Hypertrophic osteoarthropathy.

abstract：PURPOSE OF REVIEW:Renal complications are important in scleroderma (systemic sclerosis) and include scleroderma renal crisis. This is a medical emergency that requires careful management. Recent cohort studies have highlighted key aspects of management and outcome and these are reviewed. RECENT FINDINGS:Two recent art...

journal_title：Current opinion in rheumatology

authors： Penn H,Denton CP

更新日期：2008-11-01 00:00:00

abstract：:Churg-Strauss syndrome (CSS) is a form of primary vasculitis characterized by allergy and angiitis. In the organ systems involved (lung, heart, peripheral nervous system, and so forth), eosinophilic infiltration can be found. Eosinophilia and normochromic normocytic anemia are leading laboratory findings together with...

journal_title：Current opinion in rheumatology

authors： Gross WL

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent work has continued to clarify the role of major histocompatibility complex class I in the pathogenesis of autoimmune myositis. In the past year, several new observations have been made in this area. This review describes these findings and discusses their relevance to the pathogenesis of autoim...

journal_title：Current opinion in rheumatology

authors： Nagaraju K

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Systemic sclerosis, or scleroderma, is a systemic autoimmune disease manifest by vascular damage and fibrosis within the skin and visceral organs. Whereas scleroderma is a heterogenous disorder in terms of disease symptoms and clinical course, scleroderma-specific autoantibody profiles associate stron...

journal_title：Current opinion in rheumatology

authors： Harris ML,Rosen A

更新日期：2003-11-01 00:00:00

abstract：:New information on the treatment of juvenile rheumatoid arthritis emphasizes more aggressive control of arthritis, particularly the use of methotrexate, both in low- and higher-dose regimens. Information concerning drug toxicity, including that of the nonsteroidal anti-inflammatory drugs, second-line agents, and metho...

journal_title：Current opinion in rheumatology

authors： Emery HM

更新日期：1993-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Cryoglobulinemic vasculitis is an immune-complex-mediated systemic vasculitis involving small-medium-sized vessels. A causative role of hepatitis C virus in over 80% patients has been definitively established, with heterogeneous geographical distribution. This review focuses on recent etiopathogenetic...

journal_title：Current opinion in rheumatology

authors： Ferri C,Mascia MT

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is a common disorder among older adults. The diagnosis is based solely on radiographic abnormalities defined using the Resnick criteria. DISH is characterized by ossification of the anterior longitudinal ligament of the spine and v...

journal_title：Current opinion in rheumatology

authors： Sarzi-Puttini P,Atzeni F

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Myositis, or idiopathic inflammatory myopathy, is an overarching concept that includes dermatomyositis, polymyositis, immune-mediated necrotizing myopathy and the antisynthetase syndrome. Glucocorticoids are still considered the mainstay of treatment of myositis but some patients require add-on immuno...

journal_title：Current opinion in rheumatology

authors： Pipitone N,Salvarani C

更新日期：2020-11-01 00:00:00

abstract：:A growing body of evidence is shedding light on how vascular injury, tissue mononuclear cell infiltrates, and fibrogenesis are related in the pathogenesis of systemic sclerosis. Recent evidence points to a role for adhesion molecules in the binding of mononuclear leukocytes to endothelium and transvascular migration o...

journal_title：Current opinion in rheumatology

authors： Postlethwaite AE

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:As the most common arthritis and a leading cause of chronic disability, osteoarthritis is associated with substantial cost to the individual and to society. Epidemiologic studies have supplied, in addition to incidence, prevalence and risk factor data, much of what is known about the natural history o...

journal_title：Current opinion in rheumatology

authors： Sharma L,Kapoor D,Issa S

更新日期：2006-03-01 00:00:00

abstract：:The emergence of various therapeutic possibilities in the field of osteoarthritis has strongly prompted clinicians to conduct studies to evaluate the symptomatic as well as the potential chondromodulating effects of these treatments. For this purpose, some authors recently proposed guidelines with regard not only to t...

journal_title：Current opinion in rheumatology

authors： Dougados M

更新日期：1995-03-01 00:00:00

abstract：:Acute bacterial arthritis continues to be a common occurrence, and despite improved treatment regimens, the prognosis has not improved significantly over the past 20 years. During the past year, the emergence of unique predisposing factors for bacterial arthritis, including prosthetic joints and HIV infection, were em...

journal_title：Current opinion in rheumatology

authors： Goldenberg DL

更新日期：1994-07-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been a tremendous interest to understand the mechanisms that regulate gene expression in autoimmunity and their effect on disease phenotypes by exploring different epigenetic mechanisms. In this review, we will introduce lupus epigenetics through reviewing historical key findings, then we wi...

journal_title：Current opinion in rheumatology

authors： Altorok N,Sawalha AH

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant advances in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis have been made in the past 10 years. This review aims to detail advances in treatment aimed at induction of remission. RECENT FINDINGS:Cyclophosphamide-based regimes remain the standard of care, at leas...

journal_title：Current opinion in rheumatology

authors： Harper L

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes the current evidence on the management of primary and secondary central nervous system (CNS) vasculitis. RECENT FINDINGS:Two recent retrospective cohort studies have described the treatment and outcomes of patients with adult primary central nervous system vasculitis (PCNSV). ...

