Nonimmune mechanisms of muscle damage in myositis: role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis.

abstract：:The last few years have brought a resurgence in interest in managing systemic sclerosis. In the past year, there have been reports of small series of patients and several well-designed, double-blind, controlled trials. Treatment has been directed at a variety of potential pathogenic mechanisms. Stanazol, iloprost, pla...

journal_title：Current opinion in rheumatology

authors： Steen V

更新日期：1991-12-01 00:00:00

abstract：:Churg-Strauss syndrome (CSS) is a form of primary vasculitis characterized by allergy and angiitis. In the organ systems involved (lung, heart, peripheral nervous system, and so forth), eosinophilic infiltration can be found. Eosinophilia and normochromic normocytic anemia are leading laboratory findings together with...

journal_title：Current opinion in rheumatology

authors： Gross WL

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Autoimmune pancreatitis (AIP) is a peculiar type of pancreatitis with a presumed autoimmune etiology. AIP is frequently associated with stenosis of the bile duct in the form of IgG4-related sclerosing cholangitis. This article reviews recent advances in clinicopathological findings for AIP and IgG4-re...

journal_title：Current opinion in rheumatology

authors： Takuma K,Kamisawa T,Igarashi Y

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Two diseases associated with chronic kidney disease (CKD) have benefited from advances in the past year which are of great importance for rheumatologists: renal osteodystrophy, which is now clearly associated with vascular calcification and cardiovascular death, and nephogenic systemic fibrosis, which...

journal_title：Current opinion in rheumatology

authors： Bardin T,Richette P

更新日期：2009-01-01 00:00:00

abstract：:In primary hyperparathyroidism (PHPT), asymptomatic bone disease can be detected by bone densitometry. The bone mineral density is about 10% lower than normal control values, especially in the cortical radius. Without parathyroidectomy, bone mineral density is frequently stable, but a few patients, mostly postmenopaus...

journal_title：Current opinion in rheumatology

authors： Cormier C,Souberbielle JC,Kindermans C

更新日期：2000-07-01 00:00:00

abstract：:Angiitis of the central nervous system (CNS) remains a poorly understood and clinically challenging form of vascular inflammatory disease. Primary angiitis of the CNS (PACNS) has been viewed as a relentless and uniformly fatal disorder if untreated. In addition, recent trends have demonstrated an increasing reliance o...

journal_title：Current opinion in rheumatology

authors： Calabrese LH,Duna GF

更新日期：1995-01-01 00:00:00

abstract：:Osteoporosis occurs in patients with rheumatoid arthritis, acromegaly, anorexia nervosa, chronic liver disease, sickle cell hemoglobinopathies, and mastocytosis. Osteomalacia occurs in patients with renal tubular acidosis, and with tumors. ...

journal_title：Current opinion in rheumatology

authors： Cormier C

更新日期：1991-06-01 00:00:00

abstract：:Organ transplantation offers new life to patients who suffer from incurable disease. The problem of rejection of the transplanted organ has been overcome with the use of potent immunosuppressive drugs. These drugs, although they allow graft tolerance and graft survival, also are associated with complications such as o...

journal_title：Current opinion in rheumatology

authors： Epstein S,Shane E,Bilezikian JP

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The history of ankylosing spondylitis, the main representative of the spondyloarthritides, is dating back to several thousand years BC and recently proven for medieval skeleton by HLA-B27 typing with modern molecular techniques. In modern time, the history of spondyloarthritis (SpA) is characterized b...

journal_title：Current opinion in rheumatology

authors： Zeidler H,Calin A,Amor B

更新日期：2011-07-01 00:00:00

abstract：:Inherited connective tissue disorders, among them Ehlers-Danlos syndrome, osteogenesis imperfecta, Marfan syndrome, and Larsen syndrome, are characterized by generalized joint hypermobility. Others, such as Morquio syndrome or achondroplasia, have hypermobility in a more limited distribution. Recent clinical and molec...

journal_title：Current opinion in rheumatology

authors： Raff ML,Byers PH

更新日期：1996-09-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been a tremendous interest to understand the mechanisms that regulate gene expression in autoimmunity and their effect on disease phenotypes by exploring different epigenetic mechanisms. In this review, we will introduce lupus epigenetics through reviewing historical key findings, then we wi...

journal_title：Current opinion in rheumatology

authors： Altorok N,Sawalha AH

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review radiographic and MRI developments in measuring osteoarthritis progression in the tibiofemoral compartment of the knee. RECENT FINDINGS:Standardized techniques for measuring joint space width in the medial tibiofemoral compartment, using standardized radiographic protocols, have become accep...

journal_title：Current opinion in rheumatology

authors： Hunter DJ,Le Graverand MP,Eckstein F

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Current trends in the management of Behçet's syndrome will be reviewed in this article. RECENT FINDINGS:Biologic agents have gained increasing importance over the years in the management of Behçet's syndrome. Long-term results of observational studies have shown that anti-tumor necrosis factor agents...

journal_title：Current opinion in rheumatology

authors： Ozguler Y,Hatemi G

更新日期：2016-01-01 00:00:00

abstract：:The eosinophilia-myalgia syndrome, which is associated with the ingestion of L-tryptophan that contained products, occurred as an epidemic in the United States in 1989. Eosinophilia-myalgia syndrome is similar in many ways to the toxic-oil syndrome, which occurred in Spain in 1981, and to diffuse fasciitis with eosino...

journal_title：Current opinion in rheumatology

authors： Silver RM

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the most updated literature of muscle disease in scleroderma in the past year. RECENT FINDINGS:In the past year, two studies have highlighted that fibrosis is a prevalent histopathologic feature in muscle biopsies of patients with scleroderma muscle disease. In addition, microan...

