Disease, treatment, and outcome differences between men and women with follicular lymphoma in the United States.

Abstract:

:We aimed to comprehensively study sex differences in disease and patients' characteristics, treatment and outcomes in patients with follicular lymphoma (FL) in the United States (USA) utilizing the National LymphoCare Study registry (2004-2014). Among evaluable males (n = 1277) and females (n = 1375) with FL, females less commonly received anthracyclines and were more likely to receive rituximab monotherapy. Overall response rates were comparable between sex groups. With a median follow-up of 8.1 years, male sex emerged as an adverse factor for PFS (HR, 0.84, 95% CI, 0.72-0.97). Lymphoma-related mortality (HR, 0.46; 0.23-0.93) and overall survival (HR, 0.63; 0.41-0.97) favored females aged ≤60 years. There are subtle differences in outcomes between male and female FL patients diagnosed and treated in the contemporary era. These data represent the largest prospective analysis of FL patients in the USA based on sex and can aid design of clinical trials for this disease. Am. J. Hematol. 91:770-775, 2016. © 2016 Wiley Periodicals, Inc.

journal_name

Am J Hematol

authors

Nabhan C,Zhou X,Day BM,Dawson K,Zelenetz AD,Friedberg JW,Cerhan JR,Link BK,Flowers CR

doi

10.1002/ajh.24401

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

770-5

issue

8

eissn

0361-8609

issn

1096-8652

journal_volume

91

pub_type

杂志文章
  • CD20-positive adult T-cell leukemia.

    abstract::A 67-year-old woman was admitted to our hospital because of lymphadenopathy and lymphocytosis. Monoclonal integration of HTLV-I provirus DNA was detected, and a diagnosis of adult T-cell leukemia (ATL) was made. Flow cytometry revealed that the ATL cells expressed CD20 as well as T-cell-associated antigens, and expres...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/1096-8652(200101)66:1<39::AID-AJH1005>3.0.

    authors: Yasukawa M,Arai J,Kakimoto M,Sakai I,Kohno H,Fujita S

    更新日期:2001-01-01 00:00:00

  • Genotypic analysis using a Y-chromosome-specific probe following bone marrow transplantation.

    abstract::To monitor successful engraftment after bone marrow transplantation, we performed Southern hybridization analysis or dot blot analysis of DNA in a set of sex-mismatched cases using a Y-chromosome-specific DNA probe (pHY10). This method was extremely sensitive and rapid for checking which cells contain the Y-chromosome...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830270108

    authors: Morisaki H,Morisaki T,Nakahori Y,Ogura H,Kanno H,Tani K,Kodo H,Fujii H,Asano S,Miwa S

    更新日期:1988-01-01 00:00:00

  • Laparoscopic splenectomies for idiopathic thrombocytopenic purpura: experience of sixty cases.

    abstract::We performed a laparoscopic splenectomy (LS) in 60 patients (age 9-83, 45 females) with idiopathic thrombocytopenic purpura (ITP) who did not achieve sustained remission on steroid therapy. Using a modified procedure, the mean duration of LS was 78 min (range 25-240 min) and surgery was associated with only 5% major a...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(200001)63:1<7::aid-ajh2>3.

    authors: Szold A,Schwartz J,Abu-Abeid S,Bulvik S,Eldor A

    更新日期:2000-01-01 00:00:00

  • Heterogeneity in type IIB von Willebrand disease: two unrelated cases with no family history and mild abnormalities of ristocetin-induced interaction between von Willebrand factor and platelets.

    abstract::Two patients from two separate families were diagnosed as having type IIB von Willebrand disease, because they had lifelong bleeding tendencies, prolonged bleeding times, no large von Willebrand factor multimers, and low levels of ristocetin cofactor in plasma with heightened ristocetin-induced platelet aggregation. T...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830230410

    authors: Federici AB,Mannucci PM,Bader R,Lombardi R,Lattuada A

    更新日期:1986-12-01 00:00:00

  • Acute renal failure after intravenous anti-D immune globulin in an adult with immune thrombocytopenic purpura.

