T cell-mediated immune mechanisms in myositis.


:Advances in molecular biologic techniques and the availability of novel immunologic reagents have allowed new approaches to understanding the pathogenesis of human autoimmune diseases, including the idiopathic inflammatory myopathies. Indirect evidence that autoreactive T cells mediate muscle inflammation in the human myositis syndromes has been strengthened by recent studies describing restricted T cell receptor gene expression in certain clinical and/or serologic groups of myositis patients. These findings are supported by other investigations documenting abnormal patterns of cytokine, adhesion molecule, and major histocompatibility complex antigen expression within inflammatory lesions. The major challenge of future studies is to identify the specific antigen(s) responsible for initiating and perpetuating these harmful immune responses.


Curr Opin Rheumatol


O'Hanlon TP,Miller FW




Has Abstract


1995-11-01 00:00:00












  • Chronic periaortitis: a large-vessel vasculitis?

    abstract:PURPOSE OF REVIEW:Chronic periaortitis is characterized by a fibro-inflammatory process spreading from the abdominal aorta and the iliac arteries. Originally, chronic periaortitis was considered a localized inflammatory response to severe aortic atherosclerosis. However, subsequent studies have shown that chronic peria...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Vaglio A,Pipitone N,Salvarani C

    更新日期:2011-01-01 00:00:00

  • Treatment of Behçet's disease.

    abstract::Behçet's disease is a systemic inflammatory disorder capable of inducing thrombophlebitis. Clinicopathologically, it is characterized by neutrophil and platelet hyperfunction. Lesions are formed presumably because neutrophils infiltrating the affected tissue release active oxygen and lysosomal enzymes in large amounts...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Hashimoto T,Takeuchi A

    更新日期:1992-02-01 00:00:00

  • The immunopathogenesis of rheumatic immune adverse events from checkpoint inhibitors: prospects for targeted therapy.

    abstract:PURPOSE OF REVIEW:The introduction of checkpoint inhibitors as well as other allied advances in cancer immunology has made immunotherapy a pillar in the treatment of cancer. At the same time, these therapies have been associated with a remarkable array of immune-mediated toxicities observed in virtually every organ sys...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Calabrese LH,Calabrese C

    更新日期:2020-03-01 00:00:00

  • Efficacy of rehabilitation interventions in rheumatic conditions.

    abstract::All industrialized nations are facing a crisis in health care financing. Rising expectations coupled with increasing specialization and technologic capacities have forced health care payers to examine their assumptions and to seek data on the outcomes of medical interventions. Clinical investigators who have been taug...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Stucki G,Liang MH

    更新日期:1994-03-01 00:00:00

  • Understanding the genetic contribution to rheumatoid arthritis.

    abstract:PURPOSE OF REVIEW:The identification of the genetic variants that mediate the risk for susceptibility and severity of rheumatoid arthritis will allow the development of new drug targets and also increase the ability to predict disease course. Technical and methodologic progress has fueled the advances in this field. R...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: van der Helm-van Mil AH,Wesoly JZ,Huizinga TW

    更新日期:2005-05-01 00:00:00

  • Novel immunomodulating and immunotherapies, and novel therapies and strategies for inflammatory arthropathy.

    abstract::During the past year, another disease possibly influenced by intravenous gammaglobulin was identified as dermatomyositis/polymyositis. Additional studies provided further information regarding the use of monoclonal anti-CD4 antibody and combination therapy in rheumatoid arthritis, antithymocyte globulin in scleroderma...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Trentham DE

    更新日期:1992-06-01 00:00:00

  • Autoimmune pancreatitis and IgG4-related sclerosing cholangitis.

    abstract:PURPOSE OF REVIEW:Autoimmune pancreatitis (AIP) is a peculiar type of pancreatitis with a presumed autoimmune etiology. AIP is frequently associated with stenosis of the bile duct in the form of IgG4-related sclerosing cholangitis. This article reviews recent advances in clinicopathological findings for AIP and IgG4-re...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Takuma K,Kamisawa T,Igarashi Y

    更新日期:2011-01-01 00:00:00

  • Metabolic bone disease associated with systemic disorders.

    abstract::Osteoporosis occurs in patients with rheumatoid arthritis, acromegaly, anorexia nervosa, chronic liver disease, sickle cell hemoglobinopathies, and mastocytosis. Osteomalacia occurs in patients with renal tubular acidosis, and with tumors. ...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Cormier C

    更新日期:1991-06-01 00:00:00

  • Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases.

