Eosinophilic myopathic syndromes.

abstract：PURPOSE OF REVIEW:We aim to give an overview of the recent progress in the knowledge of the genetic component of vasculitides. RECENT FINDINGS:Using a state-of-the-art imputation method to analyse the major histocompatibility complex (MHC) region, Ombrello and colleagues narrowed down the association between human leu...

journal_title：Current opinion in rheumatology

authors： Carmona FD,Martín J,González-Gay MA

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Idiopathic inflammatory myopathy is characterized by the production of autoantibodies to various cellular constituents. These autoantibodies closely correlate with certain clinical conditions and prognosis of disease. This review examines recent progress in myositis-specific autoantibodies, particular...

journal_title：Current opinion in rheumatology

authors： Mimori T,Imura Y,Nakashima R,Yoshifuji H

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent work has continued to clarify the role of major histocompatibility complex class I in the pathogenesis of autoimmune myositis. In the past year, several new observations have been made in this area. This review describes these findings and discusses their relevance to the pathogenesis of autoim...

journal_title：Current opinion in rheumatology

authors： Nagaraju K

更新日期：2005-11-01 00:00:00

abstract：:Animal models of systemic connective tissue diseases have provided valuable insights into the causative mechanisms and the pathogenesis of these diseases, and have provided the means to test potentially useful therapeutic interventions. Although numerous animal models for systemic sclerosis (SSc) have been described, ...

journal_title：Current opinion in rheumatology

authors： Jimenez SA,Christner PJ

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent developments in the nosology of primary systemic vasculitis are placed in the context of an historical overview. The ongoing attempts to develop criteria for classification and diagnosis are discussed. RECENT FINDINGS:Giant cell arteritis has supplanted temporal arteritis as the preferred term...

journal_title：Current opinion in rheumatology

authors： Jennette JC,Falk RJ

更新日期：2007-01-01 00:00:00

abstract：:Information detailing the socioeconomic impact of the vasculitides on society has been difficult to obtain. Recent published studies provide preliminary information suggesting that the impact of systemic vasculitis may be significant and far greater than previously anticipated. A rough estimate of expenditures for vas...

journal_title：Current opinion in rheumatology

authors： Cotch MF

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article provides an update on the recent findings on autoantibodies to modified proteins in rheumatoid arthritis (RA). RECENT FINDINGS:In the past few years, the knowledge on the autoantibodies to citrullinated antigens has expanded considerably. More specifically, it is now clear that many diff...

journal_title：Current opinion in rheumatology

authors： Toes RE,Huizinga TJ

更新日期：2015-05-01 00:00:00

abstract：:A polymyositis syndrome has been described as a rare complication in patients who develop chronic graft-versus-host disease after allogeneic bone marrow transplantation. Chronic graft-versus-host disease is a cellular immune-mediated donor bone marrow versus patient rejection reaction, which may also lead to an autoim...

journal_title：Current opinion in rheumatology

authors： Parker PM,Openshaw H,Forman SJ

更新日期：1997-11-01 00:00:00

abstract：:Refinement of criteria for classifying childhood rheumatic diseases has contributed to earlier, more complete, and more precise diagnosis of children with spondyloarthropathies. Recent additions to the literature have contributed new international perspectives relating to the prevalence of juvenile spondyloarthropathi...

journal_title：Current opinion in rheumatology

authors： Rosenberg AM

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine recent developments relating to cardiac involvement in the adult idiopathic inflammatory myopathies (IIM) and those inherited muscle diseases which may present in adulthood and mimic IIM. RECENT FINDINGS:Cardiac involvement is a common feature of IIM and inherited muscle diseases. Frequenc...

journal_title：Current opinion in rheumatology

authors： Lilleker JB,Roberts M,Diederichsen L

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The spectrum of periodic fever syndromes (PFS)/autoinflammation diseases is continuously expanding. This review provides an overview of the primary research and an update on the main clinical developments in these disorders published in the past 12-18 months. RECENT FINDINGS:IL-1β is pivotal to the p...

journal_title：Current opinion in rheumatology

authors： Savic S,Dickie LJ,Battellino M,McDermott MF

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) pathogenesis is complex. Aberrancies of immune function that previously were described but not well understood are now becoming better characterized, in part through recognition of monogenic cases of lupus-like disease. RECENT FINDINGS:We highlight here recent descr...

journal_title：Current opinion in rheumatology

authors： Lo MS,Tsokos GC

更新日期：2018-03-01 00:00:00

abstract：:Due to our increasing knowledge of mechanisms underlying pathogenic events in autoimmune rheumatic diseases, biologic agents have been further explored and tested in open and controlled clinical trials. Based on the results of placebo-controlled trials, monoclonal antibodies to CD4+ T cells have been found ineffective...

journal_title：Current opinion in rheumatology

authors： Kalden JR,Manger B

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The article reviews recent advances in the research of fractures in patients with systemic lupus erythematosus (SLE), highlighting their clinical, scientific, and economic impact. RECENT FINDINGS:Recent studies demonstrated an increased incidence of osteoporosis and symptomatic fractures in patients ...

journal_title：Current opinion in rheumatology

authors： Bultink IE,Lems WF

更新日期：2016-07-01 00:00:00

abstract：:Organ transplantation offers new life to patients who suffer from incurable disease. The problem of rejection of the transplanted organ has been overcome with the use of potent immunosuppressive drugs. These drugs, although they allow graft tolerance and graft survival, also are associated with complications such as o...