    abstract::Intravenous anti-D immune globulin (anti-D IGIV) is indicated for the treatment of immune thrombocytopenic purpura (ITP) in nonsplenectomized patients who are Rh(D)-positive. Recent reports have described episodes of intravascular hemolysis (IVH) and acute renal failure (ARF) after anti-D IGIV. We report the first adu...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.10432

    authors: Chun NS,Savani B,Seder RH,Taplin ME

    更新日期:2003-12-01 00:00:00

  • Hepatosplenic gammadelta T-cell lymphoma in a 10-year-old boy successfully treated with hematopoietic stem cell transplantation.

    abstract::The authors report a 10-year-old boy with hepatosplenic gammadelta T-cell lymphoma, a rare form of lymphoma that is highly aggressive, exceedingly rare in children, and primarily seen in young men. Conventional multi-agent chemotherapy appears to be inadequate for cure. This is the first report with this type of lymph...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.10466

    authors: Gassas A,Kirby M,Weitzman S,Ngan B,Abla O,Doyle JJ

    更新日期:2004-02-01 00:00:00

  • World Health Organization-defined classification of myeloproliferative neoplasms: morphological reproducibility and clinical correlations--the Danish experience.

    abstract::We examined inter- and intraobserver reproducibility and concordance between histological diagnosis and independently collected clinical findings in a large series of patients with the major subtypes of myeloproliferative neoplasms (MPNs) and controls. Seven hematopathologists reviewed 272 bone marrow biopsies includi...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23554

    authors: Madelung AB,Bondo H,Stamp I,Loevgreen P,Nielsen SL,Falensteen A,Knudsen H,Ehinger M,Dahl-Sørensen R,Mortensen NB,Svendsen KD,Lange T,Ralfkiaer E,Nielsen K,Hasselbalch HC,Thiele J

    更新日期:2013-12-01 00:00:00

  • Early lymphopenia as a risk factor for chemotherapy-induced febrile neutropenia.

    abstract::Febrile neutropenia (FN) is a frequent complication of cancer chemotherapy, which causes death in 4-21% of patients and worsens the quality of life of patients. As a simple and accurate way of identifying patients who are at risk of FN, a lymphocyte count on post-chemotherapy day 5 was suggested. To confirm the feasib...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.10363

    authors: Choi CW,Sung HJ,Park KH,Yoon SY,Kim SJ,Oh SC,Seo JH,Kim BS,Shin SW,Kim YH,Kim JS

    更新日期:2003-08-01 00:00:00

  • Myelodysplastic syndrome treatment with danazol and cis-retinoic acid.

    abstract::We prospectively treated 46 patients with favorable myelodysplastic syndrome classified as refractory anemia (RA), refractory cytopenia (RC), or refractory anemia with ringed sideroblasts (RARS). These patients received one of two schedules of 13-Cis-Retinoic Acid (low dose 80 mg daily for 6 months vs. high dose 200 m...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/ajh.2830480405

    authors: Letendre L,Levitt R,Pierre RV,Schroeder G,Krook JA,Mailliard JE,Morton RF,Tschetter LK

    更新日期:1995-04-01 00:00:00

  • Cell-mediated immune-pancytopenia complicating primary Sjögren's syndrome.

    abstract::A 64-year-old woman with mild bilateral parotid gland swelling and bilateral lower extremity purpura was admitted for evaluation of xerostomia and pancytopenia. The patient had an increased erythrocyte sedimentation rate, pancytopenia, and positive tests for antibodies to nuclear antigen, SS-A, and SS-B. Impaired cell...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830430312

    authors: Seki T,Kiyosawa K,Monno S,Imai Y,Furukawa K,Kumazawa S,Ota M,Saito H,Furuta S,Nakahata T

    更新日期:1993-07-01 00:00:00

  • Overexpression of cyclooxygenase-2 in multiple myeloma: association with reduced survival.

