Abstract:
PURPOSE OF REVIEW:This review discusses the most updated literature of muscle disease in scleroderma in the past year. RECENT FINDINGS:In the past year, two studies have highlighted that fibrosis is a prevalent histopathologic feature in muscle biopsies of patients with scleroderma muscle disease. In addition, microangiopathy was a common co-feature on muscle biopsies. A fibrosing myopathy, or fibrosis predominance on muscle histopathology, is associated with a unique clinical phenotype in patients with scleroderma. When compared with those with an inflammatory myopathy, patients with a fibrosing myopathy tend to have diffuse scleroderma, lower muscle enzymes, nonirritable myopathy, and elevated cardiac enzymes. These patients are also reported to have a higher risk of cardiopulmonary complications and cardiac death when compared with those with an inflammatory myopathy. SUMMARY:Although there are clear cases of overlap myositis, it is clear that muscle disease in scleroderma is being redefined, and it is crucial to start recognizing that the muscle is an organ that can directly be affected by scleroderma. Fibrosis can occur early in scleroderma muscle disease, and a unique histologic subtype of muscle disease, fibrosing myopathy, is associated with a higher risk of mortality.
journal_name
Curr Opin Rheumatoljournal_title
Current opinion in rheumatologyauthors
Paik JJdoi
10.1097/BOR.0000000000000552subject
Has Abstractpub_date
2018-11-01 00:00:00pages
576-580issue
6eissn
1040-8711issn
1531-6963journal_volume
30pub_type
杂志文章,评审abstract::Diffuse alveolar hemorrhage (DAH) is a rare yet serious and frequently life-threatening complication of a variety of conditions. DAH may result from coagulation disorders, inhaled toxins, or infections. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as antineutrophil cyt...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200101000-00003
更新日期:2001-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This article critically reviews the advances in medical management of giant cell arteritis (GCA) and Takayasu arteritis (TAK) with a focus on recent developments in targeted biologic therapy. RECENT FINDINGS:The role of biologics in the treatment of large vessel vasculitis (LVV) is expanding. TNFα in...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000265
更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide a summary of recent advances in the pathophysiology of rheumatoid arthritis. RECENT FINDINGS:Highlights include further elucidation of the relationship between the shared epitope, smoking and anticitrullinated protein/peptide antibody generation, including identification of putative citrul...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32834518a3
更新日期:2011-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To inform readers of recent advances in our understanding of the development and function of Th17 T cells and emerging data suggesting that the interleukin-23/interleukin-17 axis may be involved in the pathogenesis of spondyloarthritis. RECENT FINDINGS:The discovery of CD4+ Th17 T cells and the inter...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328303204b
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes recent advances in pulmonary hypertension, a leading cause of morbidity and mortality in scleroderma (SSc). RECENT FINDINGS:Although WHO Group I pulmonary arterial hypertension (PAH) is the most common cause of pulmonary hypertension, all WHO Groups can occur. PAH is now a crit...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000114
更新日期:2014-11-01 00:00:00
abstract::Neoplasia in an important cause of rheumatic disease. The mechanisms are either direct infiltration of the bone and joint, or indirect infiltration with manifestations distant from the site of neoplastic involvement. Many of the reports reviewed in this article center on direct associations. In particular, there is a ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199102000-00020
更新日期:1991-02-01 00:00:00
abstract::Recent population-based studies have examined the incidence, prevalence, and survival rates of patients with psoriatic arthritis (PsA). Although there are still no completely satisfactory diagnostic criteria for PsA, Moll and Wright's criteria--although not a true classification/diagnostic scheme--are the most used. T...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199807000-00004
更新日期:1998-07-01 00:00:00
abstract::The heritable disorders of connective tissue encompass a broad range of diseases, many of which occur in childhood and present to the pediatric rheumatologist's attention. The underlying theme of these disorders is fragility of connective tissue components such as bone, cartilage, and blood vessels. Over the past few ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1992-10-01 00:00:00
abstract:PURPOSE OF THE REVIEW:To define gout conditions and hyperuricemia. RECENT FINDINGS:Gout is defined as an arthritic condition resulting from the deposition of monosodium urate (MSU) crystals in and/or around joints, following long-standing hyperuricemia. Several recent ultrasound studies disclosed MSU deposits in a lar...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000028
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Clinical use of immune checkpoint inhibitor (ICI) therapy has revolutionized the therapeutic landscape of cancer. By activating the immune system using monoclonal anti-CTLA-4 and PD(L)-1 antibodies, remission can be induced in previously terminal cancers. However, these breakthroughs come at a price. ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000672
更新日期:2020-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This review examines thresholds for treatment of traditional cardiovascular disease (CVD) risk factors among patients with rheumatoid arthritis (RA) and whether RA-specific treatment modulates cardiovascular risk. RECENT FINDINGS:There are substantial data demonstrating an increased CVD risk among pa...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32835fd7f8
更新日期:2013-05-01 00:00:00
abstract::The increased bone remodeling in women after menopause induces an imbalance between bone resorption and formation, leading to decreased bone mass, altered bone microarchitecture, and increased fracture risk. Current antiosteoporotic drugs decrease bone remodeling or increase bone formation. Strontium ranelate (Protelo...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章
doi:10.1097/01.bor.0000229522.89546.7b
更新日期:2006-06-01 00:00:00
abstract::Acute bacterial arthritis continues to be a common occurrence, and despite improved treatment regimens, the prognosis has not improved significantly over the past 20 years. During the past year, the emergence of unique predisposing factors for bacterial arthritis, including prosthetic joints and HIV infection, were em...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199407000-00008
更新日期:1994-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental compo...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000299
更新日期:2016-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent interest in gout has led to development of new drugs for acute gout and long-term urate-lowering, as well as interest in improving the use of older drugs. The patients' comorbidities and concomitant medications may contribute to the risk of adverse drug reactions with anti-gout therapies. This ...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000031
更新日期:2014-03-01 00:00:00
abstract::New data concerning the epidemiology, etiology, diagnostic evaluation, and treatment of low back pain have been reported over the past year. Patients who have a longer period of pain during the initial episode of pain are at greatest risk of recurrence of pain. Abnormalities of fibrinolytic activity may have predictiv...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199403000-00017
更新日期:1994-03-01 00:00:00
abstract::Recent advances in renal osteodystrophy deal with the pathogenesis of the disease, in particular in early renal failure, with the mechanisms of skeletal resistance to parathyroid hormone, with the potential role of iron, and with increased knowledge of adynamic bone disease. For the control of phosphatemia, aluminum-c...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199206000-00018
更新日期:1992-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims at covering the role of muscle MRI in supporting the diagnosis of myositis, in aiding to differentiate it from other muscle disorders, and in monitoring myositis patients over time by assessing response to treatment and by discriminating between muscle inflammation and chronic damage....
