Stroke recurrence in children with sickle cell disease treated with hydroxyurea following first clinical stroke.

abstract：:Autoimmune hemolytic anemia is thought to be mediated via auto-antibodies produced by lymphoid B cells. This may be an idiopathic process or secondary to an underlying infection or lymphoproliferative disorder. Conventional treatment comprises immunosuppression with corticosteroids and, in some cases, splenectomy. A p...

journal_title：American journal of hematology

authors： Ramanathan S,Koutts J,Hertzberg MS

更新日期：2005-02-01 00:00:00

abstract：:Post-transfusion purpura (PTP) with severe thrombocytopenia occurred eight days after transfusion in a 28-year-old woman and responded to treatment with prednisone and plasma exchange. In contrast to nearly all previously studied cases of PTP, the patient's platelets were PlA1-positive and anti-PlA1 antibody could not...

journal_title：American journal of hematology

authors： Keimowitz RM,Collins J,Davis K,Aster RH

更新日期：1986-01-01 00:00:00

abstract：:Sickle cell (SS) disease is a complex of various genetic conditions. In some, homozygosity for the beta S gene may be present alone or in combination with the heterozygous or homozygous alpha-thalassemia-2 condition. Such combinations might ameliorate the clinical and hematological condition of the patient. The same m...

journal_title：American journal of hematology

authors： Huisman TH

更新日期：1979-01-01 00:00:00

abstract：:Thromboembolic complications following splenectomy for hematologic diseases occur in up to 10% of patients and may range from portal vein thrombosis (PVT) to pulmonary embolism (PE) and deep vein thrombosis (DVT). Up to now there exist no recommendations for the duration and intensity of prophylactic anticoagulation, ...

journal_title：American journal of hematology

authors： Mohren M,Markmann I,Dworschak U,Franke A,Maas C,Mewes S,Weiss G,Jentsch-Ullrich K

更新日期：2004-06-01 00:00:00

abstract：:Although karyotypic abnormalities are well documented in B-cell chronic lymphocytic leukemia (B-CLL), few sequential cytogenetic studies have been done. In this study, peripheral blood lymphocytes from fifty-one patients with B-CLL were sequentially karyotyped over a mean interval of 13.8 months (range, one to 51 mont...

journal_title：American journal of hematology

authors： Finn WG,Kay NE,Kroft SH,Church S,Peterson LC

更新日期：1998-11-01 00:00:00

abstract：:Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their beta S chromosomes. One subject had an alpha-thalassemia (-alpha/-alpha). The haplotypes were the common type #19, associated with severe disease, and type #31, n...

journal_title：American journal of hematology

authors： Bakioglu I,Hattori Y,Kutlar A,Mathew C,Huisman TH

更新日期：1985-11-01 00:00:00

abstract：:An infectious episode is the presenting manifestation of hairy cell leukemia (HCL) in approximately 30% of cases. Most often this is bacterial and only rare cases of opportunistic fungal infection are described. We report a patient who presented with sporotrichal involvement of multiple cutaneous sites and lymph nodes...

journal_title：American journal of hematology

authors： Kumar S,Kumar D,Gourley WK,Alperin JB

更新日期：1994-06-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is considered to be a pleuripotential stem cell disorder with the capacity to differentiate into myeloid, erythroid, megakaryocytic, and lymphoid cell lines. Consequently, blast crisis (BC) involving each of the above lineages has been well described. Among lymphoblastic crises, differen...

journal_title：American journal of hematology

authors： Advani SH,Malhotra H,Kadam PR,Iyer RS,Nanjangud G,Balsara B,Saikia T,Gopal R,Nair CN

更新日期：1991-02-01 00:00:00

abstract：:A case of idiopathic immune-mediated von Willebrand's disease (AvWD) associated angiodysplasia and recurrent lower gastrointestinal bleeding is reported. Coagulation parameters at presentation were activated partial thromboplastin time of 41 sec, bleeding time >15 min, factor VIII procoagulant activity, 5%; von Willeb...

journal_title：American journal of hematology

authors： Alhumood SA,Devine DV,Lawson L,Nantel SH,Carter CJ

更新日期：1999-02-01 00:00:00

abstract：DISEASE OVERVIEW:Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, and lymphadenopathy. DIAGNOSIS:Presence of IgM monoclonal protein associated with 10% clonal lymphoplasmacytic cell...

journal_title：American journal of hematology

authors： Gertz MA

更新日期：2011-05-01 00:00:00

abstract：:To clarify the idea that an alteration of the transferrin receptor (TF-R) gene, localized to 3q26, may be of pathogenetic significance in hematological disorders with 3q anomaly, we studied the TF-R systems of erythroblasts from both functional and genetic aspects. The patient described here had refractory anemia with...

