Abstract:
PURPOSE OF REVIEW:An increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consequences of this observation. RECENT FINDINGS:Autoantigens from dying cells trigger plasmacytoid dendritic cells to a continuous synthesis of type I IFN, which is promoted by natural killer (NK) cells and B cells. A growing number of genes connected to type I IFN production and response associates with an increased susceptibility to autoimmunity. Besides type I IFN, type III IFN (IFN-λ) may contribute to the IFN signature. In SLE and primary Sjögren's syndrome, a prominent IFN signature is connected to an active disease, whereas in rheumatoid arthritis the IFN signature defines a disease subset with poor clinical outcome and treatment failure to B-cell depleting therapy. Several therapies aiming to inhibit the IFN signature are in clinical trials and early data suggest clinical benefits without major safety problems. SUMMARY:The observed IFN signature in several autoimmune diseases is a biomarker of active disease and is investigated as a tool when selecting treatment for individual patients.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Rönnblom L,Eloranta MLdoi
10.1097/BOR.0b013e32835c7e32subject
Has Abstractpub_date
2013-03-01 00:00:00pages
248-53issue
2eissn
1040-8711issn
1531-6963journal_volume
25pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Two diseases associated with chronic kidney disease (CKD) have benefited from advances in the past year which are of great importance for rheumatologists: renal osteodystrophy, which is now clearly associated with vascular calcification and cardiovascular death, and nephogenic systemic fibrosis, which...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32831ca5c5
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Current trends in the management of Behçet's syndrome will be reviewed in this article. RECENT FINDINGS:Biologic agents have gained increasing importance over the years in the management of Behçet's syndrome. Long-term results of observational studies have shown that anti-tumor necrosis factor agents...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000231
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To review radiographic and MRI developments in measuring osteoarthritis progression in the tibiofemoral compartment of the knee. RECENT FINDINGS:Standardized techniques for measuring joint space width in the medial tibiofemoral compartment, using standardized radiographic protocols, have become accep...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3283235add
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:There is an increasing interest in improving the understanding of pathophysiology, outcome measures, and therapies of rheumatic skin disease. Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheum...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328333b9e2
更新日期:2010-01-01 00:00:00
abstract::Major changes have taken place in the diagnosis and treatment of rotator cuff tears. It seems that magnetic resonance imaging alone as a diagnostic tool is still not sensitive enough, particularly in the diagnosis of partial tears. Arthrography and arthroscopy are still considered essential for an accurate preoperativ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199603000-00011
更新日期:1996-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review provides an update on recent findings with regards to the genetics of hyperuricemia and gout, including recent data from genome-wide association studies (GWAS). RECENT FINDINGS:Five GWAS around the same time reported that genetic variants of SLC2A9/GLUT9 were associated with lower serum u...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32833645e8
更新日期:2010-03-01 00:00:00
abstract::Eosinophilic infiltration into skeletal muscle, although rare, has been described in a diverse group of conditions. It most commonly occurs in parasitic infection as focal eosinophilic myositis but can be a feature of systemic hypereosinophilic conditions such as eosinophilia-myalgia syndrome and idiopathic hypereosin...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199811000-00002
更新日期:1998-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Chronic periaortitis is characterized by a fibro-inflammatory process spreading from the abdominal aorta and the iliac arteries. Originally, chronic periaortitis was considered a localized inflammatory response to severe aortic atherosclerosis. However, subsequent studies have shown that chronic peria...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328341137d
更新日期:2011-01-01 00:00:00
abstract::In this review, we address current concepts and recent experimental results that relate to heterogeneity in the physiologic, biochemical, and morphologic properties of mammalian skeletal muscle fibers. Recent data reinforce some of these current concepts while questioning others. The biochemical bases of the concepts ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199305060-00002
更新日期:1993-11-01 00:00:00
abstract::Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antinuclear antibodies (ANAs), including pathogenic specificities to DNA. As shown by recent research, ANA production is a genetically determined process in which self antigens drive B and T cells that have escaped the normal mechanisms o...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200009000-00002
更新日期:2000-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Rheumatoid arthritis (RA) is a potentially destructive disease with profound impact on patients' function and quality of life. Newer therapeutic agents have revolutionized outcomes but have not resulted in best outcomes for all patients. In this article, we will review recent progress in the developme...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32835fd294
更新日期:2013-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Arthritogenic alphaviruses are globally distributed mosquito-borne RNA viruses causing epidemics of polyarthritis/arthralgia, with disease emerging or reemerging and increasingly being reported in travelers. This article summarizes the current knowledge of these diseases, focusing on recent developmen...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000130537.76808.26
更新日期:2004-07-01 00:00:00
abstract:PURPOSE OF REVIEW:We discuss pathology-based characterization and classification of acquired immune and inflammatory myopathies (IIMs). RECENT FINDINGS:Several types of IIMs do not fit well into the typical IIM subclassifications: dermatomyositis, polymyositis and inclusion body myositis (IBM). Myopathologic features ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32834bab42
更新日期:2011-11-01 00:00:00
