Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia.

abstract：:The molecular mechanisms of the primary immunodeficiencies have been further explored and provide insights into the regulation of the immune response and its role in autoimmune disease, infection, and malignancy. The critical role of CD40-CD40 ligand-mediated effects in T cell-dependent B cell activation, shown throug...

journal_title：Current opinion in rheumatology

authors： Stein CM

更新日期：1996-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) pathogenesis is complex. Aberrancies of immune function that previously were described but not well understood are now becoming better characterized, in part through recognition of monogenic cases of lupus-like disease. RECENT FINDINGS:We highlight here recent descr...

journal_title：Current opinion in rheumatology

authors： Lo MS,Tsokos GC

更新日期：2018-03-01 00:00:00

abstract：:The first part of this article draws together descriptive studies on the direct medical costs of osteoporosis. The second part is devoted to economic evaluation of 1) osteoporosis treatment on the basis of clinical criteria and 2) preventive strategies, some of them including bone mineral density screening. These anal...

journal_title：Current opinion in rheumatology

authors： Joel ME,Le Gales C

更新日期：1998-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Juvenile dermatomyositis is a rare chronic inflammatory disease that primarily affects the muscles and skin. Immunosuppressive therapy has played a very important role in reducing mortality rates and morbidity. The review focuses on the spectrum of medications currently used in the treatment of juveni...

journal_title：Current opinion in rheumatology

authors： Stringer E,Feldman BM

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the advances that have been made in our understanding of the genetics of idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on dermatomyositis and polymyositis. RECENT FINDINGS:Fine-mapping studies in the major histocompatibility complex region in Caucasia...

journal_title：Current opinion in rheumatology

authors： Rothwell S,Chinoy H,Lamb JA

更新日期：2019-11-01 00:00:00

abstract：:Although there are excellent rationales for the use of biologic agents, no published novel therapeutic strategy in patients with early or late rheumatoid arthritis has thus far been proven in controlled clinical studies to prevent or retard cartilage destruction. Although T-cell-specific therapies in chronic rheumatoi...

journal_title：Current opinion in rheumatology

authors： Häuselmann HJ

更新日期：1997-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the present state of efforts at registry implementation which exist internationally. These efforts are contrasted with those in the USA. RECENT FINDINGS:The implications of the different data which are derived from diverse registry sources are discussed. The need for long-term ...

journal_title：Current opinion in rheumatology

authors： Kremer JM,Gibofsky A,Greenberg JD

更新日期：2008-03-01 00:00:00

abstract：:All industrialized nations are facing a crisis in health care financing. Rising expectations coupled with increasing specialization and technologic capacities have forced health care payers to examine their assumptions and to seek data on the outcomes of medical interventions. Clinical investigators who have been taug...

journal_title：Current opinion in rheumatology

authors： Stucki G,Liang MH

更新日期：1994-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the genetics and immunologic basis of autoinflammatory bone disorders including chronic recurrent multifocal osteomyelitis including the monogenic forms of the disease. RECENT FINDINGS:Ongoing research in murine, canine and human models of sterile bone inflammation has solidif...

journal_title：Current opinion in rheumatology

authors： Sharma M,Ferguson PJ

更新日期：2013-09-01 00:00:00

abstract：:Interstitial lung disease frequently complicates rheumatic disorders, especially polymyositis-dermatomyositis, rheumatoid arthritis, systemic sclerosis, and mixed connective tissue disease. In this article, we review the current data supporting the use of azathioprine, cyclophosphamide, chlorambucil, cyclosporine, and...

journal_title：Current opinion in rheumatology

authors： McCune WJ,Vallance DK,Lynch JP 3rd

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent progress in the understanding of various aspects of renal transport of urate. RECENT FINDINGS:Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to the transport of urate have been identified. The mo...

journal_title：Current opinion in rheumatology

authors： Anzai N,Kanai Y,Endou H

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Modern molecular biology offers a unique opportunity to gain a comprehensive picture of gene expression in a disease state. This review presents recent findings in the field of synovial fibroblast biology contributing to knowledge of the pathogenesis of rheumatoid arthritis. RECENT FINDINGS:Recently ...

journal_title：Current opinion in rheumatology

authors： Stanczyk J,Ospelt C,Gay RE,Gay S

更新日期：2006-05-01 00:00:00

abstract：:Raloxifene, a selective estrogen receptor modulator, is currently used for both prevention and treatment of postmenopausal osteoporosis. Recent data from the MORE (Multiple Outcomes of Raloxifene Evaluation) trial have evaluated health-related quality of life, 1-year clinical vertebral fracture reduction, and the corr...

journal_title：Current opinion in rheumatology

authors： Gluck O,Maricic M

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent developments in the nosology of primary systemic vasculitis are placed in the context of an historical overview. The ongoing attempts to develop criteria for classification and diagnosis are discussed. RECENT FINDINGS:Giant cell arteritis has supplanted temporal arteritis as the preferred term...

journal_title：Current opinion in rheumatology

authors： Jennette JC,Falk RJ

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this study was to evaluate the relationship between infection with SARS-CoV-2 and autoimmunity. RECENT FINDINGS:Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome (SARS) associated coronavirus 2 (SARS-CoV-2). Although most of the infect...

journal_title：Current opinion in rheumatology

authors： Liu Y,Sawalha AH,Lu Q

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Two diseases associated with chronic kidney disease (CKD) have benefited from advances in the past year which are of great importance for rheumatologists: renal osteodystrophy, which is now clearly associated with vascular calcification and cardiovascular death, and nephogenic systemic fibrosis, which...

