EGFR mutation detection on lung cancer cytological specimens by the novel fully automated PCR-based Idylla EGFR Mutation Assay.

abstract：AIMS:To develop a quantitative reverse transcriptase polymerase chain reaction (Q-RT-PCR) for severe acute respiratory syndrome coronavirus (SARS-CoV) detection and explore the potential of using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as an internal control to exclude false negative results. METHODS:SAR...

journal_title：Journal of clinical pathology

authors： Wong SC,Chan JK,Lee KC,Lo ES,Tsang DN

更新日期：2005-03-01 00:00:00

abstract：:IgD myeloma is a rare disorder with a very poor prognosis. An unusual case is reported where prolonged remission was obtained. Immunohistochemical staining of the bone marrow trephine biopsy specimen proved invaluable in documenting early relapse. It is suggested that immunohistochemistry should be adopted more widely...

journal_title：Journal of clinical pathology

authors： Kettle P,Morris TC

更新日期：1994-08-01 00:00:00

abstract：:Five hundred and seven strains of bacteria isolated from the urine of patients with significant bacteriuria (more than 10(8) colony-forming units per litre) were tested for sensitivity to co-trimoxazole by the agar diffusion technique. Each organism was tested with a combined disk containing trimethoprim and sulphamet...

journal_title：Journal of clinical pathology

authors： Amyes SG,Telfer Brunton WA

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Laboratories traditionally culture toxoplasma tachyzoites in animals for testing and experimental use. This article considers why available cell culture methods are not used more often. AIM:To compare HeLa cell culture and animal culture for production of toxoplasma tachyzoites. METHODS:In 2000 HeLa cultur...

journal_title：Journal of clinical pathology

authors： Chatterton JM,McDonagh S,Ho-Yen DO

更新日期：2010-05-01 00:00:00

abstract：AIMS:Meticillin-resistant Staphylococcus aureus (MRSA) strains isolated in Tawam Hospital, a tertiary care hospital in the United Arab Emirates, were examined in order to understand the reasons for a doubling of its incidence between 2003 and 2008 while maintaining the same infection control measures. METHODS:All cons...

journal_title：Journal of clinical pathology

authors： Sonnevend Á,Blair I,Alkaabi M,Jumaa P,Al Haj M,Ghazawi A,Akawi N,Jouhar FS,Hamadeh MB,Pál T

更新日期：2012-02-01 00:00:00

abstract：AIMS:To identify the number and geographical distribution of post mortem examinations performed on HIV infected cadavers; to identify the areas that perform post mortem examinations so that, by invitation and discussion, a national post mortem network could be initiated. METHODS:A nationwide survey of Royal College of...

journal_title：Journal of clinical pathology

authors： Davies J,Everall IP,Lantos PL

更新日期：1993-12-01 00:00:00

abstract：:Endocardial fibroelastosis, defined as an endocardium in excess of 30 microns thick, was found in 10 out of 34 cases of hydrops fetalis in a review of 1589 perinatal necropsies carried out between 1976 and 1989. The infants comprised 16 cases of rhesus haemolytic disease, of whom three had endocardial fibroelastosis, ...

journal_title：Journal of clinical pathology

authors： Newbould MJ,Armstrong GR,Barson AJ

更新日期：1991-07-01 00:00:00

abstract：:Incomplete expression of human haemoglobin beta-chains at birth may lead to difficulty in the early demonstration of an inherited beta-chain variant. In this case, the rare unstable variant, Hb Tacoma beta30 (B12) arg leads to ser, although not present in cord blood in sufficient amounts to be easily detected by routi...

journal_title：Journal of clinical pathology

authors： Deacon-Smith RA,Lee-Potter JP

更新日期：1978-09-01 00:00:00

abstract：AIM:To compare the sensitivity and staining pattern of the new immunohistochemical antibody to tyrosinase (T311) with S-100, HMB45, and the recently evaluated antibody to melan-A (A103) in a range of melanocytic lesions. METHOD:Archival, formalin fixed, paraffin wax embedded sections from 50 benign and malignant melan...

journal_title：Journal of clinical pathology

authors： Clarkson KS,Sturdgess IC,Molyneux AJ

更新日期：2001-03-01 00:00:00

abstract：:Automation in clinical chemistry is a powerful tool. Like most innovations it is posing many questions as well as resolving some. Its use in population screening has led to questioning the validity of the old system of ;normal values' and to the search for better methods of indicating the significance of laboratory te...

