Abstract:
:The occurrence of factor VIII inhibitors in non-hemophilic patients is a rare event with a potentially lethal outcome. Despite its infrequent occurrence, the association of this inhibitor with multiple autoimmune diseases is well recognized. We report the case of a patient with the recently described autoimmune lymphoproliferative syndrome (ALPS) who developed an inhibitor to factor VIII. ALPS is a disease characterized by defective lymphocyte apoptosis due to inherited mutations in genes that regulate apoptosis, with the resulting enlargement of lymphoid organs and a variety of autoimmune manifestations. Published 2000 Wiley-Liss, Inc.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Fang BS,Sneller MC,Straus SE,Frenkel L,Dale JK,Rick MEdoi
10.1002/1096-8652(200007)64:3<214::aid-ajh14>3.0.ckeywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
214-7issue
3eissn
0361-8609issn
1096-8652pii
10.1002/1096-8652(200007)64:3<214::AID-AJH14>3.0.Cjournal_volume
64pub_type
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