rheumatic skin disease. Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheum...

journal_title：Current opinion in rheumatology

authors： Clarke JT,Werth VP

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides a risk-stratified and evidence-based management for subsets of systemic sclerosis (SSc) patients in the first five years from disease onset. RECENT FINDINGS:Cardiopulmonary disease remains the primary cause of mortality in SSc patients. Morbidity and mortality in SSc-associated p...

journal_title：Current opinion in rheumatology

authors： Roofeh D,Khanna D

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent evidence for infection rates in patients with systemic vasculitides, the role of specific infectious agents in the pathogenesis of vasculitis and recent breakthroughs in the treatment of virus-associated vasculitides. RECENT FINDINGS:In well designed recent studies, infections were f...

journal_title：Current opinion in rheumatology

authors： Thomas K,Vassilopoulos D

更新日期：2017-01-01 00:00:00

abstract：:Significant advances were made this year in the understanding of serum amyloid A isotypes and in the definition of different amyloid light-chain proteins. Increasing numbers of hereditary amyloid-related transthyretin mutations have been reported (more than 30 to date). Two new hereditary amyloid proteins in several d...

journal_title：Current opinion in rheumatology

authors： Cohen AS

更新日期：1994-01-01 00:00:00

abstract：:The concept suggesting the involvement of the proinflammatory cytokine tumor necrosis factor (TNF)-alpha in the pathogenesis of rheumatoid arthritis (RA) has been demonstrated by several clinical trials targeting TNF-alpha. In addition to reduction of pain and swelling, a dramatic effect of TNF blocking therapies on t...

journal_title：Current opinion in rheumatology

authors： Graninger WB,Smolen JS

更新日期：2001-05-01 00:00:00

abstract：:Low back pain continues to affect a significant proportion of the younger, working population between 35 and 45 years of age. An important study has correlated macroscopic and microscopic intervertebral disc alterations starting in the second decade of life with oxidative stress manifested by the presence of N-(carbox...

journal_title：Current opinion in rheumatology

authors： Borenstein DG

更新日期：1999-03-01 00:00:00

abstract：:Eosinophilic infiltration into skeletal muscle, although rare, has been described in a diverse group of conditions. It most commonly occurs in parasitic infection as focal eosinophilic myositis but can be a feature of systemic hypereosinophilic conditions such as eosinophilia-myalgia syndrome and idiopathic hypereosin...

journal_title：Current opinion in rheumatology

authors： Pickering MC,Walport MJ

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical use of immune checkpoint inhibitor (ICI) therapy has revolutionized the therapeutic landscape of cancer. By activating the immune system using monoclonal anti-CTLA-4 and PD(L)-1 antibodies, remission can be induced in previously terminal cancers. However, these breakthroughs come at a price. ...

journal_title：Current opinion in rheumatology

authors： Boland P,Heath J,Sandigursky S

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent progress in the understanding of various aspects of renal transport of urate. RECENT FINDINGS:Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to the transport of urate have been identified. The mo...

journal_title：Current opinion in rheumatology

authors： Anzai N,Kanai Y,Endou H

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout. This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion. RECENT FINDINGS:The disco...

journal_title：Current opinion in rheumatology

authors： Taniguchi A,Kamatani N

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the present knowledge of the role of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in the pathogenesis of fibrotic diseases. RECENT FINDINGS:ER stress and UPR occur in a number of diseases associated with organ fibrosis; however, the contribution of these pathways to...

journal_title：Current opinion in rheumatology

authors： Lenna S,Trojanowska M

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the central role of pain in osteoarthritis, until recently, relatively little attention was paid to the osteoarthritis pain experience, including the features of osteoarthritis pain that are most important to people living with this disease. The focus of this review is on recent advances in ou...

journal_title：Current opinion in rheumatology

authors： Hawker GA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Cryoglobulinemic vasculitis is an immune-complex-mediated systemic vasculitis involving small-medium-sized vessels. A causative role of hepatitis C virus in over 80% patients has been definitively established, with heterogeneous geographical distribution. This review focuses on recent etiopathogenetic...