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000326
更新日期:2016-11-01 00:00:00
abstract::In 1990, there were signs of a renewed interest in clinical studies about several aspects of osteoarthritis. The work-up of classic data and the use of new information from epidemiologic surveys as well as careful radiographic monitoring of selected groups of patients have brought us broader views on the general cours...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199108000-00017
更新日期:1991-08-01 00:00:00
abstract::Raynaud's phenomenon (RP) is a peripheral circulatory disorder characterized by sudden episodes of digital artery spasm, often precipitated by cold temperature or emotional stress. Although the cause of RP is not fully known, it appears to involve inappropriate adrenergic response to cold stimuli. Treatment of RP is c...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章
doi:10.1097/00002281-199811000-00013
更新日期:1998-11-01 00:00:00
abstract::Nitric oxide (NO) and prostaglandin E2 (PGE2) are two pleiotropic inflammatory mediators overproduced in arthritis-affected joints. The inducible isoform of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are found both in the synovial tissue and in the cartilage. Their expression is regulated by catabolic cyt...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-199905000-00009
更新日期:1999-05-01 00:00:00
abstract::Although there are excellent rationales for the use of biologic agents, no published novel therapeutic strategy in patients with early or late rheumatoid arthritis has thus far been proven in controlled clinical studies to prevent or retard cartilage destruction. Although T-cell-specific therapies in chronic rheumatoi...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1997-05-01 00:00:00
abstract:PURPOSE OF REVIEW:With progressive age, the immune system and the propensity for abnormal immunity change fundamentally. Individuals greater than 50 years of age are not only more susceptible to infection and cancer, but also at higher risk for chronic inflammation and immune-mediated tissue damage. The process of immu...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000011
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Arthritogenic alphaviruses are globally distributed mosquito-borne RNA viruses causing epidemics of polyarthritis/arthralgia, with disease emerging or reemerging and increasingly being reported in travelers. This article summarizes the current knowledge of these diseases, focusing on recent developmen...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/01.bor.0000130537.76808.26
更新日期:2004-07-01 00:00:00
abstract::This study reviews articles published in 2000 and 2001 about occupational physical activities as risk factors for osteoarthritis (OA) of the knee and hip. Six studies were identified in MEDLINE and EMBASE; five case-control studies and one cross-sectional study. Criteria for OA were: (on the waiting list for) joint re...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200203000-00002
更新日期:2002-03-01 00:00:00
abstract:PURPOSE OF REVIEW:There is an increasing interest in improving the understanding of pathophysiology, outcome measures, and therapies of rheumatic skin disease. Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheum...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e328333b9e2
更新日期:2010-01-01 00:00:00
abstract::The results of twin and family studies clearly implicate an important role for genetic factors in the etiology of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, the complex nature of these diseases has hampered progress in defining the genetic determinants. Recent advances in molecular gene...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/00002281-200003000-00001
更新日期:2000-03-01 00:00:00
abstract:PURPOSE OF REVIEW:We reviewed recent quality improvement initiatives in the field of rheumatology to identify common strategies and themes leading to measurable change. RECENT FINDINGS:Efforts to improve quality of care in rheumatology have accelerated in the last 5 years. Most studies in this area have focused on int...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0000000000000586
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Myositis, or idiopathic inflammatory myopathy, is an overarching concept that includes dermatomyositis, polymyositis, immune-mediated necrotizing myopathy and the antisynthetase syndrome. Glucocorticoids are still considered the mainstay of treatment of myositis but some patients require add-on immuno...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章
doi:10.1097/BOR.0000000000000745
更新日期:2020-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, with typical skin manifestations of dermatomyositis but little or no evidence of myositis. This review focuses on updates on epidemiology, clinical manifestations, and autoantibody profiles in patients with CADM. RECE...
journal_title:Current opinion in rheumatology
pub_type: 杂志文章,评审
doi:10.1097/BOR.0b013e32833f1987
更新日期:2010-11-01 00:00:00