Abstract:
PURPOSE OF REVIEW:Modern molecular biology offers a unique opportunity to gain a comprehensive picture of gene expression in a disease state. This review presents recent findings in the field of synovial fibroblast biology contributing to knowledge of the pathogenesis of rheumatoid arthritis. RECENT FINDINGS:Recently it has become apparent that innate immune response pathways play a critical role in driving synovial activation and contribute significantly to the turnover of leukocytes in the synovial compartment. In addition, microparticles have been identified as a new class of potent mediators, broadening the known spectrum of cell-derived modulators in the joint. Numerous research groups gained new insights into detailed molecular mechanisms leading to the invasiveness of rheumatoid arthritis synovial fibroblasts, the disturbance in the regulation of apoptosis, and synovial cell-cell and cell-matrix interactions. SUMMARY:The key role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis has been highlighted by the fact that these cells not only are the main executors of cartilage and bone destruction but also modulate numerous interactions in rheumatoid joints. Moreover, it has become evident that integration of a large body of information is indispensable to get a comprehensive outlook on synovial activation in the pathology of rheumatoid arthritis.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Stanczyk J,Ospelt C,Gay RE,Gay Sdoi
10.1097/01.bor.0000218947.42730.ddkeywords:
subject
Has Abstractpub_date
2006-05-01 00:00:00pages
262-7issue
3eissn
1040-8711issn
1531-6963pii
00002281-200605000-00009journal_volume
18pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Cryoglobulinemic vasculitis is an immune-complex-mediated systemic vasculitis involving small-medium-sized vessels. A causative role of hepatitis C virus in over 80% patients has been definitively established, with heterogeneous geographical distribution. This review focuses on recent etiopathogenetic...
journal_title:Current opinion in rheumatology
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doi:10.1097/01.bor.0000198002.42826.c2
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abstract:PURPOSE OF REVIEW:To review the advances that have been made in our understanding of the genetics of idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on dermatomyositis and polymyositis. RECENT FINDINGS:Fine-mapping studies in the major histocompatibility complex region in Caucasia...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,meta分析,评审
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abstract:PURPOSE OF REVIEW:It is well recognized that the complement system plays multiple roles in systemic lupus erythematosus. Activation of the classical pathway by immune complexes leads to the generation of inflammatory mediators, thus promoting tissue injury. Complement activation also plays an important role in the main...
journal_title:Current opinion in rheumatology
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更新日期:2005-09-01 00:00:00
abstract::Recent findings suggest that biologic, psychologic, and social variables interact to determine an individual's response to rheumatic disease. Data indicate that specific coping responses and quality of social support modulate the psychosocial impact of the disease. Additional current developments are 1) an increased e...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199104000-00015
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2004-09-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000326
更新日期:2016-11-01 00:00:00
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3280126b66
更新日期:2007-03-01 00:00:00
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journal_title:Current opinion in rheumatology
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doi:10.1097/00002281-199701000-00005
更新日期:1997-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Clinical use of immune checkpoint inhibitor (ICI) therapy has revolutionized the therapeutic landscape of cancer. By activating the immune system using monoclonal anti-CTLA-4 and PD(L)-1 antibodies, remission can be induced in previously terminal cancers. However, these breakthroughs come at a price. ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000672
更新日期:2020-01-01 00:00:00
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doi:10.1097/BOR.0b013e32834518a3
更新日期:2011-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1097/00002281-199110000-00006
更新日期:1991-10-01 00:00:00
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
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journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
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更新日期:2003-11-01 00:00:00