journal_title：Current opinion in rheumatology

authors： Ferri C,Mascia MT

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) and Sjogren's syndrome are chronic inflammatory diseases characterized by the dysfunction of T cells, B cells, and dendritic cells and the production of antinuclear autoantibodies. Here, we evaluate newly discovered molecular and cellular targets for the treatment of...

journal_title：Current opinion in rheumatology

authors： Perl A

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article provides an update on the recent findings on autoantibodies to modified proteins in rheumatoid arthritis (RA). RECENT FINDINGS:In the past few years, the knowledge on the autoantibodies to citrullinated antigens has expanded considerably. More specifically, it is now clear that many diff...

journal_title：Current opinion in rheumatology

authors： Toes RE,Huizinga TJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic sclerosis, or scleroderma, is a systemic autoimmune disease manifest by vascular damage and fibrosis within the skin and visceral organs. Whereas scleroderma is a heterogenous disorder in terms of disease symptoms and clinical course, scleroderma-specific autoantibody profiles associate stron...

journal_title：Current opinion in rheumatology

authors： Harris ML,Rosen A

更新日期：2003-11-01 00:00:00

abstract：:Myositis-overlap syndromes are characterized by a heterogeneous group of clinical syndromes of which many are closely linked with specific autoantibodies. Clinical and laboratory-based research into this fascinating group of syndromes have given us clues in elucidating the role of immunogenetic, environmental influenc...

journal_title：Current opinion in rheumatology

authors： Ioannou Y,Sultan S,Isenberg DA

更新日期：1999-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in pulmonary hypertension, a leading cause of morbidity and mortality in scleroderma (SSc). RECENT FINDINGS:Although WHO Group I pulmonary arterial hypertension (PAH) is the most common cause of pulmonary hypertension, all WHO Groups can occur. PAH is now a crit...

journal_title：Current opinion in rheumatology

authors： Highland KB

更新日期：2014-11-01 00:00:00

abstract：:Advances in molecular biologic techniques and the availability of novel immunologic reagents have allowed new approaches to understanding the pathogenesis of human autoimmune diseases, including the idiopathic inflammatory myopathies. Indirect evidence that autoreactive T cells mediate muscle inflammation in the human...

journal_title：Current opinion in rheumatology

authors： O'Hanlon TP,Miller FW

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent literature in inflammatory myopathies suggests that both immune (cell-mediated and humoral) and nonimmune [endoplasmic reticulum (ER) stress and autophagy] mechanisms play a role in muscle fiber damage and dysfunction. This review describes these findings and discusses their relevance to diseas...

journal_title：Current opinion in rheumatology

authors： Henriques-Pons A,Nagaraju K

更新日期：2009-11-01 00:00:00

abstract：:In this review, recent data relevant to better understanding of the immunogenetics of the spondyloarthropathies are discussed or, in a somewhat broader sense, the HLA-B27 disease associations. Although in 1993 much more is known about the B27 molecule than was known in 1992, its contribution to the pathogenesis of dis...

journal_title：Current opinion in rheumatology

authors： Ivanyi P

更新日期：1993-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Exercise was established as an integral part of the nonpharmacological treatment of fibromyalgia approximately 20 years ago. Since then many studies have investigated the effects of exercise-either alone or in combination with other interventions. This review will discuss the benefits of exercise alon...

journal_title：Current opinion in rheumatology

authors： Gowans SE,deHueck A

更新日期：2004-03-01 00:00:00

abstract：:New information on the treatment of juvenile rheumatoid arthritis emphasizes more aggressive control of arthritis, particularly the use of methotrexate, both in low- and higher-dose regimens. Information concerning drug toxicity, including that of the nonsteroidal anti-inflammatory drugs, second-line agents, and metho...

journal_title：Current opinion in rheumatology

authors： Emery HM

更新日期：1993-09-01 00:00:00

abstract：:The immune defense against extracellular pathogens is largely dependent on antibody production. Class switch recombination and somatic hypermutation shape the secondary antibody repertoire in peripheral lymphoid tissue. In the past few years, a series of primary immune deficiencies characterized by defects in these pr...

journal_title：Current opinion in rheumatology

authors： Gulino AV,Notarangelo LD

更新日期：2003-07-01 00:00:00