当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > The anti-tumor effect and bioactive phytochemicals of Hedyotis diffusa willd on ovarian cancer cells.

The anti-tumor effect and bioactive phytochemicals of Hedyotis diffusa willd on ovarian cancer cells.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Hedyotis diffusa willd (HDW) is a widely used medicinal herb in China. It processed various medicinal properties including antioxidative, anti-inflamatory and anti-cancer effects. This study aimed to investigate the anti-tumor effects of HDW on ovarian cancer cells and the underlying mechanisms as well as identify the bioactive compounds. MATERIALS AND METHODS:Effects of HDW on the viability of ovarian cancer A2780 cells were detected by MTT assay. Apoptosis was detected by cell morphologic observation through DAPI staining and flow cytometry analysis. The migration of ovarian cancer cells which exposed to HDW were detected by wound healing and transwell assays. The protein levels of caspase 3/9, Bcl-2 and MMP-2/9 in human ovarian cancer cells treated with HDW were assessed by western blotting analysis. The potential bioactive compounds were characterized by HPLC-Q-TOF-MS. RESULTS:HDW significantly inhibited the growth of A2780 ovarian cancer cells and induced apoptosis. The induction of apoptosis by HDW was associated with down-regulation of anti-apoptotic protein Bcl-2 and the activation of caspase 3/9. Wound healing and transwell chamber assays indicated HDW suppressed the migration of ovarian cancer cells. HDW dramatically decreased MMP-2/9 expression. A HPLC-Q-TOF-MS analysis of HDW indicated the presence of 13 flavonoids compounds and one anthraquinone compound, which may contribute to the anticancer activity of the HDW. CONCLUSIONS:HDW effectively restricted the growth of ovarian cancer cells and induced apoptosis through the mitochondria-associated apoptotic pathway. Furthermore, HDW suppressed the migration of ovarian cancer cells through down-regulation of MMP-2 and MMP-9 expression. These results showed that HDW hold potential therapeutic effect for ovarian cancer patients.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Zhang L,Zhang J,Qi B,Jiang G,Liu J,Zhang P,Ma Y,Li W

doi

10.1016/j.jep.2016.07.027

subject

Has Abstract

pub_date

2016-11-04 00:00:00

pages

132-139

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(16)30449-4

journal_volume

192

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Acridone alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Citrus aurantium L. (Rutaceae) is used, either singly or as a part of a polyherbal preparation, in Nigerian traditional medicine for the management of cancer and inflammatory diseases. Currently, there is a dearth of knowledge demonstrating its anticancer potential. AIM OF THE STUDY:This...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.08.039

    authors： Segun PA,Ismail FMD,Ogbole OO,Nahar L,Evans AR,Ajaiyeoba EO,Sarker SD

    更新日期：2018-12-05 00:00:00

  • Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Synadenium grantii Hook f. has traditionally been used to treat various neoplastic diseases in southern Brazil. AIM OF STUDY:Evaluation of the antitumoural potential of Synadenium grantii latex against B16F10 melanoma cell line using in vitro and in vivo models, as well as a phytochemica...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.08.033

    authors： de Oliveira TL,Munhoz AC,Lemes BM,Minozzo BR,Nepel A,Barison A,Fávero GM,Campagnoli EB,Beltrame FL

    更新日期：2013-10-28 00:00:00

  • Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat.

    abstract：:Comparative studies of the effects of tetrandrine (TET) and fangchinoline (FAN), two major components of the Radix of Stephannia tetrandrae, on vasodilations and on calcium movement in vascular smooth muscle, and studies of hypotensive effects on stroke-prone spontaneously hypertensive rats (SHRSP) were performed in t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)00092-5

    authors： Kim HS,Zhang YH,Oh KW,Ahn HY

    更新日期：1997-10-01 00:00:00

  • Antioxidant, antimicrobial and antiverotoxic potentials of extracts of Curtisia dentata.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:There is an increase in antimicrobial resistance and complexities arising from verotoxic related bacterial infections as well as rise in demand for application of natural antioxidants to combat oxidative damage by free radicals in many oxidative stress-mediated disease conditions such as ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.03.051

    authors： Doughari JH,Ndakidemi PA,Human IS,Benade S

    更新日期：2012-06-14 00:00:00

  • Pharmacology of Casimiroa edulis IV. Hypotensive effects of compounds isolated from methanolic extracts in rats and guinea pigs.

