Personalized risk prediction for event-free survival at 24 months in patients with diffuse large B-cell lymphoma.


:We recently defined event-free survival at 24 months (EFS24) as a clinically relevant outcome for patients with DLBCL. Patients who fail EFS24 have very poor overall survival, while those who achieve EFS24 have a subsequent overall survival equivalent to that of the age- and sex-matched general population. Here, we develop and validate a clinical risk calculator (IPI24) for EFS24. Model building was performed on a discovery dataset of 1,348 patients with DLBCL and treated with anthracycline-based immunochemotherapy. A multivariable model containing age, Ann Arbor stage, normalized serum LDH, ALC, ECOG performance status, bulky disease, and sex was identified. The model was then applied to an independent validation dataset of 1,177 DLBCL patients. The IPI24 score estimates the probability of failing to achieve the EFS24 endpoint for an individual patient. The IPI24 model showed superior discriminatory ability (c-statistic = 0.671) in the validation dataset compared to the IPI (c-statistic = 0.649) or the NCCN-IPI (c-statistic = 0.657). After recalibration of the model on the combined dataset, the median predicted probability of failing to achieve EFS24 was 36% (range, 12-88%), and the IPI24 showed an EFS24 gradient in all IPI groups. The IPI24 also identified a significant percentage of patients with high risk disease, with over 20% of patients having a 50% or higher risk of failing to achieve EFS24. The IPI24 provides an individual patient level probability of achieving the clinically relevant EFS24 endpoint. It can be used via electronic apps.


Am J Hematol


Maurer MJ,Jais JP,Ghesquières H,Witzig TE,Hong F,Haioun C,Thompson CA,Thieblemont C,Micallef IN,Porrata LF,Ribrag V,Nowakowski GS,Casasnovas O,Bologna S,Morschhauser F,Morrison VA,Peterson BA,Macon WR,Copie-Bergman C




Has Abstract


2016-02-01 00:00:00












  • Disease, treatment, and outcome differences between men and women with follicular lymphoma in the United States.

    abstract::We aimed to comprehensively study sex differences in disease and patients' characteristics, treatment and outcomes in patients with follicular lymphoma (FL) in the United States (USA) utilizing the National LymphoCare Study registry (2004-2014). Among evaluable males (n = 1277) and females (n = 1375) with FL, females ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Nabhan C,Zhou X,Day BM,Dawson K,Zelenetz AD,Friedberg JW,Cerhan JR,Link BK,Flowers CR

    更新日期:2016-08-01 00:00:00

  • Efficacy and safety of rituximab for systemic lupus erythematosus-associated immune cytopenias: A multicenter retrospective cohort study of 71 adults.

    abstract::The aim of the study was to assess the efficacy and safety of rituximab (RTX) for treating systemic lupus erythematosus (SLE)-associated immune cytopenias. This multicenter retrospective cohort study of adults from French referral centers and networks for adult immune cytopenias and SLE involved patients ≥18 years old...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Serris A,Amoura Z,Canouï-Poitrine F,Terrier B,Hachulla E,Costedoat-Chalumeau N,Papo T,Lambotte O,Saadoun D,Hié M,Blanche P,Lioger B,Gottenberg JE,Godeau B,Michel M

    更新日期:2018-03-01 00:00:00

  • Utilizing multiparametric flow cytometry in the diagnosis of patients with primary plasma cell leukemia.

    abstract::The diagnosis of primary plasma cell leukemia (pPCL) has been made by quantifying circulating plasma cells (cPCs) morphologically on a peripheral blood (PB) smear. However, this technique is not sufficiently sensitive. Multiparametric flow cytometry (MFC) provides a readily available and highly sensitive method to ide...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Evans LA,Jevremovic D,Nandakumar B,Dispenzieri A,Buadi FK,Dingli D,Lacy MQ,Hayman SR,Kapoor P,Leung N,Fonder A,Hobbs M,Hwa YL,Muchtar E,Warsame R,Kourelis TV,Go R,Russell S,Lust JA,Lin Y,Siddiqui M,Kyle RA,Ger

    更新日期:2020-06-01 00:00:00

  • Transfusion-related acute lung injury following intravenous anti-D administration in an adolescent.

    abstract::Transfusion-related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14-year-old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti-D. F...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Berger-Achituv S,Ellis MH,Curtis BR,Wolach B

    更新日期:2008-08-01 00:00:00

  • AL amyloidosis associated with B-cell lymphoproliferative disorders: frequency and treatment outcomes.

    abstract::AL amyloidosis, a systemic disorder characterized by widespread deposition of amyloid fibrils derived from monoclonal Ig light chains in organs and soft tissues, is typically caused by an underlying plasma cell dyscrasia. However, this disease can also be associated rarely with a B-cell lymphoproliferative disorder. I...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Sanchorawala V,Blanchard E,Seldin DC,O'Hara C,Skinner M,Wright DG

