Epigenetics in the pathogenesis of systemic lupus erythematosus.

abstract：:Ankylosing spondylitis and IgA nephropathy share some immunologic features, eg, elevated serum IgA and IgA-immune complex levels. These entities are frequently found as being associated. IgA and IgA immune complex catabolism involves asialoglycoprotein receptors and specific IgA Fc receptors (FcalphaR or CD89) on tiss...

journal_title：Current opinion in rheumatology

authors： Montenegro V,Monteiro RC

更新日期：1999-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent literature in inflammatory myopathies suggests that both immune (cell-mediated and humoral) and nonimmune [endoplasmic reticulum (ER) stress and autophagy] mechanisms play a role in muscle fiber damage and dysfunction. This review describes these findings and discusses their relevance to diseas...

journal_title：Current opinion in rheumatology

authors： Henriques-Pons A,Nagaraju K

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Current trends in the management of Behçet's syndrome will be reviewed in this article. RECENT FINDINGS:Biologic agents have gained increasing importance over the years in the management of Behçet's syndrome. Long-term results of observational studies have shown that anti-tumor necrosis factor agents...

journal_title：Current opinion in rheumatology

authors： Ozguler Y,Hatemi G

更新日期：2016-01-01 00:00:00

abstract：:Behçet's disease and Takayasu's disease in children are uncommon and may have an insidious course leading to a delayed diagnosis. Both diseases usually occur in late childhood, although disease onset in the first year of life has been reported. Compared with adults, Behçet's disease in children appears to be character...

journal_title：Current opinion in rheumatology

authors： Martini A

更新日期：1995-09-01 00:00:00

abstract：:Arthropathy is one of the leading clinical manifestations of hereditary hemochromatosis (HH). Although cirrhosis of the liver is crucial for mortality in patients with HH, arthropathy has the greatest impact on the quality of life. Several mutations in the HFE and other genes have recently been identified, and the pre...

journal_title：Current opinion in rheumatology

authors： von Kempis J

更新日期：2001-01-01 00:00:00

abstract：:HLA-B27 is virtually absent in most of the sub-Saharan Africa populations, and ankylosing spondylitis is rare; only a few patients have been reported from central and southern Africa. HLA-B27 was present in only one of 17 patients (6%). The disease shows clinical features that are similar to those observed in white HL...

journal_title：Current opinion in rheumatology

authors： Mijiyawa M,Oniankitan O,Khan MA

更新日期：2000-07-01 00:00:00

abstract：:A polymyositis syndrome has been described as a rare complication in patients who develop chronic graft-versus-host disease after allogeneic bone marrow transplantation. Chronic graft-versus-host disease is a cellular immune-mediated donor bone marrow versus patient rejection reaction, which may also lead to an autoim...

journal_title：Current opinion in rheumatology

authors： Parker PM,Openshaw H,Forman SJ

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Infections have been suggested to contribute to disease induction and reactivation in many of the idiopathic vasculitides. This review describes and evaluates the evidence that microbes are involved in the etiopathogenesis of these diseases. RECENT FINDINGS:Large-vessel vasculitis has recently been a...

journal_title：Current opinion in rheumatology

authors： van Timmeren MM,Heeringa P,Kallenberg CG

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Rapid introduction of newly developed drugs in the absence of clear understanding of the pathophysiologic mechanisms behind drug-induced lupus erythematosus (DILE) can sometimes make DILE difficult to recognize in clinical practice. The purpose of this review is to summarize drugs most recently report...

journal_title：Current opinion in rheumatology

authors： He Y,Sawalha AH

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article was to review the recent contributions to the scoring methods of PET in vasculitis as well as to its role in the diagnostic work-up. RECENT FINDINGS:Both visual and semiquantitative scoring methods can be used to interpret PET scans. PET has been shown to be both sensitive and...

journal_title：Current opinion in rheumatology

authors： Pipitone NAM,Versari A,Salvarani C

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Parasitic worms have evolved strategies to manipulate the host immune system, some of which may lead to a reduction in inflammation. Characterisation of the ways in which these organisms mediate an anti-inflammatory response and identification of parasite-derived molecules involved in immune modulatio...

journal_title：Current opinion in rheumatology

authors： Cooke A

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Microscopic polyangiitis is defined within the context of primary systemic vasculitis. The presentation and management of renal involvement in microscopic polyangiitis is discussed, with emphasis on prognosis and outcomes. Potential roles of newer therapies are reviewed. RECENT FINDINGS:The histologi...

journal_title：Current opinion in rheumatology

authors： Jayne D

更新日期：2008-01-01 00:00:00

abstract：:Major changes have taken place in the diagnosis and treatment of rotator cuff tears. It seems that magnetic resonance imaging alone as a diagnostic tool is still not sensitive enough, particularly in the diagnosis of partial tears. Arthrography and arthroscopy are still considered essential for an accurate preoperativ...

journal_title：Current opinion in rheumatology

authors： Uhthoff HK

更新日期：1996-03-01 00:00:00

abstract：:Fibroblasts within the skin of scleroderma patients constitute a phenotypically heterogeneous population with regard to expression of collagens, cytokines, and cytokine receptors. By in situ hybridization techniques, scleroderma skin is shown to contain a subpopulation of fibroblasts that are stimulated for expression...

journal_title：Current opinion in rheumatology

authors： Unemori EN,Amento EP

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Exercise was established as an integral part of the nonpharmacological treatment of fibromyalgia approximately 20 years ago. Since then many studies have investigated the effects of exercise-either alone or in combination with other interventions. This review will discuss the benefits of exercise alon...

