Recent advances to achieve remission induction in antineutrophil cytoplasmic antibody-associated vasculitis.

abstract：PURPOSE OF REVIEW:The autoinflammatory diseases are a group of conditions that include the hereditary fever syndromes, and result from upregulated innate immune responses. The discovery of the genetic basis for these conditions led to the description of novel intracellular receptors for infectious and noninfectious dan...

journal_title：Current opinion in rheumatology

authors： Ryan JG,Goldbach-Mansky R

更新日期：2008-01-01 00:00:00

abstract：:Interstitial lung disease frequently complicates rheumatic disorders, especially polymyositis-dermatomyositis, rheumatoid arthritis, systemic sclerosis, and mixed connective tissue disease. In this article, we review the current data supporting the use of azathioprine, cyclophosphamide, chlorambucil, cyclosporine, and...

journal_title：Current opinion in rheumatology

authors： McCune WJ,Vallance DK,Lynch JP 3rd

更新日期：1994-05-01 00:00:00

abstract：:The emergence of various therapeutic possibilities in the field of osteoarthritis has strongly prompted clinicians to conduct studies to evaluate the symptomatic as well as the potential chondromodulating effects of these treatments. For this purpose, some authors recently proposed guidelines with regard not only to t...

journal_title：Current opinion in rheumatology

authors： Dougados M

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to evaluate recent trials and studies of different types of physical activity programs for individuals with chronic arthritis and to discuss recommendations and findings from systematic reviews of physical activity interventions. RECENT FINDINGS:Recent randomized control...

journal_title：Current opinion in rheumatology

authors： Callahan LF

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will explore two new aspects of the involvement of viruses in multiple sclerosis pathogenesis. The first aspect is the complex interactions between viruses. The second aspect is the proposal of a mechanism by which autoreactive T cells are able to escape thymic selection and potentially re...

journal_title：Current opinion in rheumatology

authors： Cusick MF,Libbey JE,Fujinami RS

更新日期：2013-07-01 00:00:00

abstract：:A polymyositis syndrome has been described as a rare complication in patients who develop chronic graft-versus-host disease after allogeneic bone marrow transplantation. Chronic graft-versus-host disease is a cellular immune-mediated donor bone marrow versus patient rejection reaction, which may also lead to an autoim...

journal_title：Current opinion in rheumatology

authors： Parker PM,Openshaw H,Forman SJ

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:There are currently several available biologics for rheumatoid arthritis (RA) with similar efficacy in most trials. A major consideration therefore in choosing a biologic, continues to be safety concerns such as infection. Considerable advances have been made in the understanding of biologic safety on...

journal_title：Current opinion in rheumatology

authors： Jani M,Barton A,Hyrich K

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In contrast to the disease remission enjoyed by a majority of rheumatoid arthritis (RA) patients during pregnancy, the immediate postpartum period is generally characterized by flare. Managing symptoms during this time is challenging because the potential transfer of medication into the breast milk of...

journal_title：Current opinion in rheumatology

authors： Sammaritano LR,Bermas BL

更新日期：2014-05-01 00:00:00

abstract：:The Achilles tendon is the strongest tendon in the human body. Because most Achilles tendon injuries take place in sports and there has been an common upsurge in sporting activities, the number and incidence of the Achilles tendon overuse injuries and complete ruptures have increased in the industrialized countries du...

journal_title：Current opinion in rheumatology

authors： Järvinen TA,Kannus P,Paavola M,Järvinen TL,Józsa L,Järvinen M

更新日期：2001-03-01 00:00:00

abstract：:In the United States, Lyme disease is the most common arthropod-borne infection. The majority of cases are reported from the Northeast, the Midwest, and California, which are areas with established foci of Borrelia burgdorferi. Advances in the understanding of the epidemiology of Ixodes ticks, the established vector f...

journal_title：Current opinion in rheumatology

authors： Evans J

更新日期：1995-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the spectrum of nonautoimmune myopathies that may be misdiagnosed as autoimmune myopathy. RECENT FINDINGS:Inherited myopathies, such as dysferlinopathy, calpainopathy, and facioscapulohumeral dystrophy may be misdiagnosed as autoimmune myopathy, especially when they have inflammatory muscl...

journal_title：Current opinion in rheumatology

authors： Mammen AL

更新日期：2017-11-01 00:00:00

abstract：:During the past 2 years, four papers describing new research studies and three papers reviewing the literature were published. These seven papers address longstanding issues, including 1) the presence or absence of cognitive impairment in systemic lupus erythematosus (SLE), 2) the prevalence of such impairment within ...

journal_title：Current opinion in rheumatology

authors： Bleiberg J,Bunning R

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the present state of efforts at registry implementation which exist internationally. These efforts are contrasted with those in the USA. RECENT FINDINGS:The implications of the different data which are derived from diverse registry sources are discussed. The need for long-term ...

journal_title：Current opinion in rheumatology

authors： Kremer JM,Gibofsky A,Greenberg JD

更新日期：2008-03-01 00:00:00

abstract：:Behçet's disease and Takayasu's disease in children are uncommon and may have an insidious course leading to a delayed diagnosis. Both diseases usually occur in late childhood, although disease onset in the first year of life has been reported. Compared with adults, Behçet's disease in children appears to be character...

journal_title：Current opinion in rheumatology

authors： Martini A

更新日期：1995-09-01 00:00:00

abstract：:Autoantibodies in systemic lupus erythematosus (SLE) are targeted predominantly to intracellular nucleoprotein particles. Following analysis of the quantitative and qualitative properties of the humoral immune response as well as identification of the major particles recognized as antigens, current studies are address...