    abstract:PURPOSE OF REVIEW:The spectrum of periodic fever syndromes (PFS)/autoinflammation diseases is continuously expanding. This review provides an overview of the primary research and an update on the main clinical developments in these disorders published in the past 12-18 months. RECENT FINDINGS:IL-1β is pivotal to the p...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Savic S,Dickie LJ,Battellino M,McDermott MF

    更新日期:2012-01-01 00:00:00

  • Social and economic aspects of osteoporosis.

    abstract::The first part of this article draws together descriptive studies on the direct medical costs of osteoporosis. The second part is devoted to economic evaluation of 1) osteoporosis treatment on the basis of clinical criteria and 2) preventive strategies, some of them including bone mineral density screening. These anal...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Joel ME,Le Gales C

    更新日期:1998-07-01 00:00:00

  • Clinical assessment of osteoarthritis in clinical trials.

    abstract::The emergence of various therapeutic possibilities in the field of osteoarthritis has strongly prompted clinicians to conduct studies to evaluate the symptomatic as well as the potential chondromodulating effects of these treatments. For this purpose, some authors recently proposed guidelines with regard not only to t...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Dougados M

    更新日期:1995-03-01 00:00:00

  • Work disability in rheumatic diseases.

    abstract:PURPOSE OF REVIEW:To review developments in the literature concerning work disability in the rheumatic diseases. RECENT FINDINGS:There have been three sets of studies to emerge in the last year. In the first, several studies analyze alternative research methods to document work disability. The second set uses qualitat...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Yelin E

    更新日期:2007-03-01 00:00:00

  • Achilles tendon injuries.

    abstract::The Achilles tendon is the strongest tendon in the human body. Because most Achilles tendon injuries take place in sports and there has been an common upsurge in sporting activities, the number and incidence of the Achilles tendon overuse injuries and complete ruptures have increased in the industrialized countries du...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Järvinen TA,Kannus P,Paavola M,Järvinen TL,Józsa L,Järvinen M

    更新日期:2001-03-01 00:00:00

  • Rheumatic manifestations of neoplasia.

    abstract::Neoplasia in an important cause of rheumatic disease. The mechanisms are either direct infiltration of the bone and joint, or indirect infiltration with manifestations distant from the site of neoplastic involvement. Many of the reports reviewed in this article center on direct associations. In particular, there is a ...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Schwarzer AC,Schrieber L

    更新日期:1991-02-01 00:00:00

  • Hyperparathyroidism: the limits of surgery in cases of bone or cardiovascular involvement.

    abstract::In primary hyperparathyroidism (PHPT), asymptomatic bone disease can be detected by bone densitometry. The bone mineral density is about 10% lower than normal control values, especially in the cortical radius. Without parathyroidectomy, bone mineral density is frequently stable, but a few patients, mostly postmenopaus...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Cormier C,Souberbielle JC,Kindermans C

    更新日期:2000-07-01 00:00:00

  • Epidemiology of the rheumatic diseases.

    abstract::Epidemiologic studies of rheumatic diseases can be broadly divided into those that describe the occurrence of specific disorders, those that attempt to quantify the role of putative risk factors for disease occurrence, and those that define the outcome and factors associated with it. Studies in this area have tended t...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Rooney BK,Silman AJ

    更新日期:1999-03-01 00:00:00

  • Emerging cytokine targets in rheumatoid arthritis.

    abstract:PURPOSE OF REVIEW:The utility of cytokines as therapeutic targets in rheumatoid arthritis has been unequivocally demonstrated by the success of tumour necrosis factor blockade in clinical practice. Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive ...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Asquith DL,McInnes IB

    更新日期:2007-05-01 00:00:00

  • The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies.

    abstract:PURPOSE OF REVIEW:The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental compo...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Asquith M,Rosenbaum JT

    更新日期:2016-07-01 00:00:00

  • Rational use of calcium-channel antagonists in Raynaud's phenomenon.

    abstract::Raynaud's phenomenon (RP) is a peripheral circulatory disorder characterized by sudden episodes of digital artery spasm, often precipitated by cold temperature or emotional stress. Although the cause of RP is not fully known, it appears to involve inappropriate adrenergic response to cold stimuli. Treatment of RP is c...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章


    authors: Sturgill MG,Seibold JR

    更新日期:1998-11-01 00:00:00

  • Overlapping syndromes, undifferentiated connective tissue disease, and other fibrosing conditions.

    abstract::Connective tissue diseases (CTDs) frequently present with one or only a few symptoms, which does not allow prompt diagnosis. Raynaud's phenomenon is one of those symptoms. However, only a minority of patients who present with Raynaud's phenomenon develop a CTD. Prognostic factors for the future development of CTD in s...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Kallenberg CG

