Abstract:
:The evolution of total knee replacement designs and techniques has made possible predictable and long-lasting pain relief in the treatment of knee arthritis. Excellent long-term results have been obtained with cemented knee replacement, with or without preservation of the posterior cruciate ligament. Attempts to achieve similar results with cementless implants have been hampered by designs with thin polyethylene and high-contact stresses, leading to early failure. Unicompartmental replacement can be used in the treatment of focal arthritis in one compartment, but designs with thin polyethylene must be avoided. Low molecular weight heparin can be a useful adjunct to warfarin in the prevention of deep-vein thrombosis. Further studies must be made to lower the incidence of infection, mechanical failure, and wear-debris generation.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Buly RL,Sculco TPdoi
10.1097/00002281-199503000-00007subject
Has Abstractpub_date
1995-03-01 00:00:00pages
107-13issue
2eissn
1040-8711issn
1531-6963journal_volume
7pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:This review examines recent advances in the analysis of genetic determinants of bone mass. It addresses both human and animal linkage studies as well as genetic manipulations in animals, inbred mouse models, and candidate gene analyses. RECENT FINDINGS:Recent studies have implicated novel regulatory ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000127828.34643.b4
更新日期:2004-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent work has continued to clarify the role of major histocompatibility complex class I in the pathogenesis of autoimmune myositis. In the past year, several new observations have been made in this area. This review describes these findings and discusses their relevance to the pathogenesis of autoim...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000179947.58271.9a
更新日期:2005-11-01 00:00:00
abstract::Patients with inflammatory arthritides such as rheumatoid arthritis develop both localized and generalized osteoporosis and have an increased risk of fracture. Bone loss can occur early and is directly related to the inflammatory process as well as to the indirect effects of arthritis on physical activity. Corticoster...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199607000-00015
更新日期:1996-07-01 00:00:00
abstract::Information detailing the socioeconomic impact of the vasculitides on society has been difficult to obtain. Recent published studies provide preliminary information suggesting that the impact of systemic vasculitis may be significant and far greater than previously anticipated. A rough estimate of expenditures for vas...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200001000-00004
更新日期:2000-01-01 00:00:00
abstract::Systemic lupus erythematosus and Sjögren syndrome remain elusive in the description of their underlying etiologic causes and pathogenic mechanisms. Although underlying genetic predisposition appears to contribute to both diseases based on twin and other genetic studies, additional factors must play a role. Over the de...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200109000-00005
更新日期:2001-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review highlights the present state of efforts at registry implementation which exist internationally. These efforts are contrasted with those in the USA. RECENT FINDINGS:The implications of the different data which are derived from diverse registry sources are discussed. The need for long-term ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3282f50eb1
更新日期:2008-03-01 00:00:00
abstract::Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antinuclear antibodies (ANAs), including pathogenic specificities to DNA. As shown by recent research, ANA production is a genetically determined process in which self antigens drive B and T cells that have escaped the normal mechanisms o...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200009000-00002
更新日期:2000-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000480
更新日期:2018-03-01 00:00:00
abstract::Low back pain continues to affect a significant proportion of the younger, working population between 35 and 45 years of age. An important study has correlated macroscopic and microscopic intervertebral disc alterations starting in the second decade of life with oxidative stress manifested by the presence of N-(carbox...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199903000-00012
更新日期:1999-03-01 00:00:00
abstract:PURPOSE OF REVIEW:It is an understatement to say that drug approvals in systemic lupus erythematosus (SLE), lupus nephritis, and Sjogren's syndrome have lagged far behind those in other autoimmune diseases, such as rheumatoid arthritis and psoriatic arthritis. Reasons for this are multiple and include the molecular and...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章
doi:10.1097/BOR.0000000000000754
更新日期:2020-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This review focuses on recent progress in the understanding of various aspects of renal transport of urate. RECENT FINDINGS:Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to the transport of urate have been identified. The mo...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328032781a
更新日期:2007-03-01 00:00:00
abstract::During the past 2 years, four papers describing new research studies and three papers reviewing the literature were published. These seven papers address longstanding issues, including 1) the presence or absence of cognitive impairment in systemic lupus erythematosus (SLE), 2) the prevalence of such impairment within ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199809000-00008
更新日期:1998-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Evidence accumulated since 2010 indicates that human osteoarthritis should now be reclassified as a systemic musculoskeletal disease rather than a focal disorder of synovial joints. RECENT FINDINGS:Inflammation was seen as the key component promoting synovitis as well as progression of cartilage and ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000162
更新日期:2015-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The history of ankylosing spondylitis, the main representative of the spondyloarthritides, is dating back to several thousand years BC and recently proven for medieval skeleton by HLA-B27 typing with modern molecular techniques. In modern time, the history of spondyloarthritis (SpA) is characterized b...
