Childhood systemic sclerosis.

abstract：PURPOSE OF REVIEW:To provide an overview of recently published work on autologous hematopoietic stem-cell transplantation (HSCT) in patients with systemic sclerosis (SSc). RECENT FINDINGS:Superiority of HSCT vs. intravenous cyclophosphamide pulses was demonstrated in the randomized controlled American Scleroderma: Cyc...

journal_title：Current opinion in rheumatology

authors： Spierings J,van Rhijn-Brouwer FCC,van Laar JM

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent advances in the analysis of genetic determinants of bone mass. It addresses both human and animal linkage studies as well as genetic manipulations in animals, inbred mouse models, and candidate gene analyses. RECENT FINDINGS:Recent studies have implicated novel regulatory ...

journal_title：Current opinion in rheumatology

authors： Baldock PA,Eisman JA

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Modern molecular biology offers a unique opportunity to gain a comprehensive picture of gene expression in a disease state. This review presents recent findings in the field of synovial fibroblast biology contributing to knowledge of the pathogenesis of rheumatoid arthritis. RECENT FINDINGS:Recently ...

journal_title：Current opinion in rheumatology

authors： Stanczyk J,Ospelt C,Gay RE,Gay S

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The autoinflammatory diseases are a group of conditions that include the hereditary fever syndromes, and result from upregulated innate immune responses. The discovery of the genetic basis for these conditions led to the description of novel intracellular receptors for infectious and noninfectious dan...

journal_title：Current opinion in rheumatology

authors： Ryan JG,Goldbach-Mansky R

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Regeneration of damaged articular cartilage remains one of the most challenging problems in orthopedic surgery. Distinct surgical procedures were developed for the repair of focal cartilage defects and this review will focus on recent aspects of cell-based healing approaches that aim to achieve restor...

journal_title：Current opinion in rheumatology

authors： Richter W

更新日期：2007-09-01 00:00:00

abstract：:This article reviews evidence that subchondral bone plays a role in the degeneration of cartilage in osteoarthrosis. Whether the bony changes precede the cartilage degeneration remains unproven but may best be considered necessary for progression of the disease. Epidemiologic studies clearly show increasing subchondra...

journal_title：Current opinion in rheumatology

authors： Burr DB

更新日期：1998-05-01 00:00:00

abstract：:The increased bone remodeling in women after menopause induces an imbalance between bone resorption and formation, leading to decreased bone mass, altered bone microarchitecture, and increased fracture risk. Current antiosteoporotic drugs decrease bone remodeling or increase bone formation. Strontium ranelate (Protelo...

journal_title：Current opinion in rheumatology

authors： Marie PJ

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To investigate the association between systemic sclerosis (SSc) to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) carriage. We utilized the database of Clalit Health Services, the largest healthcare organization in Israel and performed a cross-sectional study. RECENT FINDINGS:The study i...

journal_title：Current opinion in rheumatology

authors： Tiosano S,Cohen AD,Amital H

更新日期：2019-09-01 00:00:00

abstract：:In this review, recent data relevant to better understanding of the immunogenetics of the spondyloarthropathies are discussed or, in a somewhat broader sense, the HLA-B27 disease associations. Although in 1993 much more is known about the B27 molecule than was known in 1992, its contribution to the pathogenesis of dis...

journal_title：Current opinion in rheumatology

authors： Ivanyi P

更新日期：1993-07-01 00:00:00

abstract：:Due to our increasing knowledge of mechanisms underlying pathogenic events in autoimmune rheumatic diseases, biologic agents have been further explored and tested in open and controlled clinical trials. Based on the results of placebo-controlled trials, monoclonal antibodies to CD4+ T cells have been found ineffective...

journal_title：Current opinion in rheumatology

authors： Kalden JR,Manger B

更新日期：1995-05-01 00:00:00

abstract：:Fibroblasts within the skin of scleroderma patients constitute a phenotypically heterogeneous population with regard to expression of collagens, cytokines, and cytokine receptors. By in situ hybridization techniques, scleroderma skin is shown to contain a subpopulation of fibroblasts that are stimulated for expression...

journal_title：Current opinion in rheumatology

authors： Unemori EN,Amento EP

更新日期：1991-12-01 00:00:00

abstract：:Osteoarthritis is the most common form of arthritis in adults and its incidence increases with age. More than 50% of people aged 65 and older have radiographic changes of knee osteoarthritis. Calcium crystals, including calcium pyrophosphate dihydrate and basic calcium phosphate crystals, are also common in the elderl...

journal_title：Current opinion in rheumatology

authors： Jaovisidha K,Rosenthal AK

更新日期：2002-05-01 00:00:00

abstract：:Osteoporosis occurs in patients with rheumatoid arthritis, acromegaly, anorexia nervosa, chronic liver disease, sickle cell hemoglobinopathies, and mastocytosis. Osteomalacia occurs in patients with renal tubular acidosis, and with tumors. ...

journal_title：Current opinion in rheumatology

authors： Cormier C

更新日期：1991-06-01 00:00:00

abstract：:In the United States, Lyme disease is the most common arthropod-borne infection. The majority of cases are reported from the Northeast, the Midwest, and California, which are areas with established foci of Borrelia burgdorferi. Advances in the understanding of the epidemiology of Ixodes ticks, the established vector f...

journal_title：Current opinion in rheumatology

authors： Evans J

更新日期：1995-07-01 00:00:00

abstract：:Although the pathogenesis of systemic sclerosis is poorly understood, an increasing number of high quality clinical research trials are attempting to modify the overall disease outcome. Survival has improved, largely through therapies focused on single organs. Candidate outcome measures have been tested and a consensu...