    abstract：:Bioassay-directed fractionation of the methanolic extract of seeds of Casimiroa edulis led to the isolation of seven constituents with cardiovascular activity, namely the new compound synephrine acetonide and the known compounds N-monomethylhistamine, N,N-dimethylhistamine, proline, N-methylproline, gamma-aminobutyric...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00101-9

    authors： Magos GA,Vidrio H,Reynolds WF,Enríquez RG

    更新日期：1999-01-01 00:00:00

  • Metabolomic strategy to study therapeutic and synergistic effects of tanshinone IIA, salvianolic acid B and ginsenoside Rb1 in myocardial ischemia rats.

    abstract：AIM OF THE STUDY:Tanshinone IIA (T), salvianolic acid B (S) and ginsenoside Rb1 (G) are the three major active ingredients of Compound Danshen Formula (CDF) for its protective effects on myocardial ischemia (MI). In this study, we aimed to investigate therapeutic and synergistic effects of TSG (combination of T, S and ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.11.048

    authors： Lu Y,Liu X,Liang X,Xiang L,Zhang W

    更新日期：2011-03-08 00:00:00

  • Himatanthus drasticus (Apocynaceae) latex reduces oxidative stress and modulates CD4+, CD8+, FoxP3+ and HSP-60+ expressions in Sarcoma 180-bearing mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Brazil, latex of Himatanthus drasticus is used to treat inflammation, wound healing and cancer. The present study evaluated the antitumoral potential of H. drasticus latex (HdCL) in Sarcoma 180-bearing mice (S180). MATERIALS AND METHODS:HdCL was obtained in Crato-CE, Brazil. Qualitati...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.09.043

    authors： Santos GJL,Oliveira ES,Pinheiro ADN,da Costa PM,de Freitas JCC,de Araújo Santos FG,Maia FMM,de Morais SM,Nunes-Pinheiro DCS

    更新日期：2018-06-28 00:00:00

  • Utilization of the extract of Cedrus deodara (Roxb. ex D.Don) G. Don against the biofilm formation and the expression of virulence genes of cariogenic bacterium Streptococcus mutans.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cedrus deodara (Roxb. ex D.Don) G. Don is applied as anti-inflammatory and anti-infection agents in folklore medicine. AIM OF THE STUDY:The present study aimed to assess the antimicrobial activity of Cedrus deodara (Roxb. ex D.Don) G. Don extract (CDE) against Streptococcus mutans biofil...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112856

    authors： Zhang Z,Lyu X,Xu Q,Li C,Lu M,Gong T,Tang B,Wang L,Zeng W,Li Y

    更新日期：2020-07-15 00:00:00

  • Salix caprea inhibits skin carcinogenesis in murine skin: inhibition of oxidative stress, ornithine decarboxylase activity and DNA synthesis.

    abstract：:Chemoprevention of free radical-mediated diseases including cancer by natural products is an emerging discipline due to its wider applicability and acceptance. The present study deals with the chemopreventive effect of Salix caprea against phorbol ester-induced oxidative stress and tumor promotion in murine skin. In t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.12.028

    authors： Sultana S,Saleem M

    更新日期：2004-04-01 00:00:00

  • The genus Pterocaulon (Asteraceae) - A review on traditional medicinal uses, chemical constituents and biological properties.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Species of the genus Pterocaulon (Asteraceae) are used in different parts of the world for treating skin and liver diseases, as well as disorders of the respiratory system, among others. AIM OF THE STUDY:This review aims to discuss the present state of the art concerning the ethnobotanic...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2018.06.012

    authors： Medeiros-Neves B,Teixeira HF,von Poser GL

    更新日期：2018-10-05 00:00:00

  • Immunostimulant effects of Capparis zeylanica Linn. leaves.

    abstract：:The present study was undertaken to explore the immunomodulatory activity of ethanolic and water extracts of Capparis zeylanica Linn. (family: Capparidaceae) leaves on neutrophil adhesion test, humoral response to sheep red blood cells, delayed-type hypersensitivity, phagocytic activity and cyclophosphamide-induced my...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.03.041

    authors： Ghule BV,Murugananthan G,Nakhat PD,Yeole PG

    更新日期：2006-11-24 00:00:00

  • Bioguided identification of triterpenoids and neolignans as bioactive compounds from anti-infectious medicinal plants of the Taira Atacama's community (Calama, Chile).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Previous ethnobotanical surveys from the north Andean part of Chile, where different ethnic groups are co-existing, with the preeminence of Aymara and Atacama traditions, revealed an extensive domestic use of the local flora. In these communities, traditional medicinal uses are mainly rel...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.10.029

    authors： Ortiz S,Lecsö-Bornet M,Bonnal C,Houze S,Michel S,Grougnet R,Boutefnouchet S

    更新日期：2019-03-01 00:00:00

  • Hypoglycaemic effect of spergularia purpurea in normal and streptozotocin-induced diabetic rats.

