Innate immunity in host-microbial interactions: beyond B27 in the spondyloarthropathies.

abstract：PURPOSE OF REVIEW:The purpose of this study is to review the evidence and recent developments leading to novel therapeutics in scleroderma. RECENT FINDINGS:Recent advances have been made in understanding the key pathogenetic aspects of scleroderma, and these have led to potential targeted therapeutic agents for the ma...

journal_title：Current opinion in rheumatology

authors： Ong VH,Denton CP

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental compo...

journal_title：Current opinion in rheumatology

authors： Asquith M,Rosenbaum JT

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Wound healing is a normal physiological response to tissue injury which can occur in any organ. Mechanisms that orchestrate wound healing in different organs are surprisingly generic, involving generation of fibroblasts and myofibroblasts by differentiation processes that require extensive alterations...

journal_title：Current opinion in rheumatology

authors： Mann J,Mann DA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The severity of each organ involvement, natural course, and response to therapies are extremely heterogeneous among patients with systemic sclerosis (SSc). The discovery and validation of biomarkers can help identify disease risk, improve early diagnosis and prognosis, better design clinical trials an...

journal_title：Current opinion in rheumatology

authors： Manetti M

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The utility of cytokines as therapeutic targets in rheumatoid arthritis has been unequivocally demonstrated by the success of tumour necrosis factor blockade in clinical practice. Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive ...

journal_title：Current opinion in rheumatology

authors： Asquith DL,McInnes IB

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine recent developments relating to cardiac involvement in the adult idiopathic inflammatory myopathies (IIM) and those inherited muscle diseases which may present in adulthood and mimic IIM. RECENT FINDINGS:Cardiac involvement is a common feature of IIM and inherited muscle diseases. Frequenc...

journal_title：Current opinion in rheumatology

authors： Lilleker JB,Roberts M,Diederichsen L

更新日期：2020-11-01 00:00:00

abstract：:Cytokines and growth factors are important in bone tissue as mediators of cell-to-cell and matrix-to-cell communication. Cytokines also locally mediate the effects of several hormones on bone cells. Indeed, calciotropic hormones modulate the bone-cell production rate of these factors and, conversely, can change the nu...

journal_title：Current opinion in rheumatology

authors： de Vernejoul MC,Cohen-Solal M,Orcel P

更新日期：1993-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Idiopathic inflammatory myopathy is characterized by the production of autoantibodies to various cellular constituents. These autoantibodies closely correlate with certain clinical conditions and prognosis of disease. This review examines recent progress in myositis-specific autoantibodies, particular...

journal_title：Current opinion in rheumatology

authors： Mimori T,Imura Y,Nakashima R,Yoshifuji H

更新日期：2007-11-01 00:00:00

abstract：:Methotrexate has become a standard therapy for the treatment of rheumatoid arthritis. This review summarizes the recent literature on low-dose methotrexate in the rheumatologic illnesses. The effect of methotrexate on in vivo rheumatoid factor production and suppression of ex vivo leukotriene B4 generation is reviewed...

journal_title：Current opinion in rheumatology

authors： Grosflam J,Weinblatt ME

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) pathogenesis is complex. Aberrancies of immune function that previously were described but not well understood are now becoming better characterized, in part through recognition of monogenic cases of lupus-like disease. RECENT FINDINGS:We highlight here recent descr...

journal_title：Current opinion in rheumatology

authors： Lo MS,Tsokos GC

更新日期：2018-03-01 00:00:00

abstract：:In 1990, there were signs of a renewed interest in clinical studies about several aspects of osteoarthritis. The work-up of classic data and the use of new information from epidemiologic surveys as well as careful radiographic monitoring of selected groups of patients have brought us broader views on the general cours...

journal_title：Current opinion in rheumatology

authors： Peyron JG

更新日期：1991-08-01 00:00:00

abstract：:Idiopathic inflammatory myositis in children includes multiple disease entities, but is primarily made up of juvenile dermatomyositis and, to a lesser degree, juvenile polymyositis. Much new information has been published in the last few years about these diseases, including the epidemiology, pathogenesis, clinical di...

journal_title：Current opinion in rheumatology

authors： Reed AM

更新日期：2001-09-01 00:00:00

abstract：:Inherited connective tissue disorders, among them Ehlers-Danlos syndrome, osteogenesis imperfecta, Marfan syndrome, and Larsen syndrome, are characterized by generalized joint hypermobility. Others, such as Morquio syndrome or achondroplasia, have hypermobility in a more limited distribution. Recent clinical and molec...

journal_title：Current opinion in rheumatology

authors： Raff ML,Byers PH

更新日期：1996-09-01 00:00:00

abstract：:Recent studies have revealed the important role of streptococci in the etiology of Behçet's disease. Among patients with Behçet's disease, there is a high incidence of a history of streptococcal infections. Certain antigens of streptococci induced not only cutaneous, delayed-type hypersensitivity, but also systemic at...

journal_title：Current opinion in rheumatology

authors： Mizushima Y

更新日期：1991-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To review radiographic and MRI developments in measuring osteoarthritis progression in the tibiofemoral compartment of the knee. RECENT FINDINGS:Standardized techniques for measuring joint space width in the medial tibiofemoral compartment, using standardized radiographic protocols, have become accep...