journal_title：Current opinion in rheumatology

authors： Paik JJ

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Rapid introduction of newly developed drugs in the absence of clear understanding of the pathophysiologic mechanisms behind drug-induced lupus erythematosus (DILE) can sometimes make DILE difficult to recognize in clinical practice. The purpose of this review is to summarize drugs most recently report...

journal_title：Current opinion in rheumatology

authors： He Y,Sawalha AH

更新日期：2018-09-01 00:00:00

abstract：:This article describes the magnitude, extent, and economic consequences of some of the more common, work-related musculoskeletal disorders. In addition, it provides a brief historic overview of the state-federal vocational rehabilitation program in the United States. It identifies and considers a constellation of risk...

journal_title：Current opinion in rheumatology

authors： Straaton KV,Fine PR,White MB,Maisiak RS

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the emergence, clinical features, pathogenesis, and treatment of acute chikungunya (CHIK) fever and chronic CHIK arthritis. RECENT FINDINGS:Since 2004, CHIK, an arboviral infection, has spread throughout the world, infecting millions of people. The illness occurs in two phases: an acute vir...

journal_title：Current opinion in rheumatology

authors： Sutaria RB,Amaral JK,Schoen RT

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the advances that have been made in our understanding of the genetics of idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on dermatomyositis and polymyositis. RECENT FINDINGS:Fine-mapping studies in the major histocompatibility complex region in Caucasia...

journal_title：Current opinion in rheumatology

authors： Rothwell S,Chinoy H,Lamb JA

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammatory changes in joint tissues can be detected by modern imaging techniques in osteoarthritis patients, but may be clinically subtle compared with many other types of arthritis. These changes associate with disease progression and clinical severity, and many inflammatory mediators may have biom...

journal_title：Current opinion in rheumatology

authors： Scanzello CR

更新日期：2017-01-01 00:00:00

abstract：:HLA-B27 is virtually absent in most of the sub-Saharan Africa populations, and ankylosing spondylitis is rare; only a few patients have been reported from central and southern Africa. HLA-B27 was present in only one of 17 patients (6%). The disease shows clinical features that are similar to those observed in white HL...

journal_title：Current opinion in rheumatology

authors： Mijiyawa M,Oniankitan O,Khan MA

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses genomic investigations in ankylosing spondylitis (AS) beyond genome-wide association (GWA) studies, but prior to this, genetic variants achieving genome-wide significance will be summarized highlighting key pathways contributing to disease pathogenesis. RECENT FINDINGS:Evidence...

journal_title：Current opinion in rheumatology

authors： O'Rielly DD,Uddin M,Rahman P

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article was to review the recent contributions to the scoring methods of PET in vasculitis as well as to its role in the diagnostic work-up. RECENT FINDINGS:Both visual and semiquantitative scoring methods can be used to interpret PET scans. PET has been shown to be both sensitive and...

journal_title：Current opinion in rheumatology

authors： Pipitone NAM,Versari A,Salvarani C

更新日期：2018-01-01 00:00:00

abstract：:The Achilles tendon is the strongest tendon in the human body. Because most Achilles tendon injuries take place in sports and there has been an common upsurge in sporting activities, the number and incidence of the Achilles tendon overuse injuries and complete ruptures have increased in the industrialized countries du...

journal_title：Current opinion in rheumatology

authors： Järvinen TA,Kannus P,Paavola M,Järvinen TL,Józsa L,Järvinen M

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the spectrum of clinical, histological, and serological features in patients with immune-mediated necrotizing myopathies (IMNMs). RECENT FINDINGS:Autoantibodies recognizing the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) define tw...

journal_title：Current opinion in rheumatology

authors： Pinal-Fernandez I,Mammen AL

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease characterized by IgG-autoantibodies to nuclear antigens that can deposit in the kidney and trigger lupus nephritis. Neutrophils accumulate in the kidneys of patients with proliferative LUPUS NEPHRITIS and neutrophil products and a s...

journal_title：Current opinion in rheumatology

authors： Nishi H,Mayadas TN

更新日期：2019-03-01 00:00:00

abstract：:Low back pain continues to affect a significant proportion of the younger, working population between 35 and 45 years of age. An important study has correlated macroscopic and microscopic intervertebral disc alterations starting in the second decade of life with oxidative stress manifested by the presence of N-(carbox...

journal_title：Current opinion in rheumatology

authors： Borenstein DG

更新日期：1999-03-01 00:00:00

abstract：PURPOSE OF THE REVIEW:To define gout conditions and hyperuricemia. RECENT FINDINGS:Gout is defined as an arthritic condition resulting from the deposition of monosodium urate (MSU) crystals in and/or around joints, following long-standing hyperuricemia. Several recent ultrasound studies disclosed MSU deposits in a lar...

journal_title：Current opinion in rheumatology

authors： Bardin T,Richette P

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study is to review the evidence and recent developments leading to novel therapeutics in scleroderma. RECENT FINDINGS:Recent advances have been made in understanding the key pathogenetic aspects of scleroderma, and these have led to potential targeted therapeutic agents for the ma...

journal_title：Current opinion in rheumatology

authors： Ong VH,Denton CP

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To investigate the association between systemic sclerosis (SSc) to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) carriage. We utilized the database of Clalit Health Services, the largest healthcare organization in Israel and performed a cross-sectional study. RECENT FINDINGS:The study i...

journal_title：Current opinion in rheumatology

authors： Tiosano S,Cohen AD,Amital H

更新日期：2019-09-01 00:00:00