Clinical assessment of osteoarthritis in clinical trials.

abstract：:Recent studies have revealed the important role of streptococci in the etiology of Behçet's disease. Among patients with Behçet's disease, there is a high incidence of a history of streptococcal infections. Certain antigens of streptococci induced not only cutaneous, delayed-type hypersensitivity, but also systemic at...

journal_title：Current opinion in rheumatology

authors： Mizushima Y

更新日期：1991-02-01 00:00:00

abstract：:New information on the treatment of juvenile rheumatoid arthritis emphasizes more aggressive control of arthritis, particularly the use of methotrexate, both in low- and higher-dose regimens. Information concerning drug toxicity, including that of the nonsteroidal anti-inflammatory drugs, second-line agents, and metho...

journal_title：Current opinion in rheumatology

authors： Emery HM

更新日期：1993-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To present an updated summary of the relationship between joint shape and the development of osteoarthritis, with a particular focus on osteoarthritis of the hip. RECENT FINDINGS:Osteoarthritis of the hip is highly heritable, with a genetic contribution estimated at 60%. Among the genes that have bee...

journal_title：Current opinion in rheumatology

authors： Baker-LePain JC,Lane NE

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) pathogenesis is complex. Aberrancies of immune function that previously were described but not well understood are now becoming better characterized, in part through recognition of monogenic cases of lupus-like disease. RECENT FINDINGS:We highlight here recent descr...

journal_title：Current opinion in rheumatology

authors： Lo MS,Tsokos GC

更新日期：2018-03-01 00:00:00

abstract：:In this review, four areas are discussed: fluoroquinolone-induced tendinitis, volar flexor tenosynovitis (trigger finger), Achilles tendon lesions, and occupational medicine issues. The relationship of fluoroquinolone treatment to musculoskeletal lesions, especially Achilles tendinitis and tear, is most intriguing. Th...

journal_title：Current opinion in rheumatology

authors： Biundo JJ Jr,Mipro RC Jr,Fahey P

更新日期：1997-03-01 00:00:00

abstract：:Recent findings suggest that biologic, psychologic, and social variables interact to determine an individual's response to rheumatic disease. Data indicate that specific coping responses and quality of social support modulate the psychosocial impact of the disease. Additional current developments are 1) an increased e...

journal_title：Current opinion in rheumatology

authors： Wegener ST

更新日期：1991-04-01 00:00:00

abstract：:Assessment of children and adults with rheumatic diseases, both in clinical practice and controlled clinical trials in rheumatology, has traditionally focused on the measurement of disease activity. More recently emphasis has been placed on the need to incorporate estimates of physical, social, and mental functioning ...

journal_title：Current opinion in rheumatology

authors： Duffy CM,Duffy KN

更新日期：1997-09-01 00:00:00

abstract：:Over the past year, many reports have been published on a variety of clinical manifestations related to antiphospholipid antibodies. The low prevalence of anticardiolipin antibodies with the rare occurrence of thrombosis and a low rate of fetal loss in studies in Malaysia and China showed a potential role for local fa...

journal_title：Current opinion in rheumatology

authors： Sugai S

更新日期：1992-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Rapid introduction of newly developed drugs in the absence of clear understanding of the pathophysiologic mechanisms behind drug-induced lupus erythematosus (DILE) can sometimes make DILE difficult to recognize in clinical practice. The purpose of this review is to summarize drugs most recently report...

journal_title：Current opinion in rheumatology

authors： He Y,Sawalha AH

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) and Sjogren's syndrome are chronic inflammatory diseases characterized by the dysfunction of T cells, B cells, and dendritic cells and the production of antinuclear autoantibodies. Here, we evaluate newly discovered molecular and cellular targets for the treatment of...

journal_title：Current opinion in rheumatology

authors： Perl A

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To critically appraise the literature related to the pathophysiology of rheumatoid arthritis (RA) focusing on the contribution of synovial tissue pathology (synovitis) in determining diverse clinical outcome/therapeutic response. RECENT FINDINGS:RA synovitis is highly heterogeneous with diverse cellu...

journal_title：Current opinion in rheumatology

authors： Pitzalis C,Kelly S,Humby F

更新日期：2013-05-01 00:00:00

abstract：:Significant advances were made this year in the understanding of serum amyloid A isotypes and in the definition of different amyloid light-chain proteins. Increasing numbers of hereditary amyloid-related transthyretin mutations have been reported (more than 30 to date). Two new hereditary amyloid proteins in several d...

journal_title：Current opinion in rheumatology

authors： Cohen AS

更新日期：1994-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To investigate the association between systemic sclerosis (SSc) to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) carriage. We utilized the database of Clalit Health Services, the largest healthcare organization in Israel and performed a cross-sectional study. RECENT FINDINGS:The study i...

journal_title：Current opinion in rheumatology

authors： Tiosano S,Cohen AD,Amital H

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide a summary of recent advances in the pathophysiology of rheumatoid arthritis. RECENT FINDINGS:Highlights include further elucidation of the relationship between the shared epitope, smoking and anticitrullinated protein/peptide antibody generation, including identification of putative citrul...

journal_title：Current opinion in rheumatology

authors： Cooles FA,Isaacs JD

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The intestinal microbiome is thought to play a role in the pathogenesis of inflammatory bowel disease (IBD). There are many shared clinical manifestations between IBD and spondyloarthritis (SpA), of which the most common are peripheral arthritis and uveitis. Clinical overlap along with similar genetic...