journal_title：Current opinion in rheumatology

authors： Hunter DJ,Le Graverand MP,Eckstein F

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Two diseases associated with chronic kidney disease (CKD) have benefited from advances in the past year which are of great importance for rheumatologists: renal osteodystrophy, which is now clearly associated with vascular calcification and cardiovascular death, and nephogenic systemic fibrosis, which...

journal_title：Current opinion in rheumatology

authors： Bardin T,Richette P

更新日期：2009-01-01 00:00:00

abstract：:Information detailing the socioeconomic impact of the vasculitides on society has been difficult to obtain. Recent published studies provide preliminary information suggesting that the impact of systemic vasculitis may be significant and far greater than previously anticipated. A rough estimate of expenditures for vas...

journal_title：Current opinion in rheumatology

authors： Cotch MF

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines thresholds for treatment of traditional cardiovascular disease (CVD) risk factors among patients with rheumatoid arthritis (RA) and whether RA-specific treatment modulates cardiovascular risk. RECENT FINDINGS:There are substantial data demonstrating an increased CVD risk among pa...

journal_title：Current opinion in rheumatology

authors： Barbhaiya M,Solomon DH

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in pulmonary hypertension, a leading cause of morbidity and mortality in scleroderma (SSc). RECENT FINDINGS:Although WHO Group I pulmonary arterial hypertension (PAH) is the most common cause of pulmonary hypertension, all WHO Groups can occur. PAH is now a crit...

journal_title：Current opinion in rheumatology

authors： Highland KB

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In contrast to the disease remission enjoyed by a majority of rheumatoid arthritis (RA) patients during pregnancy, the immediate postpartum period is generally characterized by flare. Managing symptoms during this time is challenging because the potential transfer of medication into the breast milk of...

journal_title：Current opinion in rheumatology

authors： Sammaritano LR,Bermas BL

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant advances in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis have been made in the past 10 years. This review aims to detail advances in treatment aimed at induction of remission. RECENT FINDINGS:Cyclophosphamide-based regimes remain the standard of care, at leas...

journal_title：Current opinion in rheumatology

authors： Harper L

更新日期：2010-01-01 00:00:00

abstract：:Connective tissue diseases (CTDs) frequently present with one or only a few symptoms, which does not allow prompt diagnosis. Raynaud's phenomenon is one of those symptoms. However, only a minority of patients who present with Raynaud's phenomenon develop a CTD. Prognostic factors for the future development of CTD in s...

journal_title：Current opinion in rheumatology

authors： Kallenberg CG

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review focuses on the most significant recent findings regarding selective estrogen receptor modulators (SERMs) and selective androgen receptor modulators (SARMs). SERMs, which interact with estrogen receptor-alpha and estrogen receptor-beta in multiple tissues, continue to generate clinic...

journal_title：Current opinion in rheumatology

authors： Clarke BL,Khosla S

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on proteinase 3 (PR3), the preferred target of antineutrophil cytoplasmic antibodies (ANCAs) in Wegener's granulomatosis. Deciphering the molecular associations that PR3 can make with its cognate partners might help to understand its pathophysiological significance in Wegener's gra...

journal_title：Current opinion in rheumatology

authors： Witko-Sarsat V,Reuter N,Mouthon L

更新日期：2010-01-01 00:00:00

abstract：:Raloxifene, a selective estrogen receptor modulator, is currently used for both prevention and treatment of postmenopausal osteoporosis. Recent data from the MORE (Multiple Outcomes of Raloxifene Evaluation) trial have evaluated health-related quality of life, 1-year clinical vertebral fracture reduction, and the corr...

journal_title：Current opinion in rheumatology

authors： Gluck O,Maricic M

更新日期：2002-07-01 00:00:00

abstract：:Systemic lupus erythematosus and Sjögren syndrome remain elusive in the description of their underlying etiologic causes and pathogenic mechanisms. Although underlying genetic predisposition appears to contribute to both diseases based on twin and other genetic studies, additional factors must play a role. Over the de...

journal_title：Current opinion in rheumatology

authors： James JA,Harley JB,Scofield RH

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease characterized by IgG-autoantibodies to nuclear antigens that can deposit in the kidney and trigger lupus nephritis. Neutrophils accumulate in the kidneys of patients with proliferative LUPUS NEPHRITIS and neutrophil products and a s...

journal_title：Current opinion in rheumatology

authors： Nishi H,Mayadas TN

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to discuss the mechanisms of central and peripheral tolerance in relation to T-cell mediated autoimmunity in rheumatoid arthritis (RA). RECENT FINDINGS:The well established association between major histocompatibility complex class II and RA has led us to understand that...

journal_title：Current opinion in rheumatology

authors： Cosway E,Anderson G,Garside P,Prendergast C

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Although 6 years have elapsed since the initial report describing the presence of microchimeric cells in affected tissues from patients with systemic sclerosis, a mechanism by which these cells might contribute to the pathogenesis of the disease is still unknown. This article reviews the published lit...

journal_title：Current opinion in rheumatology

authors： Jimenez SA,Artlett CM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:There are currently several available biologics for rheumatoid arthritis (RA) with similar efficacy in most trials. A major consideration therefore in choosing a biologic, continues to be safety concerns such as infection. Considerable advances have been made in the understanding of biologic safety on...

journal_title：Current opinion in rheumatology

authors： Jani M,Barton A,Hyrich K

更新日期：2019-05-01 00:00:00