Recent advances in scleroderma-associated pulmonary hypertension.

abstract：PURPOSE OF REVIEW:Juvenile systemic sclerosis has a variety of clinical manifestations, sometimes different from the adult form. Early recognition, proper classification and treatment may improve the long-term outcome. RECENT FINDINGS:A large multicenter study coordinated by the Pediatric Rheumatology European Society...

journal_title：Current opinion in rheumatology

authors： Zulian F,Martini G

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Rapid introduction of newly developed drugs in the absence of clear understanding of the pathophysiologic mechanisms behind drug-induced lupus erythematosus (DILE) can sometimes make DILE difficult to recognize in clinical practice. The purpose of this review is to summarize drugs most recently report...

journal_title：Current opinion in rheumatology

authors： He Y,Sawalha AH

更新日期：2018-09-01 00:00:00

abstract：:Behçet's disease and Takayasu's disease in children are uncommon and may have an insidious course leading to a delayed diagnosis. Both diseases usually occur in late childhood, although disease onset in the first year of life has been reported. Compared with adults, Behçet's disease in children appears to be character...

journal_title：Current opinion in rheumatology

authors： Martini A

更新日期：1995-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The history of ankylosing spondylitis, the main representative of the spondyloarthritides, is dating back to several thousand years BC and recently proven for medieval skeleton by HLA-B27 typing with modern molecular techniques. In modern time, the history of spondyloarthritis (SpA) is characterized b...

journal_title：Current opinion in rheumatology

authors： Zeidler H,Calin A,Amor B

更新日期：2011-07-01 00:00:00

abstract：:Recent findings suggest that biologic, psychologic, and social variables interact to determine an individual's response to rheumatic disease. Data indicate that specific coping responses and quality of social support modulate the psychosocial impact of the disease. Additional current developments are 1) an increased e...

journal_title：Current opinion in rheumatology

authors： Wegener ST

更新日期：1991-04-01 00:00:00

abstract：:Churg-Strauss syndrome (CSS) is a form of primary vasculitis characterized by allergy and angiitis. In the organ systems involved (lung, heart, peripheral nervous system, and so forth), eosinophilic infiltration can be found. Eosinophilia and normochromic normocytic anemia are leading laboratory findings together with...

journal_title：Current opinion in rheumatology

authors： Gross WL

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent interest in gout has led to development of new drugs for acute gout and long-term urate-lowering, as well as interest in improving the use of older drugs. The patients' comorbidities and concomitant medications may contribute to the risk of adverse drug reactions with anti-gout therapies. This ...

journal_title：Current opinion in rheumatology

authors： Stamp LK

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The spectrum of periodic fever syndromes (PFS)/autoinflammation diseases is continuously expanding. This review provides an overview of the primary research and an update on the main clinical developments in these disorders published in the past 12-18 months. RECENT FINDINGS:IL-1β is pivotal to the p...

journal_title：Current opinion in rheumatology

authors： Savic S,Dickie LJ,Battellino M,McDermott MF

更新日期：2012-01-01 00:00:00

abstract：:Patients with inflammatory arthritides such as rheumatoid arthritis develop both localized and generalized osteoporosis and have an increased risk of fracture. Bone loss can occur early and is directly related to the inflammatory process as well as to the indirect effects of arthritis on physical activity. Corticoster...

journal_title：Current opinion in rheumatology

authors： Henderson NK,Sambrook PN

更新日期：1996-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent advances in the analysis of genetic determinants of bone mass. It addresses both human and animal linkage studies as well as genetic manipulations in animals, inbred mouse models, and candidate gene analyses. RECENT FINDINGS:Recent studies have implicated novel regulatory ...

journal_title：Current opinion in rheumatology

authors： Baldock PA,Eisman JA

更新日期：2004-07-01 00:00:00

abstract：:In this review, we address current concepts and recent experimental results that relate to heterogeneity in the physiologic, biochemical, and morphologic properties of mammalian skeletal muscle fibers. Recent data reinforce some of these current concepts while questioning others. The biochemical bases of the concepts ...

journal_title：Current opinion in rheumatology

authors： Talmadge RJ,Roy RR,Edgerton VR

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To help clinicians to distinguish between myositis (and other immune-mediated and immunosuppressant-responsive disorders) and its many clinical mimics. RECENT FINDINGS:Increasing experience has shown that findings from conventional investigations, such as muscle biopsy, can be misleading. More specia...

journal_title：Current opinion in rheumatology

authors： Hilton-Jones D

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine recent developments relating to cardiac involvement in the adult idiopathic inflammatory myopathies (IIM) and those inherited muscle diseases which may present in adulthood and mimic IIM. RECENT FINDINGS:Cardiac involvement is a common feature of IIM and inherited muscle diseases. Frequenc...

journal_title：Current opinion in rheumatology

authors： Lilleker JB,Roberts M,Diederichsen L

更新日期：2020-11-01 00:00:00

abstract：:Systemic lupus erythematosus is a complex, multisystem autoimmune disease characterized by production of high-titer autoantibodies directed against ubiquitously expressed self-antigens. Autoantigens in systemic lupus erythematosus are highly diverse in terms of structure and location in control cells, but become clust...

