Abstract:
:A number of unexpected pathophysiological connections linking different neurodegenerative diseases have emerged over the past decade. An example is provided by prion and Alzheimer's diseases. Despite being distinct pathologies, these disorders share several neurotoxic mechanisms, including accumulation of misfolded protein isoforms, stress of the protein synthesis machinery, and activation of a neurotoxic signaling mediated by the cellular prion protein. Here, in addition to reviewing these mechanisms, we will discuss the potential therapeutic interventions for prion and Alzheimer's diseases that are arising from the comprehension of their common neurodegenerative pathways.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Elezgarai SR,Biasini Edoi
10.1515/hsz-2016-0190subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1115-1124issue
11eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2016-0190/hsz-2016-0190.journal_volume
397pub_type
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