The thymus and rheumatology: should we care?

abstract：PURPOSE OF REVIEW:It is an understatement to say that drug approvals in systemic lupus erythematosus (SLE), lupus nephritis, and Sjogren's syndrome have lagged far behind those in other autoimmune diseases, such as rheumatoid arthritis and psoriatic arthritis. Reasons for this are multiple and include the molecular and...

journal_title：Current opinion in rheumatology

authors： Narain S,Berman N,Furie R

更新日期：2020-11-01 00:00:00

abstract：:Although there are excellent rationales for the use of biologic agents, no published novel therapeutic strategy in patients with early or late rheumatoid arthritis has thus far been proven in controlled clinical studies to prevent or retard cartilage destruction. Although T-cell-specific therapies in chronic rheumatoi...

journal_title：Current opinion in rheumatology

authors： Häuselmann HJ

更新日期：1997-05-01 00:00:00

abstract：:Churg-Strauss syndrome (CSS) is a form of primary vasculitis characterized by allergy and angiitis. In the organ systems involved (lung, heart, peripheral nervous system, and so forth), eosinophilic infiltration can be found. Eosinophilia and normochromic normocytic anemia are leading laboratory findings together with...

journal_title：Current opinion in rheumatology

authors： Gross WL

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:There are currently several available biologics for rheumatoid arthritis (RA) with similar efficacy in most trials. A major consideration therefore in choosing a biologic, continues to be safety concerns such as infection. Considerable advances have been made in the understanding of biologic safety on...

journal_title：Current opinion in rheumatology

authors： Jani M,Barton A,Hyrich K

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Although 6 years have elapsed since the initial report describing the presence of microchimeric cells in affected tissues from patients with systemic sclerosis, a mechanism by which these cells might contribute to the pathogenesis of the disease is still unknown. This article reviews the published lit...

journal_title：Current opinion in rheumatology

authors： Jimenez SA,Artlett CM

更新日期：2005-01-01 00:00:00

abstract：:Recent findings suggest that biologic, psychologic, and social variables interact to determine an individual's response to rheumatic disease. Data indicate that specific coping responses and quality of social support modulate the psychosocial impact of the disease. Additional current developments are 1) an increased e...

journal_title：Current opinion in rheumatology

authors： Wegener ST

更新日期：1991-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Since their discovery over 15 years ago, intensive research has focused on the presence, phenotype and function of FOXP3(+) regulatory T cells (Treg) in autoimmune diseases such as rheumatoid arthritis (RA). The questions of whether Treg deficiencies underlie autoimmune pathology and whether or how Tr...

journal_title：Current opinion in rheumatology

authors： Mijnheer G,Prakken BJ,van Wijk F

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent interest in gout has led to development of new drugs for acute gout and long-term urate-lowering, as well as interest in improving the use of older drugs. The patients' comorbidities and concomitant medications may contribute to the risk of adverse drug reactions with anti-gout therapies. This ...

journal_title：Current opinion in rheumatology

authors： Stamp LK

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF THE REVIEW:To define gout conditions and hyperuricemia. RECENT FINDINGS:Gout is defined as an arthritic condition resulting from the deposition of monosodium urate (MSU) crystals in and/or around joints, following long-standing hyperuricemia. Several recent ultrasound studies disclosed MSU deposits in a lar...

journal_title：Current opinion in rheumatology

authors： Bardin T,Richette P

更新日期：2014-03-01 00:00:00

abstract：:Recent advances in renal osteodystrophy deal with the pathogenesis of the disease, in particular in early renal failure, with the mechanisms of skeletal resistance to parathyroid hormone, with the potential role of iron, and with increased knowledge of adynamic bone disease. For the control of phosphatemia, aluminum-c...

journal_title：Current opinion in rheumatology

authors： Bardin T

更新日期：1992-06-01 00:00:00

abstract：PURPOSE OF REVIEW:With progressive age, the immune system and the propensity for abnormal immunity change fundamentally. Individuals greater than 50 years of age are not only more susceptible to infection and cancer, but also at higher risk for chronic inflammation and immune-mediated tissue damage. The process of immu...

journal_title：Current opinion in rheumatology

authors： Weyand CM,Yang Z,Goronzy JJ

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on recent findings with regards to the genetics of hyperuricemia and gout, including recent data from genome-wide association studies (GWAS). RECENT FINDINGS:Five GWAS around the same time reported that genetic variants of SLC2A9/GLUT9 were associated with lower serum u...

journal_title：Current opinion in rheumatology

authors： Choi HK,Zhu Y,Mount DB

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the spectrum of clinical, histological, and serological features in patients with immune-mediated necrotizing myopathies (IMNMs). RECENT FINDINGS:Autoantibodies recognizing the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) define tw...

journal_title：Current opinion in rheumatology

authors： Pinal-Fernandez I,Mammen AL

更新日期：2016-11-01 00:00:00

abstract：:The immune defense against extracellular pathogens is largely dependent on antibody production. Class switch recombination and somatic hypermutation shape the secondary antibody repertoire in peripheral lymphoid tissue. In the past few years, a series of primary immune deficiencies characterized by defects in these pr...

journal_title：Current opinion in rheumatology

authors： Gulino AV,Notarangelo LD

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To review studies that clarify the rheumatic manifestations of autoimmune hepatitis, elucidate shared pathogenic pathways, and encourage innovative site-specific therapies. RECENT FINDINGS:Autoimmune hepatitis has clinical manifestations, serological markers, pathogenic mechanisms, genetic predisposi...

