Clinical manifestations of disease activity, its measurement, and associated morbidity in systemic lupus erythematosus.

abstract：PURPOSE OF REVIEW:Pulmonary fibrosis is a devastating disease that affects millions of people worldwide. Among the most common forms of lung fibrosis are idiopathic pulmonary fibrosis (IPF) and scleroderma-related interstitial lung disease (SSc-ILD). Despite a wealth of literature regarding each of these diseases, stud...

journal_title：Current opinion in rheumatology

authors： Murray LA,Rubinowitz A,Herzog EL

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Many patients with psoriatic arthritis (PsA) have additional medical problems that can have an impact on morbidity and mortality. The goal of this review is to summarize the available evidence to date on the association of medical comorbidities with PsA and the implications these comorbidities have on...

journal_title：Current opinion in rheumatology

authors： Ogdie A,Schwartzman S,Husni ME

更新日期：2015-03-01 00:00:00

abstract：:Osteoarthritis is a disabling joint disease that is characterized by the progressive destruction of articular cartilage. Diagnosis is based on clinical symptoms in combination with radiography, which is relatively insensitive and provides only an indication of accumulated damage. Alternative methods, such as molecular...

journal_title：Current opinion in rheumatology

authors： DeGroot J,Bank RA,Tchetverikov I,Verzijl N,TeKoppele JM

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The utility of cytokines as therapeutic targets in rheumatoid arthritis has been unequivocally demonstrated by the success of tumour necrosis factor blockade in clinical practice. Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive ...

journal_title：Current opinion in rheumatology

authors： Asquith DL,McInnes IB

更新日期：2007-05-01 00:00:00

abstract：:Although the pathogenesis of systemic sclerosis is poorly understood, an increasing number of high quality clinical research trials are attempting to modify the overall disease outcome. Survival has improved, largely through therapies focused on single organs. Candidate outcome measures have been tested and a consensu...

journal_title：Current opinion in rheumatology

authors： Seibold JR

更新日期：2001-11-01 00:00:00

abstract：:In primary hyperparathyroidism (PHPT), asymptomatic bone disease can be detected by bone densitometry. The bone mineral density is about 10% lower than normal control values, especially in the cortical radius. Without parathyroidectomy, bone mineral density is frequently stable, but a few patients, mostly postmenopaus...

journal_title：Current opinion in rheumatology

authors： Cormier C,Souberbielle JC,Kindermans C

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Arthritogenic alphaviruses are globally distributed mosquito-borne RNA viruses causing epidemics of polyarthritis/arthralgia, with disease emerging or reemerging and increasingly being reported in travelers. This article summarizes the current knowledge of these diseases, focusing on recent developmen...

journal_title：Current opinion in rheumatology

authors： Suhrbier A,La Linn M

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To compare the recently published European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for SLE with the Systemic Lupus International Collaborating Centers (SLICC) criteria and the earlier ACR criteria, focusing on their key concepts. RECENT FINDING...

journal_title：Current opinion in rheumatology

authors： Aringer M,Petri M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout. This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion. RECENT FINDINGS:The disco...

journal_title：Current opinion in rheumatology

authors： Taniguchi A,Kamatani N

更新日期：2008-03-01 00:00:00

abstract：:The spondyloarthropathies are diseases influenced by genetic predisposition and, to a varying extent, infectious triggers. A causal role for bacterial infections is most clear for reactive arthritis. Recent insights into arthritogenic components of bacteria may set the stage for a better understanding of disease patho...

journal_title：Current opinion in rheumatology

authors： Pacheco-Tena C,Zhang X,Stone M,Burgos-Vargas R,Inman RD

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe recent advancements in diagnostic and therapeutic approaches to inclusion body myositis (IBM). RECENT FINDINGS:Our understanding of the implications of anti-cytosolic 5'-nucleotidase 1A autoantibody status in IBM and other diseases is increasing. Muscle imaging using magnetic resonance te...

journal_title：Current opinion in rheumatology

authors： Lilleker JB

更新日期：2018-11-01 00:00:00

abstract：:Within the past year information has accumulated on the role of infections in the pathogenesis of vasculitis. Superantigens play an important role in the stimulation of the immune system. Behçet's syndrome is a vasculitis that affects children as well as adults. Recently published childhood studies highlight the impor...

journal_title：Current opinion in rheumatology

authors： Ozen S

更新日期：1999-09-01 00:00:00

abstract：:Assessment of children and adults with rheumatic diseases, both in clinical practice and controlled clinical trials in rheumatology, has traditionally focused on the measurement of disease activity. More recently emphasis has been placed on the need to incorporate estimates of physical, social, and mental functioning ...

journal_title：Current opinion in rheumatology

authors： Duffy CM,Duffy KN

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:Gene expression profiling is emerging as a promising methodology in pediatric rheumatology research. There is considerable interest in using this technology as the basis for diagnostic assays. This review will summarize the new knowledge. RECENT FINDINGS:Most gene expression studies of children ...

journal_title：Current opinion in rheumatology

authors： Jarvis JN

更新日期：2005-09-01 00:00:00

abstract：:Replication of similar findings in diverse study populations using different study designs provides important evidence for causal inferences regarding risk factors reported in epidemiologic studies. Risk factors for knee osteoarthritis have been substantiated in a number of cross-sectional and longitudinal cohort stud...

