Current concepts in the prevention, detection, and treatment of deep vein thrombosis in total hip and knee replacement.

abstract：PURPOSE OF REVIEW:Current treatment of ankylosing spondylitis such as non-steroidal anti-inflammatory drugs and tumor necrosis factor (TNF)-blockers have shown a good efficacy on sign and symptoms. However, it is less clear whether and how structural damage, determined mainly by new bone formation, can be prevented. Re...

journal_title：Current opinion in rheumatology

authors： Sieper J

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To critically appraise the literature related to the pathophysiology of rheumatoid arthritis (RA) focusing on the contribution of synovial tissue pathology (synovitis) in determining diverse clinical outcome/therapeutic response. RECENT FINDINGS:RA synovitis is highly heterogeneous with diverse cellu...

journal_title：Current opinion in rheumatology

authors： Pitzalis C,Kelly S,Humby F

更新日期：2013-05-01 00:00:00

abstract：:The spectrum of clinical descriptions and clinicopathologic studies on patients with primary and secondary forms of antiphospholipid antibody syndrome continues to widen. Some differences exist for patients with lupus compared with those with Sjogren's syndrome. Some new thoughts regarding pathogenetic mechanisms and ...

journal_title：Current opinion in rheumatology

authors： McCarty-Farid GA

更新日期：1993-09-01 00:00:00

abstract：:Churg-Strauss syndrome (CSS) is a form of primary vasculitis characterized by allergy and angiitis. In the organ systems involved (lung, heart, peripheral nervous system, and so forth), eosinophilic infiltration can be found. Eosinophilia and normochromic normocytic anemia are leading laboratory findings together with...

journal_title：Current opinion in rheumatology

authors： Gross WL

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent advances in the analysis of genetic determinants of bone mass. It addresses both human and animal linkage studies as well as genetic manipulations in animals, inbred mouse models, and candidate gene analyses. RECENT FINDINGS:Recent studies have implicated novel regulatory ...

journal_title：Current opinion in rheumatology

authors： Baldock PA,Eisman JA

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Juvenile systemic sclerosis has a variety of clinical manifestations, sometimes different from the adult form. Early recognition, proper classification and treatment may improve the long-term outcome. RECENT FINDINGS:A large multicenter study coordinated by the Pediatric Rheumatology European Society...

journal_title：Current opinion in rheumatology

authors： Zulian F,Martini G

更新日期：2007-11-01 00:00:00

abstract：:This article describes the magnitude, extent, and economic consequences of some of the more common, work-related musculoskeletal disorders. In addition, it provides a brief historic overview of the state-federal vocational rehabilitation program in the United States. It identifies and considers a constellation of risk...

journal_title：Current opinion in rheumatology

authors： Straaton KV,Fine PR,White MB,Maisiak RS

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the recent efficacy and safety data comparing methotrexate (MTX) and leflunomide (LEF) monotherapy, in combination with biologic therapies and in combination with each other. RECENT FINDINGS:MTX is the 'anchor drug' in all rheumatoid arthritis treatment strategies. Patients with contraindic...

journal_title：Current opinion in rheumatology

authors： Singer O,Gibofsky A

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:An increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consequences of this ob...

journal_title：Current opinion in rheumatology

authors： Rönnblom L,Eloranta ML

更新日期：2013-03-01 00:00:00

abstract：:Patients with inflammatory arthritides such as rheumatoid arthritis develop both localized and generalized osteoporosis and have an increased risk of fracture. Bone loss can occur early and is directly related to the inflammatory process as well as to the indirect effects of arthritis on physical activity. Corticoster...

journal_title：Current opinion in rheumatology

authors： Henderson NK,Sambrook PN

更新日期：1996-07-01 00:00:00

abstract：:Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antinuclear antibodies (ANAs), including pathogenic specificities to DNA. As shown by recent research, ANA production is a genetically determined process in which self antigens drive B and T cells that have escaped the normal mechanisms o...

journal_title：Current opinion in rheumatology

authors： Pisetsky DS

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review provides an update on novel treatment strategies striving for remission in patients with recent onset of rheumatoid arthritis. RECENT FINDINGS:As early treatment is crucial to achieve optimal results, identifying patients with rheumatoid arthritis early is imperative to achieve cli...

journal_title：Current opinion in rheumatology

authors： van der Kooij SM,Allaart CF,Dijkmans BA,Breedveld FC

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite its critical roles in body movement, structure, and metabolism, skeletal muscle remains underappreciated in the context of rheumatoid arthritis. In rheumatoid arthritis, chronic inflammation, physical inactivity, and medication toxicities impair skeletal muscle. These skeletal muscle alteratio...

journal_title：Current opinion in rheumatology

authors： Andonian BJ,Huffman KM

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The objective of this review is to provide an update on exercise and clinical assessment in the idiopathic inflammatory myopathies. RECENT FINDINGS:Polymyositis, dermatomyositis and inclusion body myositis are rare conditions with muscle weakness as a common prominent feature. Earlier, these patients...