    abstract：:Single and repeated oral administration of the water extracts of Spergularia purpurea (SP) at a dose of 10 mg/kg were tested on hypoglycaemic activity in normal and streptozotocin-induced diabetic rats. In normal rats, the water extract of SP decreased significantly the plasma glucose levels 4 h after single oral admi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(99)00199-3

    authors： Jouad H,Eddouks M,Lacaille-Dubois MA,Lyoussi B

    更新日期：2000-07-01 00:00:00

  • Asian elephant self-medication as a source of ethnoveterinary knowledge among Karen mahouts in northern Thailand.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ethnoveterinary medicine is often assumed to be a subset of human medicinal knowledge. Here we investigate the possibility that some ethnoveterinary medicine rather originates from observations of animal self-medication. We document and analyze the ethnoveterinary medicine used by Karen m...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112823

    authors： Greene AM,Panyadee P,Inta A,Huffman MA

    更新日期：2020-09-15 00:00:00

  • The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: possible involvement of indirect antioxidant action.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Boesenbergia rotunda (L) Mansf. has been used for the treatment of gastrointestinal disorders including peptic ulcer. In the current study we aimed to investiagte the anti-ulcer activities of methanolic extract of B. rotunda (MEBR) and its main active compound, pinostrobin on ethanol-indu...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.07.010

    authors： Abdelwahab SI,Mohan S,Abdulla MA,Sukari MA,Abdul AB,Taha MM,Syam S,Ahmad S,Lee KH

    更新日期：2011-09-02 00:00:00

  • Antifungal activity of some coumarins obtained from species of Pterocaulon (Asteraceae).

    abstract：:Fractionation of antifungal hexane extracts of the aerial parts of three Pterocaulon spp., Pterocaulon alopecuroides, Pterocaulon balansae and Pterocaulon polystachyum (Asteraceae) from South Brazil traditionally used to treat animal mycoses, afforded the coumarins 5-methoxy-6,7-methylenedioxycoumarin, 7-(2',3'-epoxy-...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.02.009

    authors： Stein AC,Alvarez S,Avancini C,Zacchino S,von Poser G

    更新日期：2006-08-11 00:00:00

  • The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Fufang Chuanxiong capsule consists of Angelica sinensis radix and Chuanxiong rhizome, which are used in the traditional Chinese medicine for the treatment of coronary artery disease, and Xinyue capsule is composed of panax quinquefolius saponin extracted from leaves and stems of Panax qui...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jep.2019.112354

    authors： Zhang DW,Wang SL,Wang PL,Du JP,Gao ZY,Wang CL,Xu H,Shi DZ

    更新日期：2020-02-10 00:00:00

  • Antibacterial activities of extracts from Ugandan medicinal plants used for oral care.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants are widely used for treatment of oral/dental diseases in Uganda. AIM OF THE STUDY:To investigate antibacterial activities of 16 commonly used medicinal plants on microorganisms associated with periodontal diseases (PD) and dental caries (DC). MATERIALS AND METHODS:Pulp ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.06.027

    authors： Ocheng F,Bwanga F,Joloba M,Borg-Karlson AK,Gustafsson A,Obua C

    更新日期：2014-08-08 00:00:00

  • Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.

    abstract：:A total of seventeen phytochemicals including seven alkaloids (piperine, strychnine, brucine, stachydrine, tetrandrine, frangchinoline and sinomenine), four phenols (paeonol, honokiol, magnolol and eugenol) and six anthraquinones (emodin, rhein, chrysorphanol, aloe-emodin, physcion and 1,8-dihydroxyanthraquinone) was ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.01.013

    authors： Kong LD,Cheng CH,Tan RX

    更新日期：2004-04-01 00:00:00

  • Immunomodulatory activities of the ethanolic extract of Caesalpinia bonducella seeds.

    abstract：UNLABELLED:Caesalpinia bonducella FLEMING (Caesalpiniaceae) is a plant well known for its medicinal value in Indian Ayurveda. However, to prove its efficiency for the clinical utilization, more experimental data will be beneficial. AIMS OF THE STUDY:The present study involved the investigation of immunomodulatory acti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.07.002

    authors： Shukla S,Mehta A,John J,Mehta P,Vyas SP,Shukla S

    更新日期：2009-09-07 00:00:00

  • A history of the therapeutic use of liquorice in Europe.

    abstract：:Liquorice root has been used in Europe since prehistoric times, and is well documented in written form starting with the ancient Greeks. In this review we compare the independent development of medical uses of this botanical drug in several ancient cultures, attempting to show the rationality of specific indications a...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.jep.2005.04.015

    authors： Fiore C,Eisenhut M,Ragazzi E,Zanchin G,Armanini D

    更新日期：2005-07-14 00:00:00

  • Preliminary results on the protective effect of (-)-edunol, a pterocarpan from Brongniartia podalyrioides (Leguminosae), against Bothrops atrox venom in mice.

