Cryoglobulinemic vasculitis.

abstract：:Ankylosing spondylitis and IgA nephropathy share some immunologic features, eg, elevated serum IgA and IgA-immune complex levels. These entities are frequently found as being associated. IgA and IgA immune complex catabolism involves asialoglycoprotein receptors and specific IgA Fc receptors (FcalphaR or CD89) on tiss...

journal_title：Current opinion in rheumatology

authors： Montenegro V,Monteiro RC

更新日期：1999-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Inclusion body myositis (IBM) is a poorly understood autoimmune and degenerative disorder of skeletal muscle. Here, pathophysiological and diagnostic biomarkers of IBM are reviewed. RECENT FINDINGS:Muscle histopathological biomarkers have been successful in stimulating the study of IBM pathophysiolog...

journal_title：Current opinion in rheumatology

authors： Greenberg SA

更新日期：2013-11-01 00:00:00

abstract：:Patients with inflammatory arthritides such as rheumatoid arthritis develop both localized and generalized osteoporosis and have an increased risk of fracture. Bone loss can occur early and is directly related to the inflammatory process as well as to the indirect effects of arthritis on physical activity. Corticoster...

journal_title：Current opinion in rheumatology

authors： Henderson NK,Sambrook PN

更新日期：1996-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Takayasu arteritis remains a therapeutic challenge. In spite of current treatments, progression of vascular lesions is observed frequently. The purpose of this article is to describe advances in therapeutic strategies for Takayasu arteritis. RECENT FINDINGS:Immunosuppressive agents including methotre...

journal_title：Current opinion in rheumatology

authors： Liang P,Hoffman GS

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the central role of pain in osteoarthritis, until recently, relatively little attention was paid to the osteoarthritis pain experience, including the features of osteoarthritis pain that are most important to people living with this disease. The focus of this review is on recent advances in ou...

journal_title：Current opinion in rheumatology

authors： Hawker GA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review focuses on the most significant recent findings regarding selective estrogen receptor modulators (SERMs) and selective androgen receptor modulators (SARMs). SERMs, which interact with estrogen receptor-alpha and estrogen receptor-beta in multiple tissues, continue to generate clinic...

journal_title：Current opinion in rheumatology

authors： Clarke BL,Khosla S

更新日期：2009-07-01 00:00:00

abstract：:The concept suggesting the involvement of the proinflammatory cytokine tumor necrosis factor (TNF)-alpha in the pathogenesis of rheumatoid arthritis (RA) has been demonstrated by several clinical trials targeting TNF-alpha. In addition to reduction of pain and swelling, a dramatic effect of TNF blocking therapies on t...

journal_title：Current opinion in rheumatology

authors： Graninger WB,Smolen JS

更新日期：2001-05-01 00:00:00

abstract：:The recent literature pertaining to tumors of articular structures and bone is reviewed. In pigmented villonodular synovitis, the bone resorptive cell is a macrophage polykaryon rather than an osteoclast. Complete arthroscopic synovectomy was successful in most diffuse articular forms of the disease. The early synovia...

journal_title：Current opinion in rheumatology

authors： Abraham JH 3rd,Canoso JJ

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammatory changes in joint tissues can be detected by modern imaging techniques in osteoarthritis patients, but may be clinically subtle compared with many other types of arthritis. These changes associate with disease progression and clinical severity, and many inflammatory mediators may have biom...

journal_title：Current opinion in rheumatology

authors： Scanzello CR

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Renal complications are important in scleroderma (systemic sclerosis) and include scleroderma renal crisis. This is a medical emergency that requires careful management. Recent cohort studies have highlighted key aspects of management and outcome and these are reviewed. RECENT FINDINGS:Two recent art...

journal_title：Current opinion in rheumatology

authors： Penn H,Denton CP

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Autoimmune pancreatitis (AIP) is a peculiar type of pancreatitis with a presumed autoimmune etiology. AIP is frequently associated with stenosis of the bile duct in the form of IgG4-related sclerosing cholangitis. This article reviews recent advances in clinicopathological findings for AIP and IgG4-re...

journal_title：Current opinion in rheumatology

authors： Takuma K,Kamisawa T,Igarashi Y

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The autoinflammatory diseases are a group of conditions that include the hereditary fever syndromes, and result from upregulated innate immune responses. The discovery of the genetic basis for these conditions led to the description of novel intracellular receptors for infectious and noninfectious dan...

journal_title：Current opinion in rheumatology

authors： Ryan JG,Goldbach-Mansky R

更新日期：2008-01-01 00:00:00

abstract：:The increased bone remodeling in women after menopause induces an imbalance between bone resorption and formation, leading to decreased bone mass, altered bone microarchitecture, and increased fracture risk. Current antiosteoporotic drugs decrease bone remodeling or increase bone formation. Strontium ranelate (Protelo...

journal_title：Current opinion in rheumatology

authors： Marie PJ

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of recently published work on autologous hematopoietic stem-cell transplantation (HSCT) in patients with systemic sclerosis (SSc). RECENT FINDINGS:Superiority of HSCT vs. intravenous cyclophosphamide pulses was demonstrated in the randomized controlled American Scleroderma: Cyc...

journal_title：Current opinion in rheumatology

authors： Spierings J,van Rhijn-Brouwer FCC,van Laar JM

更新日期：2018-11-01 00:00:00

abstract：:Tumor necrosis factor-alpha, acting through its receptors expressed on all cells of the body, is a key mediator of inflammation and immunity. However, its overproduction may also lead to pathologic changes. The latter situation occurs often in chronic inflammatory diseases such as rheumatoid arthritis. The concept sug...

