Cardioprotective effect of metoprolol and enalapril in doxorubicin-treated lymphoma patients: a prospective, parallel-group, randomized, controlled study with 36-month follow-up.

abstract：:Although treatment with plasma exchange increased the survival of patients with thrombotic thrombocytopenia purpura to 80% in the 1980s, no further increase of survival occurred over the next 20 years. However, more consistent use of adjuvant treatment with corticosteroids and rituximab in recent years has begun to fu...

journal_title：American journal of hematology

authors： George JN

更新日期：2012-05-01 00:00:00

abstract：:The investigation of kindreds with recurrent thrombotic disease has advanced the understanding of the mechanisms of coagulation and fibrinolysis. In those cases where an etiology has been established, congenital thrombotic disorders are associated either with deficiencies or qualitative abnormalities in inhibitors of ...

journal_title：American journal of hematology

authors： Rodgers GM,Shuman MA

更新日期：1986-04-01 00:00:00

abstract：:Gaucher disease (GD) is a lysosomal storage disorder; symptomatic patients with type 1 GD need long-term disease-specific therapy of which the standard of care has been enzyme replacement therapy (ERT). Thirty-eight of 40 patients (aged 9-71 years) clinically stable on ERT with imiglucerase, safely switched to a compa...

journal_title：American journal of hematology

authors： Elstein D,Mehta A,Hughes DA,Giraldo P,Charrow J,Smith L,Shankar SP,Hangartner TN,Kunes Y,Wang N,Crombez E,Zimran A

更新日期：2015-07-01 00:00:00

abstract：:Over 300,000 infants are born annually with sickle cell anemia (SCA) in sub-Saharan Africa, and >50% die young from infection or anemia, usually without diagnosis of SCA. Early identification by newborn screening (NBS), followed by simple interventions dramatically reduced the mortality of SCA in the United States, bu...

journal_title：American journal of hematology

authors： McGann PT,Ferris MG,Ramamurthy U,Santos B,de Oliveira V,Bernardino L,Ware RE

更新日期：2013-12-01 00:00:00

abstract：:Long-term survival following chemotherapy or autologous bone marrow transplantation in adults with relapsed/refractory non-Hodgkin's lymphoma was evaluated. English language articles published from January 1, 1988 to September 1, 1993 were obtained from a broad-based MEDLINE search retrieving 3,854 citations regarding...

journal_title：American journal of hematology

authors： Meehan KR,Pritchard RS,Leichter JW,Littenberg B,Welch HG

更新日期：1995-10-01 00:00:00

abstract：:This study concerned the gamma chain composition of Hb F and the haplotypes of 44 patients with beta-thalassemia major or intermedia and many of their relatives. Seventeen patients came from Northern (Turkish) Cyprus, 12 from the Istanbul area, and 15 from Macedonia and Bulgaria. Analysis of the A gamma T-G gamma-A ga...

journal_title：American journal of hematology

authors： Aksoy M,Kutlar A,Efremov GD,Nikolov N,Petkov G,Reese AL,Harano T,Chen SS,Huisman TH

更新日期：1985-09-01 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) has a wide range of presentations after hematopoietic stem-cell transplantation (HSCT). We retrospectively studied the risk factors and outcomes of patients with early (≤day 100) and late (>day 100) TA-TMA. Among the 1451 HSCT recipients, early TA-TMA occurred ...

journal_title：American journal of hematology

authors： Heybeli C,Sridharan M,Alkhateeb HB,Villasboas Bisneto JC,Buadi FK,Chen D,Dingli D,Dispenzieri A,Gertz MA,Go RS,Hashmi SK,Hayman SR,Hogan WJ,Inwards DJ,Kenderian SS,Kumar SK,Litzow MR,Porrata LF,Lacy MQ,Micallef IN,