journal_title：Current opinion in rheumatology

authors： Choi RY,Asquith M,Rosenbaum JT

更新日期：2018-07-01 00:00:00

abstract：:Autoantibodies in systemic lupus erythematosus (SLE) are targeted predominantly to intracellular nucleoprotein particles. Following analysis of the quantitative and qualitative properties of the humoral immune response as well as identification of the major particles recognized as antigens, current studies are address...

journal_title：Current opinion in rheumatology

authors： Elkon K

更新日期：1995-09-01 00:00:00

abstract：:Fibroblasts within the skin of scleroderma patients constitute a phenotypically heterogeneous population with regard to expression of collagens, cytokines, and cytokine receptors. By in situ hybridization techniques, scleroderma skin is shown to contain a subpopulation of fibroblasts that are stimulated for expression...

journal_title：Current opinion in rheumatology

authors： Unemori EN,Amento EP

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the present state of efforts at registry implementation which exist internationally. These efforts are contrasted with those in the USA. RECENT FINDINGS:The implications of the different data which are derived from diverse registry sources are discussed. The need for long-term ...

journal_title：Current opinion in rheumatology

authors： Kremer JM,Gibofsky A,Greenberg JD

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The incidence and mortality of cardiovascular disease are increased in the context of rheumatoid arthritis. The purpose of this review is to examine our evolving understanding of the pathogenesis of cardiovascular disease in rheumatoid arthritis and to underscore the importance of tailored prevention ...

journal_title：Current opinion in rheumatology

authors： Snow MH,Mikuls TR

更新日期：2005-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The introduction of checkpoint inhibitors as well as other allied advances in cancer immunology has made immunotherapy a pillar in the treatment of cancer. At the same time, these therapies have been associated with a remarkable array of immune-mediated toxicities observed in virtually every organ sys...

journal_title：Current opinion in rheumatology

authors： Calabrese LH,Calabrese C

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic sclerosis, or scleroderma, is a systemic autoimmune disease manifest by vascular damage and fibrosis within the skin and visceral organs. Whereas scleroderma is a heterogenous disorder in terms of disease symptoms and clinical course, scleroderma-specific autoantibody profiles associate stron...

journal_title：Current opinion in rheumatology

authors： Harris ML,Rosen A

更新日期：2003-11-01 00:00:00

abstract：:Interstitial lung disease frequently complicates rheumatic disorders, especially polymyositis-dermatomyositis, rheumatoid arthritis, systemic sclerosis, and mixed connective tissue disease. In this article, we review the current data supporting the use of azathioprine, cyclophosphamide, chlorambucil, cyclosporine, and...

journal_title：Current opinion in rheumatology

authors： McCune WJ,Vallance DK,Lynch JP 3rd

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent findings on new pathogenic mechanisms of interaction between genetic and environmental factors and between innate and adaptive immunity in primary Sjögren's syndrome and to reconcile pathogenesis and treatment by focusing on the crucial pathogenic steps that could be targeted by em...

journal_title：Current opinion in rheumatology

authors： Mariette X,Gottenberg JE

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent evidence pointing to the importance of inflammatory factors in the onset and progression of age-related muscle wasting, also known as sarcopenia, and discusses critical areas of uncertainty within the literature that require further development in order to identify novel ...

journal_title：Current opinion in rheumatology

authors： Roth SM,Metter EJ,Ling S,Ferrucci L

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of recently published work on autologous hematopoietic stem-cell transplantation (HSCT) in patients with systemic sclerosis (SSc). RECENT FINDINGS:Superiority of HSCT vs. intravenous cyclophosphamide pulses was demonstrated in the randomized controlled American Scleroderma: Cyc...

journal_title：Current opinion in rheumatology

authors： Spierings J,van Rhijn-Brouwer FCC,van Laar JM

更新日期：2018-11-01 00:00:00

abstract：:Osteoarthritis is the most common form of arthritis in adults and its incidence increases with age. More than 50% of people aged 65 and older have radiographic changes of knee osteoarthritis. Calcium crystals, including calcium pyrophosphate dihydrate and basic calcium phosphate crystals, are also common in the elderl...

journal_title：Current opinion in rheumatology

authors： Jaovisidha K,Rosenthal AK

更新日期：2002-05-01 00:00:00

abstract：:This article reviews evidence that subchondral bone plays a role in the degeneration of cartilage in osteoarthrosis. Whether the bony changes precede the cartilage degeneration remains unproven but may best be considered necessary for progression of the disease. Epidemiologic studies clearly show increasing subchondra...

journal_title：Current opinion in rheumatology

authors： Burr DB

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Provide an update of studies published in last 2 years on the outcomes and therapies in childhood-onset systemic lupus erythematous (cSLE). RECENT FINDINGS:Additional evidence has been provided about the benefits of universal hydroxychloroquine in SLE patients, although antimalarial maculopathy may b...

journal_title：Current opinion in rheumatology

authors： Rodriguez-Smith J,Brunner HI

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Infections have been suggested to contribute to disease induction and reactivation in many of the idiopathic vasculitides. This review describes and evaluates the evidence that microbes are involved in the etiopathogenesis of these diseases. RECENT FINDINGS:Large-vessel vasculitis has recently been a...

journal_title：Current opinion in rheumatology

authors： van Timmeren MM,Heeringa P,Kallenberg CG

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:Signal transduction pathways are the intracellular mechanism by which cells respond and adapt to environmental stress. Understanding the critical networks in diseases like rheumatoid arthritis can potentially identify novel therapeutic targets. RECENT FINDINGS:Dissecting the complex pathways involved in rheuma...

journal_title：Current opinion in rheumatology

authors： Sweeney SE,Firestein GS

更新日期：2004-05-01 00:00:00