journal_title：Current opinion in rheumatology

authors： Czaja AJ

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammatory changes in joint tissues can be detected by modern imaging techniques in osteoarthritis patients, but may be clinically subtle compared with many other types of arthritis. These changes associate with disease progression and clinical severity, and many inflammatory mediators may have biom...

journal_title：Current opinion in rheumatology

authors： Scanzello CR

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In contrast to the disease remission enjoyed by a majority of rheumatoid arthritis (RA) patients during pregnancy, the immediate postpartum period is generally characterized by flare. Managing symptoms during this time is challenging because the potential transfer of medication into the breast milk of...

journal_title：Current opinion in rheumatology

authors： Sammaritano LR,Bermas BL

更新日期：2014-05-01 00:00:00

abstract：:Nitric oxide (NO) and prostaglandin E2 (PGE2) are two pleiotropic inflammatory mediators overproduced in arthritis-affected joints. The inducible isoform of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are found both in the synovial tissue and in the cartilage. Their expression is regulated by catabolic cyt...

journal_title：Current opinion in rheumatology

authors： Amin AR,Attur M,Abramson SB

更新日期：1999-05-01 00:00:00

abstract：:Work originating in the 1940s led to the characterization of a rare, chronic inflammatory disorder with a unique predilection for the cornea and vestibuloauditory apparatus, now called Cogan's syndrome (CS) after the ophthalmologist who first described it. CS occurs primarily in young adults and typically presents wit...

journal_title：Current opinion in rheumatology

authors： St Clair EW,McCallum RM

更新日期：1999-01-01 00:00:00

abstract：:Animal models of systemic connective tissue diseases have provided valuable insights into the causative mechanisms and the pathogenesis of these diseases, and have provided the means to test potentially useful therapeutic interventions. Although numerous animal models for systemic sclerosis (SSc) have been described, ...

journal_title：Current opinion in rheumatology

authors： Jimenez SA,Christner PJ

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:Gene expression profiling is emerging as a promising methodology in pediatric rheumatology research. There is considerable interest in using this technology as the basis for diagnostic assays. This review will summarize the new knowledge. RECENT FINDINGS:Most gene expression studies of children ...

journal_title：Current opinion in rheumatology

authors： Jarvis JN

更新日期：2005-09-01 00:00:00

abstract：:The recent literature pertaining to tumors of articular structures and bone is reviewed. In pigmented villonodular synovitis, the bone resorptive cell is a macrophage polykaryon rather than an osteoclast. Complete arthroscopic synovectomy was successful in most diffuse articular forms of the disease. The early synovia...

journal_title：Current opinion in rheumatology

authors： Abraham JH 3rd,Canoso JJ

更新日期：1993-03-01 00:00:00

abstract：:In this review, we address current concepts and recent experimental results that relate to heterogeneity in the physiologic, biochemical, and morphologic properties of mammalian skeletal muscle fibers. Recent data reinforce some of these current concepts while questioning others. The biochemical bases of the concepts ...

journal_title：Current opinion in rheumatology

authors： Talmadge RJ,Roy RR,Edgerton VR

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:We aim to give an overview of the recent progress in the knowledge of the genetic component of vasculitides. RECENT FINDINGS:Using a state-of-the-art imputation method to analyse the major histocompatibility complex (MHC) region, Ombrello and colleagues narrowed down the association between human leu...

journal_title：Current opinion in rheumatology

authors： Carmona FD,Martín J,González-Gay MA

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The autoinflammatory diseases are a group of conditions that include the hereditary fever syndromes, and result from upregulated innate immune responses. The discovery of the genetic basis for these conditions led to the description of novel intracellular receptors for infectious and noninfectious dan...

journal_title：Current opinion in rheumatology

authors： Ryan JG,Goldbach-Mansky R

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the most updated literature of muscle disease in scleroderma in the past year. RECENT FINDINGS:In the past year, two studies have highlighted that fibrosis is a prevalent histopathologic feature in muscle biopsies of patients with scleroderma muscle disease. In addition, microan...

journal_title：Current opinion in rheumatology

authors： Paik JJ

更新日期：2018-11-01 00:00:00

abstract：:There has been a renewed interest in the use of low doses of prednisone in the treatment of early rheumatoid arthritis. This is because it has been conclusively shown that low doses of prednisone retard bone damage, and physicians use prednisone because it helps control tender and swollen joints. Two studies appeared ...

journal_title：Current opinion in rheumatology

authors： Conn DL,Lim SS

更新日期：2003-05-01 00:00:00

abstract：:Raloxifene, a selective estrogen receptor modulator, is currently used for both prevention and treatment of postmenopausal osteoporosis. Recent data from the MORE (Multiple Outcomes of Raloxifene Evaluation) trial have evaluated health-related quality of life, 1-year clinical vertebral fracture reduction, and the corr...

journal_title：Current opinion in rheumatology

authors： Gluck O,Maricic M

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence accumulated since 2010 indicates that human osteoarthritis should now be reclassified as a systemic musculoskeletal disease rather than a focal disorder of synovial joints. RECENT FINDINGS:Inflammation was seen as the key component promoting synovitis as well as progression of cartilage and ...

journal_title：Current opinion in rheumatology

authors： Malemud CJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Arthritogenic alphaviruses are globally distributed mosquito-borne RNA viruses causing epidemics of polyarthritis/arthralgia, with disease emerging or reemerging and increasingly being reported in travelers. This article summarizes the current knowledge of these diseases, focusing on recent developmen...

journal_title：Current opinion in rheumatology

authors： Suhrbier A,La Linn M

更新日期：2004-07-01 00:00:00