journal_title：American journal of hematology

authors： Abe Y,Muta K,Yufu Y,Takahira H,Nishimura J,Nawata H

更新日期：1990-03-01 00:00:00

abstract：:This report describes the bone marrow findings in four patients whose marrow was involved by anaplastic large-cell Ki-1 lymphoma, an uncommon event in this type of lymphoma. In the marrow aspirate smears, the involvement was subtle, and was in the form of isolated large cells with irregular nuclear configuration, coar...

journal_title：American journal of hematology

authors： Wong KF,Chan JK,Ng CS,Chu YC,Lam PW,Yuen HL

更新日期：1991-06-01 00:00:00

abstract：:Defects in stomatin, alpha-adducin, and beta-adducin have been implicated in erythrocyte disorders of cation permeability. We performed linkage analysis of the genetic loci for these proteins in a large kindred with xerocytosis (dehydrated hereditary stomatocytosis). Using polymerase chain reaction-based genotyping te...

journal_title：American journal of hematology

authors： Innes DS,Sinard JH,Gilligan DM,Snyder LM,Gallagher PG,Morrow JS

更新日期：1999-01-01 00:00:00

abstract：:Congenital malformations of the inferior vena cava (IVC) are uncommon and may be associated with an increased risk of venous thrombosis. We report the case of a man with congenital absence of the IVC and remote history of deep venous thrombosis who now presents with severe abdominal wall superficial thrombophlebitis. ...

journal_title：American journal of hematology

authors： Evanchuk DM,Von Gehr A,Zehnder JL

更新日期：2008-03-01 00:00:00

abstract：:Celecoxib, a specific cyclooxygenase-2 (Cox-2) inhibitor, has been shown to possess antitumor activity in a variety of cancer cells. However, the antitumor activity of celecoxib in hematopoietic tumors, especially in chronic myeloid leukemia (CML), has not been well established. This study was designed to investigate ...

journal_title：American journal of hematology

authors： Zhang GS,Liu DS,Dai CW,Li RJ

更新日期：2006-04-01 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) is a complex acquired coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetrical complications, sepsis, cancer, and trauma. Numerous laboratory tests are avail...

journal_title：American journal of hematology

authors： Carey MJ,Rodgers GM

更新日期：1998-09-01 00:00:00

abstract：:Achievement of a complete response has been associated with improved outcomes in patients with multiple myeloma. Recently, increasing application of minimal residual disease (MRD) assessment has shown that MRD negativity is a powerful prognostic factor for survival outcomes. We wanted to examine the impact of the poly...

journal_title：American journal of hematology

authors： Tschautscher MA,Jevremovic D,Rajkumar V,Dispenzieri A,Lacy MQ,Gertz MA,Buadi FK,Dingli D,Hwa YL,Fonder AL,Hobbs MA,Hayman SR,Zeldenrust SR,Lust JA,Russell SJ,Leung N,Kapoor P,Go RS,Lin Y,Gonsalves WI,Kourelis T,

更新日期：2019-07-01 00:00:00

abstract：:The role of peripheral platelet destruction as a reversible etiology of thrombocytopenia in chronic lymphocytic leukemia (CLL) was evaluated in nine patients with CLL and refractory thrombocytopenia who underwent splenectomy. The patients' ages ranged from 54 to 74 years. Progressive thrombocytopenia refractory to ant...

journal_title：American journal of hematology

authors： Merl SA,Theodorakis ME,Goldberg J,Gottlieb AJ

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:T-cell lymphomas make up approximately 10%-15% of lymphoid malignancies. The frequency of these lymphomas varies geographically, with the highest incidence in parts of Asia. DIAGNOSIS:The diagnosis of aggressive peripheral T-cell lymphoma (PTCL) is usually made using the World Health Organization classifica...

journal_title：American journal of hematology

authors： Armitage JO

更新日期：2015-07-01 00:00:00

abstract：:A risk score based on three biological features (CD38, ZAP-70, and IGHV mutational status) was previously developed to predict progression-free survival (PFS) in untreated Binet A CLL patients. Here we perform a score validation analysis in a prospective and independent cohort of patients. Biological markers (CD38, ZA...

journal_title：American journal of hematology

authors： Gentile M,Cutrona G,Mosca L,Matis S,Fabris S,Lionetti M,Ilariucci F,Zupo S,Musolino C,Levato L,Molica S,Di Raimondo F,Vincelli I,Di Rienzo N,Pesce EA,Angrilli F,Federico M,Neri A,Ferrarini M,Morabito F