    更新日期:1995-11-01 00:00:00

  • Diffuse alveolar hemorrhage syndromes.

    abstract::Diffuse alveolar hemorrhage (DAH) is a rare yet serious and frequently life-threatening complication of a variety of conditions. DAH may result from coagulation disorders, inhaled toxins, or infections. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as antineutrophil cyt...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Specks U

    更新日期:2001-01-01 00:00:00

  • Infections and systemic vasculitis.

    abstract::Bacterial infections can clinically mimic a primary vasculitic syndrome and can directly cause a vasculitis that may respond to prompt recognition and treatment of the infection. Increasing direct and indirect evidence is establishing links between certain infections and vasculopathies, including aortitis, atheroscler...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Mandell BF,Calabrese LH

    更新日期:1998-01-01 00:00:00

  • Epigenetic regulation of wound healing and fibrosis.

    abstract:PURPOSE OF REVIEW:Wound healing is a normal physiological response to tissue injury which can occur in any organ. Mechanisms that orchestrate wound healing in different organs are surprisingly generic, involving generation of fibroblasts and myofibroblasts by differentiation processes that require extensive alterations...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Mann J,Mann DA

    更新日期:2013-01-01 00:00:00

  • Uric acid in heart disease: a new C-reactive protein?

    abstract:PURPOSE OF REVIEW:To review and interpret the recently published data on hyperuricemia and cardiovascular disease to present an opinion on the nature of link between serum uric acid concentration and the risk for cardiovascular outcomes, and to comment on its implications for clinical practice. RECENT FINDINGS:Evidenc...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Krishnan E,Sokolove J

    更新日期:2011-03-01 00:00:00

  • Management of primary and secondary central nervous system vasculitis.

    abstract:PURPOSE OF REVIEW:This article summarizes the current evidence on the management of primary and secondary central nervous system (CNS) vasculitis. RECENT FINDINGS:Two recent retrospective cohort studies have described the treatment and outcomes of patients with adult primary central nervous system vasculitis (PCNSV). ...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Salvarani C,Pipitone N,Hunder GG

    更新日期:2016-01-01 00:00:00

  • Skeletal muscle disease in rheumatoid arthritis: the center of cardiometabolic comorbidities?

    abstract:PURPOSE OF REVIEW:Despite its critical roles in body movement, structure, and metabolism, skeletal muscle remains underappreciated in the context of rheumatoid arthritis. In rheumatoid arthritis, chronic inflammation, physical inactivity, and medication toxicities impair skeletal muscle. These skeletal muscle alteratio...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Andonian BJ,Huffman KM

    更新日期:2020-05-01 00:00:00

  • Joint hypermobility syndromes.

    abstract::Inherited connective tissue disorders, among them Ehlers-Danlos syndrome, osteogenesis imperfecta, Marfan syndrome, and Larsen syndrome, are characterized by generalized joint hypermobility. Others, such as Morquio syndrome or achondroplasia, have hypermobility in a more limited distribution. Recent clinical and molec...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Raff ML,Byers PH

    更新日期:1996-09-01 00:00:00

  • What can we learn from epigenetics in the year 2009?

    abstract:PURPOSE OF REVIEW:Rheumatoid arthritis (RA) is a systemic, autoimmune disease resulting in the destruction of affected joints. Even though current therapies with biologics such as tumor necrosis factor-alpha blockers yield significant improvement for the patients, the disease is not curable yet. Therefore, we need nove...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Jüngel A,Ospelt C,Gay S

    更新日期:2010-05-01 00:00:00

  • The socioeconomic impact of vasculitis.

    abstract::Information detailing the socioeconomic impact of the vasculitides on society has been difficult to obtain. Recent published studies provide preliminary information suggesting that the impact of systemic vasculitis may be significant and far greater than previously anticipated. A rough estimate of expenditures for vas...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Cotch MF

    更新日期:2000-01-01 00:00:00

  • Innate immunity in host-microbial interactions: beyond B27 in the spondyloarthropathies.

    abstract::The spondyloarthropathies are diseases influenced by genetic predisposition and, to a varying extent, infectious triggers. A causal role for bacterial infections is most clear for reactive arthritis. Recent insights into arthritogenic components of bacteria may set the stage for a better understanding of disease patho...

    journal_title:Current opinion in rheumatology

    pub_type: 杂志文章,评审


    authors: Pacheco-Tena C,Zhang X,Stone M,Burgos-Vargas R,Inman RD

    更新日期:2002-07-01 00:00:00