journal_title：Journal of clinical pathology

authors： Wilson JM

更新日期：1973-08-01 00:00:00

abstract：:Targeted next-generation sequencing using the 50-gene Ion AmpliSeq Cancer Hotspot Panel v2 identified two significant point mutations in endometrial stromal sarcomas (ESS). Case 1 is a uterine mass from a quadragenarian woman with a karyotype lacking any known ESS rearrangements but demonstrated to have a CTNNB1-activ...

journal_title：Journal of clinical pathology

authors： Patel SB,McCormack C,Hodge JC

更新日期：2020-12-01 00:00:00

abstract：AIM:Ultraviolet light (UV) is known to cause DNA damage in the epidermis. The damaged DNA is repaired or deleted by apoptosis to prevent the generation of cancer. It has been suggested that a deficient apoptotic mechanism may predispose individuals to skin cancer. Therefore, the response of normal controls and patients...

journal_title：Journal of clinical pathology

authors： Murphy M,Mabruk MJ,Lenane P,Liew A,McCann P,Buckley A,O Flatharta C,Hevey D,Billet P,Robertson W,Javed S,Leader M,Kay E,Murphy GM

更新日期：2002-11-01 00:00:00

abstract：:The calcium, vitamin D, and osteocalcin concentrations were investigated in 17 patients with anorexia nervosa. Serum 25-hydroxyvitamin D (25 OHD) concentrations below normal were observed in 15 (88%); only two patients has serum 1,25 dihydroxycholecalciferol (1,25(OH)2D) concentrations below normal. Serum parathyroid ...

journal_title：Journal of clinical pathology

authors： Fonseca VA,D'Souza V,Houlder S,Thomas M,Wakeling A,Dandona P

更新日期：1988-02-01 00:00:00

abstract：:Experience gained in the last four years concerning the capabilities and limitations of an 8K Elliott 903 (18-bit word) computer with magnetic tape backing store in the routine operation of a clinical chemistry laboratory is described. Designed as a total system, routine operation has latterly had to be confined to da...

journal_title：Journal of clinical pathology

authors： Whitby LG,Simpson D

更新日期：1973-07-01 00:00:00

abstract：:The cellularity of 104 primary breast carcinomata was determined by semiautomated image analysis to allow the relation between cellularity and oestrogen receptor content values to be assessed. The oestrogen receptor content of tumours detected by a steroid binding assay showed no correlation with cellularity, although...

journal_title：Journal of clinical pathology

authors： Parham DM,Baker PR,Robertson AJ,Vasishta A,Baker PG,Smith G

更新日期：1989-11-01 00:00:00

abstract：:Platelet adhesiveness has been measured in citrated whole blood and in platelet-rich plasma obtained from normal subjects, splenectomized patients, and from patients in whom the diagnosis of recurrent venous thrombosis had been made. The duration of centrifugation used in the preparation of platelet-rich plasma was fo...

journal_title：Journal of clinical pathology

authors： McBride JA

更新日期：1968-05-01 00:00:00

abstract：:A patient with multiple injuries developed a severe coagulation defect due to a deficiency of vitamin K. None of the usual predisposing factors was present and the patient's diet was very poor. Dietary deficiency of vitamin K and the importance of antibiotic therapy in its production are discussed. ...

journal_title：Journal of clinical pathology

authors： Colvin BT,Lloyd MJ

更新日期：1977-12-01 00:00:00

abstract：AIMS:To use the polymerase chain reaction to detect monoclonality at the immunoglobulin heavy chain gene locus in cells derived from lymph node aspirates. METHODS:A nested two-stage polymerase chain reaction (PCR) for the VDJ region of the immunoglobulin heavy chain gene was used to detect monoclonality. The total num...

journal_title：Journal of clinical pathology

authors： Wan JH,Sykes PJ,Orell SR,Morley AA

更新日期：1992-05-01 00:00:00

abstract：:DNA typing was requested to investigate a presumptive cancer diagnosis error by confirming whether benign and cancerous prostatic tissue in the same presurgical haematoxylin and eosin stained slide belonged to the same person. After independent histological re-examination of the slide by a pathologist, manual slide di...

journal_title：Journal of clinical pathology

authors： Alonso A,Alves C,Suárez-Mier MP,Albarrán C,Pereira L,Fernández de Simón L,Martín P,García O,Gusmão L,Sancho M,Amorim A

更新日期：2005-01-01 00:00:00

abstract：AIM:To develop a unified diagnostic approach for the detection of human papillomavirus (HPV) DNA in skin and mucosal biopsies from both immunocompetent and immunosuppressed individuals using a degenerate polymerase chain reaction (PCR) method. METHODS:The sensitivity and specificity of three published degenerate prime...