更新日期：2020-07-02 00:00:00

abstract：:A discordance between p53 protein overexpression and the presence of mutations in the gene has been observed in many types of tumors, including human lymphomas. To probe this finding, we have studied a large series of 94 lymphomas of different pathologic types and histologic differentiation. Analyzing exons 5-9, we ha...

journal_title：American journal of hematology

authors： Martinez-Delgado B,Robledo M,Arranz E,Infantes F,Echezarreta G,Marcos B,Sanz C,Rivas C,Benitez J

更新日期：1997-05-01 00:00:00

abstract：:Retroviral-mediated gene transfer into hematopoietic stem cells provides the only means of stable transduction of these cells and their progeny for use with a variety of potentially therapeutic genes. Expression of the Moloney amphotropic retroviral receptor-pit-2 or GLVR-2-is critical to the recognition and entry of ...

journal_title：American journal of hematology

authors： Kaubisch A,Ward M,Schoetz S,Hesdorffer C,Bank A

更新日期：1999-08-01 00:00:00

abstract：:Acquired pure megakaryocytic aplasia is a rare disorder defined by severe thrombocytopenia with no other hematologic abnormalities and absent, or severely decreased marrow megakaryocytes. The etiology may be immune suppression of megakaryocyte development. Two patients are described who both responded rapidly to a com...

journal_title：American journal of hematology

authors： Leach JW,Hussein KK,George JN

更新日期：1999-10-01 00:00:00

abstract：:Twenty-eight patients undergoing cardiac surgery were prospectively studied and were assigned to two groups. The patients received 0.8- (Group L) or 2.0-fold (Group H) dose of protamine for the neutralization after cardiopulmonary bypass (CPB) which was determined by Hepcon HMS(R) assay system in which the reagent cha...

journal_title：American journal of hematology

authors： Miyashita T,Nakajima T,Hayashi Y,Kuro M

更新日期：2000-06-01 00:00:00

abstract：:We studied 15 patients with essential thrombocythemia (ET) before treatment and after normalization of platelet count by anagrelide. Significantly increased plasma levels of PDGF, TGFbeta, and bFGF were found. Patients with mild reticulin fibrosis in bone marrow had higher PDGF levels. During treatment, plasma TGFbeta...

journal_title：American journal of hematology

authors： Lev PR,Marta RF,Vassallu P,Molinas FC

更新日期：2002-06-01 00:00:00

abstract：:Cobalamin (vitamin B12) deficiency is a common cause of megaloblastic anemia in Western populations. Laboratory evaluation of megaloblastic anemia frequently includes the assessment of patient cobalamin and folate status. Current total serum cobalamin measurements are performed in the clinical laboratory with competit...

journal_title：American journal of hematology

authors： Oberley MJ,Yang DT

更新日期：2013-06-01 00:00:00

abstract：:Hairy cell leukemia is a chronic lymphoproliferative disorder characterized clinically by splenomegaly and cytopenias. Spontaneous remissions are rare and splenectomy is often performed when the blood counts worsen and cause symptoms. Three of our patients with hairy cell leukemia developed recurrent pancytopenia and ...

journal_title：American journal of hematology

authors： Keefer MJ,Weber MJ,Bottomley SS,Solanki DL,Hosty TA

更新日期：1987-07-01 00:00:00

abstract：:Fourteen patients, aged 65-85 years, with refractory (11) or relapsing (3) multiple myeloma were treated with a "protracted-sequential" protocol comprising vincristine 1-2 mg or vindesine 3 mg/M(2) (max. 5 mg) IVI over 4 hr on D1, prednisolone 40-50 mg PO D1-14, and melphalan 2-4 mg PO or cyclophosphamide 50-100 mg PO...

journal_title：American journal of hematology

authors： Manoharan A

更新日期：2000-09-01 00:00:00

abstract：:The case of a 21 year-old female with echinocytosis and a littoral cell hemangioma is reported. The patient had no significant past medical history and presented with abdominal pain and splenomegaly. A large percentage of echinocytes were noted on her peripheral smear in the absence of any known causes. A CT-recognize...

