Abstract：
PURPOSE OF REVIEW:Chronic periaortitis is characterized by a fibro-inflammatory process spreading from the abdominal aorta and the iliac arteries. Originally, chronic periaortitis was considered a localized inflammatory response to severe aortic atherosclerosis. However, subsequent studies have shown that chronic periaortitis may also involve other arteries and present with features of auto-immune diseases. This article reviews the issue of large-vessel involvement in chronic periaortitis and its implications in the pathogenesis and nosography of the disease. RECENT FINDINGS:In many reports, chronic periaortitis has been shown to involve not only the aorto-iliac axis but also other vascular segments such as the thoracic aorta, the proximal epiaortic arteries, the coronary, renal, and mesenteric arteries. Thoracic aorta involvement may manifest as thoracic periaortitis with or without aneurysmal dilatation, or simply as thoracic aorta aneurysm. Thoracic periaortitis can also be a feature of the so-called IgG4-related systemic disease, with which chronic periaortitis may sometimes be associated. Histopathologic studies of chronic periaortitis show adventitial inflammation and fibrosis, vasculitis of vasa vasorum, and adventitial lymphoid follicles with germinal centers, suggesting that chronic periaortitis could be a primary aortitis. Genetic studies have demonstrated an association with HLA-DRB1*03, a marker of auto-immunity, and with the CCR5Δ32 polymorphism, which has been mapped to a Th2 response. Taken together, these findings support the notion of a primary inflammatory or immune-mediated disorder. SUMMARY:Chronic periaortitis is an inflammatory or immune-mediated disorder characterized histopathologically by adventitial inflammation and clinically by variable involvement of different arteries, mainly of large caliber. These findings raise the issue of whether chronic periaortitis should be considered a large-vessel vasculitis.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Vaglio A,Pipitone N,Salvarani Cdoi
10.1097/BOR.0b013e328341137dsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
1-6issue
1eissn
1040-8711issn
1531-6963pii
00002281-201101000-00002journal_volume
23pub_type
杂志文章,评审abstract：:This study reviews articles published in 2000 and 2001 about occupational physical activities as risk factors for osteoarthritis (OA) of the knee and hip. Six studies were identified in MEDLINE and EMBASE; five case-control studies and one cross-sectional study. Criteria for OA were: (on the waiting list for) joint re...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-200203000-00002
更新日期：2002-03-01 00:00:00
abstract：:Organ transplantation offers new life to patients who suffer from incurable disease. The problem of rejection of the transplanted organ has been overcome with the use of potent immunosuppressive drugs. These drugs, although they allow graft tolerance and graft survival, also are associated with complications such as o...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-199505000-00018
更新日期：1995-05-01 00:00:00
abstract：:Behçet's disease and Takayasu's disease in children are uncommon and may have an insidious course leading to a delayed diagnosis. Both diseases usually occur in late childhood, although disease onset in the first year of life has been reported. Compared with adults, Behçet's disease in children appears to be character...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-199509000-00015
更新日期：1995-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Since their discovery over 15 years ago, intensive research has focused on the presence, phenotype and function of FOXP3(+) regulatory T cells (Treg) in autoimmune diseases such as rheumatoid arthritis (RA). The questions of whether Treg deficiencies underlie autoimmune pathology and whether or how Tr...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0b013e32835d0ee4
更新日期：2013-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Regeneration of damaged articular cartilage remains one of the most challenging problems in orthopedic surgery. Distinct surgical procedures were developed for the repair of focal cartilage defects and this review will focus on recent aspects of cell-based healing approaches that aim to achieve restor...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0b013e3282a95e4c
更新日期：2007-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Clinical use of immune checkpoint inhibitor (ICI) therapy has revolutionized the therapeutic landscape of cancer. By activating the immune system using monoclonal anti-CTLA-4 and PD(L)-1 antibodies, remission can be induced in previously terminal cancers. However, these breakthroughs come at a price. ...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0000000000000672
更新日期：2020-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Rapid introduction of newly developed drugs in the absence of clear understanding of the pathophysiologic mechanisms behind drug-induced lupus erythematosus (DILE) can sometimes make DILE difficult to recognize in clinical practice. The purpose of this review is to summarize drugs most recently report...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0000000000000522
更新日期：2018-09-01 00:00:00
abstract：PURPOSE OF REVIEW:In the present review, recent findings regarding silicone breast implants (SBIs) complicated by rheumatic autoimmune diseases are described. RECENT FINDINGS:Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may 'bleed' ...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0000000000000391
更新日期：2017-07-01 00:00:00
abstract：:Methotrexate has become a standard therapy for the treatment of rheumatoid arthritis. This review summarizes the recent literature on low-dose methotrexate in the rheumatologic illnesses. The effect of methotrexate on in vivo rheumatoid factor production and suppression of ex vivo leukotriene B4 generation is reviewed...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1991-06-01 00:00:00
abstract：:With the opportunity for long-term follow-up, it has been appreciated that disease severity may vary considerably in patients with Wegener's granulomatosis, polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome. Although combined therapy with cyclophosphamide and glucocorticoids continues to be th...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-199701000-00005
更新日期：1997-01-01 00:00:00
abstract：:Osteoporosis occurs in patients with rheumatoid arthritis, acromegaly, anorexia nervosa, chronic liver disease, sickle cell hemoglobinopathies, and mastocytosis. Osteomalacia occurs in patients with renal tubular acidosis, and with tumors. ...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-199106000-00020
更新日期：1991-06-01 00:00:00
abstract：:Behçet's disease is a systemic inflammatory disorder capable of inducing thrombophlebitis. Clinicopathologically, it is characterized by neutrophil and platelet hyperfunction. Lesions are formed presumably because neutrophils infiltrating the affected tissue release active oxygen and lysosomal enzymes in large amounts...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1992-02-01 00:00:00