journal_title：Current opinion in rheumatology

authors： Epstein S,Shane E,Bilezikian JP

更新日期：1995-05-01 00:00:00

abstract：:In this review, we address current concepts and recent experimental results that relate to heterogeneity in the physiologic, biochemical, and morphologic properties of mammalian skeletal muscle fibers. Recent data reinforce some of these current concepts while questioning others. The biochemical bases of the concepts ...

journal_title：Current opinion in rheumatology

authors： Talmadge RJ,Roy RR,Edgerton VR

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review focuses on the most significant recent findings regarding selective estrogen receptor modulators (SERMs) and selective androgen receptor modulators (SARMs). SERMs, which interact with estrogen receptor-alpha and estrogen receptor-beta in multiple tissues, continue to generate clinic...

journal_title：Current opinion in rheumatology

authors： Clarke BL,Khosla S

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Raynaud phenomenon is the earliest and most common clinical manifestations of scleroderma (systemic sclerosis). Therefore, Raynaud phenomenon offers the best window into the investigation of the early steps in the pathogenesis of systemic sclerosis. This review focuses on the differential diagnosis of...

journal_title：Current opinion in rheumatology

authors： Kahaleh MB

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To give an overview of recently published articles addressing the mechanisms underlying sex bias in autoimmune disease. RECENT FINDINGS:Recent studies investigating the origins of sex bias in autoimmune disease have revealed an extensive and interconnected network of genetic, hormonal, microbial, and...

journal_title：Current opinion in rheumatology

authors： Billi AC,Kahlenberg JM,Gudjonsson JE

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout. This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion. RECENT FINDINGS:The disco...

journal_title：Current opinion in rheumatology

authors： Taniguchi A,Kamatani N

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:There are currently several available biologics for rheumatoid arthritis (RA) with similar efficacy in most trials. A major consideration therefore in choosing a biologic, continues to be safety concerns such as infection. Considerable advances have been made in the understanding of biologic safety on...

journal_title：Current opinion in rheumatology

authors： Jani M,Barton A,Hyrich K

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review focuses on the new therapeutic opportunities offered by the combination of biological drugs, mainly Rituximab, with direct-acting antiviral agents (DAAs). RECENT FINDINGS:Hepatitis C virus (HCV) is known to be the etiologic agent in the majority of patients with mixed cryoglobuline...

journal_title：Current opinion in rheumatology

authors： Roccatello D,Fenoglio R,Sciascia S

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Renal complications are important in scleroderma (systemic sclerosis) and include scleroderma renal crisis. This is a medical emergency that requires careful management. Recent cohort studies have highlighted key aspects of management and outcome and these are reviewed. RECENT FINDINGS:Two recent art...

journal_title：Current opinion in rheumatology

authors： Penn H,Denton CP

更新日期：2008-11-01 00:00:00

abstract：:Idiopathic inflammatory myositis in children includes multiple disease entities, but is primarily made up of juvenile dermatomyositis and, to a lesser degree, juvenile polymyositis. Much new information has been published in the last few years about these diseases, including the epidemiology, pathogenesis, clinical di...

journal_title：Current opinion in rheumatology

authors： Reed AM

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Autoimmune pancreatitis (AIP) is a peculiar type of pancreatitis with a presumed autoimmune etiology. AIP is frequently associated with stenosis of the bile duct in the form of IgG4-related sclerosing cholangitis. This article reviews recent advances in clinicopathological findings for AIP and IgG4-re...

journal_title：Current opinion in rheumatology

authors： Takuma K,Kamisawa T,Igarashi Y

更新日期：2011-01-01 00:00:00

abstract：:In this review, recent data relevant to better understanding of the immunogenetics of the spondyloarthropathies are discussed or, in a somewhat broader sense, the HLA-B27 disease associations. Although in 1993 much more is known about the B27 molecule than was known in 1992, its contribution to the pathogenesis of dis...

journal_title：Current opinion in rheumatology

authors： Ivanyi P

更新日期：1993-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Although 6 years have elapsed since the initial report describing the presence of microchimeric cells in affected tissues from patients with systemic sclerosis, a mechanism by which these cells might contribute to the pathogenesis of the disease is still unknown. This article reviews the published lit...

journal_title：Current opinion in rheumatology

authors： Jimenez SA,Artlett CM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss pathology-based characterization and classification of acquired immune and inflammatory myopathies (IIMs). RECENT FINDINGS:Several types of IIMs do not fit well into the typical IIM subclassifications: dermatomyositis, polymyositis and inclusion body myositis (IBM). Myopathologic features ...

journal_title：Current opinion in rheumatology

authors： Pestronk A

更新日期：2011-11-01 00:00:00

abstract：:Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antinuclear antibodies (ANAs), including pathogenic specificities to DNA. As shown by recent research, ANA production is a genetically determined process in which self antigens drive B and T cells that have escaped the normal mechanisms o...

journal_title：Current opinion in rheumatology

authors： Pisetsky DS

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease characterized by IgG-autoantibodies to nuclear antigens that can deposit in the kidney and trigger lupus nephritis. Neutrophils accumulate in the kidneys of patients with proliferative LUPUS NEPHRITIS and neutrophil products and a s...

journal_title：Current opinion in rheumatology

authors： Nishi H,Mayadas TN

更新日期：2019-03-01 00:00:00