Abstract:
PURPOSE OF REVIEW:Recent work has continued to clarify the role of major histocompatibility complex class I in the pathogenesis of autoimmune myositis. In the past year, several new observations have been made in this area. This review describes these findings and discusses their relevance to the pathogenesis of autoimmune myositis. RECENT FINDINGS:Recent studies have confirmed earlier observations of the up-regulation of major histocompatibility complex class I antigens in myositis. In particular, a recent study has strengthened the conclusion that major histocompatibility complex class I expression is highly specific to inflammatory myopathies and may be of diagnostic value. Two new studies have indicated that endoplasmic reticulum stress response pathway (the endoplasmic reticulum overload [NF-kB] and unfolded protein response [GRP78]) are highly activated in patients with myositis. One study using transgenic mice has further indicated that abnormal accumulation of major histocompatibility complex class I in the endoplasmic reticulum of muscle may be responsible for the initiation of this endoplasmic reticulum stress response. Furthermore, studies of normal muscle cells have shown that endoplasmic reticulum stress also plays an important role in skeletal muscle development. Investigations of autoantigen expression in myositis biopsies have revealed that regenerating muscle cells express high levels of autoantigens and major histocompatibility complex class I, indicating that these cells are the targets of cytotoxic T-cell attack and may participate in the initiation of a myositis-specific autoimmune response. SUMMARY:Defining the role of major histocompatibility complex class I in autoimmune myositis may be useful not only for diagnosis of this group of diseases but also for therapeutic opportunities for these difficult disorders.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Nagaraju Kdoi
10.1097/01.bor.0000179947.58271.9akeywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
725-30issue
6eissn
1040-8711issn
1531-6963pii
00002281-200511000-00007journal_volume
17pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:This review provides an update on recent findings with regards to the genetics of hyperuricemia and gout, including recent data from genome-wide association studies (GWAS). RECENT FINDINGS:Five GWAS around the same time reported that genetic variants of SLC2A9/GLUT9 were associated with lower serum u...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32833645e8
更新日期:2010-03-01 00:00:00
abstract::In the 2 years following menarche, bone mass increases substantially; this is an important new finding concerning peak bone mass. Studies of twins have given significant insights into the effect of heredity on bone mass. Many determinants of bone mass, bone gain, and bone loss thus have been characterized for people o...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199405000-00015
更新日期:1994-05-01 00:00:00
abstract::Neoplasia in an important cause of rheumatic disease. The mechanisms are either direct infiltration of the bone and joint, or indirect infiltration with manifestations distant from the site of neoplastic involvement. Many of the reports reviewed in this article center on direct associations. In particular, there is a ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199102000-00020
更新日期:1991-02-01 00:00:00
abstract::During the past year, another disease possibly influenced by intravenous gammaglobulin was identified as dermatomyositis/polymyositis. Additional studies provided further information regarding the use of monoclonal anti-CD4 antibody and combination therapy in rheumatoid arthritis, antithymocyte globulin in scleroderma...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199206000-00006
更新日期:1992-06-01 00:00:00
abstract:PURPOSE OF REVIEW:There has been a tremendous interest to understand the mechanisms that regulate gene expression in autoimmunity and their effect on disease phenotypes by exploring different epigenetic mechanisms. In this review, we will introduce lupus epigenetics through reviewing historical key findings, then we wi...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328364206f
更新日期:2013-09-01 00:00:00
abstract::Recent population-based studies have examined the incidence, prevalence, and survival rates of patients with psoriatic arthritis (PsA). Although there are still no completely satisfactory diagnostic criteria for PsA, Moll and Wright's criteria--although not a true classification/diagnostic scheme--are the most used. T...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199807000-00004
更新日期:1998-07-01 00:00:00
abstract::Osteoporosis occurs in patients with rheumatoid arthritis, acromegaly, anorexia nervosa, chronic liver disease, sickle cell hemoglobinopathies, and mastocytosis. Osteomalacia occurs in patients with renal tubular acidosis, and with tumors. ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199106000-00020
更新日期:1991-06-01 00:00:00
abstract::Inherited connective tissue disorders, among them Ehlers-Danlos syndrome, osteogenesis imperfecta, Marfan syndrome, and Larsen syndrome, are characterized by generalized joint hypermobility. Others, such as Morquio syndrome or achondroplasia, have hypermobility in a more limited distribution. Recent clinical and molec...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199609000-00012
更新日期:1996-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout. This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion. RECENT FINDINGS:The disco...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3282f33f87
更新日期:2008-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review addresses diagnostic methods for crystalline arthritis including synovial fluid analysis, ultrasound, and dual energy CT scan (DECT). RECENT FINDINGS:There are new technologies on the horizon to improve the ease, sensitivity, and specificity of synovial fluid analysis. Raman spectr...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000582
更新日期:2019-03-01 00:00:00
abstract::The number of reported cases of Lyme disease in the United States has increased steadily since 1982, and the increase coincides with a growth in deer populations in endemic regions. Application of careful epidemiologic principles has led to the identification of two new pathogens that produce syndromes closely related...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199707000-00010
更新日期:1997-07-01 00:00:00
abstract:PURPOSE OF REVIEW:An increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consequences of this ob...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32835c7e32
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:There is an increasing interest in improving the understanding of pathophysiology, outcome measures, and therapies of rheumatic skin disease. Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheum...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328333b9e2