journal_title：Current opinion in rheumatology

authors： White S,Rosen A

更新日期：2003-09-01 00:00:00

abstract：:Osteoporosis occurs in patients with rheumatoid arthritis, acromegaly, anorexia nervosa, chronic liver disease, sickle cell hemoglobinopathies, and mastocytosis. Osteomalacia occurs in patients with renal tubular acidosis, and with tumors. ...

journal_title：Current opinion in rheumatology

authors： Cormier C

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims at covering the role of muscle MRI in supporting the diagnosis of myositis, in aiding to differentiate it from other muscle disorders, and in monitoring myositis patients over time by assessing response to treatment and by discriminating between muscle inflammation and chronic damage....

journal_title：Current opinion in rheumatology

authors： Pipitone N

更新日期：2016-11-01 00:00:00

abstract：:Osteoarthritis is a disabling joint disease that is characterized by the progressive destruction of articular cartilage. Diagnosis is based on clinical symptoms in combination with radiography, which is relatively insensitive and provides only an indication of accumulated damage. Alternative methods, such as molecular...

journal_title：Current opinion in rheumatology

authors： DeGroot J,Bank RA,Tchetverikov I,Verzijl N,TeKoppele JM

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the ...

journal_title：Current opinion in rheumatology

authors： Stojan G,Petri M

更新日期：2018-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The severity of each organ involvement, natural course, and response to therapies are extremely heterogeneous among patients with systemic sclerosis (SSc). The discovery and validation of biomarkers can help identify disease risk, improve early diagnosis and prognosis, better design clinical trials an...

journal_title：Current opinion in rheumatology

authors： Manetti M

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the spectrum of clinical, histological, and serological features in patients with immune-mediated necrotizing myopathies (IMNMs). RECENT FINDINGS:Autoantibodies recognizing the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) define tw...

journal_title：Current opinion in rheumatology

authors： Pinal-Fernandez I,Mammen AL

更新日期：2016-11-01 00:00:00

abstract：:Recent population-based studies have examined the incidence, prevalence, and survival rates of patients with psoriatic arthritis (PsA). Although there are still no completely satisfactory diagnostic criteria for PsA, Moll and Wright's criteria--although not a true classification/diagnostic scheme--are the most used. T...

journal_title：Current opinion in rheumatology

authors： Salvarani C,Olivieri I,Cantini F,Macchioni L,Boiardi L

更新日期：1998-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The autoinflammatory diseases are a group of conditions that include the hereditary fever syndromes, and result from upregulated innate immune responses. The discovery of the genetic basis for these conditions led to the description of novel intracellular receptors for infectious and noninfectious dan...

journal_title：Current opinion in rheumatology

authors： Ryan JG,Goldbach-Mansky R

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the central role of pain in osteoarthritis, until recently, relatively little attention was paid to the osteoarthritis pain experience, including the features of osteoarthritis pain that are most important to people living with this disease. The focus of this review is on recent advances in ou...

journal_title：Current opinion in rheumatology

authors： Hawker GA

更新日期：2009-09-01 00:00:00

abstract：:The recent literature pertaining to tumors of articular structures and bone is reviewed. In pigmented villonodular synovitis, the bone resorptive cell is a macrophage polykaryon rather than an osteoclast. Complete arthroscopic synovectomy was successful in most diffuse articular forms of the disease. The early synovia...

journal_title：Current opinion in rheumatology

authors： Abraham JH 3rd,Canoso JJ

更新日期：1993-03-01 00:00:00

abstract：:Although the pathogenesis of systemic sclerosis is poorly understood, an increasing number of high quality clinical research trials are attempting to modify the overall disease outcome. Survival has improved, largely through therapies focused on single organs. Candidate outcome measures have been tested and a consensu...

journal_title：Current opinion in rheumatology

authors： Seibold JR

更新日期：2001-11-01 00:00:00

abstract：:Animal models of systemic connective tissue diseases have provided valuable insights into the causative mechanisms and the pathogenesis of these diseases, and have provided the means to test potentially useful therapeutic interventions. Although numerous animal models for systemic sclerosis (SSc) have been described, ...

journal_title：Current opinion in rheumatology

authors： Jimenez SA,Christner PJ

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammatory changes in joint tissues can be detected by modern imaging techniques in osteoarthritis patients, but may be clinically subtle compared with many other types of arthritis. These changes associate with disease progression and clinical severity, and many inflammatory mediators may have biom...

journal_title：Current opinion in rheumatology

authors： Scanzello CR

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Many patients with psoriatic arthritis (PsA) have additional medical problems that can have an impact on morbidity and mortality. The goal of this review is to summarize the available evidence to date on the association of medical comorbidities with PsA and the implications these comorbidities have on...

journal_title：Current opinion in rheumatology

authors： Ogdie A,Schwartzman S,Husni ME

更新日期：2015-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with rheumatoid arthritis and other inflammatory arthritides treated with tumor necrosis factor inhibitors frequently undergo orthopedic procedures. These patients may be at risk for serious postoperative infections as antitumor necrosis factor agents may be associated with impaired immunity ...

journal_title：Current opinion in rheumatology

authors： Pappas DA,Giles JT

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The utility of cytokines as therapeutic targets in rheumatoid arthritis has been unequivocally demonstrated by the success of tumour necrosis factor blockade in clinical practice. Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive ...

journal_title：Current opinion in rheumatology

authors： Asquith DL,McInnes IB

更新日期：2007-05-01 00:00:00