abstract：:Longitudinal studies of large cohorts of patients with Raynaud's Phenomenon have addressed the predictors of developing a secondary disease. New insights have been reported into the pathogenesis of Raynaud's phenomenon and the consequences of ischemia. Studies have suggested that more than one defect may cause Raynaud...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1996-11-01 00:00:00
abstract：:Current advances in the study of hypertrophic osteoarthropathy are discussed. An update of the classification of hypertrophic osteoarthropathy is given in which the POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome is included among the associated diseases. Cyanotic heart disea...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:Acute bacterial arthritis continues to be a common occurrence, and despite improved treatment regimens, the prognosis has not improved significantly over the past 20 years. During the past year, the emergence of unique predisposing factors for bacterial arthritis, including prosthetic joints and HIV infection, were em...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-199407000-00008
更新日期：1994-07-01 00:00:00
abstract：PURPOSE OF REVIEW:There is an increasing interest in improving the understanding of pathophysiology, outcome measures, and therapies of rheumatic skin disease. Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheum...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0b013e328333b9e2
更新日期：2010-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Recent work has continued to clarify the role of major histocompatibility complex class I in the pathogenesis of autoimmune myositis. In the past year, several new observations have been made in this area. This review describes these findings and discusses their relevance to the pathogenesis of autoim...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/01.bor.0000179947.58271.9a
更新日期：2005-11-01 00:00:00
abstract：:Idiopathic inflammatory myositis in children includes multiple disease entities, but is primarily made up of juvenile dermatomyositis and, to a lesser degree, juvenile polymyositis. Much new information has been published in the last few years about these diseases, including the epidemiology, pathogenesis, clinical di...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-200109000-00015
更新日期：2001-09-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this study is to review the evidence and recent developments leading to novel therapeutics in scleroderma. RECENT FINDINGS:Recent advances have been made in understanding the key pathogenetic aspects of scleroderma, and these have led to potential targeted therapeutic agents for the ma...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0b013e328337c3d6
更新日期：2010-05-01 00:00:00
abstract：:Bacterial infections can clinically mimic a primary vasculitic syndrome and can directly cause a vasculitis that may respond to prompt recognition and treatment of the infection. Increasing direct and indirect evidence is establishing links between certain infections and vasculopathies, including aortitis, atheroscler...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-199801000-00008
更新日期：1998-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Axial spondyloarthritis (axSpA) is a chronic inflammatory condition with articular and extra-articular manifestations. Remission, a state of absence of clinical and imaging signs of disease activity over time, is the goal of management. This review addresses the concept of minimal disease activity (MD...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0000000000000387
更新日期：2017-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Osteoporosis guidelines do not usually provide specific recommendations regarding what medication is most appropriate for individual patients. Generic oral bisphosphonates are often considered first-line treatment for osteoporosis, but treatment duration is limited, based on potential long-term safety...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0000000000000509
更新日期：2018-07-01 00:00:00
abstract：PURPOSE OF REVIEW:The article reviews recent advances in the research of fractures in patients with systemic lupus erythematosus (SLE), highlighting their clinical, scientific, and economic impact. RECENT FINDINGS:Recent studies demonstrated an increased incidence of osteoporosis and symptomatic fractures in patients ...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0000000000000290
更新日期：2016-07-01 00:00:00
abstract：:Psoriatic arthritis is an inflammatory arthropathy associated with psoriasis and is classified as a seronegative spondyloarthropathy. It occurs in approximately 5% to 7% of patients with psoriasis. The etiopathogenesis of psoriatic arthritis is not well known, but interaction among genetic, immunologic, and environmen...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1992-08-01 00:00:00
abstract：:The number of reported cases of Lyme disease in the United States has increased steadily since 1982, and the increase coincides with a growth in deer populations in endemic regions. Application of careful epidemiologic principles has led to the identification of two new pathogens that produce syndromes closely related...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-199707000-00010
更新日期：1997-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Systemic sclerosis, or scleroderma, is a systemic autoimmune disease manifest by vascular damage and fibrosis within the skin and visceral organs. Whereas scleroderma is a heterogenous disorder in terms of disease symptoms and clinical course, scleroderma-specific autoantibody profiles associate stron...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/00002281-200311000-00016
更新日期：2003-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Although 6 years have elapsed since the initial report describing the presence of microchimeric cells in affected tissues from patients with systemic sclerosis, a mechanism by which these cells might contribute to the pathogenesis of the disease is still unknown. This article reviews the published lit...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/01.bor.0000145516.45854.7b
更新日期：2005-01-01 00:00:00
abstract：PURPOSE OF REVIEW:To review the present knowledge of the role of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in the pathogenesis of fibrotic diseases. RECENT FINDINGS:ER stress and UPR occur in a number of diseases associated with organ fibrosis; however, the contribution of these pathways to...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0b013e3283588dbb
更新日期：2012-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Renal complications are important in scleroderma (systemic sclerosis) and include scleroderma renal crisis. This is a medical emergency that requires careful management. Recent cohort studies have highlighted key aspects of management and outcome and these are reviewed. RECENT FINDINGS:Two recent art...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0b013e3283108df7
更新日期：2008-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) pathogenesis is complex. Aberrancies of immune function that previously were described but not well understood are now becoming better characterized, in part through recognition of monogenic cases of lupus-like disease. RECENT FINDINGS:We highlight here recent descr...
journal_title：Current opinion in rheumatology
pub_type： 杂志文章,评审
doi：10.1097/BOR.0000000000000474
更新日期：2018-03-01 00:00:00