journal_title：American journal of hematology

authors： Altomare I,Desman G,Aledort LM

更新日期：2006-07-01 00:00:00

abstract：:Chronic transfusion therapy is the treatment of choice for preventing stroke recurrence in children with sickle cell disease (SCD). The majority of children affected by this devastating complication live in the developing world where access to regular blood transfusions may be impractical. Since 2000, in the absence o...

journal_title：American journal of hematology

authors： Ali SB,Moosang M,King L,Knight-Madden J,Reid M

更新日期：2011-10-01 00:00:00

abstract：:Immunomodulatory drugs (IMiDs) are a cornerstone in the treatment of multiple myeloma (MM), but specific markers to predict outcome are still missing. Recent work pointed to a prognostic role for IMiD target genes (e.g. CRBN). Moreover, indirect activity of IMiDs on immune cells correlated with outcome, raising the po...

journal_title：American journal of hematology

authors： Bolomsky A,Hübl W,Spada S,Müldür E,Schlangen K,Heintel D,Rocci A,Weißmann A,Fritz V,Willheim M,Zojer N,Palumbo A,Ludwig H

更新日期：2017-03-01 00:00:00

abstract：:Gamma inferferon (gamma IFN), alpha tumor necrosis factor (alpha TNF), and interleukin 6 (IL-60) are cytokines produced by a wide variety of cells, including T lymphocytes and NK cells. These cytokines affect B-cell proliferation and differentiation into immunoglobulin secreting cells. In addition, gamma IFN and alpha...

journal_title：American journal of hematology

authors： Garcia-Suarez J,Prieto A,Reyes E,Manzano L,Arribalzaga K,Alvarez-Mon M

更新日期：1995-08-01 00:00:00

abstract：:Sickle cell disease (SCD) nephropathy and lower estimated glomerular filtration rate (eGFR) are risk factors for early mortality. Furthermore, rate of eGFR decline predicts progression to end-stage renal disease in many clinical settings. However, factors predicting renal function decline in SCD are poorly documented....

journal_title：American journal of hematology

authors： Xu JZ,Garrett ME,Soldano KL,Chen ST,Clish CB,Ashley-Koch AE,Telen MJ

更新日期：2018-12-01 00:00:00

abstract：:National AIDS surveillance suggests that approximately 3.5% of all hemophilic patients in the United States have developed AIDS as of February 1988; however, the cumulative incidence of AIDS among seropositive patients at individual hemophilia treatment centers (HTCs) has been reported to be as high as 12%. The purpos...

journal_title：American journal of hematology

authors： Stehr-Green JK,Jason JM,Evatt BL

更新日期：1989-11-01 00:00:00

abstract：:Polycythemia vera (PCV) and multiple myeloma are both clonal disorders of hematopoietic stem cells. The simultaneous occurrence of these diseases in an individual patient is rare. A case of synchronous PCV and smoldering myeloma is presented and the literature is reviewed. The issues of clinical importance in this unu...

journal_title：American journal of hematology

authors： Fink L,Bauer F,Perry JJ

更新日期：1993-11-01 00:00:00

abstract：:Indolent non-hodgkin lymphomas (iNHL) are a rare cause of monoclonal immunoglobulin deposits-related glomerulopathy (mIgGN). In patients with iNHL-related mIgGN, whether treatment should include either single or a combination of drug(s) to target the malignant clone and renal inflammation remains elusive. In this retr...

journal_title：American journal of hematology

authors： Perry M,Delarche A,Ribes D,Vergez F,Guilbeau-Frugier C,Laurent C,Huart A,Tavitian S,El Hachem H,Oberic L,Chauveau D,Michallet AS,Ysebaert L,Faguer S

