Systemic AL amyloidosis with acquired factor X deficiency: A study of perioperative bleeding risk and treatment outcomes in 60 patients.

abstract：:By using Dexter-type long-term marrow cultures (D-LTMC), it has been shown previously that hematopoietic progenitor cells (HPC) from patients with aplastic anemia (AA) have a deficient proliferation in vitro. The studies reported to date, however, have focused exclusively on granulomonocytic progenitors and no informa...

journal_title：American journal of hematology

authors： Gómez-Morales E,Martinez-Jaramillo G,Sánchez-Valle E,Valencia-Plata I,Arana-Trejo RM,Castro MA,Pizzuto-Chávez J,Mayani H

更新日期：1998-10-01 00:00:00

abstract：:Polycythemia vera (PV) is associated with a high incidence of thrombosis. The association of apparent and secondary polycythemia with thrombosis is not clear. It was suggested that activation of the coagulation system contributes to thrombus formation in PV. However, the mechanism of activation is unknown. Monocytes g...

journal_title：American journal of hematology

authors： Kornberg A,Rahimi-Levene N,Yona R,Mor A,Rachmilewitz EA

更新日期：1997-09-01 00:00:00

abstract：:Variable survival outcomes are seen following treatment for aggressive non-Hodgkin lymphoma (NHL). This study examined whether outcomes for aggressive B-cell NHL are associated with single nucleotide polymorphisms (SNPs) in oxidative stress-related genes, which can alter drug metabolism and immune responses. Genotypes...

journal_title：American journal of hematology

authors： Gustafson HL,Yao S,Goldman BH,Lee K,Spier CM,LeBlanc ML,Rimsza LM,Cerhan JR,Habermann TM,Link BK,Maurer MJ,Slager SL,Persky DO,Miller TP,Fisher RI,Ambrosone CB,Briehl MM

更新日期：2014-06-01 00:00:00

abstract：:Bacterial and protozoal infections can cause thrombocytopenia and may mimic idiopathic thrombocytopenic purpura (ITP). Brucella species and Toxoplasma are among the infectious agents with protean clinical manifestations which may induce immune thrombocytopenia. In rare cases, thrombocytopenia can be severe and may res...

journal_title：American journal of hematology

authors： Gürkan E,Başlamişli F,Güvenç B,Bozkurt B,Unsal C

更新日期：2003-09-01 00:00:00

abstract：:Intravenous (IV) granulocyte colony stimulating factor (G-CSF) might be safer and more convenient than subcutaneous (SC) administration to hospitalized hemato-oncological patients receiving chemotherapy. To compare IV vs. SC G-CSF administration, we conducted a randomized, open-label trial. We included inpatients rece...

journal_title：American journal of hematology

authors： Paul M,Ram R,Kugler E,Farbman L,Peck A,Leibovici L,Lahav M,Yeshurun M,Shpilberg O,Herscovici C,Wolach O,Itchaki G,Bar-Natan M,Vidal L,Gafter-Gvili A,Raanani P

更新日期：2014-03-01 00:00:00

abstract：:Responsiveness of bone marrow erythropoietic stem cells (CFU-E and BFU-E) to recombinant human erythropoietin (rh-Ep) was examined in vitro in 23 patients with aplastic anemia and 14 with myelodysplastic syndrome (MDS) to investigate the clinical use of rh-Ep for these diseases. Bone marrow mononuclear cells were cult...

journal_title：American journal of hematology

authors： Aoki I,Higashi K,Homori M,Chikazawa H,Ishikawa K

更新日期：1990-09-01 00:00:00

abstract：:We present a female patient with T-gamma LGL leukemia, who was followed for the last 20 years. Over these years she developed several autoimmune disorders, including Sjögren's syndrome, Hashimoto's thyroiditis, premature ovarian failure (compatible with type II autoimmune polyglandular syndrome), amegakaryocytic throm...

journal_title：American journal of hematology

authors： Ergas D,Tsimanis A,Shtalrid M,Duskin C,Berrebi A

更新日期：2002-02-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is considered to be a pleuripotential stem cell disorder with the capacity to differentiate into myeloid, erythroid, megakaryocytic, and lymphoid cell lines. Consequently, blast crisis (BC) involving each of the above lineages has been well described. Among lymphoblastic crises, differen...

journal_title：American journal of hematology

authors： Advani SH,Malhotra H,Kadam PR,Iyer RS,Nanjangud G,Balsara B,Saikia T,Gopal R,Nair CN

更新日期：1991-02-01 00:00:00

abstract：:Severe pruritus is frequently associated with myeloproliferative and other systemic illnesses, and often fails to respond to conventional measures. We used danazol (Danocrine), a synthetic attenuated androgen, in the treatment of severe pruritus refractory to conventional therapy. Eight patients had myeloproliferative...

journal_title：American journal of hematology

authors： Kolodny L,Horstman LL,Sevin BU,Brown H,Ahn YS

更新日期：1996-02-01 00:00:00

abstract：:Anthracyclines have contributed to a marked increase in survival in different types of cancer [1,2]. Unfortunately, they are associated with dose-dependent cardiotoxicity and heart failure (HF) [3–8]. Change to a weekly dosage schedule with slow infusions has been tested, a strategy that requires more frequent hospita...