    更新日期:2006-09-01 00:00:00

  • Demonstration of additional benefit in adding lenalidomide to azacitidine in patients with higher-risk myelodysplastic syndromes.

    abstract::Lenalidomide and azacitidine are active in MDS patients, and may complement each other by targeting the bone marrow microenvironment and the malignant clone. A recent Phase I trial testing the lenalidomide and azacitidine combination yielded encouraging results; however, lenalidomide’s contribution was unclear. In thi...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Sekeres MA,O'Keefe C,List AF,Paulic K,Afable M 2nd,Englehaupt R,Maciejewski JP

    更新日期:2011-01-01 00:00:00

  • Prevalence of abnormal iron studies in heterozygotes for hereditary hemochromatosis: an analysis of 255 heterozygotes.

    abstract::Iron studies were compared in 434 patients from 80 hemochromatosis families classified as putative homozygotes, heterozygotes, and normal by HLA typing. There were 28 of 255 (11%) heterozygotes with an elevated serum ferritin and 22 of 255 (8.6%) with an elevated transferrin saturation. Serum ferritin (140 +/- 10.2 mi...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Adams PC

    更新日期:1994-02-01 00:00:00

  • B-cell chronic lymphocytic leukaemia: prognostic value of the immunophenotype and the clinico-haematological features.

    abstract::Sixty-two previously untreated patients with B-cell chronic lymphocytic leukaemia were analysed to study the prognostic value of both the immunologic phenotype and the clinicobiologic characteristics. Univariate studies showed that none of the immunological markers analysed, sheep-rosette, mouse-rosette, slg, and HLA/...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Orfao A,Gonzalez M,San Miguel JF,Rios A,Canizo MC,Hernandez J,Maricato ML,Lopez Borrasca A

    更新日期:1989-05-01 00:00:00

  • Abnormalities of von Willebrand factor multimers in drug-associated thrombotic microangiopathies.

    abstract::Six patients with thrombotic microangiopathy associated with drug therapy had serial analyses of von Willebrand factor (vWF) multimeric patterns in their EDTA-plasma samples by sodium dodecyl sulfate-1% agarose gel electrophoresis and autoradiography. In the plasma of five patients (one with chronic myelogenous leukem...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Charba D,Moake JL,Harris MA,Hester JP

    更新日期:1993-03-01 00:00:00

  • Validation of a patient-reported outcomes symptom measure for patients with nontransfusion-dependent thalassemia (NTDT-PRO© ).

    abstract::This study demonstrates the quantitative characteristics of the first patient-reported outcome (PRO) tool developed for patients with nontransfusion-dependent β-thalassemia (NTDT), the NTDT-PRO© . A multicenter validation study was performed over 24 weeks, involving 48 patients from Italy, Lebanon, Greece, and Thailan...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Taher A,Cappellini MD,Viprakasit V,Sutcharitchan P,Mahmoud D,Laadem A,Khan A,Gwaltney C,Harding G,Attie K,Zhang X,Zou J,Pariseau J,Henry Hu X,Kattamis A

    更新日期:2019-02-01 00:00:00

  • Lack of evidence of circulating retroviral antibodies in patients with classic Hodgkin's disease.

    abstract::Because of the T-cell abnormalities observed in Hodgkin's disease and the growing number of Hodgkin's disease cases observed in association with the acquired immunodeficiency syndrome (AIDS), concern has been expressed that a retrovirus may be the primary cause of Hodgkin's disease. We examined plasma specimens from 1...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Chorba TL,Kalyanaraman VS,Lacher MJ,Schulof RS

    更新日期:1988-01-01 00:00:00

  • Echinocytosis--an unusual manifestation of hemangioma.

    abstract::The case of a 21 year-old female with echinocytosis and a littoral cell hemangioma is reported. The patient had no significant past medical history and presented with abdominal pain and splenomegaly. A large percentage of echinocytes were noted on her peripheral smear in the absence of any known causes. A CT-recognize...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Altomare I,Desman G,Aledort LM

    更新日期:2006-07-01 00:00:00

  • A serum ferritin assay for prevalence studies of iron deficiency.

    abstract::A specialized serum ferritin assay has been developed for the detection of iron deficiency in epidemiologic studies. An enzyme immunoassay (EIA) was employed to eliminate the need for radioisotopes. The problem of low sensitivity inherent with the EIA for serum ferritin was eliminated by the use of monoclonal immunolo...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Flowers CA,Kuizon M,Beard JL,Skikne BS,Covell AM,Cook JD

    更新日期:1986-10-01 00:00:00

  • Idiopathic autoimmune thrombocytopenia: evidence for redistribution of platelet antibodies into the circulation after immunoadsorption treatment.