    abstract::Cyclooxygenases (COX) are key enzymes in the conversion of arachidonic acid to prostaglandins. Several studies have shown a relation between angiogenesis and COX-2 expression. Elevated expression of cyclooxygenase-2 (COX-2), however, has not been reported in multiple myeloma (MM) in the literature. The aim of this stu...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20460

    authors: Cetin M,Buyukberber S,Demir M,Sari I,Sari I,Deniz K,Eser B,Altuntas F,Camci C,Oztürk A,Turgut B,Vural O,Unal A

    更新日期:2005-11-01 00:00:00

  • A 10-year experience with treatment of high and standard risk Hodgkin disease: six cycles of tailored BEACOPP, with interim scintigraphy, are effective and female fertility is preserved.

    abstract::Therapy of Hodgkin lymphoma (HL) is designed to prolong survival and minimize toxicity. A total of 124 patients with newly diagnosed HL and adverse prognostic factors were prospectively studied between July, 1999 and August, 2005. Patients with early unfavorable and advanced disease were eligible for the study. Patien...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.22187

    authors: Dann EJ,Blumenfeld Z,Bar-Shalom R,Avivi I,Ben-Shachar M,Goor O,Libster D,Gaitini D,Rowe JM,Epelbaum R

    更新日期:2012-01-01 00:00:00

  • Incidence, management, and outcome of high-grade transformation of nodular lymphocyte predominant Hodgkin lymphoma: long-term outcomes from a 30-year experience.

    abstract::Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare form of Hodgkin lymphoma that typically presents as early stage, indolent disease in young adult males. The relationship between NLPHL and DLBCL is incompletely understood, and there remains a paucity of data with regard the incidence and management of ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23989

    authors: Eyre TA,Gatter K,Collins GP,Hall GW,Watson C,Hatton CS

    更新日期:2015-06-01 00:00:00

  • Systemic AL amyloidosis with acquired factor X deficiency: A study of perioperative bleeding risk and treatment outcomes in 60 patients.

    abstract::Systemic light-chain (AL) amyloidosis may be associated with acquired factor X (FX) deficiency and optimal management of this coagulopathy is unknown. We reviewed our experience with 60 patients with isolated FX deficiency (< or =50%) due to AL amyloidosis that underwent an invasive procedure between 1975 and 2007. Th...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.21603

    authors: Thompson CA,Kyle R,Gertz M,Heit J,Pruthi R,Pardanani A

    更新日期:2010-03-01 00:00:00

  • Retraction: 'Number needed to treat with 4-factor prothrombin complex concentrate for urgent warfarin reversal' by Andrew Chua, Vishal Patel, Allison Perrin, Lee Stern, Jenifer Ehreth, Laurel Omert, Christopher Hood, Julie Farley, Michael McGlynn and Lipi

    abstract::The above abstract from the THSNA 2016 Summit Abstract Proceedings, first published online in the American Journal of Hematology on 20 July 2016 in Wiley OnlineLibrary (www.onlinelibrary.wiley.com), and in Volume 91, Issue 9, p. E427, has been retracted by agreement between the authors, the journal Editor-in-Chief, Ca...

    journal_title:American journal of hematology

    pub_type: 杂志文章,撤回出版物

    doi:10.1002/ajh.24678

    authors:

    更新日期:2017-04-01 00:00:00

  • Prenatal diagnosis of thalassemia in the Chinese.

    abstract::There is a high prevalence of thalassemia in the Taiwan area. Prenatal diagnosis of severe forms of thalassemia is important for the prevention of this disease. We performed prenatal diagnosis in 167 cases, of which 59 cases were diagnosed by chorionic villi biopsy, 91 cases by amniotic fluid analysis, and 17 cases by...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199706)55:2<65::aid-ajh3>3

    authors: Liu TC,Lin SF,Yang TY,Lee JP,Chen TP,Chang JG

    更新日期:1997-06-01 00:00:00

  • Vasoactive factors in sickle cell disease: in vitro evidence for endothelin-1-mediated vasoconstriction.