journal_title：Current opinion in rheumatology

authors： Ziolkowska M,Maslinski W

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on recent findings with regards to the genetics of hyperuricemia and gout, including recent data from genome-wide association studies (GWAS). RECENT FINDINGS:Five GWAS around the same time reported that genetic variants of SLC2A9/GLUT9 were associated with lower serum u...

journal_title：Current opinion in rheumatology

authors： Choi HK,Zhu Y,Mount DB

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the emergence, clinical features, pathogenesis, and treatment of acute chikungunya (CHIK) fever and chronic CHIK arthritis. RECENT FINDINGS:Since 2004, CHIK, an arboviral infection, has spread throughout the world, infecting millions of people. The illness occurs in two phases: an acute vir...

journal_title：Current opinion in rheumatology

authors： Sutaria RB,Amaral JK,Schoen RT

更新日期：2018-05-01 00:00:00

abstract：:Diffuse alveolar hemorrhage (DAH) is a rare yet serious and frequently life-threatening complication of a variety of conditions. DAH may result from coagulation disorders, inhaled toxins, or infections. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as antineutrophil cyt...

journal_title：Current opinion in rheumatology

authors： Specks U

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review provides an update on novel treatment strategies striving for remission in patients with recent onset of rheumatoid arthritis. RECENT FINDINGS:As early treatment is crucial to achieve optimal results, identifying patients with rheumatoid arthritis early is imperative to achieve cli...

journal_title：Current opinion in rheumatology

authors： van der Kooij SM,Allaart CF,Dijkmans BA,Breedveld FC

更新日期：2008-05-01 00:00:00

abstract：:All industrialized nations are facing a crisis in health care financing. Rising expectations coupled with increasing specialization and technologic capacities have forced health care payers to examine their assumptions and to seek data on the outcomes of medical interventions. Clinical investigators who have been taug...

journal_title：Current opinion in rheumatology

authors： Stucki G,Liang MH

更新日期：1994-03-01 00:00:00

abstract：:The spectrum of clinical descriptions and clinicopathologic studies on patients with primary and secondary forms of antiphospholipid antibody syndrome continues to widen. Some differences exist for patients with lupus compared with those with Sjogren's syndrome. Some new thoughts regarding pathogenetic mechanisms and ...

journal_title：Current opinion in rheumatology

authors： McCarty-Farid GA

更新日期：1993-09-01 00:00:00

abstract：:A growing body of evidence is shedding light on how vascular injury, tissue mononuclear cell infiltrates, and fibrogenesis are related in the pathogenesis of systemic sclerosis. Recent evidence points to a role for adhesion molecules in the binding of mononuclear leukocytes to endothelium and transvascular migration o...

journal_title：Current opinion in rheumatology

authors： Postlethwaite AE

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) and Sjogren's syndrome are chronic inflammatory diseases characterized by the dysfunction of T cells, B cells, and dendritic cells and the production of antinuclear autoantibodies. Here, we evaluate newly discovered molecular and cellular targets for the treatment of...

journal_title：Current opinion in rheumatology

authors： Perl A

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The intestinal microbiome is thought to play a role in the pathogenesis of inflammatory bowel disease (IBD). There are many shared clinical manifestations between IBD and spondyloarthritis (SpA), of which the most common are peripheral arthritis and uveitis. Clinical overlap along with similar genetic...

journal_title：Current opinion in rheumatology

authors： Choi RY,Asquith M,Rosenbaum JT

更新日期：2018-07-01 00:00:00

abstract：:Angiitis of the central nervous system (CNS) remains a poorly understood and clinically challenging form of vascular inflammatory disease. Primary angiitis of the CNS (PACNS) has been viewed as a relentless and uniformly fatal disorder if untreated. In addition, recent trends have demonstrated an increasing reliance o...

journal_title：Current opinion in rheumatology

authors： Calabrese LH,Duna GF

更新日期：1995-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Exercise was established as an integral part of the nonpharmacological treatment of fibromyalgia approximately 20 years ago. Since then many studies have investigated the effects of exercise-either alone or in combination with other interventions. This review will discuss the benefits of exercise alon...

journal_title：Current opinion in rheumatology

authors： Gowans SE,deHueck A

更新日期：2004-03-01 00:00:00

abstract：:In this review, four areas are discussed: fluoroquinolone-induced tendinitis, volar flexor tenosynovitis (trigger finger), Achilles tendon lesions, and occupational medicine issues. The relationship of fluoroquinolone treatment to musculoskeletal lesions, especially Achilles tendinitis and tear, is most intriguing. Th...

journal_title：Current opinion in rheumatology

authors： Biundo JJ Jr,Mipro RC Jr,Fahey P

更新日期：1997-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Individuals with systemic lupus erythematosus (SLE) have an increased susceptibility to certain types of cancer. Given concerns focused on this issue, we present a review of this important topic. RECENT FINDINGS:In non-Hodgkin lymphoma (NHL), a several-fold increased risk is seen in SLE versus the ge...

journal_title：Current opinion in rheumatology

authors： Bernatsky S,Kale M,Ramsey-Goldman R,Gordon C,Clarke AE

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Current treatment of ankylosing spondylitis such as non-steroidal anti-inflammatory drugs and tumor necrosis factor (TNF)-blockers have shown a good efficacy on sign and symptoms. However, it is less clear whether and how structural damage, determined mainly by new bone formation, can be prevented. Re...

journal_title：Current opinion in rheumatology

authors： Sieper J

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the present state of efforts at registry implementation which exist internationally. These efforts are contrasted with those in the USA. RECENT FINDINGS:The implications of the different data which are derived from diverse registry sources are discussed. The need for long-term ...

journal_title：Current opinion in rheumatology

authors： Kremer JM,Gibofsky A,Greenberg JD

更新日期：2008-03-01 00:00:00