Epidemiology of the rheumatic diseases.

abstract：PURPOSE OF REVIEW:The objective of this review is to provide an update on exercise and clinical assessment in the idiopathic inflammatory myopathies. RECENT FINDINGS:Polymyositis, dermatomyositis and inclusion body myositis are rare conditions with muscle weakness as a common prominent feature. Earlier, these patients...

journal_title：Current opinion in rheumatology

authors： Alexanderson H,Lundberg IE

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:It is well recognized that the complement system plays multiple roles in systemic lupus erythematosus. Activation of the classical pathway by immune complexes leads to the generation of inflammatory mediators, thus promoting tissue injury. Complement activation also plays an important role in the main...

journal_title：Current opinion in rheumatology

authors： Karp DR

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review pharmacologic and nonpharmacologic therapies in the treatment of systemic sclerosis (SSc) from 2011 to 2014 through a systematic review. RECENT FINDINGS:Our systematic review identifies randomized controlled trials, meta-analyses, systematic reviews, case series, and observational studies w...

journal_title：Current opinion in rheumatology

authors： Young A,Khanna D

更新日期：2015-05-01 00:00:00

abstract：:Low back pain continues to affect a significant proportion of the younger, working population between 35 and 45 years of age. An important study has correlated macroscopic and microscopic intervertebral disc alterations starting in the second decade of life with oxidative stress manifested by the presence of N-(carbox...

journal_title：Current opinion in rheumatology

authors： Borenstein DG

更新日期：1999-03-01 00:00:00

abstract：:Significant advances were made this year in the understanding of serum amyloid A isotypes and in the definition of different amyloid light-chain proteins. Increasing numbers of hereditary amyloid-related transthyretin mutations have been reported (more than 30 to date). Two new hereditary amyloid proteins in several d...

journal_title：Current opinion in rheumatology

authors： Cohen AS

更新日期：1994-01-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed recent quality improvement initiatives in the field of rheumatology to identify common strategies and themes leading to measurable change. RECENT FINDINGS:Efforts to improve quality of care in rheumatology have accelerated in the last 5 years. Most studies in this area have focused on int...

journal_title：Current opinion in rheumatology

authors： Liu LH,Choden S,Yazdany J

更新日期：2019-03-01 00:00:00

abstract：:Angiitis of the central nervous system (CNS) remains a poorly understood and clinically challenging form of vascular inflammatory disease. Primary angiitis of the CNS (PACNS) has been viewed as a relentless and uniformly fatal disorder if untreated. In addition, recent trends have demonstrated an increasing reliance o...

journal_title：Current opinion in rheumatology

authors： Calabrese LH,Duna GF

更新日期：1995-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The severity of each organ involvement, natural course, and response to therapies are extremely heterogeneous among patients with systemic sclerosis (SSc). The discovery and validation of biomarkers can help identify disease risk, improve early diagnosis and prognosis, better design clinical trials an...

journal_title：Current opinion in rheumatology

authors： Manetti M

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Across the world, osteoarthritis is the most commonly occurring musculoskeletal disease of the elderly, affecting more than 25% of the population older than 60 years of age. By far the single greatest risk factor for the development of osteoarthritis is age, but a mechanism to explain this relation ha...

journal_title：Current opinion in rheumatology

authors： Verzijl N,Bank RA,TeKoppele JM,DeGroot J

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on the new interleukin-1 (IL-1) cytokine family members in inflammatory diseases with focus on recent findings concerning the family members IL-36, IL-37, and IL-38 and their different expression patterns. RECENT FINDINGS:The IL-1 cytokines are known to be involved in m...

journal_title：Current opinion in rheumatology

authors： Hahn M,Frey S,Hueber AJ

更新日期：2017-03-01 00:00:00

abstract：:Recent findings suggest that biologic, psychologic, and social variables interact to determine an individual's response to rheumatic disease. Data indicate that specific coping responses and quality of social support modulate the psychosocial impact of the disease. Additional current developments are 1) an increased e...

journal_title：Current opinion in rheumatology

authors： Wegener ST

更新日期：1991-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review studies that clarify the rheumatic manifestations of autoimmune hepatitis, elucidate shared pathogenic pathways, and encourage innovative site-specific therapies. RECENT FINDINGS:Autoimmune hepatitis has clinical manifestations, serological markers, pathogenic mechanisms, genetic predisposi...

journal_title：Current opinion in rheumatology

authors： Czaja AJ

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Rapid introduction of newly developed drugs in the absence of clear understanding of the pathophysiologic mechanisms behind drug-induced lupus erythematosus (DILE) can sometimes make DILE difficult to recognize in clinical practice. The purpose of this review is to summarize drugs most recently report...

journal_title：Current opinion in rheumatology

authors： He Y,Sawalha AH

更新日期：2018-09-01 00:00:00

abstract：:A growing body of evidence is shedding light on how vascular injury, tissue mononuclear cell infiltrates, and fibrogenesis are related in the pathogenesis of systemic sclerosis. Recent evidence points to a role for adhesion molecules in the binding of mononuclear leukocytes to endothelium and transvascular migration o...

journal_title：Current opinion in rheumatology

authors： Postlethwaite AE

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will explore two new aspects of the involvement of viruses in multiple sclerosis pathogenesis. The first aspect is the complex interactions between viruses. The second aspect is the proposal of a mechanism by which autoreactive T cells are able to escape thymic selection and potentially re...