journal_title：Current opinion in rheumatology

authors： Alexanderson H,Lundberg IE

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The hyper-IgD and periodic fever syndrome (HIDS) is one of the classical monogenetic hereditary autoinflammatory disorders, and together with the more severe mevalonic aciduria it is also known as 'mevalonate kinase deficiency' (MKD). In this study, we will give an overview of the primary research on ...

journal_title：Current opinion in rheumatology

authors： Stoffels M,Simon A

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is a common disorder among older adults. The diagnosis is based solely on radiographic abnormalities defined using the Resnick criteria. DISH is characterized by ossification of the anterior longitudinal ligament of the spine and v...

journal_title：Current opinion in rheumatology

authors： Sarzi-Puttini P,Atzeni F

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Incorporation of the patients' perspective in clinical research is critical to ensure that outcomes measured reflect those, which matter most to patients. This review summarizes recent efforts to include the patients' perspective in the development of outcome measures and the importance of encouraging...

journal_title：Current opinion in rheumatology

authors： Hsiao B,Fraenkel L

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Since their discovery over 15 years ago, intensive research has focused on the presence, phenotype and function of FOXP3(+) regulatory T cells (Treg) in autoimmune diseases such as rheumatoid arthritis (RA). The questions of whether Treg deficiencies underlie autoimmune pathology and whether or how Tr...

journal_title：Current opinion in rheumatology

authors： Mijnheer G,Prakken BJ,van Wijk F

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:As the most common arthritis and a leading cause of chronic disability, osteoarthritis is associated with substantial cost to the individual and to society. Epidemiologic studies have supplied, in addition to incidence, prevalence and risk factor data, much of what is known about the natural history o...

journal_title：Current opinion in rheumatology

authors： Sharma L,Kapoor D,Issa S

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, with typical skin manifestations of dermatomyositis but little or no evidence of myositis. This review focuses on updates on epidemiology, clinical manifestations, and autoantibody profiles in patients with CADM. RECE...

journal_title：Current opinion in rheumatology

authors： Sato S,Kuwana M

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to discuss the mechanisms of central and peripheral tolerance in relation to T-cell mediated autoimmunity in rheumatoid arthritis (RA). RECENT FINDINGS:The well established association between major histocompatibility complex class II and RA has led us to understand that...

journal_title：Current opinion in rheumatology

authors： Cosway E,Anderson G,Garside P,Prendergast C

更新日期：2016-03-01 00:00:00

abstract：:Recent findings suggest that biologic, psychologic, and social variables interact to determine an individual's response to rheumatic disease. Data indicate that specific coping responses and quality of social support modulate the psychosocial impact of the disease. Additional current developments are 1) an increased e...

journal_title：Current opinion in rheumatology

authors： Wegener ST

更新日期：1991-04-01 00:00:00

abstract：:Arthropathy is one of the leading clinical manifestations of hereditary hemochromatosis (HH). Although cirrhosis of the liver is crucial for mortality in patients with HH, arthropathy has the greatest impact on the quality of life. Several mutations in the HFE and other genes have recently been identified, and the pre...

journal_title：Current opinion in rheumatology

authors： von Kempis J

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:There are currently several available biologics for rheumatoid arthritis (RA) with similar efficacy in most trials. A major consideration therefore in choosing a biologic, continues to be safety concerns such as infection. Considerable advances have been made in the understanding of biologic safety on...

journal_title：Current opinion in rheumatology

authors： Jani M,Barton A,Hyrich K

更新日期：2019-05-01 00:00:00

abstract：:Systemic lupus erythematosus is a complex, multisystem autoimmune disease characterized by production of high-titer autoantibodies directed against ubiquitously expressed self-antigens. Autoantigens in systemic lupus erythematosus are highly diverse in terms of structure and location in control cells, but become clust...

journal_title：Current opinion in rheumatology

authors： White S,Rosen A

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental compo...

journal_title：Current opinion in rheumatology

authors： Asquith M,Rosenbaum JT

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Takayasu arteritis remains a therapeutic challenge. In spite of current treatments, progression of vascular lesions is observed frequently. The purpose of this article is to describe advances in therapeutic strategies for Takayasu arteritis. RECENT FINDINGS:Immunosuppressive agents including methotre...

journal_title：Current opinion in rheumatology

authors： Liang P,Hoffman GS

更新日期：2005-01-01 00:00:00

abstract：:There is growing evidence that distinct molecular and cellular interactions in the rheumatoid synovium result in a complex cascade of pathophysiologic events. These interactions finally lead to progressive joint destruction, in a way that is different from all other joint diseases. Keystones are inflammation, prolifer...

journal_title：Current opinion in rheumatology

authors： Müller-Ladner U

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite the central role of pain in osteoarthritis, until recently, relatively little attention was paid to the osteoarthritis pain experience, including the features of osteoarthritis pain that are most important to people living with this disease. The focus of this review is on recent advances in ou...

journal_title：Current opinion in rheumatology

authors： Hawker GA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Much has been documented in recent years on the possible involvement of angiogenesis in osteoarthritis. An understanding of the various regulatory mechanisms controlling blood vessel growth in the joint should lead to novel therapeutics, which selectively inhibit undesirable angiogenesis. Here, we sum...

journal_title：Current opinion in rheumatology

authors： Ashraf S,Walsh DA

更新日期：2008-09-01 00:00:00