    abstract::Platelet antibodies are detectable in only about 50% of patients with chronic autoimmune thrombocytopenia (AITP). We determined platelet antibodies against GPIa/IIa, GPIb/IX, GPIIb/IIIa, and GPV and reticulated platelets in three female patients with AITP, before and after immunoadsorption treatment. None of the three...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Leitner GC,Stiegler G,Horvath M,Hoecker P,Sagaster P,Panzer S

    更新日期:2003-05-01 00:00:00

  • Hypercalcemia in idiopathic myelofibrosis: modulation of calcium and collagen homeostasis by 1,25-dihydroxyvitamin D3.

    abstract::A case of idiopathic myelofibrosis (IMF) presenting with hypercalcemia and hypercalcitriolemia is reported. It is proposed that ectopic production of the active vitamin D metabolite related to ongoing clonal expansion in the bone marrow accounts for the hypercalcemic state. Consistently low levels of circulating type ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Voss A,Schmidt K,Hasselbalch H,Junker P

    更新日期:1992-03-01 00:00:00

  • Transgenic mouse model of pharmacologic induction of fetal hemoglobin: studies using a new ribonucleotide reductase inhibitor, Didox.

    abstract::Evaluation of pharmacologic agents that stimulate fetal hemoglobin production has been done mainly in baboons and macaques. We investigated whether results in transgenic mice can predict the stimulation of fetal hemoglobin in primates, by testing gamma globin induction in response to a new ribonucleotide reductase inh...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Pace BS,Elford HL,Stamatoyannopoulos G

    更新日期:1994-02-01 00:00:00

  • Bone marrow failure and myelofibrosis in a case of PVP storage disease.

    abstract::"PVP storage disease" is a disorder occurring in patients who have received high molecular weight polyvinylpyrrolidone (PVP), which cannot be excreted from the body. These large polymers deposit in the histiocytes and cause proliferation and infiltration of histiocytes in the reticuloendothelial system. There was usua...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Dunn P,Kuo T,Shih LY,Wang PN,Sun CF,Chang MJ

    更新日期:1998-01-01 00:00:00

  • Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.

    abstract::How often elevated serum ferritin in primary-care patients reflects increased iron stores (normally 0.8 g in men, 0.4 g in women) is not known. The Hereditary Hemochromatosis and Iron Overload Screening (HEIRS) study screened 101,168 primary-care participants (44% Caucasians, 27% African-Americans, 14% Asians/Pacific ...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Gordeuk VR,Reboussin DM,McLaren CE,Barton JC,Acton RT,McLaren GD,Harris EL,Reiss JA,Adams PC,Speechley M,Phatak PD,Sholinsky P,Eckfeldt JH,Chen WP,Passmore L,Dawkins FW

    更新日期:2008-08-01 00:00:00

  • Diagnostic workup of acute leukemias of ambiguous lineage.

    abstract::Acute leukemias of ambiguous lineage (ALAL) comprise acute undifferentiated leukemias (AUL) and mixed-phenotype acute leukemias (MPAL). In the revised fourth edition of the World Health Organization (WHO) classification provided further refinements to the diagnostic criteria for ALAL. Molecular characterization of MPA...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Patel SS,Weinberg OK

    更新日期:2020-06-01 00:00:00

  • Treatment of acquired severe aplastic anemia with antilymphocyte globulin, cyclosporin A, methyprednisolone, and granulocyte colony-stimulating factor.

    abstract::Fifty-six adult patients with newly diagnosed acquired severe aplastic anemia (SAA) received horse antilymphocyte globulin (ALG), cyclosporin A (CyA), methylprednisolone (Mpred), granulocyte colony-stimulating factor (G-CSF) as first-line therapy. The median age was 34 (range, 17-72) and median neutrophil count 0.280 ...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章


    authors: Dinçol G,Aktan M,Diz-Küçükkaya R,Yavuz S,Nalçaci M,Oztürk S,Palanduz S,Doğan O,Ağan M

    更新日期:2007-09-01 00:00:00

  • Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry.

    abstract::Severe chronic neutropenia (SCN) is defined as an absolute neutrophil (ANC) of less than 0.5 x 10(9)/L, lasting for months or years. Congenital, cyclic, and idiopathic neutropenia are principal categories of SCN. Since 1994, the Severe Chronic Neutropenia International Registry (SCNIR) has collected data to monitor th...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Dale DC,Cottle TE,Fier CJ,Bolyard AA,Bonilla MA,Boxer LA,Cham B,Freedman MH,Kannourakis G,Kinsey SE,Davis R,Scarlata D,Schwinzer B,Zeidler C,Welte K

    更新日期:2003-02-01 00:00:00

  • Immune thrombocytopenic purpura associated with Brucella and Toxoplasma infections.

