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The androgen-binding protein gene is expressed in CD1 mouse testis.

Abstract：

:Androgen-binding protein (ABP) is a testicular Sertoli cell secretory protein that acts as a carrier of androgen in the male reproductive tract. ABP has been characterized from a wide range of animal species, including man, rabbit and rat. However, it has been widely accepted that mice do not produce testicular ABP. We have used immunological and molecular biological techniques to demonstrate that the ABP gene is expressed in the CD1 mouse. Steroid-binding, radioimmunoassay and immunocytochemical studies demonstrated that ABP is present in mouse testis and epididymis, but at 1/50 to 1/25 the level of rat epididymis. A 1.7 kilobase mRNA, homologous with rat ABP cDNA, was identified in mouse testis and Sertoli cells by Northern blot hybridization, but at a much lower level than in the rat. An ABP cDNA was isolated from a mouse testis cDNA library and encoded a protein (403 residues) with 89% of the amino acid residues identical to rat ABP, including a signal peptide. Our results indicate that ABP is expressed in the mouse and past failures to detect androgen-binding activity were due to the low level of ABP protein.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Wang YM,Sullivan PM,Petrusz P,Yarbrough W,Joseph DR

doi

10.1016/0303-7207(89)90084-1

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

85-92

issue

1-2

eissn

0303-7207

issn

1872-8057

journal_volume

63

pub_type

杂志文章

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