journal_title：Current opinion in rheumatology

authors： Seibold JR

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Across the world, osteoarthritis is the most commonly occurring musculoskeletal disease of the elderly, affecting more than 25% of the population older than 60 years of age. By far the single greatest risk factor for the development of osteoarthritis is age, but a mechanism to explain this relation ha...

journal_title：Current opinion in rheumatology

authors： Verzijl N,Bank RA,TeKoppele JM,DeGroot J

更新日期：2003-09-01 00:00:00

abstract：:Organ transplantation offers new life to patients who suffer from incurable disease. The problem of rejection of the transplanted organ has been overcome with the use of potent immunosuppressive drugs. These drugs, although they allow graft tolerance and graft survival, also are associated with complications such as o...

journal_title：Current opinion in rheumatology

authors： Epstein S,Shane E,Bilezikian JP

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:An increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consequences of this ob...

journal_title：Current opinion in rheumatology

authors： Rönnblom L,Eloranta ML

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this study was to evaluate the relationship between infection with SARS-CoV-2 and autoimmunity. RECENT FINDINGS:Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome (SARS) associated coronavirus 2 (SARS-CoV-2). Although most of the infect...

journal_title：Current opinion in rheumatology

authors： Liu Y,Sawalha AH,Lu Q

更新日期：2021-03-01 00:00:00

abstract：:In the 2 years following menarche, bone mass increases substantially; this is an important new finding concerning peak bone mass. Studies of twins have given significant insights into the effect of heredity on bone mass. Many determinants of bone mass, bone gain, and bone loss thus have been characterized for people o...

journal_title：Current opinion in rheumatology

authors： Cormier C

更新日期：1994-05-01 00:00:00

abstract：:In primary hyperparathyroidism (PHPT), asymptomatic bone disease can be detected by bone densitometry. The bone mineral density is about 10% lower than normal control values, especially in the cortical radius. Without parathyroidectomy, bone mineral density is frequently stable, but a few patients, mostly postmenopaus...

journal_title：Current opinion in rheumatology

authors： Cormier C,Souberbielle JC,Kindermans C

更新日期：2000-07-01 00:00:00

abstract：:The results of twin and family studies clearly implicate an important role for genetic factors in the etiology of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, the complex nature of these diseases has hampered progress in defining the genetic determinants. Recent advances in molecular gene...

journal_title：Current opinion in rheumatology

authors： Criswell LA,Amos CI

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:A severe decrease of CD4 T cells predisposes humans to opportunistic infections. In adults, HIV is certainly the most common cause of CD4 lymphocytopenia, but other causes, such as infections, autoimmune diseases, immunosuppressive therapy, lymphoma and idiopathic forms need to be considered. This rev...

journal_title：Current opinion in rheumatology

authors： Walker UA,Warnatz K

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Mesenchymal stromal/stem cells (MSCs) have potent anti-inflammatory and immunomodulatory properties, in addition to their ability to form cartilage and bone. The purpose of this review is to highlight recent developments and current knowledge gaps in our understanding of the protective effects of MSCs...

journal_title：Current opinion in rheumatology

authors： Ansboro S,Roelofs AJ,De Bari C

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:It is an understatement to say that drug approvals in systemic lupus erythematosus (SLE), lupus nephritis, and Sjogren's syndrome have lagged far behind those in other autoimmune diseases, such as rheumatoid arthritis and psoriatic arthritis. Reasons for this are multiple and include the molecular and...

journal_title：Current opinion in rheumatology

authors： Narain S,Berman N,Furie R

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:With progressive age, the immune system and the propensity for abnormal immunity change fundamentally. Individuals greater than 50 years of age are not only more susceptible to infection and cancer, but also at higher risk for chronic inflammation and immune-mediated tissue damage. The process of immu...

journal_title：Current opinion in rheumatology

authors： Weyand CM,Yang Z,Goronzy JJ

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Cryoglobulinemic vasculitis is an immune-complex-mediated systemic vasculitis involving small-medium-sized vessels. A causative role of hepatitis C virus in over 80% patients has been definitively established, with heterogeneous geographical distribution. This review focuses on recent etiopathogenetic...

journal_title：Current opinion in rheumatology

authors： Ferri C,Mascia MT

更新日期：2006-01-01 00:00:00

abstract：:In the last few years, several novel strategies have been proposed for the treatment of rheumatoid arthritis (RA). Among them, gene therapy is considered a promising concept bearing the potential of highly specific targeting of relevant pathomechanisms. Early studies using gene transfer focused mainly on studying dise...

journal_title：Current opinion in rheumatology

authors： Pap T,Gay RE,Gay S

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Glucocorticoids are used in the treatment of most rheumatic diseases, and are used chronically in up to 50% of cases of rheumatoid arthritis. The frequency of their use has in the past been incompletely supported by trial evidence of their benefit and by incomplete understanding of their mechanisms of...

journal_title：Current opinion in rheumatology

authors： Morand EF

更新日期：2007-05-01 00:00:00

abstract：:Although there are excellent rationales for the use of biologic agents, no published novel therapeutic strategy in patients with early or late rheumatoid arthritis has thus far been proven in controlled clinical studies to prevent or retard cartilage destruction. Although T-cell-specific therapies in chronic rheumatoi...

journal_title：Current opinion in rheumatology

authors： Häuselmann HJ

更新日期：1997-05-01 00:00:00