Epidemiology, etiology, diagnostic evaluation, and treatment of low back pain.

abstract：PURPOSE OF REVIEW:Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout. This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion. RECENT FINDINGS:The disco...

journal_title：Current opinion in rheumatology

authors： Taniguchi A,Kamatani N

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical use of immune checkpoint inhibitor (ICI) therapy has revolutionized the therapeutic landscape of cancer. By activating the immune system using monoclonal anti-CTLA-4 and PD(L)-1 antibodies, remission can be induced in previously terminal cancers. However, these breakthroughs come at a price. ...

journal_title：Current opinion in rheumatology

authors： Boland P,Heath J,Sandigursky S

更新日期：2020-01-01 00:00:00

abstract：:All industrialized nations are facing a crisis in health care financing. Rising expectations coupled with increasing specialization and technologic capacities have forced health care payers to examine their assumptions and to seek data on the outcomes of medical interventions. Clinical investigators who have been taug...

journal_title：Current opinion in rheumatology

authors： Stucki G,Liang MH

更新日期：1994-03-01 00:00:00

abstract：:Current advances in the study of hypertrophic osteoarthropathy are discussed. An update of the classification of hypertrophic osteoarthropathy is given in which the POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome is included among the associated diseases. Cyanotic heart disea...

journal_title：Current opinion in rheumatology

authors： Martínez-Lavín M

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to evaluate recent trials and studies of different types of physical activity programs for individuals with chronic arthritis and to discuss recommendations and findings from systematic reviews of physical activity interventions. RECENT FINDINGS:Recent randomized control...

journal_title：Current opinion in rheumatology

authors： Callahan LF

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:It is well recognized that the complement system plays multiple roles in systemic lupus erythematosus. Activation of the classical pathway by immune complexes leads to the generation of inflammatory mediators, thus promoting tissue injury. Complement activation also plays an important role in the main...

journal_title：Current opinion in rheumatology

authors： Karp DR

更新日期：2005-09-01 00:00:00

abstract：:Idiopathic inflammatory myositis in children includes multiple disease entities, but is primarily made up of juvenile dermatomyositis and, to a lesser degree, juvenile polymyositis. Much new information has been published in the last few years about these diseases, including the epidemiology, pathogenesis, clinical di...

journal_title：Current opinion in rheumatology

authors： Reed AM

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article critically reviews the advances in medical management of giant cell arteritis (GCA) and Takayasu arteritis (TAK) with a focus on recent developments in targeted biologic therapy. RECENT FINDINGS:The role of biologics in the treatment of large vessel vasculitis (LVV) is expanding. TNFα in...

journal_title：Current opinion in rheumatology

authors： Koster MJ,Matteson EL,Warrington KJ

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To help clinicians to distinguish between myositis (and other immune-mediated and immunosuppressant-responsive disorders) and its many clinical mimics. RECENT FINDINGS:Increasing experience has shown that findings from conventional investigations, such as muscle biopsy, can be misleading. More specia...

journal_title：Current opinion in rheumatology

authors： Hilton-Jones D

更新日期：2014-11-01 00:00:00

abstract：:Work originating in the 1940s led to the characterization of a rare, chronic inflammatory disorder with a unique predilection for the cornea and vestibuloauditory apparatus, now called Cogan's syndrome (CS) after the ophthalmologist who first described it. CS occurs primarily in young adults and typically presents wit...

journal_title：Current opinion in rheumatology

authors： St Clair EW,McCallum RM

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss pathology-based characterization and classification of acquired immune and inflammatory myopathies (IIMs). RECENT FINDINGS:Several types of IIMs do not fit well into the typical IIM subclassifications: dermatomyositis, polymyositis and inclusion body myositis (IBM). Myopathologic features ...

journal_title：Current opinion in rheumatology

authors： Pestronk A

更新日期：2011-11-01 00:00:00

abstract：:Tumor necrosis factor-alpha, acting through its receptors expressed on all cells of the body, is a key mediator of inflammation and immunity. However, its overproduction may also lead to pathologic changes. The latter situation occurs often in chronic inflammatory diseases such as rheumatoid arthritis. The concept sug...

journal_title：Current opinion in rheumatology

authors： Ziolkowska M,Maslinski W

更新日期：2003-05-01 00:00:00

abstract：:Systemic lupus erythematosus is a complex, multisystem autoimmune disease characterized by production of high-titer autoantibodies directed against ubiquitously expressed self-antigens. Autoantigens in systemic lupus erythematosus are highly diverse in terms of structure and location in control cells, but become clust...

journal_title：Current opinion in rheumatology

authors： White S,Rosen A

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Infections have been suggested to contribute to disease induction and reactivation in many of the idiopathic vasculitides. This review describes and evaluates the evidence that microbes are involved in the etiopathogenesis of these diseases. RECENT FINDINGS:Large-vessel vasculitis has recently been a...

journal_title：Current opinion in rheumatology

authors： van Timmeren MM,Heeringa P,Kallenberg CG

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite its critical roles in body movement, structure, and metabolism, skeletal muscle remains underappreciated in the context of rheumatoid arthritis. In rheumatoid arthritis, chronic inflammation, physical inactivity, and medication toxicities impair skeletal muscle. These skeletal muscle alteratio...