journal_title：Current opinion in rheumatology

authors： Salvarani C,Pipitone N,Hunder GG

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent developments in the nosology of primary systemic vasculitis are placed in the context of an historical overview. The ongoing attempts to develop criteria for classification and diagnosis are discussed. RECENT FINDINGS:Giant cell arteritis has supplanted temporal arteritis as the preferred term...

journal_title：Current opinion in rheumatology

authors： Jennette JC,Falk RJ

更新日期：2007-01-01 00:00:00

abstract：:Myositis-overlap syndromes are characterized by a heterogeneous group of clinical syndromes of which many are closely linked with specific autoantibodies. Clinical and laboratory-based research into this fascinating group of syndromes have given us clues in elucidating the role of immunogenetic, environmental influenc...

journal_title：Current opinion in rheumatology

authors： Ioannou Y,Sultan S,Isenberg DA

更新日期：1999-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Rapid introduction of newly developed drugs in the absence of clear understanding of the pathophysiologic mechanisms behind drug-induced lupus erythematosus (DILE) can sometimes make DILE difficult to recognize in clinical practice. The purpose of this review is to summarize drugs most recently report...

journal_title：Current opinion in rheumatology

authors： He Y,Sawalha AH

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an increasing interest in improving the understanding of pathophysiology, outcome measures, and therapies of rheumatic skin disease. Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheum...

journal_title：Current opinion in rheumatology

authors： Clarke JT,Werth VP

更新日期：2010-01-01 00:00:00

abstract：:Estimates of the prevalence and incidence of knee osteoarthritis increase with age and are higher for women. Other differences in such estimates arise due to methodologic variables, including radiographic techniques. The risk for knee osteoarthritis increases with increasing body weight, long-term occupational joint s...

journal_title：Current opinion in rheumatology

authors： Slemenda CW

更新日期：1992-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Although osteoarthritis (OA) has received a paucity of attention from researchers in terms of drug development, there have been some significant findings relevant to clinical issues in OA that are summarized in this review. RECENT FINDINGS:Recent osteoarthritis research has focused on synovial, subch...

journal_title：Current opinion in rheumatology

authors： Kalunian KC

更新日期：2016-05-01 00:00:00

abstract：:Fibroblasts within the skin of scleroderma patients constitute a phenotypically heterogeneous population with regard to expression of collagens, cytokines, and cytokine receptors. By in situ hybridization techniques, scleroderma skin is shown to contain a subpopulation of fibroblasts that are stimulated for expression...

journal_title：Current opinion in rheumatology

authors： Unemori EN,Amento EP

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The article reviews recent advances in the research of fractures in patients with systemic lupus erythematosus (SLE), highlighting their clinical, scientific, and economic impact. RECENT FINDINGS:Recent studies demonstrated an increased incidence of osteoporosis and symptomatic fractures in patients ...

journal_title：Current opinion in rheumatology

authors： Bultink IE,Lems WF

更新日期：2016-07-01 00:00:00

abstract：:Interstitial lung disease frequently complicates rheumatic disorders, especially polymyositis-dermatomyositis, rheumatoid arthritis, systemic sclerosis, and mixed connective tissue disease. In this article, we review the current data supporting the use of azathioprine, cyclophosphamide, chlorambucil, cyclosporine, and...

journal_title：Current opinion in rheumatology

authors： McCune WJ,Vallance DK,Lynch JP 3rd

更新日期：1994-05-01 00:00:00

abstract：:The spectrum of clinical descriptions and clinicopathologic studies on patients with primary and secondary forms of antiphospholipid antibody syndrome continues to widen. Some differences exist for patients with lupus compared with those with Sjogren's syndrome. Some new thoughts regarding pathogenetic mechanisms and ...

journal_title：Current opinion in rheumatology

authors： McCarty-Farid GA

更新日期：1993-09-01 00:00:00

abstract：:The immune defense against extracellular pathogens is largely dependent on antibody production. Class switch recombination and somatic hypermutation shape the secondary antibody repertoire in peripheral lymphoid tissue. In the past few years, a series of primary immune deficiencies characterized by defects in these pr...

journal_title：Current opinion in rheumatology

authors： Gulino AV,Notarangelo LD

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Modern molecular biology offers a unique opportunity to gain a comprehensive picture of gene expression in a disease state. This review presents recent findings in the field of synovial fibroblast biology contributing to knowledge of the pathogenesis of rheumatoid arthritis. RECENT FINDINGS:Recently ...

journal_title：Current opinion in rheumatology

authors： Stanczyk J,Ospelt C,Gay RE,Gay S

更新日期：2006-05-01 00:00:00

abstract：:This article reviews recent publications related to the classification and treatment of juvenile spondyloarthropathies. We have included studies on adult onset spondyloarthropathies that are particularly relevant to childhood onset disease. Significant questions concerning classification of juvenile spondyloarthropath...

journal_title：Current opinion in rheumatology

authors： Bukulmez H,Colbert RA

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental compo...

journal_title：Current opinion in rheumatology

authors： Asquith M,Rosenbaum JT

更新日期：2016-07-01 00:00:00

abstract：:Animal models of systemic connective tissue diseases have provided valuable insights into the causative mechanisms and the pathogenesis of these diseases, and have provided the means to test potentially useful therapeutic interventions. Although numerous animal models for systemic sclerosis (SSc) have been described, ...

journal_title：Current opinion in rheumatology

authors： Jimenez SA,Christner PJ

更新日期：2002-11-01 00:00:00