Abstract:
:We aimed to comprehensively study sex differences in disease and patients' characteristics, treatment and outcomes in patients with follicular lymphoma (FL) in the United States (USA) utilizing the National LymphoCare Study registry (2004-2014). Among evaluable males (n = 1277) and females (n = 1375) with FL, females less commonly received anthracyclines and were more likely to receive rituximab monotherapy. Overall response rates were comparable between sex groups. With a median follow-up of 8.1 years, male sex emerged as an adverse factor for PFS (HR, 0.84, 95% CI, 0.72-0.97). Lymphoma-related mortality (HR, 0.46; 0.23-0.93) and overall survival (HR, 0.63; 0.41-0.97) favored females aged ≤60 years. There are subtle differences in outcomes between male and female FL patients diagnosed and treated in the contemporary era. These data represent the largest prospective analysis of FL patients in the USA based on sex and can aid design of clinical trials for this disease. Am. J. Hematol. 91:770-775, 2016. © 2016 Wiley Periodicals, Inc.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Nabhan C,Zhou X,Day BM,Dawson K,Zelenetz AD,Friedberg JW,Cerhan JR,Link BK,Flowers CRdoi
10.1002/ajh.24401subject
Has Abstractpub_date
2016-08-01 00:00:00pages
770-5issue
8eissn
0361-8609issn
1096-8652journal_volume
91pub_type
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