journal_title：Current opinion in rheumatology

authors： Andonian BJ,Huffman KM

更新日期：2020-05-01 00:00:00

abstract：:Patients with inflammatory arthritides such as rheumatoid arthritis develop both localized and generalized osteoporosis and have an increased risk of fracture. Bone loss can occur early and is directly related to the inflammatory process as well as to the indirect effects of arthritis on physical activity. Corticoster...

journal_title：Current opinion in rheumatology

authors： Henderson NK,Sambrook PN

更新日期：1996-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent evidence pointing to the importance of inflammatory factors in the onset and progression of age-related muscle wasting, also known as sarcopenia, and discusses critical areas of uncertainty within the literature that require further development in order to identify novel ...

journal_title：Current opinion in rheumatology

authors： Roth SM,Metter EJ,Ling S,Ferrucci L

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To critically appraise the literature related to the pathophysiology of rheumatoid arthritis (RA) focusing on the contribution of synovial tissue pathology (synovitis) in determining diverse clinical outcome/therapeutic response. RECENT FINDINGS:RA synovitis is highly heterogeneous with diverse cellu...

journal_title：Current opinion in rheumatology

authors： Pitzalis C,Kelly S,Humby F

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides a risk-stratified and evidence-based management for subsets of systemic sclerosis (SSc) patients in the first five years from disease onset. RECENT FINDINGS:Cardiopulmonary disease remains the primary cause of mortality in SSc patients. Morbidity and mortality in SSc-associated p...

journal_title：Current opinion in rheumatology

authors： Roofeh D,Khanna D

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The Wnt signaling pathway has been a major focus of effort in the bone field for the past 5 years. This review will examine some of the seminal findings that have brought us to our current understanding of the role of this pathway in bone metabolism. RECENT FINDINGS:The Wnt/beta-catenin signaling pat...

journal_title：Current opinion in rheumatology

authors： Johnson ML,Kamel MA

更新日期：2007-07-01 00:00:00

abstract：:This study reviews articles published in 2000 and 2001 about occupational physical activities as risk factors for osteoarthritis (OA) of the knee and hip. Six studies were identified in MEDLINE and EMBASE; five case-control studies and one cross-sectional study. Criteria for OA were: (on the waiting list for) joint re...

journal_title：Current opinion in rheumatology

authors： Schouten JS,de Bie RA,Swaen G

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Regeneration of damaged articular cartilage remains one of the most challenging problems in orthopedic surgery. Distinct surgical procedures were developed for the repair of focal cartilage defects and this review will focus on recent aspects of cell-based healing approaches that aim to achieve restor...

journal_title：Current opinion in rheumatology

authors： Richter W

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review radiographic and MRI developments in measuring osteoarthritis progression in the tibiofemoral compartment of the knee. RECENT FINDINGS:Standardized techniques for measuring joint space width in the medial tibiofemoral compartment, using standardized radiographic protocols, have become accep...

journal_title：Current opinion in rheumatology

authors： Hunter DJ,Le Graverand MP,Eckstein F

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The autoinflammatory diseases are a group of conditions that include the hereditary fever syndromes, and result from upregulated innate immune responses. The discovery of the genetic basis for these conditions led to the description of novel intracellular receptors for infectious and noninfectious dan...

journal_title：Current opinion in rheumatology

authors： Ryan JG,Goldbach-Mansky R

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Juvenile systemic sclerosis has a variety of clinical manifestations, sometimes different from the adult form. Early recognition, proper classification and treatment may improve the long-term outcome. RECENT FINDINGS:A large multicenter study coordinated by the Pediatric Rheumatology European Society...

journal_title：Current opinion in rheumatology

authors： Zulian F,Martini G

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF THE REVIEW:To define gout conditions and hyperuricemia. RECENT FINDINGS:Gout is defined as an arthritic condition resulting from the deposition of monosodium urate (MSU) crystals in and/or around joints, following long-standing hyperuricemia. Several recent ultrasound studies disclosed MSU deposits in a lar...

journal_title：Current opinion in rheumatology

authors： Bardin T,Richette P

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article was to review the recent contributions to the scoring methods of PET in vasculitis as well as to its role in the diagnostic work-up. RECENT FINDINGS:Both visual and semiquantitative scoring methods can be used to interpret PET scans. PET has been shown to be both sensitive and...

journal_title：Current opinion in rheumatology

authors： Pipitone NAM,Versari A,Salvarani C

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:Gene expression profiling is emerging as a promising methodology in pediatric rheumatology research. There is considerable interest in using this technology as the basis for diagnostic assays. This review will summarize the new knowledge. RECENT FINDINGS:Most gene expression studies of children ...

journal_title：Current opinion in rheumatology

authors： Jarvis JN

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Raynaud phenomenon is the earliest and most common clinical manifestations of scleroderma (systemic sclerosis). Therefore, Raynaud phenomenon offers the best window into the investigation of the early steps in the pathogenesis of systemic sclerosis. This review focuses on the differential diagnosis of...

journal_title：Current opinion in rheumatology

authors： Kahaleh MB

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide a summary of recent advances in the pathophysiology of rheumatoid arthritis. RECENT FINDINGS:Highlights include further elucidation of the relationship between the shared epitope, smoking and anticitrullinated protein/peptide antibody generation, including identification of putative citrul...

journal_title：Current opinion in rheumatology

authors： Cooles FA,Isaacs JD

更新日期：2011-05-01 00:00:00