Pentlandite rocks as sustainable and stable efficient electrocatalysts for hydrogen generation.

abstract：:The diploid nature of the human genome is neglected in many analyses done today, where a genome is perceived as a set of unphased variants with respect to a reference genome. This lack of haplotype-level analyses can be explained by a lack of methods that can produce dense and accurate chromosome-length haplotypes at ...

journal_title：Nature communications

authors： Porubsky D,Garg S,Sanders AD,Korbel JO,Guryev V,Lansdorp PM,Marschall T

更新日期：2017-11-03 00:00:00

abstract：:Myxofibrosarcoma (MFS) is a common adult soft tissue sarcoma characterized by an infiltrative growth pattern and a high local recurrence rate. Here we report the genetic and epigenetic landscape of MFS based on the results of whole-exome sequencing (N = 41), RNA sequencing (N = 29), and methylation analysis (N = 41), ...

journal_title：Nature communications

authors： Ogura K,Hosoda F,Arai Y,Nakamura H,Hama N,Totoki Y,Yoshida A,Nagai M,Kato M,Arakawa E,Mukai W,Rokutan H,Kawai A,Tanaka S,Shibata T

更新日期：2018-07-17 00:00:00

abstract：:Gene deletion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic pregnancy. Here we report the key autophagy regulators modulated by diabetes in the murine developing neuroepithelium. Diabetes predominantly leads to exencephaly, induces neuroepithelial cell apoptosis and sup...

journal_title：Nature communications

authors： Wang F,Xu C,Reece EA,Li X,Wu Y,Harman C,Yu J,Dong D,Wang C,Yang P,Zhong J,Yang P

更新日期：2017-05-05 00:00:00

abstract：:The atmosphere plays a fundamental role in the transport of microbes across the planet but it is often neglected as a microbial habitat. Although the ocean represents two thirds of the Earth's surface, there is little information on the atmospheric microbial load over the open ocean. Here we provide a global estimate ...

journal_title：Nature communications

authors： Mayol E,Arrieta JM,Jiménez MA,Martínez-Asensio A,Garcias-Bonet N,Dachs J,González-Gaya B,Royer SJ,Benítez-Barrios VM,Fraile-Nuez E,Duarte CM

更新日期：2017-08-04 00:00:00

abstract：:Rapid and, in many cases, unprecedented Arctic climate changes are having far-reaching impacts on natural and human systems. Despite state-of-the-art climate models capturing the rapid nature of Arctic climate change, termed Arctic amplification, they significantly disagree on its magnitude. Using a regional, process-...

journal_title：Nature communications

authors： Boeke RC,Taylor PC

更新日期：2018-11-27 00:00:00

abstract：:Myoblast fusion is an indispensable step for skeletal muscle development, postnatal growth, and regeneration. Myeloid differentiation primary response gene 88 (MyD88) is an adaptor protein that mediates Toll-like receptors and interleukin-1 receptor signaling. Here we report a cell-autonomous role of MyD88 in the regu...

journal_title：Nature communications

authors： Hindi SM,Shin J,Gallot YS,Straughn AR,Simionescu-Bankston A,Hindi L,Xiong G,Friedland RP,Kumar A

更新日期：2017-11-20 00:00:00

abstract：:Seed germination and young seedling establishment should be tightly regulated to maximize plant survival and thereby enable successful propagation. Plants have evolved developmental signalling networks to integrate environmental cues for proper control of these critical processes, in which brassinosteroids are known t...

journal_title：Nature communications

authors： Ryu H,Cho H,Bae W,Hwang I

更新日期：2014-06-18 00:00:00

abstract：:Self-repairable materials strive to emulate curable and resilient biological tissue; however, their performance is currently insufficient for commercialization purposes because mending and toughening are mutually exclusive. Herein, we report a carbonate-type thermoplastic polyurethane elastomer that self-heals at 35 °...

journal_title：Nature communications

authors： Eom Y,Kim SM,Lee M,Jeon H,Park J,Lee ES,Hwang SY,Park J,Oh DX

更新日期：2021-01-27 00:00:00

abstract：:Bird song has historically been considered an almost exclusively male trait, an observation fundamental to the formulation of Darwin's theory of sexual selection. Like other male ornaments, song is used by male songbirds to attract females and compete with rivals. Thus, bird song has become a textbook example of the p...

journal_title：Nature communications

authors： Odom KJ,Hall ML,Riebel K,Omland KE,Langmore NE

更新日期：2014-03-04 00:00:00

abstract：:Anthropogenic mercury (Hg(0)) emissions oxidize to gaseous Hg(II) compounds, before deposition to Earth surface ecosystems. Atmospheric reduction of Hg(II) competes with deposition, thereby modifying the magnitude and pattern of Hg deposition. Global Hg models have postulated that Hg(II) reduction in the atmosphere oc...

