Renal osteodystrophy, disorders of vitamin D metabolism, and hypophosphatasia.

abstract：:The last few years have brought a resurgence in interest in managing systemic sclerosis. In the past year, there have been reports of small series of patients and several well-designed, double-blind, controlled trials. Treatment has been directed at a variety of potential pathogenic mechanisms. Stanazol, iloprost, pla...

journal_title：Current opinion in rheumatology

authors： Steen V

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Since their discovery over 15 years ago, intensive research has focused on the presence, phenotype and function of FOXP3(+) regulatory T cells (Treg) in autoimmune diseases such as rheumatoid arthritis (RA). The questions of whether Treg deficiencies underlie autoimmune pathology and whether or how Tr...

journal_title：Current opinion in rheumatology

authors： Mijnheer G,Prakken BJ,van Wijk F

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In contrast to the disease remission enjoyed by a majority of rheumatoid arthritis (RA) patients during pregnancy, the immediate postpartum period is generally characterized by flare. Managing symptoms during this time is challenging because the potential transfer of medication into the breast milk of...

journal_title：Current opinion in rheumatology

authors： Sammaritano LR,Bermas BL

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss pathology-based characterization and classification of acquired immune and inflammatory myopathies (IIMs). RECENT FINDINGS:Several types of IIMs do not fit well into the typical IIM subclassifications: dermatomyositis, polymyositis and inclusion body myositis (IBM). Myopathologic features ...

journal_title：Current opinion in rheumatology

authors： Pestronk A

更新日期：2011-11-01 00:00:00

abstract：:Systemic lupus erythematosus and Sjögren syndrome remain elusive in the description of their underlying etiologic causes and pathogenic mechanisms. Although underlying genetic predisposition appears to contribute to both diseases based on twin and other genetic studies, additional factors must play a role. Over the de...

journal_title：Current opinion in rheumatology

authors： James JA,Harley JB,Scofield RH

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update on the new interleukin-1 (IL-1) cytokine family members in inflammatory diseases with focus on recent findings concerning the family members IL-36, IL-37, and IL-38 and their different expression patterns. RECENT FINDINGS:The IL-1 cytokines are known to be involved in m...

journal_title：Current opinion in rheumatology

authors： Hahn M,Frey S,Hueber AJ

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Inclusion body myositis (IBM) is a poorly understood autoimmune and degenerative disorder of skeletal muscle. Here, pathophysiological and diagnostic biomarkers of IBM are reviewed. RECENT FINDINGS:Muscle histopathological biomarkers have been successful in stimulating the study of IBM pathophysiolog...

journal_title：Current opinion in rheumatology

authors： Greenberg SA

更新日期：2013-11-01 00:00:00

abstract：:Eosinophilic infiltration into skeletal muscle, although rare, has been described in a diverse group of conditions. It most commonly occurs in parasitic infection as focal eosinophilic myositis but can be a feature of systemic hypereosinophilic conditions such as eosinophilia-myalgia syndrome and idiopathic hypereosin...

journal_title：Current opinion in rheumatology

authors： Pickering MC,Walport MJ

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, with typical skin manifestations of dermatomyositis but little or no evidence of myositis. This review focuses on updates on epidemiology, clinical manifestations, and autoantibody profiles in patients with CADM. RECE...

journal_title：Current opinion in rheumatology

authors： Sato S,Kuwana M

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The utility of cytokines as therapeutic targets in rheumatoid arthritis has been unequivocally demonstrated by the success of tumour necrosis factor blockade in clinical practice. Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive ...

journal_title：Current opinion in rheumatology

authors： Asquith DL,McInnes IB

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This article provides an update on the recent findings on autoantibodies to modified proteins in rheumatoid arthritis (RA). RECENT FINDINGS:In the past few years, the knowledge on the autoantibodies to citrullinated antigens has expanded considerably. More specifically, it is now clear that many diff...

journal_title：Current opinion in rheumatology

authors： Toes RE,Huizinga TJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe recent advancements in diagnostic and therapeutic approaches to inclusion body myositis (IBM). RECENT FINDINGS:Our understanding of the implications of anti-cytosolic 5'-nucleotidase 1A autoantibody status in IBM and other diseases is increasing. Muscle imaging using magnetic resonance te...

journal_title：Current opinion in rheumatology

authors： Lilleker JB

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent work has continued to clarify the role of major histocompatibility complex class I in the pathogenesis of autoimmune myositis. In the past year, several new observations have been made in this area. This review describes these findings and discusses their relevance to the pathogenesis of autoim...

journal_title：Current opinion in rheumatology

authors： Nagaraju K

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in pulmonary hypertension, a leading cause of morbidity and mortality in scleroderma (SSc). RECENT FINDINGS:Although WHO Group I pulmonary arterial hypertension (PAH) is the most common cause of pulmonary hypertension, all WHO Groups can occur. PAH is now a crit...

journal_title：Current opinion in rheumatology

authors： Highland KB

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The severity of each organ involvement, natural course, and response to therapies are extremely heterogeneous among patients with systemic sclerosis (SSc). The discovery and validation of biomarkers can help identify disease risk, improve early diagnosis and prognosis, better design clinical trials an...