    abstract::While systemic plasma endothelin-1 (ET-1) levels are increased during acute crisis in sickle cell disease, the relative levels of potent vasoactive factors that contribute to the regulation of vascular function, such as ET-1, NO, and cell-free hemoglobin, during the course of periodic vaso-occlusive episodes remain un...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20107

    authors: Ergul S,Brunson CY,Hutchinson J,Tawfik A,Kutlar A,Webb RC,Ergul A

    更新日期:2004-07-01 00:00:00

  • Studies of the effects of trimethoprim and sulfamethoxazole on human granulopoiesis.

    abstract::Trimethoprim and sulfamethoxazole (Bactrim r) is a widely used antibiotic combination effective against a broad spectrum of microbial organisms. There are reports of neutropenia developing during even brief periods of oral therapy, particularly in individuals with either folate deficiency or increased folate requireme...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830230102

    authors: Bjornson BH,McIntyre AP,Harvey JM,Tauber AI

    更新日期:1986-09-01 00:00:00

  • Diagnostic utility of cerebrospinal fluid flow cytometry in patients with and without prior hematologic malignancy.

    abstract::Flow cytometry (FCM) is an adjunct study to routine analysis of cerebrospinal fluid (CSF) to investigate for involvement by a hematologic malignancy. However, in our experience, FCM only infrequently detects abnormalities in CSF. To help optimize resources without forfeiting clinically important data, we sought to det...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/ajh.23806

    authors: Kovach AE,DeLelys ME,Kelliher AS,Dillon LJ,Hasserjian RP,Ferry JA,Preffer FI,Sohani AR

    更新日期:2014-10-01 00:00:00

  • Venous insufficiency is not the cause of leg ulcers in sickle cell disease.

    abstract::Leg ulcers are a well recognized complication of sickle cell disease that has been attributed to venous insufficiency. We studied 16 patients with sickle cell disease and active ulcers using venous pulse volume recordings and photoplethysmography (Doppler studies). Based on hemodynamic monitoring, all 16 patients exhi...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830370215

    authors: Billett HH,Patel Y,Rivers SP

    更新日期:1991-06-01 00:00:00

  • Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant.

    abstract::A 10-month-old infant with chronic myelomonocytic leukemia (CMML) of 5 months' duration, who had been treated only with transfusion, displayed leukemic transformation characterized by lymphoid morphology, PAS positivity, and myeloperoxidase negativity. Surface marker analysis of blast cells revealed expression of lymp...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-8652(199607)52:3<212::AID-AJH14

    authors: Yamamoto M,Nakagawa M,Ichimura N,Ohtsuki F,Ohtsuka Y,Tsujino Y,Tanaka A,Kamiya T,Wada H

    更新日期:1996-07-01 00:00:00

  • A single high-resolution HLA mismatch has a similar adverse impact on the outcome of related hematopoietic stem cell transplantation as a single low-resolution HLA mismatch.

    abstract::The relative importance of the resolution level of HLA typing has not been fully defined for related donor transplantation. To address this question, we retrospectively evaluated patients who underwent a first related hematopoietic stem cell transplantation (HSCT) from 2000 to 2011 from an HLA high-resolution matched ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.24028

    authors: Fuji S,Kanda J,Kato S,Ikegame K,Morishima S,Miyamoto T,Hidaka M,Kubo K,Miyamura K,Tsudo M,Kobayashi H,Maesako Y,Eto T,Adachi S,Ichinohe T,Atsuta Y,Kanda Y,HLA Working Group of the Japan Society for Hematopoietic Cell Tr

    更新日期:2015-07-01 00:00:00

  • Cell fusion is not involved in the generation of giant cells in the Hodgkin-Reed Sternberg cell line L1236.