journal_title：Current opinion in rheumatology

authors： Elkon K

更新日期：1995-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The incidence and mortality of cardiovascular disease are increased in the context of rheumatoid arthritis. The purpose of this review is to examine our evolving understanding of the pathogenesis of cardiovascular disease in rheumatoid arthritis and to underscore the importance of tailored prevention ...

journal_title：Current opinion in rheumatology

authors： Snow MH,Mikuls TR

更新日期：2005-05-01 00:00:00

abstract：:Eosinophilic infiltration into skeletal muscle, although rare, has been described in a diverse group of conditions. It most commonly occurs in parasitic infection as focal eosinophilic myositis but can be a feature of systemic hypereosinophilic conditions such as eosinophilia-myalgia syndrome and idiopathic hypereosin...

journal_title：Current opinion in rheumatology

authors： Pickering MC,Walport MJ

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The utility of cytokines as therapeutic targets in rheumatoid arthritis has been unequivocally demonstrated by the success of tumour necrosis factor blockade in clinical practice. Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive ...

journal_title：Current opinion in rheumatology

authors： Asquith DL,McInnes IB

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on proteinase 3 (PR3), the preferred target of antineutrophil cytoplasmic antibodies (ANCAs) in Wegener's granulomatosis. Deciphering the molecular associations that PR3 can make with its cognate partners might help to understand its pathophysiological significance in Wegener's gra...

journal_title：Current opinion in rheumatology

authors： Witko-Sarsat V,Reuter N,Mouthon L

更新日期：2010-01-01 00:00:00

abstract：:Acute bacterial arthritis continues to be a common occurrence, and despite improved treatment regimens, the prognosis has not improved significantly over the past 20 years. During the past year, the emergence of unique predisposing factors for bacterial arthritis, including prosthetic joints and HIV infection, were em...

journal_title：Current opinion in rheumatology

authors： Goldenberg DL

更新日期：1994-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic sclerosis, or scleroderma, is a systemic autoimmune disease manifest by vascular damage and fibrosis within the skin and visceral organs. Whereas scleroderma is a heterogenous disorder in terms of disease symptoms and clinical course, scleroderma-specific autoantibody profiles associate stron...

journal_title：Current opinion in rheumatology

authors： Harris ML,Rosen A

更新日期：2003-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The spectrum of periodic fever syndromes (PFS)/autoinflammation diseases is continuously expanding. This review provides an overview of the primary research and an update on the main clinical developments in these disorders published in the past 12-18 months. RECENT FINDINGS:IL-1β is pivotal to the p...

journal_title：Current opinion in rheumatology

authors： Savic S,Dickie LJ,Battellino M,McDermott MF

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Inclusion body myositis (IBM) is a poorly understood autoimmune and degenerative disorder of skeletal muscle. Here, pathophysiological and diagnostic biomarkers of IBM are reviewed. RECENT FINDINGS:Muscle histopathological biomarkers have been successful in stimulating the study of IBM pathophysiolog...

journal_title：Current opinion in rheumatology

authors： Greenberg SA

更新日期：2013-11-01 00:00:00

abstract：:Significant advances were made this year in the understanding of serum amyloid A isotypes and in the definition of different amyloid light-chain proteins. Increasing numbers of hereditary amyloid-related transthyretin mutations have been reported (more than 30 to date). Two new hereditary amyloid proteins in several d...

journal_title：Current opinion in rheumatology

authors： Cohen AS

更新日期：1994-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses genomic investigations in ankylosing spondylitis (AS) beyond genome-wide association (GWA) studies, but prior to this, genetic variants achieving genome-wide significance will be summarized highlighting key pathways contributing to disease pathogenesis. RECENT FINDINGS:Evidence...

journal_title：Current opinion in rheumatology

authors： O'Rielly DD,Uddin M,Rahman P

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent evidence for infection rates in patients with systemic vasculitides, the role of specific infectious agents in the pathogenesis of vasculitis and recent breakthroughs in the treatment of virus-associated vasculitides. RECENT FINDINGS:In well designed recent studies, infections were f...

journal_title：Current opinion in rheumatology

authors： Thomas K,Vassilopoulos D

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Wound healing is a normal physiological response to tissue injury which can occur in any organ. Mechanisms that orchestrate wound healing in different organs are surprisingly generic, involving generation of fibroblasts and myofibroblasts by differentiation processes that require extensive alterations...

journal_title：Current opinion in rheumatology

authors： Mann J,Mann DA

更新日期：2013-01-01 00:00:00

abstract：:Estimates of the prevalence and incidence of knee osteoarthritis increase with age and are higher for women. Other differences in such estimates arise due to methodologic variables, including radiographic techniques. The risk for knee osteoarthritis increases with increasing body weight, long-term occupational joint s...

journal_title：Current opinion in rheumatology

authors： Slemenda CW

更新日期：1992-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Rheumatoid arthritis (RA) is a potentially destructive disease with profound impact on patients' function and quality of life. Newer therapeutic agents have revolutionized outcomes but have not resulted in best outcomes for all patients. In this article, we will review recent progress in the developme...

journal_title：Current opinion in rheumatology

authors： Bykerk VP,Schoels MM

更新日期：2013-05-01 00:00:00

abstract：:Advances in molecular biologic techniques and the availability of novel immunologic reagents have allowed new approaches to understanding the pathogenesis of human autoimmune diseases, including the idiopathic inflammatory myopathies. Indirect evidence that autoreactive T cells mediate muscle inflammation in the human...

journal_title：Current opinion in rheumatology

authors： O'Hanlon TP,Miller FW

更新日期：1995-11-01 00:00:00