journal_title：American journal of hematology

authors： Georgakopoulos P,Roussou P,Matsakas E,Karavidas A,Anagnostopoulos N,Marinakis T,Galanopoulos A,Georgiakodis F,Zimeras S,Kyriakidis M,Ahimastos A

更新日期：2010-11-01 00:00:00

abstract：:In HIV-positive patients with non-Hodgkin lymphoma (NHL), no benefit of adding rituximab to chemotherapy was seen in a randomized controlled trial (RCT). We performed a meta-analysis of prospective studies to ascertain outcomes in HIV-positive NHL patients treated with chemotherapy (chemo) versus rituximab and chemo (...

journal_title：American journal of hematology

authors： Castillo JJ,Echenique IA

更新日期：2012-03-01 00:00:00

abstract：:It has been suggested that alterations of cell cycle genes probably contribute to the pathogenesis of endemic Burkitt's lymphoma (BL) in addition to c-MYC translocation. Mutations disrupting the normal nuclear localization signal of the retinoblastoma-related gene Rb2/p130 have been documented in BL cell lines and pri...

journal_title：American journal of hematology

authors： Klumb CE,Magluta EP,Rezende LM,Apa AG,Alonso JF,Maia RC

更新日期：2007-03-01 00:00:00

abstract：:Imatinib is currently the standard treatment for chronic myeloid leukemia(CML). Previous studies have shown that imatinib affects bone metabolism in CML patients. However, these effects are not well-studied prospectively. The authors studied bone-mineral density (BMD) and bone metabolism in 17 CML patients and matched...

journal_title：American journal of hematology

authors： Jönsson S,Standal T,Olsson B,Mellström D,Wadenvik H

更新日期：2012-05-01 00:00:00

abstract：:The purpose of the study was to assess consensus and interobserver agreement among an international panel of six hematopathologists regarding characterization and reproducibility of bone marrow (BM) histologic features used to diagnose early stage myeloproliferative neoplasms, in particular differentiation of so-calle...

journal_title：American journal of hematology

authors： Kvasnicka HM,Orazi A,Thiele J,Barosi G,Bueso-Ramos CE,Vannucchi AM,Hasserjian RP,Kiladjian JJ,Gianelli U,Silver R,Mughal TI,Barbui T

更新日期：2017-10-01 00:00:00

abstract：:The increased adhesiveness of sickle erythrocytes (SS RBC) to endothelial cells has been confirmed in a static system utilizing fresh umbilical vein endothelium. Adherence of SS RBC to the endothelium was as great in the presence of calcium-containing buffer as when incubated in plasma. SS RBC suspended in autologous ...

journal_title：American journal of hematology

authors： Antonucci R,Walker R,Herion J,Orringer E

更新日期：1990-05-01 00:00:00

abstract：DISEASE OVERVIEW:Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms primarily characterized by erythrocytosis and thrombocytosis, respectively. Other disease features include leukocytosis, splenomegaly, thrombohemorrhagic complications, vasomotor disturbances, pruritus, and a sma...

journal_title：American journal of hematology

authors： Tefferi A

更新日期：2011-03-01 00:00:00

abstract：:After the patents of biopharmaceuticals have expired, based on specific regulatory approval pathways copied products ("biosimilars" or "follow-on biologics") have been launched in the EU. This article summarizes experiences with hematopoietic medicines, namely the epoetins (two biosimilars traded under five different ...

journal_title：American journal of hematology

authors： Jelkmann W

更新日期：2010-10-01 00:00:00

abstract：:Neutrophil elastase (NE) is a serine protease stored in the primary granules of neutrophils that proteolytically cleaves multiple cytokines and cell surface proteins on release from activated neutrophils. Recent reports of mutations in the gene encoding this enzyme in some patients with neutropenic syndromes prompted ...

journal_title：American journal of hematology

authors： Hunter MG,Druhan LJ,Massullo PR,Avalos BR

更新日期：2003-11-01 00:00:00

abstract：:Total body irradiation (TBI) has been thought to promote donor cell engraftment in allogeneic hematopoietic cell transplantation (HCT) from alternative donors. However, recent progress in HCT strategies may affect the clinical significance of TBI on neutrophil engraftment. With the use of a Japanese transplant registr...

journal_title：American journal of hematology

authors： Nakasone H,Fuji S,Yakushijin K,Onizuka M,Shinohara A,Ohashi K,Miyamura K,Uchida N,Takanashi M,Ichinohe T,Atsuta Y,Fukuda T,Ogata M,Complication Working Group of Japanese Society for Hematopoietic Cell Transplantation.