journal_title：Current opinion in rheumatology

authors： Bardin T,Richette P

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the recent efficacy and safety data comparing methotrexate (MTX) and leflunomide (LEF) monotherapy, in combination with biologic therapies and in combination with each other. RECENT FINDINGS:MTX is the 'anchor drug' in all rheumatoid arthritis treatment strategies. Patients with contraindic...

journal_title：Current opinion in rheumatology

authors： Singer O,Gibofsky A

更新日期：2011-05-01 00:00:00

abstract：:Longitudinal studies of large cohorts of patients with Raynaud's Phenomenon have addressed the predictors of developing a secondary disease. New insights have been reported into the pathogenesis of Raynaud's phenomenon and the consequences of ischemia. Studies have suggested that more than one defect may cause Raynaud...

journal_title：Current opinion in rheumatology

authors： Wigley FM

更新日期：1996-11-01 00:00:00

abstract：SUMMARY:Relapsing polychondritis is a unique, rare autoimmune disorder in which the cartilaginous tissues are the primary targets of destruction but the immune damage can spread to involve noncartilaginous tissues like the kidney, blood vessels, and so forth. The manifestations of the disease can take many different fo...

journal_title：Current opinion in rheumatology

authors： Kent PD,Michet CJ Jr,Luthra HS

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Glucocorticoids are used in the treatment of most rheumatic diseases, and are used chronically in up to 50% of cases of rheumatoid arthritis. The frequency of their use has in the past been incompletely supported by trial evidence of their benefit and by incomplete understanding of their mechanisms of...

journal_title：Current opinion in rheumatology

authors： Morand EF

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The identification of the genetic variants that mediate the risk for susceptibility and severity of rheumatoid arthritis will allow the development of new drug targets and also increase the ability to predict disease course. Technical and methodologic progress has fueled the advances in this field. R...

journal_title：Current opinion in rheumatology

authors： van der Helm-van Mil AH,Wesoly JZ,Huizinga TW

更新日期：2005-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide a summary of recent advances in the pathophysiology of rheumatoid arthritis. RECENT FINDINGS:Highlights include further elucidation of the relationship between the shared epitope, smoking and anticitrullinated protein/peptide antibody generation, including identification of putative citrul...

journal_title：Current opinion in rheumatology

authors： Cooles FA,Isaacs JD

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review developments in the literature concerning work disability in the rheumatic diseases. RECENT FINDINGS:There have been three sets of studies to emerge in the last year. In the first, several studies analyze alternative research methods to document work disability. The second set uses qualitat...

journal_title：Current opinion in rheumatology

authors： Yelin E

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Pulmonary fibrosis is a devastating disease that affects millions of people worldwide. Among the most common forms of lung fibrosis are idiopathic pulmonary fibrosis (IPF) and scleroderma-related interstitial lung disease (SSc-ILD). Despite a wealth of literature regarding each of these diseases, stud...

journal_title：Current opinion in rheumatology

authors： Murray LA,Rubinowitz A,Herzog EL

更新日期：2012-11-01 00:00:00

abstract：:The spectrum of clinical descriptions and clinicopathologic studies on patients with primary and secondary forms of antiphospholipid antibody syndrome continues to widen. Some differences exist for patients with lupus compared with those with Sjogren's syndrome. Some new thoughts regarding pathogenetic mechanisms and ...

journal_title：Current opinion in rheumatology

authors： McCarty-Farid GA

更新日期：1993-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Infections play a role in the pathogenesis of autoimmune diseases (AID). Several bacterial and viral pathogens play a double role, as both inducers and inhibitors of AID. In this review, we will present current evidence and discuss different aspects of this notion. RECENT FINDINGS:Infectors that both...

journal_title：Current opinion in rheumatology

authors： Shamriz O,Shoenfeld Y

更新日期：2018-07-01 00:00:00

abstract：:New information on the treatment of juvenile rheumatoid arthritis emphasizes more aggressive control of arthritis, particularly the use of methotrexate, both in low- and higher-dose regimens. Information concerning drug toxicity, including that of the nonsteroidal anti-inflammatory drugs, second-line agents, and metho...

journal_title：Current opinion in rheumatology

authors： Emery HM

更新日期：1993-09-01 00:00:00

abstract：:Systemic lupus erythematosus is a complex, multisystem autoimmune disease characterized by production of high-titer autoantibodies directed against ubiquitously expressed self-antigens. Autoantigens in systemic lupus erythematosus are highly diverse in terms of structure and location in control cells, but become clust...

journal_title：Current opinion in rheumatology

authors： White S,Rosen A

更新日期：2003-09-01 00:00:00

abstract：:There is growing evidence that distinct molecular and cellular interactions in the rheumatoid synovium result in a complex cascade of pathophysiologic events. These interactions finally lead to progressive joint destruction, in a way that is different from all other joint diseases. Keystones are inflammation, prolifer...

journal_title：Current opinion in rheumatology

authors： Müller-Ladner U

更新日期：1996-05-01 00:00:00

abstract：:The results of twin and family studies clearly implicate an important role for genetic factors in the etiology of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, the complex nature of these diseases has hampered progress in defining the genetic determinants. Recent advances in molecular gene...

journal_title：Current opinion in rheumatology

authors： Criswell LA,Amos CI

更新日期：2000-03-01 00:00:00