Immune checkpoint inhibitors and vasculitis.

abstract：:In primary hyperparathyroidism (PHPT), asymptomatic bone disease can be detected by bone densitometry. The bone mineral density is about 10% lower than normal control values, especially in the cortical radius. Without parathyroidectomy, bone mineral density is frequently stable, but a few patients, mostly postmenopaus...

journal_title：Current opinion in rheumatology

authors： Cormier C,Souberbielle JC,Kindermans C

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The history of ankylosing spondylitis, the main representative of the spondyloarthritides, is dating back to several thousand years BC and recently proven for medieval skeleton by HLA-B27 typing with modern molecular techniques. In modern time, the history of spondyloarthritis (SpA) is characterized b...

journal_title：Current opinion in rheumatology

authors： Zeidler H,Calin A,Amor B

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To compare the recently published European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for SLE with the Systemic Lupus International Collaborating Centers (SLICC) criteria and the earlier ACR criteria, focusing on their key concepts. RECENT FINDING...

journal_title：Current opinion in rheumatology

authors： Aringer M,Petri M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To investigate the association between systemic sclerosis (SSc) to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) carriage. We utilized the database of Clalit Health Services, the largest healthcare organization in Israel and performed a cross-sectional study. RECENT FINDINGS:The study i...

journal_title：Current opinion in rheumatology

authors： Tiosano S,Cohen AD,Amital H

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:An increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consequences of this ob...

journal_title：Current opinion in rheumatology

authors： Rönnblom L,Eloranta ML

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:It is well recognized that the complement system plays multiple roles in systemic lupus erythematosus. Activation of the classical pathway by immune complexes leads to the generation of inflammatory mediators, thus promoting tissue injury. Complement activation also plays an important role in the main...

journal_title：Current opinion in rheumatology

authors： Karp DR

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Juvenile systemic sclerosis has a variety of clinical manifestations, sometimes different from the adult form. Early recognition, proper classification and treatment may improve the long-term outcome. RECENT FINDINGS:A large multicenter study coordinated by the Pediatric Rheumatology European Society...

journal_title：Current opinion in rheumatology

authors： Zulian F,Martini G

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been a tremendous interest to understand the mechanisms that regulate gene expression in autoimmunity and their effect on disease phenotypes by exploring different epigenetic mechanisms. In this review, we will introduce lupus epigenetics through reviewing historical key findings, then we wi...

journal_title：Current opinion in rheumatology

authors： Altorok N,Sawalha AH

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The incidence and mortality of cardiovascular disease are increased in the context of rheumatoid arthritis. The purpose of this review is to examine our evolving understanding of the pathogenesis of cardiovascular disease in rheumatoid arthritis and to underscore the importance of tailored prevention ...

journal_title：Current opinion in rheumatology

authors： Snow MH,Mikuls TR

更新日期：2005-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses genomic investigations in ankylosing spondylitis (AS) beyond genome-wide association (GWA) studies, but prior to this, genetic variants achieving genome-wide significance will be summarized highlighting key pathways contributing to disease pathogenesis. RECENT FINDINGS:Evidence...

journal_title：Current opinion in rheumatology

authors： O'Rielly DD,Uddin M,Rahman P

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoporosis guidelines do not usually provide specific recommendations regarding what medication is most appropriate for individual patients. Generic oral bisphosphonates are often considered first-line treatment for osteoporosis, but treatment duration is limited, based on potential long-term safety...

journal_title：Current opinion in rheumatology

authors： Cosman F

更新日期：2018-07-01 00:00:00

abstract：:Raloxifene, a selective estrogen receptor modulator, is currently used for both prevention and treatment of postmenopausal osteoporosis. Recent data from the MORE (Multiple Outcomes of Raloxifene Evaluation) trial have evaluated health-related quality of life, 1-year clinical vertebral fracture reduction, and the corr...

journal_title：Current opinion in rheumatology

authors： Gluck O,Maricic M

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The Wnt signaling pathway has been a major focus of effort in the bone field for the past 5 years. This review will examine some of the seminal findings that have brought us to our current understanding of the role of this pathway in bone metabolism. RECENT FINDINGS:The Wnt/beta-catenin signaling pat...

journal_title：Current opinion in rheumatology

authors： Johnson ML,Kamel MA

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:IgG4-related disease (IgG4-RD) is a recently described fibroinflammatory condition that can affect nearly any organ. Our knowledge of this condition--its manifestations, diagnosis, pathogenesis and treatment--is expanding rapidly. RECENT FINDINGS:This review highlights the most recent developments in...

journal_title：Current opinion in rheumatology

authors： Wallace ZS,Stone JH

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the ...

journal_title：Current opinion in rheumatology

authors： Stojan G,Petri M

更新日期：2018-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes the current evidence on the management of primary and secondary central nervous system (CNS) vasculitis. RECENT FINDINGS:Two recent retrospective cohort studies have described the treatment and outcomes of patients with adult primary central nervous system vasculitis (PCNSV). ...