更新日期：2017-02-01 00:00:00

abstract：:Conventional treatment of mantle cell lymphoma (MCL) yields modest responses and short remissions. We report 30 hematopoietic stem cell transplants (HSCT) for MCL: 13 autologous, 10 allogeneic myeloablative, and 7 nonablative. After a median 1.2 years from diagnosis (range 0.5 to 4.7) and a median of 2 pre-HSCT chemot...

journal_title：American journal of hematology

authors： Laudi N,Arora M,Burns L,McGlave P,Miller J,Bohac G,Rogers T,Barker J,Coad J,Weisdorf D

更新日期：2006-07-01 00:00:00

abstract：:Alpha-hemoglobin stabilizing protein (AHSP) is a potential modifier of beta-thalassemia by virtue of its ability to detoxify excess free alpha-globin. However, examination of patients with beta-thalassemia from a few geographic regions failed to identify obvious AHSP mutations. We extended these studies by analyzing A...

journal_title：American journal of hematology

authors： dos Santos CO,Zhou S,Secolin R,Wang X,Cunha AF,Higgs DR,Kwiatkowski JL,Thein SL,Gallagher PG,Costa FF,Weiss MJ

更新日期：2008-02-01 00:00:00

abstract：:Matching for HLA-A, -B, -C, and -DRB1 loci (8/8 match) is currently the gold standard for unrelated donor hematopoietic cell transplantation (HCT). In Europe, patients are also matched at the HLA-DQB1 loci (10/10 match). However, there is increasing evidence that matching at HLA-DRB3/4/5 loci may help to lower transpl...

journal_title：American journal of hematology

authors： Ducreux S,Dubois V,Amokrane K,Yakoub-Agha I,Labalette M,Michallet M,Rubio MT,Kennel A,Forcade E,Lafarge X,Bulabois CE,Masson D,Daguindau E,Devys A,Moalic V,Quelvennec E,Boudifa A,Picard C,Van Endert P,de Matteis M,

更新日期：2018-05-04 00:00:00

abstract：:Sickle cell disease (SCD) nephropathy and lower estimated glomerular filtration rate (eGFR) are risk factors for early mortality. Furthermore, rate of eGFR decline predicts progression to end-stage renal disease in many clinical settings. However, factors predicting renal function decline in SCD are poorly documented....

journal_title：American journal of hematology

authors： Xu JZ,Garrett ME,Soldano KL,Chen ST,Clish CB,Ashley-Koch AE,Telen MJ

更新日期：2018-12-01 00:00:00

abstract：:Unprecedented advances in our understanding of the pathobiology, prognostication, and therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years. Heterogeneity in the clinical course of MCL-indolent vs aggressive-is further delineated by a correlation with the mutational status of the var...

journal_title：American journal of hematology

authors： Jain P,Wang M

更新日期：2019-06-01 00:00:00

abstract：:We have studied telomere length in the bone marrow cells or the granulocyte and lymphocyte cell fractions of 54 patients with myelodysplastic syndromes (MDS) by Southern blot hybridization using the (TTAGGG)4 probe. The average telomere length expressed as the peak telomere repeat array (TRA) in the peripheral blood, ...

journal_title：American journal of hematology

authors： Boultwood J,Fidler C,Kusec R,Rack K,Elliott PJ,Atoyebi O,Chapman R,Oscier DG,Wainscoat JS

更新日期：1997-12-01 00:00:00

abstract：:The biosynthesis of the minor hemoglobin FIc, which contains acetylated gamma chains, and the major hemoglobin Fo was studied during erythroid cell differentiation and maturation in cultures of erythroid precursors isolated from five human umbilical cord blood samples. A gradual decrease in the synthesis of Hb FIc was...

journal_title：American journal of hematology

authors： Abraham EC,Reese AL,Stallings M,Abraham A,Garbutt GJ,Huisman TH

更新日期：1982-05-01 00:00:00

abstract：:Morbid obesity is a health problem that has been shown to be refractory to diet, exercise, and medical treatment. Surgeries designed to promote weight loss, termed bariatric surgery and typically involving a gastric bypass procedure, have recently been implemented to treat obesity with high success rates. However, lon...

journal_title：American journal of hematology

authors： Love AL,Billett HH

更新日期：2008-05-01 00:00:00

abstract：:A 28-year-old asymptomatic male of Iranian Jewish (Meshadi) heritage was found on routine exam to have an erythrocytosis (RBC = 6.22 x 10(12)/l, Hgb = 19.2 g/dl, Hct = 58.9%). Splenomegaly was absent on physical exam. There was no family history of erythrocytosis. His oxygen dissociation curve was left-shifted with a ...

journal_title：American journal of hematology

authors： Hoyer JD,Allen SL,Beutler E,Kubik K,West C,Fairbanks VF

更新日期：2004-04-01 00:00:00

abstract：:The intravascular pool of human polymorphonuclear leukocytes (PMN) is composed of one compartment which is circulating and another that is marginated to the vascular endothelium. Administration of B-adrenergic agonists leads to a rapid demargination with an increase in the circulating PMN pool. The marginating PMN has...

journal_title：American journal of hematology

authors： Berkow RL,Dodson RW

更新日期：1987-01-01 00:00:00

abstract：DISEASE OVERVIEW:Approximately one-fourth of primary cutaneous lymphomas are B-cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCD...

journal_title：American journal of hematology

authors： Hristov AC,Tejasvi T,Wilcox RA

更新日期：2020-08-20 00:00:00