Abstract:
:The association of T-cell large granular lymphocyte (LGL) leukemia and rheumatoid arthritis is well described and it is now recognized that these patients and patients with Felty's syndrome represent different aspects of a single disease process. Most patients have rheumatoid arthritis at the time of diagnosis of LGL leukemia. This is the first detailed report of the development of rheumatoid arthritis after the diagnosis and treatment of LGL leukemia as well as the first report of rheumatoid arthritis that occurred in association with deoxycoformycin treatment. It is likely that the beneficial sustained normalization of neutrophil counts as a result of deoxycoformycin treatment played a significant role in the development of this complication. Hematological improvement occurred despite molecular genetic evidence of persistence of the abnormal T-cell clone. The role of the clonally expanded T cells in the pathogenesis of neutropenia and rheumatoid arthritis is discussed.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Yoe J,Gause BL,Curti BD,Longo DL,Bagg A,Kopp WC,Janik JEdoi
10.1002/(sici)1096-8652(199803)57:3<253::aid-ajh14subject
Has Abstractpub_date
1998-03-01 00:00:00pages
253-7issue
3eissn
0361-8609issn
1096-8652pii
10.1002/(SICI)1096-8652(199803)57:3<253::AID-AJH14journal_volume
57pub_type
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