Abstract:
PURPOSE OF REVIEW:With progressive age, the immune system and the propensity for abnormal immunity change fundamentally. Individuals greater than 50 years of age are not only more susceptible to infection and cancer, but also at higher risk for chronic inflammation and immune-mediated tissue damage. The process of immunosenescence is accelerated in rheumatoid arthritis (RA). RECENT FINDINGS:Premature T-cell senescence occurs not only in RA, but also has been involved in morbidity and mortality of chronic HIV infection. Senescent cells acquire the 'senescence-associated secretory phenotype', which promotes and sustains tissue inflammation. Molecular mechanisms underlying T-cell aging are beginning to be understood. In addition to the contraction of T-cell diversity because of uneven clonal expansion, senescent T cells have defects in balancing cytoplasmic kinase and phosphatase activities, changing their activation thresholds. Also, leakiness in repairing DNA lesions and uncapped telomeres imposes genomic stress. Age-induced changes in the tissue microenvironment may alter the T-cell responses. SUMMARY:Gain-of-function and loss-of-function in senescent T cells undermine protective immunity and create the conditions for chronic tissue inflammation, a combination typically encountered in RA. Genetic programs involved in T-cell signaling and DNA repair are of high interest in the search for underlying molecular defects.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Weyand CM,Yang Z,Goronzy JJdoi
10.1097/BOR.0000000000000011subject
Has Abstractpub_date
2014-01-01 00:00:00pages
93-100issue
1eissn
1040-8711issn
1531-6963pii
00002281-201401000-00015journal_volume
26pub_type
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journal_title:Current opinion in rheumatology
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doi:10.1097/BOR.0000000000000172
更新日期:2015-05-01 00:00:00
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journal_title:Current opinion in rheumatology
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doi:10.1097/00002281-199509000-00015
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journal_title:Current opinion in rheumatology
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更新日期:2017-07-01 00:00:00
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journal_title:Current opinion in rheumatology
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更新日期:1991-02-01 00:00:00
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2007-03-01 00:00:00
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
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更新日期:1997-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Patients with osteoporosis suffer from the morbidity and mortality associated with resultant fractures. The number of persons at risk for fractures is increasing as the US population ages. This review addresses preventive strategies that can be used to decrease the risk of minimal trauma fractures. R...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3283439426
更新日期:2011-03-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000577
更新日期:2019-03-01 00:00:00
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journal_title:Current opinion in rheumatology
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doi:10.1097/00002281-199305030-00012
更新日期:1993-05-01 00:00:00
abstract::Current advances in the study of hypertrophic osteoarthropathy are discussed. An update of the classification of hypertrophic osteoarthropathy is given in which the POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome is included among the associated diseases. Cyanotic heart disea...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::The spondyloarthropathies are diseases influenced by genetic predisposition and, to a varying extent, infectious triggers. A causal role for bacterial infections is most clear for reactive arthritis. Recent insights into arthritogenic components of bacteria may set the stage for a better understanding of disease patho...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200207000-00007
更新日期:2002-07-01 00:00:00
abstract::Although the pathogenesis of systemic sclerosis is poorly understood, an increasing number of high quality clinical research trials are attempting to modify the overall disease outcome. Survival has improved, largely through therapies focused on single organs. Candidate outcome measures have been tested and a consensu...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200111000-00011
更新日期:2001-11-01 00:00:00
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journal_title:Current opinion in rheumatology
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doi:10.1097/BOR.0b013e3282fa13db
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent work has continued to clarify the role of major histocompatibility complex class I in the pathogenesis of autoimmune myositis. In the past year, several new observations have been made in this area. This review describes these findings and discusses their relevance to the pathogenesis of autoim...
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更新日期:2018-11-01 00:00:00
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
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更新日期:2003-01-01 00:00:00
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journal_title:Current opinion in rheumatology
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更新日期:1993-09-01 00:00:00