journal_title：Current opinion in rheumatology

authors： Cusick MF,Libbey JE,Fujinami RS

更新日期：2013-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the advances that have been made in our understanding of the genetics of idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on dermatomyositis and polymyositis. RECENT FINDINGS:Fine-mapping studies in the major histocompatibility complex region in Caucasia...

journal_title：Current opinion in rheumatology

authors： Rothwell S,Chinoy H,Lamb JA

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence accumulated since 2010 indicates that human osteoarthritis should now be reclassified as a systemic musculoskeletal disease rather than a focal disorder of synovial joints. RECENT FINDINGS:Inflammation was seen as the key component promoting synovitis as well as progression of cartilage and ...

journal_title：Current opinion in rheumatology

authors： Malemud CJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with rheumatoid arthritis and other inflammatory arthritides treated with tumor necrosis factor inhibitors frequently undergo orthopedic procedures. These patients may be at risk for serious postoperative infections as antitumor necrosis factor agents may be associated with impaired immunity ...

journal_title：Current opinion in rheumatology

authors： Pappas DA,Giles JT

更新日期：2008-07-01 00:00:00

abstract：:This article reviews recent publications related to the classification and treatment of juvenile spondyloarthropathies. We have included studies on adult onset spondyloarthropathies that are particularly relevant to childhood onset disease. Significant questions concerning classification of juvenile spondyloarthropath...

journal_title：Current opinion in rheumatology

authors： Bukulmez H,Colbert RA

更新日期：2002-09-01 00:00:00

abstract：:Major changes have taken place in the diagnosis and treatment of rotator cuff tears. It seems that magnetic resonance imaging alone as a diagnostic tool is still not sensitive enough, particularly in the diagnosis of partial tears. Arthrography and arthroscopy are still considered essential for an accurate preoperativ...

journal_title：Current opinion in rheumatology

authors： Uhthoff HK

更新日期：1996-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The article reviews recent advances in the research of fractures in patients with systemic lupus erythematosus (SLE), highlighting their clinical, scientific, and economic impact. RECENT FINDINGS:Recent studies demonstrated an increased incidence of osteoporosis and symptomatic fractures in patients ...

journal_title：Current opinion in rheumatology

authors： Bultink IE,Lems WF

更新日期：2016-07-01 00:00:00

abstract：:The last few years have brought a resurgence in interest in managing systemic sclerosis. In the past year, there have been reports of small series of patients and several well-designed, double-blind, controlled trials. Treatment has been directed at a variety of potential pathogenic mechanisms. Stanazol, iloprost, pla...

journal_title：Current opinion in rheumatology

authors： Steen V

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Wound healing is a normal physiological response to tissue injury which can occur in any organ. Mechanisms that orchestrate wound healing in different organs are surprisingly generic, involving generation of fibroblasts and myofibroblasts by differentiation processes that require extensive alterations...

journal_title：Current opinion in rheumatology

authors： Mann J,Mann DA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Signal transduction pathways are the intracellular mechanism by which cells respond and adapt to environmental stress. Understanding the critical networks in diseases like rheumatoid arthritis can potentially identify novel therapeutic targets. RECENT FINDINGS:Dissecting the complex pathways involved in rheuma...

journal_title：Current opinion in rheumatology

authors： Sweeney SE,Firestein GS

更新日期：2004-05-01 00:00:00

abstract：:There is growing evidence that distinct molecular and cellular interactions in the rheumatoid synovium result in a complex cascade of pathophysiologic events. These interactions finally lead to progressive joint destruction, in a way that is different from all other joint diseases. Keystones are inflammation, prolifer...

journal_title：Current opinion in rheumatology

authors： Müller-Ladner U

更新日期：1996-05-01 00:00:00

abstract：:In 1990, there were signs of a renewed interest in clinical studies about several aspects of osteoarthritis. The work-up of classic data and the use of new information from epidemiologic surveys as well as careful radiographic monitoring of selected groups of patients have brought us broader views on the general cours...

journal_title：Current opinion in rheumatology

authors： Peyron JG

更新日期：1991-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To increase awareness and review the management of chronic viral hepatitis in individuals treated with immune-modifying agents to avoid potentially severe consequences. RECENT FINDINGS:Hepatitis B virus (HBV) reactivation has been reported with a wide variety of immunosuppressive regimens ranging fro...

journal_title：Current opinion in rheumatology

authors： Juan J,Feld JJ

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The production of autoantibodies against nuclear antigens is the hallmark of systemic lupus erythematosus. Among the large number of autoantibodies known, only a limited number appear to be clinically important. The various autoantibodies have different clinical significance in lupus patients. In this...

journal_title：Current opinion in rheumatology

authors： Sawalha AH,Harley JB

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To compare the recently published European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for SLE with the Systemic Lupus International Collaborating Centers (SLICC) criteria and the earlier ACR criteria, focusing on their key concepts. RECENT FINDING...

journal_title：Current opinion in rheumatology

authors： Aringer M,Petri M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To inform readers of recent advances in our understanding of the development and function of Th17 T cells and emerging data suggesting that the interleukin-23/interleukin-17 axis may be involved in the pathogenesis of spondyloarthritis. RECENT FINDINGS:The discovery of CD4+ Th17 T cells and the inter...

journal_title：Current opinion in rheumatology

authors： Layh-Schmitt G,Colbert RA

更新日期：2008-07-01 00:00:00