    abstract：:(-)-Edunol a prenylated pterocarpan was isolated from the roots of two Mexican 'snakeweeds', Brongniartia podalyrioides and B. intermedia (Leguminosae). Edunol (3.1 mg/kg, i.p.) reduced the expected mortality of mice previously treated by the same route with the LD50 of the venom of the serpent Bothrops atrox. The mol...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)90086-8

    authors： Reyes-Chilpa R,Gómez-Garibay F,Quijano L,Magos-Guerrero GA,Ríos T

    更新日期：1994-05-01 00:00:00

  • Mirabijalone E: a novel rotenoid from Mirabilis himalaica inhibited A549 cell growth in vitro and in vivo.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The roots of Mirabilis himalaica have been used in Tibetan folk medicine for treatment of uterine cancer, nephritis edematous, renal calculus and arthrodynia. In our previous work, the ethanol extract of roots had shown potent cytotoxicity against human cancer cells. However, no informati...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.05.034

    authors： Linghu L,Fan H,Hu Y,Zou Y,Yang P,Lan X,Liao Z,Chen M

    更新日期：2014-08-08 00:00:00

  • A cross-cultural analysis of Jammu, Kashmir and Ladakh (India) medicinal plant use.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Jammu & Kashmir (J&K) is a predominantly Himalayan state in the north-western part of India. It has three geographically distinct divisions viz., Jammu, Kashmir and Ladakh, which are immensely rich in their biological and cultural diversity. Medicinal plants are an important element of in...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2014.06.029

    authors： Gairola S,Sharma J,Bedi YS

    更新日期：2014-09-11 00:00:00

  • Best practice in research - Overcoming common challenges in phytopharmacological research.

    abstract：BACKGROUND:The pharmacology, toxicology and pharmacokinetics of bioactive preparations derived from natural sources has become a flourishing field of research. However, researching complex extracts and natural products faces numerous challenges. More broadly in recent years the critique of pharmacological research, and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2019.112230

    authors： Heinrich M,Appendino G,Efferth T,Fürst R,Izzo AA,Kayser O,Pezzuto JM,Viljoen A

    更新日期：2020-01-10 00:00:00

  • Inhibitory effect of ethanol extract of Ampelopsis brevipedunculata rhizomes on atopic dermatitis-like skin inflammation.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Extracts from various parts of Ampelopsis brevipedunculata has been used as anti-inflammatory agents in Asian folk medicine. AIM OF THE STUDY:To demonstrate the medicinal effect of the A. brevipedunculata in skin inflammation, specifically atopic dermatitis (AD). MATERIALS AND METHODS:T...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.111850

    authors： Choi YA,Yu JH,Jung HD,Lee S,Park PH,Lee HS,Kwon TK,Shin TY,Lee SW,Rho MC,Jang YH,Kim SH

    更新日期：2019-06-28 00:00:00

  • Potential antimalarials from Nigerian plants: a review.

    abstract：:Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious diseases in many tropical regions, including Nigeria, a West African country where transmission occurs all year round. Many of the inhabitants use plants as remedies against fever and other symptoms of acute malaria, as reported her...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2010.11.024

    authors： Adebayo JO,Krettli AU

    更新日期：2011-01-27 00:00:00

  • Neuropharmacological activity of Solanum nigrum fruit.

    abstract：:The ethanol extract of the fruit of Solanum nigrum L. (Solanaceae) was studied for its neuropharmacological properties on experimental animals. On intraperitoneal injection, the extract significantly prolonged pentobarbital-induced sleeping time, produced alteration in the general behavior pattern, reduced exploratory...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00059-2

    authors： Perez RM,Perez JA,Garcia LM,Sossa H

    更新日期：1998-08-01 00:00:00

  • Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Berberine is generally extracted from Rhizoma Coptidis (Coptis chinensis Franch), a traditional Chinese medicine, which can be used in the treatment of intestinal diseases, respiratory infections and cardiovascular diseases. Berberine is especially effective for the treatment of gastroint...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113206

    authors： Zhang D,Jiang L,Wang M,Jin M,Zhang X,Liu D,Wang Z,Yang L,Xu X

    更新日期：2021-01-10 00:00:00

  • Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Astragaloside IV is the primary pure saponin isolated from Astragalus membranaceus, one of the valuable traditional medical herbs. Antifibrotic activities of Astragalus membranaceus have been extensively proved. AIM OF THE STUDY:To investigate the effects of astragaloside IV on hepatic s...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.01.035

    authors： Liu H,Wei W,Sun WY,Li X

    更新日期：2009-04-21 00:00:00