更新日期：2014-07-01 00:00:00

abstract：:Children with sickle cell anemia (SCA) and a primary overt stroke are at high risk of recurrent (secondary) stroke. Chronic transfusion therapy dramatically reduces but does not eliminate this high risk, and inevitably results in transfusion-related hemosiderosis. We previously reported the use of hydroxyurea/phleboto...

journal_title：American journal of hematology

authors： Greenway A,Ware RE,Thornburg CD

更新日期：2011-04-01 00:00:00

abstract：DISEASE OVERVIEW:Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). DIAGNOSIS:The diagnosis of MF or SS requires the integration of clinical and histopathologic data. ...

journal_title：American journal of hematology

authors： Wilcox RA

更新日期：2014-08-01 00:00:00

abstract：:A patient with acute nonlymphoblastic leukemia (FAB M4), showing a near tetraploid chromosome complement on his marrow cells, was treated with low dose cytosine arabinoside and achieved remission. During remission the near tetraploid marrow chromosome complement disappeared and reappeared upon relapse of leukemia. The...

journal_title：American journal of hematology

authors： Pinkerton PH,London B,Cowan DH

更新日期：1985-08-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a unique type of lymphoma with a prognosis intermediate between indolent and aggressive types. The purpose of this study was to study blood cytokine levels in newly diagnosed and relapsed MCL patients with respect to patterns of abnormalities and relationship to the MCL International Prog...

journal_title：American journal of hematology

authors： Sonbol MB,Maurer MJ,Stenson MJ,Allmer C,LaPlant BR,Weiner GJ,Macon WR,Cerhan JR,Witzig TE,Gupta M

更新日期：2014-12-01 00:00:00

abstract：:An adolescent male patient developed functional asplenia in the course of graft versus host disease (GVHD) after successful allogeneic bone marrow transplantation (BMT) for aplastic anemia. Coincident with the onset of the asplenia, amelioration of the ongoing GVHD was observed. Unexpectedly, after 34 months of functi...

journal_title：American journal of hematology

authors： Demetrakopoulos GE,Tsokos GC,Levine AS

更新日期：1982-02-01 00:00:00

abstract：:The role of leukapheresis was explored in the management of anaemia and thrombocytopenia complicating the accumulation of lymphoid cells in patients with chronic lymphocytic leukaemia and lymphoma. The aim of this study was to determine the efficiency of this procedure in correcting these complicating features and to ...

journal_title：American journal of hematology

authors： Cooper IA,Ding JC,Adams PB,Quinn MA,Brettell M

更新日期：1979-01-01 00:00:00

abstract：:Matching for HLA-A, -B, -C, and -DRB1 loci (8/8 match) is currently the gold standard for unrelated donor hematopoietic cell transplantation (HCT). In Europe, patients are also matched at the HLA-DQB1 loci (10/10 match). However, there is increasing evidence that matching at HLA-DRB3/4/5 loci may help to lower transpl...

journal_title：American journal of hematology

authors： Ducreux S,Dubois V,Amokrane K,Yakoub-Agha I,Labalette M,Michallet M,Rubio MT,Kennel A,Forcade E,Lafarge X,Bulabois CE,Masson D,Daguindau E,Devys A,Moalic V,Quelvennec E,Boudifa A,Picard C,Van Endert P,de Matteis M,

更新日期：2018-05-04 00:00:00

abstract：:Forty-two patients with chronic lymphocytic leukemia (CLL) were studied for morphology of lymphocytes by light and electron microscopy (EM), in vitro responses of lymphocytes to a battery of physical and chemical agents, overall clinical status, immunologic status, course, and response to therapy. CLL lymphocytes coul...

journal_title：American journal of hematology

authors： Knospe WH,Gregory SA,Trobaugh FE Jr,Stedronsky JA,Schrek R

更新日期：1977-01-01 00:00:00

abstract：:A 77-year-old caucasian man presented on March 2005 with important epigastric pain without any other significant history of gastritis. Patient refers a history of cutaneous Kaposi's sarcoma (KS) treated since 1974 with surgical excision or oncovorin topical injection. He underwent endoscopic evaluation showing a 1.5-c...

journal_title：American journal of hematology

authors： Mirabile A,Devizzi L,Gianni AM,Cabras A,Carbone A

更新日期：2010-10-01 00:00:00

abstract：:We studied the prognostic value of parameters of angiogenesis on bone marrow biopsies in newly diagnosed multiple myeloma (MM) patients. Angiogenesis parameters studied were the microvessel count done manually on light microscopy (MVD-A), microvessel count done by using computerized image analyzer (MVD-B), and total v...

journal_title：American journal of hematology

authors： Bhatti SS,Kumar L,Dinda AK,Dawar R

更新日期：2006-09-01 00:00:00