journal_title：Current opinion in rheumatology

authors： Kwoh CK

更新日期：1992-04-01 00:00:00

abstract：:Neoplasia in an important cause of rheumatic disease. The mechanisms are either direct infiltration of the bone and joint, or indirect infiltration with manifestations distant from the site of neoplastic involvement. Many of the reports reviewed in this article center on direct associations. In particular, there is a ...

journal_title：Current opinion in rheumatology

authors： Schwarzer AC,Schrieber L

更新日期：1991-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will highlight recent advances functionally linking the gut microbiome with mucosal and systemic immune cell activation underlying autoimmunity. RECENT FINDINGS:Dynamic interactions between the gut microbiome and environmental cues (including diet and medicines) shape the effector potenti...

journal_title：Current opinion in rheumatology

authors： Longman RS,Littman DR

更新日期：2015-07-01 00:00:00

abstract：:Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antinuclear antibodies (ANAs), including pathogenic specificities to DNA. As shown by recent research, ANA production is a genetically determined process in which self antigens drive B and T cells that have escaped the normal mechanisms o...

journal_title：Current opinion in rheumatology

authors： Pisetsky DS

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Although 6 years have elapsed since the initial report describing the presence of microchimeric cells in affected tissues from patients with systemic sclerosis, a mechanism by which these cells might contribute to the pathogenesis of the disease is still unknown. This article reviews the published lit...

journal_title：Current opinion in rheumatology

authors： Jimenez SA,Artlett CM

更新日期：2005-01-01 00:00:00

abstract：:During the past 2 years, four papers describing new research studies and three papers reviewing the literature were published. These seven papers address longstanding issues, including 1) the presence or absence of cognitive impairment in systemic lupus erythematosus (SLE), 2) the prevalence of such impairment within ...

journal_title：Current opinion in rheumatology

authors： Bleiberg J,Bunning R

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Rapid introduction of newly developed drugs in the absence of clear understanding of the pathophysiologic mechanisms behind drug-induced lupus erythematosus (DILE) can sometimes make DILE difficult to recognize in clinical practice. The purpose of this review is to summarize drugs most recently report...

journal_title：Current opinion in rheumatology

authors： He Y,Sawalha AH

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review developments in the literature concerning work disability in the rheumatic diseases. RECENT FINDINGS:There have been three sets of studies to emerge in the last year. In the first, several studies analyze alternative research methods to document work disability. The second set uses qualitat...

journal_title：Current opinion in rheumatology

authors： Yelin E

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In the present review, recent findings regarding silicone breast implants (SBIs) complicated by rheumatic autoimmune diseases are described. RECENT FINDINGS:Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may 'bleed' ...

journal_title：Current opinion in rheumatology

authors： Cohen Tervaert JW,Colaris MJ,van der Hulst RR

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Infections have been suggested to contribute to disease induction and reactivation in many of the idiopathic vasculitides. This review describes and evaluates the evidence that microbes are involved in the etiopathogenesis of these diseases. RECENT FINDINGS:Large-vessel vasculitis has recently been a...

journal_title：Current opinion in rheumatology

authors： van Timmeren MM,Heeringa P,Kallenberg CG

更新日期：2014-07-01 00:00:00

abstract：:Diffuse alveolar hemorrhage (DAH) is a rare yet serious and frequently life-threatening complication of a variety of conditions. DAH may result from coagulation disorders, inhaled toxins, or infections. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as antineutrophil cyt...

journal_title：Current opinion in rheumatology

authors： Specks U

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Blau syndrome is a monogenic disease resulting from mutations in nucleotide oligomerization domain 2 (NOD2) and is phenotypically characterized by granulomatous polyarthritis and uveitis. Not only there has been significant progress in disease characterization but also the biological pathways associat...

journal_title：Current opinion in rheumatology

authors： Rose CD,Martin TM,Wouters CH

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent findings on new pathogenic mechanisms of interaction between genetic and environmental factors and between innate and adaptive immunity in primary Sjögren's syndrome and to reconcile pathogenesis and treatment by focusing on the crucial pathogenic steps that could be targeted by em...

journal_title：Current opinion in rheumatology

authors： Mariette X,Gottenberg JE

更新日期：2010-09-01 00:00:00

abstract：:Autoantibodies in systemic lupus erythematosus (SLE) are targeted predominantly to intracellular nucleoprotein particles. Following analysis of the quantitative and qualitative properties of the humoral immune response as well as identification of the major particles recognized as antigens, current studies are address...

journal_title：Current opinion in rheumatology

authors： Elkon K

更新日期：1995-09-01 00:00:00

abstract：:The emergence of various therapeutic possibilities in the field of osteoarthritis has strongly prompted clinicians to conduct studies to evaluate the symptomatic as well as the potential chondromodulating effects of these treatments. For this purpose, some authors recently proposed guidelines with regard not only to t...

journal_title：Current opinion in rheumatology

authors： Dougados M

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, with typical skin manifestations of dermatomyositis but little or no evidence of myositis. This review focuses on updates on epidemiology, clinical manifestations, and autoantibody profiles in patients with CADM. RECE...

journal_title：Current opinion in rheumatology

authors： Sato S,Kuwana M

更新日期：2010-11-01 00:00:00