Abstract：
UNLABELLED:Caesalpinia bonducella FLEMING (Caesalpiniaceae) is a plant well known for its medicinal value in Indian Ayurveda. However, to prove its efficiency for the clinical utilization, more experimental data will be beneficial. AIMS OF THE STUDY:The present study involved the investigation of immunomodulatory activities of ethanolic extract of Caesalpinia bonducella seeds. MATERIALS AND METHODS:Neutrophil adhesion test, haemagglutinating antibody (HA) titre, delayed-type hypersensitivity (DTH) response, phagocytic activity and cyclophosphamide-induced myelosuppression were determined by in vivo experiments. RESULTS:The evaluation of immunomodulatory potential by oral administration of ethanolic seed extract of Caesalpinia bonducella (200-500 mg/kg) evoked a significant increase in percent neutrophil adhesion to nylon fibers as well as a dose-dependent increase in antibody titre values, and potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells. Also it prevented myelosuppression in cyclophosphamide drug treated rats and good response towards phagocytosis in carbon clearance assay. CONCLUSIONS:The results obtained in this study indicate that Caesalpinia bonducella possesses potential immunomodulatory activity and has therapeutic potential for the prevention of autoimmune diseases.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Shukla S,Mehta A,John J,Mehta P,Vyas SP,Shukla Sdoi
10.1016/j.jep.2009.07.002subject
Has Abstractpub_date
2009-09-07 00:00:00pages
252-6issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(09)00430-9journal_volume
125pub_type
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