journal_title：Current opinion in rheumatology

authors： Salvarani C,Pipitone N,Hunder GG

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:As the most common arthritis and a leading cause of chronic disability, osteoarthritis is associated with substantial cost to the individual and to society. Epidemiologic studies have supplied, in addition to incidence, prevalence and risk factor data, much of what is known about the natural history o...

journal_title：Current opinion in rheumatology

authors： Sharma L,Kapoor D,Issa S

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The utility of cytokines as therapeutic targets in rheumatoid arthritis has been unequivocally demonstrated by the success of tumour necrosis factor blockade in clinical practice. Partial and non-responses to tumour necrosis factor blocking agents, however, together with the increasing clinical drive ...

journal_title：Current opinion in rheumatology

authors： Asquith DL,McInnes IB

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Infections have been suggested to contribute to disease induction and reactivation in many of the idiopathic vasculitides. This review describes and evaluates the evidence that microbes are involved in the etiopathogenesis of these diseases. RECENT FINDINGS:Large-vessel vasculitis has recently been a...

journal_title：Current opinion in rheumatology

authors： van Timmeren MM,Heeringa P,Kallenberg CG

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Regeneration of damaged articular cartilage remains one of the most challenging problems in orthopedic surgery. Distinct surgical procedures were developed for the repair of focal cartilage defects and this review will focus on recent aspects of cell-based healing approaches that aim to achieve restor...

journal_title：Current opinion in rheumatology

authors： Richter W

更新日期：2007-09-01 00:00:00

abstract：:Autoantibodies in systemic lupus erythematosus (SLE) are targeted predominantly to intracellular nucleoprotein particles. Following analysis of the quantitative and qualitative properties of the humoral immune response as well as identification of the major particles recognized as antigens, current studies are address...

journal_title：Current opinion in rheumatology

authors： Elkon K

更新日期：1995-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent advances in the analysis of genetic determinants of bone mass. It addresses both human and animal linkage studies as well as genetic manipulations in animals, inbred mouse models, and candidate gene analyses. RECENT FINDINGS:Recent studies have implicated novel regulatory ...

journal_title：Current opinion in rheumatology

authors： Baldock PA,Eisman JA

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To review radiographic and MRI developments in measuring osteoarthritis progression in the tibiofemoral compartment of the knee. RECENT FINDINGS:Standardized techniques for measuring joint space width in the medial tibiofemoral compartment, using standardized radiographic protocols, have become accep...

journal_title：Current opinion in rheumatology

authors： Hunter DJ,Le Graverand MP,Eckstein F

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent evidence on cutaneous manifestations of lupus, with a focus on evidence for pediatric patients. RECENT FINDINGS:Cutaneous manifestations of SLE are common and may precede signs or symptoms of systemic disease. Early recognition and initiation of therapy improves quality of life by re...

journal_title：Current opinion in rheumatology

authors： Arkin LM,Nguyen C,Klein-Gitelman M

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Arthritogenic alphaviruses are globally distributed mosquito-borne RNA viruses causing epidemics of polyarthritis/arthralgia, with disease emerging or reemerging and increasingly being reported in travelers. This article summarizes the current knowledge of these diseases, focusing on recent developmen...

journal_title：Current opinion in rheumatology

authors： Suhrbier A,La Linn M

更新日期：2004-07-01 00:00:00

abstract：:Methotrexate has become a standard therapy for the treatment of rheumatoid arthritis. This review summarizes the recent literature on low-dose methotrexate in the rheumatologic illnesses. The effect of methotrexate on in vivo rheumatoid factor production and suppression of ex vivo leukotriene B4 generation is reviewed...

journal_title：Current opinion in rheumatology

authors： Grosflam J,Weinblatt ME

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Many patients with psoriatic arthritis (PsA) have additional medical problems that can have an impact on morbidity and mortality. The goal of this review is to summarize the available evidence to date on the association of medical comorbidities with PsA and the implications these comorbidities have on...

journal_title：Current opinion in rheumatology

authors： Ogdie A,Schwartzman S,Husni ME

更新日期：2015-03-01 00:00:00

abstract：:Recent advances in renal osteodystrophy deal with the pathogenesis of the disease, in particular in early renal failure, with the mechanisms of skeletal resistance to parathyroid hormone, with the potential role of iron, and with increased knowledge of adynamic bone disease. For the control of phosphatemia, aluminum-c...

journal_title：Current opinion in rheumatology

authors： Bardin T

更新日期：1992-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study is to review the evidence and recent developments leading to novel therapeutics in scleroderma. RECENT FINDINGS:Recent advances have been made in understanding the key pathogenetic aspects of scleroderma, and these have led to potential targeted therapeutic agents for the ma...

journal_title：Current opinion in rheumatology

authors： Ong VH,Denton CP

更新日期：2010-05-01 00:00:00

abstract：:Information detailing the socioeconomic impact of the vasculitides on society has been difficult to obtain. Recent published studies provide preliminary information suggesting that the impact of systemic vasculitis may be significant and far greater than previously anticipated. A rough estimate of expenditures for vas...

journal_title：Current opinion in rheumatology

authors： Cotch MF

更新日期：2000-01-01 00:00:00