    abstract::The mechanism of multinucleated cell formation in Hodgkin's disease has not yet been elucidated. We asked whether the giant multinucleated cells of the H-RS cell line L1236 develop via fusion of the predominant smaller cells. As a positive control for the fusion assay, human B cells from the B-cell lymphoma cell line ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.1068

    authors: Re D,Benenson E,Beyer M,Gresch O,Draube A,Diehl V,Wolf J

    更新日期:2001-05-01 00:00:00

  • T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, Sjögren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia.

    abstract::We present a female patient with T-gamma LGL leukemia, who was followed for the last 20 years. Over these years she developed several autoimmune disorders, including Sjögren's syndrome, Hashimoto's thyroiditis, premature ovarian failure (compatible with type II autoimmune polyglandular syndrome), amegakaryocytic throm...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.10024

    authors: Ergas D,Tsimanis A,Shtalrid M,Duskin C,Berrebi A

    更新日期:2002-02-01 00:00:00

  • Enhancement of sickle erythrocyte adherence to endothelium by autologous platelets.

    abstract::The increased adhesiveness of sickle erythrocytes (SS RBC) to endothelial cells has been confirmed in a static system utilizing fresh umbilical vein endothelium. Adherence of SS RBC to the endothelium was as great in the presence of calcium-containing buffer as when incubated in plasma. SS RBC suspended in autologous ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830340110

    authors: Antonucci R,Walker R,Herion J,Orringer E

    更新日期:1990-05-01 00:00:00

  • An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer.

    abstract::Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patie...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.25418

    authors: Feins S,Kong W,Williams EF,Milone MC,Fraietta JA

    更新日期:2019-05-01 00:00:00

  • Measurement of terminal deoxynucleotidyl transferase mRNA in clinical samples: a new parameter in analysis of leukemia cells.

    abstract::A 1750 base pair cDNA to human terminal deoxynucleotidyl transferase (TdT) has been cloned. This cDNA detects a dominant 2200 base pair messenger RNA species in normal and leukemic cells synthesizing the enzyme. A quantitative dot blot assay was utilized to survey a number of clinical samples from patients with TdT po...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830250305

    authors: Wolf SC,Steinherz PG,Landau NR,Silverstone AE

    更新日期:1987-07-01 00:00:00

  • Measurement of human serum erythropoietin by erythroid colony-forming technique using fetal mouse liver cells.

    abstract::A quantitative bioassay for serum erythropoietin in anemic patients was established with erythroid colony-forming technique using methyl cellulose. Fetal mouse liver contains many erythropoietin-dependent erythroid colony-forming cells (CFU-E) with the concentration as well as sensitivity to erythropoietin being the h...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830120210

    authors: Okamoto T,Kanamaru A,Hara H,Nagai K

    更新日期:1982-04-01 00:00:00

  • Molecular basis and hematological characterization of Hb H disease in southeast Asia.

    abstract::We molecularly characterized sixty-seven cases of Hb H disease by the polymerase chain reaction. The strategy depends on amplifying the alpha-thalassemia-1 (alpha-thal-1) gene by primers flanking the breakpoint and sequence differences of the 3' end of the alpha-globin gene and the nonhomologous elements I, II, and II...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830450405

    authors: Liu TC,Chiou SS,Lin SF,Chen TP,Tseng WP,Chen PH,Chang JG

    更新日期:1994-04-01 00:00:00

  • UGT1A1 promoter polymorphisms and the development of hyperbilirubinemia and gallbladder disease in children with sickle cell anemia.

    abstract::Genetic modifiers contribute to phenotypic variability in patients with sickle cell anemia (SCA). The influence of the bilirubin UDP-glucuronosyltransferase (UGT) 1A1 (TA)(n)TAA promoter polymorphism on bilirubin levels and gallbladder disease in SCA was examined using prospectively collected data from the Cooperative...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.21264

    authors: Carpenter SL,Lieff S,Howard TA,Eggleston B,Ware RE

    更新日期:2008-10-01 00:00:00