journal_title：Nature communications

authors： Saiz-Lopez A,Sitkiewicz SP,Roca-Sanjuán D,Oliva-Enrich JM,Dávalos JZ,Notario R,Jiskra M,Xu Y,Wang F,Thackray CP,Sunderland EM,Jacob DJ,Travnikov O,Cuevas CA,Acuña AU,Rivero D,Plane JMC,Kinnison DE,Sonke JE

更新日期：2018-11-15 00:00:00

abstract：:Oceanic anoxic events have been associated with warm climates in Earth history, and there are concerns that current ocean deoxygenation may eventually lead to anoxia. Here we show results of a multi-millennial global-warming simulation that reveal, after a transitory deoxygenation, a marine oxygen inventory 6% higher ...

journal_title：Nature communications

authors： Oschlies A,Koeve W,Landolfi A,Kähler P

更新日期：2019-06-26 00:00:00

abstract：:For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemb...

journal_title：Nature communications

authors： Laine VN,Gossmann TI,Schachtschneider KM,Garroway CJ,Madsen O,Verhoeven KJ,de Jager V,Megens HJ,Warren WC,Minx P,Crooijmans RP,Corcoran P,Great Tit HapMap Consortium.,Sheldon BC,Slate J,Zeng K,van Oers K,Visser ME,Gro

更新日期：2016-01-25 00:00:00

abstract：:Stimuli-responsive behaviors of flexible metal-organic frameworks (MOFs) make these materials promising in a wide variety of applications such as gas separation, drug delivery, and molecular sensing. Considerable efforts have been made over the last decade to understand the structural changes of flexible MOFs in respo...

journal_title：Nature communications

authors： Zhao P,Fang H,Mukhopadhyay S,Li A,Rudić S,McPherson IJ,Tang CC,Fairen-Jimenez D,Tsang SCE,Redfern SAT

更新日期：2019-03-01 00:00:00

abstract：:Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-...

journal_title：Nature communications

authors： Yao Y,Chen ZL,Norris EH,Strickland S

更新日期：2014-03-03 00:00:00

abstract：:Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based flu...

journal_title：Nature communications

authors： Yang Q,Dong Y,Wu W,Zhu C,Chong H,Lu J,Yu D,Liu L,Lv F,Wang S

更新日期：2012-01-01 00:00:00

abstract：:Neuronal reward valuations provide the physiological basis for economic behaviour. Yet, how such valuations are converted to economic decisions remains unclear. Here we show that the dorsolateral prefrontal cortex (DLPFC) implements a flexible value code based on object-specific valuations by single neurons. As monkey...

journal_title：Nature communications

authors： Tsutsui KI,Grabenhorst F,Kobayashi S,Schultz W

更新日期：2016-09-13 00:00:00

abstract：:Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs. Mutations of the ion pump α2-Na/K ATPase cause familial hemiplegic migraine, but the mechanisms by which α2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely underst...

journal_title：Nature communications

authors： Smith SE,Chen X,Brier LM,Bumstead JR,Rensing NR,Ringel AE,Shin H,Oldenborg A,Crowley JR,Bice AR,Dikranian K,Ippolito JE,Haigis MC,Papouin T,Zhao G,Wong M,Culver JP,Bonni A

更新日期：2020-12-02 00:00:00

abstract：:Metal-organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be further enhanced by encapsulating functional species, such as luminescent guest molecules, within the frameworks. Al...

journal_title：Nature communications

authors： Sun CY,Wang XL,Zhang X,Qin C,Li P,Su ZM,Zhu DX,Shan GG,Shao KZ,Wu H,Li J

更新日期：2013-01-01 00:00:00

abstract：:Roughly 40% of the Earth's total heat flow is powered by radioactive decays in the crust and mantle. Geo-neutrinos produced by these decays provide important clues about the origin, formation and thermal evolution of our planet, as well as the composition of its interior. Previous measurements of geo-neutrinos have al...

journal_title：Nature communications

authors： Leyton M,Dye S,Monroe J

更新日期：2017-07-10 00:00:00

abstract：:Rising demand for ruminant meat and dairy products in developing countries is expected to double anthropogenic greenhouse gas and ammonia emissions from livestock by 2050. Mitigation strategies are urgently needed to meet demand while minimizing environmental impacts. Here, we develop scenarios for mitigating emission...

journal_title：Nature communications

authors： Du Y,Ge Y,Ren Y,Fan X,Pan K,Lin L,Wu X,Min Y,Meyerson LA,Heino M,Chang SX,Liu X,Mao F,Yang G,Peng C,Qu Z,Chang J,Didham RK