journal_title：Current opinion in rheumatology

authors： Gowans SE,deHueck A

更新日期：2004-03-01 00:00:00

abstract：:In the last few years, several novel strategies have been proposed for the treatment of rheumatoid arthritis (RA). Among them, gene therapy is considered a promising concept bearing the potential of highly specific targeting of relevant pathomechanisms. Early studies using gene transfer focused mainly on studying dise...

journal_title：Current opinion in rheumatology

authors： Pap T,Gay RE,Gay S

更新日期：2000-05-01 00:00:00

abstract：:Bacterial infections can clinically mimic a primary vasculitic syndrome and can directly cause a vasculitis that may respond to prompt recognition and treatment of the infection. Increasing direct and indirect evidence is establishing links between certain infections and vasculopathies, including aortitis, atheroscler...

journal_title：Current opinion in rheumatology

authors： Mandell BF,Calabrese LH

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent work has continued to clarify the role of major histocompatibility complex class I in the pathogenesis of autoimmune myositis. In the past year, several new observations have been made in this area. This review describes these findings and discusses their relevance to the pathogenesis of autoim...

journal_title：Current opinion in rheumatology

authors： Nagaraju K

更新日期：2005-11-01 00:00:00

abstract：:Nitric oxide (NO) and prostaglandin E2 (PGE2) are two pleiotropic inflammatory mediators overproduced in arthritis-affected joints. The inducible isoform of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are found both in the synovial tissue and in the cartilage. Their expression is regulated by catabolic cyt...

journal_title：Current opinion in rheumatology

authors： Amin AR,Attur M,Abramson SB

更新日期：1999-05-01 00:00:00

abstract：:The increased bone remodeling in women after menopause induces an imbalance between bone resorption and formation, leading to decreased bone mass, altered bone microarchitecture, and increased fracture risk. Current antiosteoporotic drugs decrease bone remodeling or increase bone formation. Strontium ranelate (Protelo...

journal_title：Current opinion in rheumatology

authors： Marie PJ

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Mesenchymal stromal/stem cells (MSCs) have potent anti-inflammatory and immunomodulatory properties, in addition to their ability to form cartilage and bone. The purpose of this review is to highlight recent developments and current knowledge gaps in our understanding of the protective effects of MSCs...

journal_title：Current opinion in rheumatology

authors： Ansboro S,Roelofs AJ,De Bari C

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Across the world, osteoarthritis is the most commonly occurring musculoskeletal disease of the elderly, affecting more than 25% of the population older than 60 years of age. By far the single greatest risk factor for the development of osteoarthritis is age, but a mechanism to explain this relation ha...

journal_title：Current opinion in rheumatology

authors： Verzijl N,Bank RA,TeKoppele JM,DeGroot J

更新日期：2003-09-01 00:00:00

abstract：:Neoplasia can be associated with a wide range of rheumatologic manifestations. Literature over the last 12 months has reviewed metastasis of solid tumors to the joint and hypertrophic pulmonary osteoarthropathy. Vasculitis has been reported as a paraneoplastic syndrome associated with both hematologic and solid malign...

journal_title：Current opinion in rheumatology

authors： Brooks PM

更新日期：1992-02-01 00:00:00

abstract：:The results of twin and family studies clearly implicate an important role for genetic factors in the etiology of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, the complex nature of these diseases has hampered progress in defining the genetic determinants. Recent advances in molecular gene...

journal_title：Current opinion in rheumatology

authors： Criswell LA,Amos CI

更新日期：2000-03-01 00:00:00

abstract：:The molecular mechanisms of the primary immunodeficiencies have been further explored and provide insights into the regulation of the immune response and its role in autoimmune disease, infection, and malignancy. The critical role of CD40-CD40 ligand-mediated effects in T cell-dependent B cell activation, shown throug...

journal_title：Current opinion in rheumatology

authors： Stein CM

更新日期：1996-01-01 00:00:00

abstract：:The spondyloarthropathies are diseases influenced by genetic predisposition and, to a varying extent, infectious triggers. A causal role for bacterial infections is most clear for reactive arthritis. Recent insights into arthritogenic components of bacteria may set the stage for a better understanding of disease patho...

journal_title：Current opinion in rheumatology

authors： Pacheco-Tena C,Zhang X,Stone M,Burgos-Vargas R,Inman RD

更新日期：2002-07-01 00:00:00

abstract：:The number of reported cases of Lyme disease in the United States has increased steadily since 1982, and the increase coincides with a growth in deer populations in endemic regions. Application of careful epidemiologic principles has led to the identification of two new pathogens that produce syndromes closely related...

journal_title：Current opinion in rheumatology

authors： Evans J

更新日期：1997-07-01 00:00:00

abstract：:The concept suggesting the involvement of the proinflammatory cytokine tumor necrosis factor (TNF)-alpha in the pathogenesis of rheumatoid arthritis (RA) has been demonstrated by several clinical trials targeting TNF-alpha. In addition to reduction of pain and swelling, a dramatic effect of TNF blocking therapies on t...

journal_title：Current opinion in rheumatology

authors： Graninger WB,Smolen JS

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Cryoglobulinemic vasculitis is an immune-complex-mediated systemic vasculitis involving small-medium-sized vessels. A causative role of hepatitis C virus in over 80% patients has been definitively established, with heterogeneous geographical distribution. This review focuses on recent etiopathogenetic...

journal_title：Current opinion in rheumatology

authors： Ferri C,Mascia MT

更新日期：2006-01-01 00:00:00

abstract：:Diffuse alveolar hemorrhage (DAH) is a rare yet serious and frequently life-threatening complication of a variety of conditions. DAH may result from coagulation disorders, inhaled toxins, or infections. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as antineutrophil cyt...

journal_title：Current opinion in rheumatology

authors： Specks U

更新日期：2001-01-01 00:00:00