journal_title：Current opinion in rheumatology

authors： Manetti M

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the ...

journal_title：Current opinion in rheumatology

authors： Stojan G,Petri M

更新日期：2018-03-01 00:00:00

abstract：:There has been a renewed interest in the use of low doses of prednisone in the treatment of early rheumatoid arthritis. This is because it has been conclusively shown that low doses of prednisone retard bone damage, and physicians use prednisone because it helps control tender and swollen joints. Two studies appeared ...

journal_title：Current opinion in rheumatology

authors： Conn DL,Lim SS

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout. This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion. RECENT FINDINGS:The disco...

journal_title：Current opinion in rheumatology

authors： Taniguchi A,Kamatani N

更新日期：2008-03-01 00:00:00

abstract：:This article describes the magnitude, extent, and economic consequences of some of the more common, work-related musculoskeletal disorders. In addition, it provides a brief historic overview of the state-federal vocational rehabilitation program in the United States. It identifies and considers a constellation of risk...

journal_title：Current opinion in rheumatology

authors： Straaton KV,Fine PR,White MB,Maisiak RS

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an increasing interest in improving the understanding of pathophysiology, outcome measures, and therapies of rheumatic skin disease. Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheum...

journal_title：Current opinion in rheumatology

authors： Clarke JT,Werth VP

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review studies that clarify the rheumatic manifestations of autoimmune hepatitis, elucidate shared pathogenic pathways, and encourage innovative site-specific therapies. RECENT FINDINGS:Autoimmune hepatitis has clinical manifestations, serological markers, pathogenic mechanisms, genetic predisposi...

journal_title：Current opinion in rheumatology

authors： Czaja AJ

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the advances that have been made in our understanding of the genetics of idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on dermatomyositis and polymyositis. RECENT FINDINGS:Fine-mapping studies in the major histocompatibility complex region in Caucasia...

journal_title：Current opinion in rheumatology

authors： Rothwell S,Chinoy H,Lamb JA

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:A severe decrease of CD4 T cells predisposes humans to opportunistic infections. In adults, HIV is certainly the most common cause of CD4 lymphocytopenia, but other causes, such as infections, autoimmune diseases, immunosuppressive therapy, lymphoma and idiopathic forms need to be considered. This rev...

journal_title：Current opinion in rheumatology

authors： Walker UA,Warnatz K

更新日期：2006-07-01 00:00:00

abstract：:Behçet's disease and Takayasu's disease in children are uncommon and may have an insidious course leading to a delayed diagnosis. Both diseases usually occur in late childhood, although disease onset in the first year of life has been reported. Compared with adults, Behçet's disease in children appears to be character...

journal_title：Current opinion in rheumatology

authors： Martini A

更新日期：1995-09-01 00:00:00

abstract：:The eosinophilia-myalgia syndrome, which is associated with the ingestion of L-tryptophan that contained products, occurred as an epidemic in the United States in 1989. Eosinophilia-myalgia syndrome is similar in many ways to the toxic-oil syndrome, which occurred in Spain in 1981, and to diffuse fasciitis with eosino...

journal_title：Current opinion in rheumatology

authors： Silver RM

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review addresses diagnostic methods for crystalline arthritis including synovial fluid analysis, ultrasound, and dual energy CT scan (DECT). RECENT FINDINGS:There are new technologies on the horizon to improve the ease, sensitivity, and specificity of synovial fluid analysis. Raman spectr...

journal_title：Current opinion in rheumatology

authors： Zell M,Zhang D,FitzGerald J

更新日期：2019-03-01 00:00:00

abstract：:In the United States, Lyme disease is the most common arthropod-borne infection. The majority of cases are reported from the Northeast, the Midwest, and California, which are areas with established foci of Borrelia burgdorferi. Advances in the understanding of the epidemiology of Ixodes ticks, the established vector f...

journal_title：Current opinion in rheumatology

authors： Evans J

更新日期：1995-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the most updated literature of muscle disease in scleroderma in the past year. RECENT FINDINGS:In the past year, two studies have highlighted that fibrosis is a prevalent histopathologic feature in muscle biopsies of patients with scleroderma muscle disease. In addition, microan...

journal_title：Current opinion in rheumatology

authors： Paik JJ

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The identification of the genetic variants that mediate the risk for susceptibility and severity of rheumatoid arthritis will allow the development of new drug targets and also increase the ability to predict disease course. Technical and methodologic progress has fueled the advances in this field. R...

journal_title：Current opinion in rheumatology

authors： van der Helm-van Mil AH,Wesoly JZ,Huizinga TW

更新日期：2005-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Provide an update of studies published in last 2 years on the outcomes and therapies in childhood-onset systemic lupus erythematous (cSLE). RECENT FINDINGS:Additional evidence has been provided about the benefits of universal hydroxychloroquine in SLE patients, although antimalarial maculopathy may b...

journal_title：Current opinion in rheumatology

authors： Rodriguez-Smith J,Brunner HI

更新日期：2019-09-01 00:00:00