更新日期：2018-10-08 00:00:00

abstract：:Amyloid aggregation of α-synuclein (α-syn) is closely associated with Parkinson's disease (PD) and other synucleinopathies. Several single amino-acid mutations (e.g. E46K) of α-syn have been identified causative to the early onset of familial PD. Here, we report the cryo-EM structure of an α-syn fibril formed by N-ter...

journal_title：Nature communications

authors： Zhao K,Li Y,Liu Z,Long H,Zhao C,Luo F,Sun Y,Tao Y,Su XD,Li D,Li X,Liu C

更新日期：2020-05-26 00:00:00

abstract：:Zig-zag nanographenes are promising candidates for the applications in organic electronics due to the electronic properties induced by their periphery. However, the synthetic access to these compounds remains virtually unexplored. There is a lack in efficient and mild strategies origins in the reduced stability, incre...

journal_title：Nature communications

authors： Lungerich D,Papaianina O,Feofanov M,Liu J,Devarajulu M,Troyanov SI,Maier S,Amsharov K

更新日期：2018-11-12 00:00:00

abstract：:Plant phytochromes are thought to transduce light signals by mediating the degradation of phytochrome-interacting transcription factors (PIFs) through the N-terminal photosensory module, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not participate in signaling. Here we show tha...

journal_title：Nature communications

authors： Qiu Y,Pasoreck EK,Reddy AK,Nagatani A,Ma W,Chory J,Chen M

更新日期：2017-12-04 00:00:00

abstract：:The extent to which the impact of regulatory genetic variants may depend on other factors, such as the expression levels of upstream transcription factors, remains poorly understood. Here we report a framework in which regulatory variants are first aggregated into sets, and using these as estimates of the total cis-ge...

journal_title：Nature communications

authors： Wragg D,Liu Q,Lin Z,Riggio V,Pugh CA,Beveridge AJ,Brown H,Hume DA,Harris SE,Deary IJ,Tenesa A,Prendergast JGD

更新日期：2020-01-17 00:00:00

abstract：:Writing artificial logic and dynamic function into complex cellular background to achieve desired phenotypes or improved outputs calls for the development of new genetic tools as well as their innovative use. In this study, we present a sensor-regulator and RNAi-based bifunctional dynamic control network that can prov...

journal_title：Nature communications

authors： Yang Y,Lin Y,Wang J,Wu Y,Zhang R,Cheng M,Shen X,Wang J,Chen Z,Li C,Yuan Q,Yan Y

更新日期：2018-08-02 00:00:00

abstract：:By electrochemically coupling microbial and abiotic catalysts, bioelectrochemical systems such as microbial electrolysis cells and microbial electrosynthesis systems synthesize energy-rich chemicals from energy-poor precursors with unmatched efficiency. However, to circumvent chemical incompatibilities between the mic...

journal_title：Nature communications

authors： Cornejo JA,Sheng H,Edri E,M Ajo-Franklin C,Frei H

更新日期：2018-06-11 00:00:00

abstract：:Scenarios that limit global warming to below 2 °C by 2100 assume significant land-use change to support large-scale carbon dioxide (CO2) removal from the atmosphere by afforestation/reforestation, avoided deforestation, and Biomass Energy with Carbon Capture and Storage (BECCS). The more ambitious mitigation scenarios...

journal_title：Nature communications

authors： Harper AB,Powell T,Cox PM,House J,Huntingford C,Lenton TM,Sitch S,Burke E,Chadburn SE,Collins WJ,Comyn-Platt E,Daioglou V,Doelman JC,Hayman G,Robertson E,van Vuuren D,Wiltshire A,Webber CP,Bastos A,Boysen L,Ciais

更新日期：2018-08-07 00:00:00

abstract：:Face recognition is highly proficient in humans and other social primates; it emerges in infancy, but the development of the neural mechanisms supporting this behaviour is largely unknown. We use blood-volume functional MRI to monitor longitudinally the responsiveness to faces, scrambled faces, and objects in macaque ...

journal_title：Nature communications

authors： Livingstone MS,Vincent JL,Arcaro MJ,Srihasam K,Schade PF,Savage T

更新日期：2017-03-31 00:00:00

abstract：:Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell types and abrogates the ability of MKs to respond to integrin. Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtB...

journal_title：Nature communications

authors： Shooshtarizadeh P,Helness A,Vadnais C,Brouwer N,Beauchemin H,Chen R,Bagci H,Staal FJT,Coté JF,Möröy T

更新日期：2019-03-20 00:00:00

abstract：:Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here we find that junctional adh...

journal_title：Nature communications

authors： Tuncay H,Brinkmann BF,Steinbacher T,Schürmann A,Gerke V,Iden S,Ebnet K

更新日期：2015-08-26 00:00:00