journal_title：Journal of clinical pathology

authors： Surentheran T,Harwood CA,Spink PJ,Sinclair AL,Leigh IM,Proby CM,McGregor JM,Breuer J

更新日期：1998-08-01 00:00:00

abstract：:A case of B-CLL which was complicated by chronic renal failure due to leukaemic infiltration of the kidney is reported. Treatment with chlorambucil, prednisolone, and renal bed irradiation resulted in a substantial improvement in renal function which persisted until the the patient's death from marrow failure some eig...

journal_title：Journal of clinical pathology

authors： Phillips JK,Bass PS,Majumdar G,Davies DR,Jones NF,Pearson TC

更新日期：1993-12-01 00:00:00

abstract：:Renal involvement as the first manifestation of sarcoidosis is rare and has never been reported in India. This report describes a 35 year old man who was admitted to the emergency department with a clinical diagnosis of acute on chronic renal failure, secondary to obstructive uropathy. Postmortem examination unexpecte...

journal_title：Journal of clinical pathology

authors： Awasthi A,Nada R,Malhotra P,Goel R,Joshi K

更新日期：2004-10-01 00:00:00

abstract：:An influenza virus vaccine containing the purified surface haemagglutinin and neuraminidase antigens of A/Victoria/75 and B/Hong Kong/73 viruses adsorbed to an aluminium hydroxide gel was assessed for reactogenicity and immunogenicity in children aged 4 to 11 years, since there is no influenza virus vaccine available ...

journal_title：Journal of clinical pathology

authors： Eastwood LM,Jennings R,Milner RD,Potter CW

更新日期：1979-06-01 00:00:00

abstract：:Inherited biochemical defects may present with acute life-threatening illness with a high mortality and morbidity. Some are treatable and have a good outcome with early appropriate intervention. However, because of their rarity, diagnosis is often delayed; they are not considered or investigated appropriately. This is...

journal_title：Journal of clinical pathology

authors： Cook P,Walker V

更新日期：2011-03-01 00:00:00

abstract：:A comprehensive neuropathological study was undertaken on 87 children aged between 2 and 15 years with fatal head injuries to identify those features which occurred at the time of head injury (fractured skull, contusions, intracranial haematoma and diffuse axonal injury) and those which were subsequently produced by c...

journal_title：Journal of clinical pathology

authors： Graham DI,Ford I,Adams JH,Doyle D,Lawrence AE,McLellan DR,Ng HK

更新日期：1989-01-01 00:00:00

abstract：:In two families with severe sex-linked muscular dystrophy, high levels of alpha-hydroxybutyrate dehydrogenase (HBD), lactate dehydrogenase (LD), aspartate transaminase (AspT), aldolase, and creatine phosphokinase (CPK) were found in the sera of three young affected males. In both families the mother had a raised level...

journal_title：Journal of clinical pathology

authors： Johnston HA,Wilkinson JH,Withycombe WA,Raymond S

更新日期：1966-05-01 00:00:00

abstract：:Although epithelial mucin has been demonstrated in ordinary mammary duct carcinomas, it is formed profusely in the uncommon mucous carcinomas. A histochemical study of mucous carcinomas of the breast and colon showed that both types produce similar mucins, viz, acid and neutral, although the mammary carcinomas produce...

journal_title：Journal of clinical pathology

authors： Cooper DJ

更新日期：1974-04-01 00:00:00

abstract：:In a retrospective study of the records of 160 necropsies it was found that, according to the clinical and gross necropsy findings, no clinically important abnormality would have been anticipated in 46% of the tissue samples. The estimated annual cost of processing this material alone was pounds 10,500, including the ...

journal_title：Journal of clinical pathology

authors： Reid WA

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:The disorders associated with metabolic syndrome (MS) can lead to renal disease. IgA nephropathy is the most common form of glomerulonephritis, and many patients with this disorder progress to renal failure. AIMS:To identify the effect of MS on IgA nephropathy by retrospectively comparing patients who had I...

journal_title：Journal of clinical pathology

authors： Wang L,Zhang Y,Chen S,Chen J,Zhuang Y,Chen J

更新日期：2010-08-01 00:00:00

abstract：:Cervical smears from 327 women were examined using the polymerase chain reaction (PCR) targeted to a sequence in the Bam H1 W region of the Epstein-Barr virus (EBV) to determine the prevalence of the virus in the cervix. EBV was detected in 131 (40%) of the 327 women. Of the 235 women with normal cytology, 98 (42%) we...

journal_title：Journal of clinical pathology

authors： Taylor Y,Melvin WT,Sewell HF,Flannelly G,Walker F

更新日期：1994-01-01 00:00:00