    abstract::Bacterial and protozoal infections can cause thrombocytopenia and may mimic idiopathic thrombocytopenic purpura (ITP). Brucella species and Toxoplasma are among the infectious agents with protean clinical manifestations which may induce immune thrombocytopenia. In rare cases, thrombocytopenia can be severe and may res...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Gürkan E,Başlamişli F,Güvenç B,Bozkurt B,Unsal C

    更新日期:2003-09-01 00:00:00

  • Effect of interleukin-1, tumor necrosis factor-alpha, and interferon-alpha on the blast cells of acute myeloblastic leukemia.

    abstract::In this study, we further established the role of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-alpha (IFN-alpha) as regulators of proliferation of acute myeloid leukemia (AML) cells. AML cells from 8 of 15 patients incorporated high levels of 3H-thymidin...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Carter A,Silvian-Draxler I,Tatarsky I

    更新日期:1992-08-01 00:00:00

  • Consensus statement on iron overload in myelodysplastic syndromes.

    abstract::In May 2005 at the 8th International Symposium on Myelodysplastic Syndromes (MDS), a consensus meeting was held on iron overload in MDS (Seymour, Hematol Oncol Clin 2005; Suppl 1:18-25). The recommendations of the 2005 consensus meeting were discussed in the context of currently available evidence at the 9th Internati...

    journal_title:American journal of hematology

    pub_type: 杂志文章,实务指引


    authors: Bennett JM,MDS Foundation's Working Group on Transfusional Iron Overload.

    更新日期:2008-11-01 00:00:00

  • In vitro generated Rh(null) red cells recapitulate the in vivo deficiency: a model for rare blood group phenotypes and erythroid membrane disorders.

    abstract::Lentiviral modification combined with ex vivo erythroid differentiation was used to stably inhibit RhAG expression, a critical component of the Rh(rhesus) membrane complex defective in the Rh(null) syndrome. The cultured red cells generated recapitulate the major alterations of native Rh(null) cells regarding antigen ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Cambot M,Mazurier C,Canoui-Poitrine F,Hebert N,Picot J,Clay D,Picard V,Ripoche P,Douay L,Dubart-Kupperschmitt A,Cartron JP

    更新日期:2013-05-01 00:00:00

  • Membrane cation and anion transport activities in erythrocytes of hereditary spherocytosis: effects of different membrane protein defects.

    abstract::Hereditary spherocytosis (HS) is due to different membrane protein defects (i.e., deficiency of spectrin and ankyrin, band 3, or band 4.2). In order to gain new insight into the relationships between band 3 function and proteins associated with the cytoskeleton, we studied erythrocyte anion transport activity in HS ch...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: De Franceschi L,Olivieri O,Miraglia del Giudice E,Perrotta S,Sabato V,Corrocher R,Iolascon A

    更新日期:1997-07-01 00:00:00

  • A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia.

    abstract::Regulatory T-cells (Tregs) are increased in chronic lymphocytic leukemia(CLL) and correlates with clinical and biological features of active/progressive disease. However, little is known about their ability to predict the time to first treatment (TFT). We evaluated 75 patients with Rai stage 0 CLL, in whom the absolut...

    journal_title:American journal of hematology

    pub_type: 信件


    authors: D'Arena G,D'Auria F,Simeon V,Laurenti L,Deaglio S,Mansueto G,Del Principe MI,Statuto T,Pietrantuono G,Guariglia R,Innocenti I,Martorelli MC,Villani O,De Feo V,Del Poeta G,Musto P

    更新日期:2012-06-01 00:00:00

  • Test of the month: The chromogenic antifactor Xa assay.

    abstract::As the number of anticoagulant drugs increases and new ones are brought to market, the utility of the routine screening coagulation tests of today--namely the prothrombin time and activated partial thromboplastin time--will be significantly reduced in many clinical situations. Although the new anticoagulants are desig...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Gehrie E,Laposata M

    更新日期:2012-02-01 00:00:00

  • The aggressive peripheral T-cell lymphomas: 2015.

    abstract:BACKGROUND:T-cell lymphomas make up approximately 10%-15% of lymphoid malignancies. The frequency of these lymphomas varies geographically, with the highest incidence in parts of Asia. DIAGNOSIS:The diagnosis of aggressive peripheral T-cell lymphoma (PTCL) is usually made using the World Health Organization classifica...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Armitage JO

    更新日期:2015-07-01 00:00:00

  • Studies of the effects of trimethoprim and sulfamethoxazole on human granulopoiesis.

    abstract::Trimethoprim and sulfamethoxazole (Bactrim r) is a widely used antibiotic combination effective against a broad spectrum of microbial organisms. There are reports of neutropenia developing during even brief periods of oral therapy, particularly in individuals with either folate deficiency or increased folate requireme...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Bjornson BH,McIntyre AP,Harvey JM,Tauber AI

    更新日期:1986-09-01 00:00:00