journal_title:Current opinion in rheumatology
pub_type: 历史文章,杂志文章
doi:10.1097/BOR.0b013e3283470ecd
更新日期:2011-07-01 00:00:00
abstract::Acute bacterial arthritis continues to be a common occurrence, and despite improved treatment regimens, the prognosis has not improved significantly over the past 20 years. During the past year, the emergence of unique predisposing factors for bacterial arthritis, including prosthetic joints and HIV infection, were em...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199407000-00008
更新日期:1994-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent literature in inflammatory myopathies suggests that both immune (cell-mediated and humoral) and nonimmune [endoplasmic reticulum (ER) stress and autophagy] mechanisms play a role in muscle fiber damage and dysfunction. This review describes these findings and discusses their relevance to diseas...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3283319265
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Juvenile dermatomyositis is a rare chronic inflammatory disease that primarily affects the muscles and skin. Immunosuppressive therapy has played a very important role in reducing mortality rates and morbidity. The review focuses on the spectrum of medications currently used in the treatment of juveni...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章
doi:10.1097/01.bor.0000240362.32089.4c
更新日期:2006-09-01 00:00:00
abstract::Significant advances were made this year in the understanding of serum amyloid A isotypes and in the definition of different amyloid light-chain proteins. Increasing numbers of hereditary amyloid-related transthyretin mutations have been reported (more than 30 to date). Two new hereditary amyloid proteins in several d...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199401000-00010
更新日期:1994-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Although osteoarthritis (OA) has received a paucity of attention from researchers in terms of drug development, there have been some significant findings relevant to clinical issues in OA that are summarized in this review. RECENT FINDINGS:Recent osteoarthritis research has focused on synovial, subch...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000273
更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To increase awareness and review the management of chronic viral hepatitis in individuals treated with immune-modifying agents to avoid potentially severe consequences. RECENT FINDINGS:Hepatitis B virus (HBV) reactivation has been reported with a wide variety of immunosuppressive regimens ranging fro...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000067
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite its critical roles in body movement, structure, and metabolism, skeletal muscle remains underappreciated in the context of rheumatoid arthritis. In rheumatoid arthritis, chronic inflammation, physical inactivity, and medication toxicities impair skeletal muscle. These skeletal muscle alteratio...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000697
更新日期:2020-05-01 00:00:00
abstract::The concept suggesting the involvement of the proinflammatory cytokine tumor necrosis factor (TNF)-alpha in the pathogenesis of rheumatoid arthritis (RA) has been demonstrated by several clinical trials targeting TNF-alpha. In addition to reduction of pain and swelling, a dramatic effect of TNF blocking therapies on t...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200105000-00010
更新日期:2001-05-01 00:00:00
abstract::Neoplasia can be associated with a wide range of rheumatologic manifestations. Literature over the last 12 months has reviewed metastasis of solid tumors to the joint and hypertrophic pulmonary osteoarthropathy. Vasculitis has been reported as a paraneoplastic syndrome associated with both hematologic and solid malign...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1992-02-01 00:00:00
abstract::Longitudinal studies of large cohorts of patients with Raynaud's Phenomenon have addressed the predictors of developing a secondary disease. New insights have been reported into the pathogenesis of Raynaud's phenomenon and the consequences of ischemia. Studies have suggested that more than one defect may cause Raynaud...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1996-11-01 00:00:00
abstract::The emergence of various therapeutic possibilities in the field of osteoarthritis has strongly prompted clinicians to conduct studies to evaluate the symptomatic as well as the potential chondromodulating effects of these treatments. For this purpose, some authors recently proposed guidelines with regard not only to t...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199503000-00003
更新日期:1995-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe recent advancements in diagnostic and therapeutic approaches to inclusion body myositis (IBM). RECENT FINDINGS:Our understanding of the implications of anti-cytosolic 5'-nucleotidase 1A autoantibody status in IBM and other diseases is increasing. Muscle imaging using magnetic resonance te...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000537
更新日期:2018-11-01 00:00:00
abstract::During the past year, another disease possibly influenced by intravenous gammaglobulin was identified as dermatomyositis/polymyositis. Additional studies provided further information regarding the use of monoclonal anti-CD4 antibody and combination therapy in rheumatoid arthritis, antithymocyte globulin in scleroderma...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199206000-00006
更新日期:1992-06-01 00:00:00
abstract::Angiitis of the central nervous system (CNS) remains a poorly understood and clinically challenging form of vascular inflammatory disease. Primary angiitis of the CNS (PACNS) has been viewed as a relentless and uniformly fatal disorder if untreated. In addition, recent trends have demonstrated an increasing reliance o...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Autoimmune pancreatitis (AIP) is a peculiar type of pancreatitis with a presumed autoimmune etiology. AIP is frequently associated with stenosis of the bile duct in the form of IgG4-related sclerosing cholangitis. This article reviews recent advances in clinicopathological findings for AIP and IgG4-re...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e3283412f60
更新日期:2011-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The Wnt signaling pathway has been a major focus of effort in the bone field for the past 5 years. This review will examine some of the seminal findings that have brought us to our current understanding of the role of this pathway in bone metabolism. RECENT FINDINGS:The Wnt/beta-catenin signaling pat...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32816e06f9
更新日期:2007-07-01 00:00:00