更新日期：2014-10-01 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is feasible and effective in selected older patients with Multiple Myeloma, but specific criteria for evaluating ASCT eligibility in elderly patients are lacking. We evaluated 131 patients aged 65-75 considered for ASCT at our center: The Charlson Comorbidity Index (CCI), He...

journal_title：American journal of hematology

authors： Belotti A,Ribolla R,Cancelli V,Crippa C,Bianchetti N,Ferrari S,Bottelli C,Cattaneo C,Tucci A,De La Fuente Barrigon C,Rossi G

更新日期：2020-07-01 00:00:00

abstract：:A case of a leukemic transformation following a 27-year history of idiopathic myelofibrosis (IMF) is presented. The patient had two chromosomal abnormalities: a deletion of chromosome 13, del 13(q12q14), and a deletion of chromosome 11, del 11(q14q23). This patient's final diagnosis was acute micromegakaryocytic leuke...

journal_title：American journal of hematology

authors： Toubai T,Tanaka J,Higa T,Ota S,Ibata M,Shono Y,Mashiko S,Miura Y,Umehara S,Kahata K,Toyoshima N,Morioka M,Asaka M,Kasai M,Imamura M

更新日期：2005-01-01 00:00:00

abstract：:Platelet-rich plasma were treated with increasing concentrations of vitamin E (alpha-tocopherol). Washed platelets were exposed to oxidized low density lipoprotein (LDL) and examined by aggregometry and electron microscopy. The treatment of washed platelets by oxidized LDL induced morphological signs of activation lik...

journal_title：American journal of hematology

authors： Szuwart T,Dierichs RB,Zhao B

更新日期：1999-03-01 00:00:00

abstract：:The objective of this case-matched study was to compare the efficacy and toxicity of the addition of clarithromycin (Biaxin) to lenalidomide/low-dose dexamethasone (BiRd) vs. lenalidomide/low-dose dexamethasone (Rd) for newly diagnosed myeloma. Data from 72 patients treated at the New York Presbyterian Hospital-Cornel...

journal_title：American journal of hematology

authors： Gay F,Rajkumar SV,Coleman M,Kumar S,Mark T,Dispenzieri A,Pearse R,Gertz MA,Leonard J,Lacy MQ,Chen-Kiang S,Roy V,Jayabalan DS,Lust JA,Witzig TE,Fonseca R,Kyle RA,Greipp PR,Stewart AK,Niesvizky R

更新日期：2010-09-01 00:00:00

abstract：:A patient with congenital protein-C deficiency was treated with stanozolol for 8 weeks to increase circulating levels of protein C. A rise in protein C was achieved, accompanied by an increase in factor II, factor X, antithrombin III, and protein S; but at the 8th week the patient suffered a transient ischemia attack....

journal_title：American journal of hematology

authors： De Stefano V,Leone G,Teofili L,Ferrelli R,Pollari G,Antonini V,Bizzi B

更新日期：1988-10-01 00:00:00

abstract：:The aim of this study was to evaluate the clinical efficacy and safety of the ultrasound-guided fine needle biopsy (UG-FNB) of the spleen in a large population of patients. We collected retrospectively the findings concerning the application of UG-FNB of the spleen from eight Italian clinical centers that utilized thi...

journal_title：American journal of hematology

authors： Civardi G,Vallisa D,Bertè R,Giorgio A,Filice C,Caremani M,Caturelli E,Pompili M,De Sio I,Buscarini E,Cavanna L

更新日期：2001-06-01 00:00:00

abstract：:The authors report a 10-year-old boy with hepatosplenic gammadelta T-cell lymphoma, a rare form of lymphoma that is highly aggressive, exceedingly rare in children, and primarily seen in young men. Conventional multi-agent chemotherapy appears to be inadequate for cure. This is the first report with this type of lymph...

journal_title：American journal of hematology

authors： Gassas A,Kirby M,Weitzman S,Ngan B,Abla O,Doyle JJ

更新日期：2004-02-01 00:00:00