abstract::Osteoarthritis is the most common form of arthritis in adults and its incidence increases with age. More than 50% of people aged 65 and older have radiographic changes of knee osteoarthritis. Calcium crystals, including calcium pyrophosphate dihydrate and basic calcium phosphate crystals, are also common in the elderl...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200205000-00018
更新日期:2002-05-01 00:00:00
abstract::The evolution of total knee replacement designs and techniques has made possible predictable and long-lasting pain relief in the treatment of knee arthritis. Excellent long-term results have been obtained with cemented knee replacement, with or without preservation of the posterior cruciate ligament. Attempts to achie...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199503000-00007
更新日期:1995-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review examines recent advances in the analysis of genetic determinants of bone mass. It addresses both human and animal linkage studies as well as genetic manipulations in animals, inbred mouse models, and candidate gene analyses. RECENT FINDINGS:Recent studies have implicated novel regulatory ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000127828.34643.b4
更新日期:2004-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the recent efficacy and safety data comparing methotrexate (MTX) and leflunomide (LEF) monotherapy, in combination with biologic therapies and in combination with each other. RECENT FINDINGS:MTX is the 'anchor drug' in all rheumatoid arthritis treatment strategies. Patients with contraindic...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328344f2e4
更新日期:2011-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The severity of each organ involvement, natural course, and response to therapies are extremely heterogeneous among patients with systemic sclerosis (SSc). The discovery and validation of biomarkers can help identify disease risk, improve early diagnosis and prognosis, better design clinical trials an...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000324
更新日期:2016-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is a common disorder among older adults. The diagnosis is based solely on radiographic abnormalities defined using the Resnick criteria. DISH is characterized by ossification of the anterior longitudinal ligament of the spine and v...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200405000-00021
更新日期:2004-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout. This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion. RECENT FINDINGS:The disco...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3282f33f87
更新日期:2008-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Juvenile dermatomyositis is a rare chronic inflammatory disease that primarily affects the muscles and skin. Immunosuppressive therapy has played a very important role in reducing mortality rates and morbidity. The review focuses on the spectrum of medications currently used in the treatment of juveni...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章
doi:10.1097/01.bor.0000240362.32089.4c
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To highlight recent evidence regarding the contribution of traditional and nontraditional [e.g. inflammatory markers, rheumatoid arthritis (RA) features] risk factors toward the excess cardiovascular risk in RA. RECENT FINDINGS:The impact of traditional risk factors on the development of cardiovascul...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32834ff2fd
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update on the genetics and immunologic basis of autoinflammatory bone disorders including chronic recurrent multifocal osteomyelitis including the monogenic forms of the disease. RECENT FINDINGS:Ongoing research in murine, canine and human models of sterile bone inflammation has solidif...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328363eb08
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Pulmonary fibrosis is a devastating disease that affects millions of people worldwide. Among the most common forms of lung fibrosis are idiopathic pulmonary fibrosis (IPF) and scleroderma-related interstitial lung disease (SSc-ILD). Despite a wealth of literature regarding each of these diseases, stud...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3283588de4
更新日期:2012-11-01 00:00:00
abstract::Bacterial infections can clinically mimic a primary vasculitic syndrome and can directly cause a vasculitis that may respond to prompt recognition and treatment of the infection. Increasing direct and indirect evidence is establishing links between certain infections and vasculopathies, including aortitis, atheroscler...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199801000-00008
更新日期:1998-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This review will explore two new aspects of the involvement of viruses in multiple sclerosis pathogenesis. The first aspect is the complex interactions between viruses. The second aspect is the proposal of a mechanism by which autoreactive T cells are able to escape thymic selection and potentially re...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328362004d
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Therapeutic inhibition of tumour necrosis factor-alpha strongly increases the risk of reactivation in latent tuberculosis infection. Recent blood tests based on antigen-specific T cell response and measuring production of interferon-gamma, so called interferon-gamma release assays (IGRAs), are promisi...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328329c6cb
更新日期:2009-05-01 00:00:00
abstract::The Achilles tendon is the strongest tendon in the human body. Because most Achilles tendon injuries take place in sports and there has been an common upsurge in sporting activities, the number and incidence of the Achilles tendon overuse injuries and complete ruptures have increased in the industrialized countries du...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200103000-00009
更新日期:2001-03-01 00:00:00
abstract::Interstitial lung disease frequently complicates rheumatic disorders, especially polymyositis-dermatomyositis, rheumatoid arthritis, systemic sclerosis, and mixed connective tissue disease. In this article, we review the current data supporting the use of azathioprine, cyclophosphamide, chlorambucil, cyclosporine, and...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199405000-00004
更新日期:1994-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the spectrum of nonautoimmune myopathies that may be misdiagnosed as autoimmune myopathy. RECENT FINDINGS:Inherited myopathies, such as dysferlinopathy, calpainopathy, and facioscapulohumeral dystrophy may be misdiagnosed as autoimmune myopathy, especially when they have inflammatory muscl...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000441
更新日期:2017-11-01 00:00:00