更新日期:2010-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss syndrome) is a peculiar hybrid condition of a systemic antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and a hypereosinophilic disorder with frequent lung involvement that occurs in people with asthma. This review foc...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000015
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Blau syndrome is a monogenic disease resulting from mutations in nucleotide oligomerization domain 2 (NOD2) and is phenotypically characterized by granulomatous polyarthritis and uveitis. Not only there has been significant progress in disease characterization but also the biological pathways associat...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328349c430
更新日期:2011-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review provides an update on novel treatment strategies striving for remission in patients with recent onset of rheumatoid arthritis. RECENT FINDINGS:As early treatment is crucial to achieve optimal results, identifying patients with rheumatoid arthritis early is imperative to achieve cli...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3282fa13db
更新日期:2008-05-01 00:00:00
abstract::Arthropathy is one of the leading clinical manifestations of hereditary hemochromatosis (HH). Although cirrhosis of the liver is crucial for mortality in patients with HH, arthropathy has the greatest impact on the quality of life. Several mutations in the HFE and other genes have recently been identified, and the pre...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200101000-00013
更新日期:2001-01-01 00:00:00
abstract::New information on the treatment of juvenile rheumatoid arthritis emphasizes more aggressive control of arthritis, particularly the use of methotrexate, both in low- and higher-dose regimens. Information concerning drug toxicity, including that of the nonsteroidal anti-inflammatory drugs, second-line agents, and metho...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199305050-00011
更新日期:1993-09-01 00:00:00
abstract::In this review, we address current concepts and recent experimental results that relate to heterogeneity in the physiologic, biochemical, and morphologic properties of mammalian skeletal muscle fibers. Recent data reinforce some of these current concepts while questioning others. The biochemical bases of the concepts ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199305060-00002
更新日期:1993-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This article summarizes the current evidence on the management of primary and secondary central nervous system (CNS) vasculitis. RECENT FINDINGS:Two recent retrospective cohort studies have described the treatment and outcomes of patients with adult primary central nervous system vasculitis (PCNSV). ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000229
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To increase awareness and review the management of chronic viral hepatitis in individuals treated with immune-modifying agents to avoid potentially severe consequences. RECENT FINDINGS:Hepatitis B virus (HBV) reactivation has been reported with a wide variety of immunosuppressive regimens ranging fro...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000067
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review focuses on the new therapeutic opportunities offered by the combination of biological drugs, mainly Rituximab, with direct-acting antiviral agents (DAAs). RECENT FINDINGS:Hepatitis C virus (HCV) is known to be the etiologic agent in the majority of patients with mixed cryoglobuline...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000624
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize the recent literature on the association of infection with early arthritis, and to discuss the possible role of such infections with respect to the development of chronic rheumatic complications. RECENT FINDINGS:Viral infections are frequently associated with arthritis. Alphaviruses belo...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000166388.47604.8b
更新日期:2005-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent interest in gout has led to development of new drugs for acute gout and long-term urate-lowering, as well as interest in improving the use of older drugs. The patients' comorbidities and concomitant medications may contribute to the risk of adverse drug reactions with anti-gout therapies. This ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000031
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent developments in the nosology of primary systemic vasculitis are placed in the context of an historical overview. The ongoing attempts to develop criteria for classification and diagnosis are discussed. RECENT FINDINGS:Giant cell arteritis has supplanted temporal arteritis as the preferred term...
journal_title:Current opinion in rheumatology
pub_type: 历史文章,杂志文章,评审
doi:10.1097/BOR.0b013e3280119877
更新日期:2007-01-01 00:00:00
abstract::The recent literature pertaining to tumors of articular structures and bone is reviewed. In pigmented villonodular synovitis, the bone resorptive cell is a macrophage polykaryon rather than an osteoclast. Complete arthroscopic synovectomy was successful in most diffuse articular forms of the disease. The early synovia...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199305020-00012
更新日期:1993-03-01 00:00:00
abstract::Estimates of the prevalence and incidence of knee osteoarthritis increase with age and are higher for women. Other differences in such estimates arise due to methodologic variables, including radiographic techniques. The risk for knee osteoarthritis increases with increasing body weight, long-term occupational joint s...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1992-08-01 00:00:00
abstract::Recent studies have revealed the important role of streptococci in the etiology of Behçet's disease. Among patients with Behçet's disease, there is a high incidence of a history of streptococcal infections. Certain antigens of streptococci induced not only cutaneous, delayed-type hypersensitivity, but also systemic at...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1991-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Mesenchymal stromal/stem cells (MSCs) have potent anti-inflammatory and immunomodulatory properties, in addition to their ability to form cartilage and bone. The purpose of this review is to highlight recent developments and current knowledge gaps in our understanding of the protective effects of MSCs...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000370
更新日期:2017-03-01 00:00:00
abstract::Patients with inflammatory arthritides such as rheumatoid arthritis develop both localized and generalized osteoporosis and have an increased risk of fracture. Bone loss can occur early and is directly related to the inflammatory process as well as to the indirect effects of arthritis on physical activity. Corticoster...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199607000-00015
更新日期:1996-07-01 00:00:00