Phase I study of oral clofarabine consolidation in adults aged 60 and older with acute myeloid leukemia.

abstract：:Although tyrosine kinase inhibitors have redefined the care of chronic myeloid leukemia (CML), these agents have not proved curative, likely due to resistance of the leukemia stem cells (LSC). While a number of potential therapeutic targets have emerged in CML, their expression in the LSC remains largely unknown. We t...

journal_title：American journal of hematology

authors： Gerber JM,Qin L,Kowalski J,Smith BD,Griffin CA,Vala MS,Collector MI,Perkins B,Zahurak M,Matsui W,Gocke CD,Sharkis SJ,Levitsky HI,Jones RJ

更新日期：2011-01-01 00:00:00

abstract：:To investigate the mechanisms that modulate granulocyte-macrophage colony-stimulating activity (GM-CSA) and burst promoting activity (BPA) elaboration, we studied human peripheral blood-derived monocyte-macrophage (M0) and T-lymphocyte (TL) interaction. Coincubation of live M0 with autologous TL at a 1:3 ratio in the ...

journal_title：American journal of hematology

authors： Verma DS,Spitzer G,Beran M

更新日期：1982-06-01 00:00:00

abstract：:Neutrophils that bear receptors for the Fc portion of immunoglobulin G have been demonstrated to be more active in assays of adherence, aggregation, and chemotaxis compared to Fc receptor-negative cells. We examined the relationship of neutrophil Fc receptor activity and cell-cell adherence or aggregation induced by p...

journal_title：American journal of hematology

authors： Spagnuolo PJ,Fain M,Bass SN

更新日期：1987-11-01 00:00:00

abstract：DISEASE OVERVIEW:Chronic neutrophilic leukemia (CNL) is a rare, often aggressive myeloproliferative neoplasm (MPN) defined by persistent mature neutrophilic leukocytosis, bone marrow granulocyte hyperplasia, and frequent hepatosplenomegaly. The seminal discovery of oncogenic driver mutations in colony-stimulating facto...

journal_title：American journal of hematology

authors： Szuber N,Elliott M,Tefferi A

更新日期：2020-02-01 00:00:00

abstract：:Fibrillar granules (FGs) represent neutrophilic primary granules containing clustered filaments. We investigated neutrophils in the bone marrow obtained from 17 patients with chronic myeloproliferative disorders (CMPD) by electron microscopy. FG-positive neutrophils were seen in 15 of the 17 CMPDs with varying frequen...

journal_title：American journal of hematology

authors： Takemori N,Hirai K,Onodera R,Saito N,Miyokawa N

更新日期：1994-11-01 00:00:00

abstract：:While systemic plasma endothelin-1 (ET-1) levels are increased during acute crisis in sickle cell disease, the relative levels of potent vasoactive factors that contribute to the regulation of vascular function, such as ET-1, NO, and cell-free hemoglobin, during the course of periodic vaso-occlusive episodes remain un...

journal_title：American journal of hematology

authors： Ergul S,Brunson CY,Hutchinson J,Tawfik A,Kutlar A,Webb RC,Ergul A

更新日期：2004-07-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with isolated thrombocytopenia and hemorrhagic risk. While many children with ITP can be safely observed, treatments are often needed for various reasons, including to decrease bleeding, or to improve health related quality of life (HRQoL). There are a n...

journal_title：American journal of hematology

authors： Grace RF,Shimano KA,Bhat R,Neunert C,Bussel JB,Klaassen RJ,Lambert MP,Rothman JA,Breakey VR,Hege K,Bennett CM,Rose MJ,Haley KM,Buchanan GR,Geddis A,Lorenzana A,Jeng M,Pastore YD,Crary SE,Neier M,Neufeld EJ,Neu N

更新日期：2019-07-01 00:00:00

abstract：:A 37-year-old untransfused, non-drinking man with Hemoglobin H-CS disease presented with insulin-dependent diabetes mellitus, markedly elevated serum ferritin level, and marked iron deposition in hepatocytes. He did not carry either of the two common mutations of the HLA-H gene for hereditary hemochromatosis, namely, ...

journal_title：American journal of hematology

authors： Chim CS,Chan V,Todd D

更新日期：1998-02-01 00:00:00

abstract：:We have investigated whether the quantitative flow cytometry is an useful tool to better characterize B-cell chronic lymphoproliferative disorders (CLDs). Peripheral blood samples from 104 patients with leukemic B-cell disorders and 20 healthy donors were analyzed. Directly phycoerythrin-conjugated CD19, CD20, CD22, C...

journal_title：American journal of hematology

authors： D'Arena G,Musto P,Cascavilla N,Dell'Olio M,Di Renzo N,Carotenuto M

更新日期：2000-08-01 00:00:00

abstract：:Matching for HLA-A, -B, -C, and -DRB1 loci (8/8 match) is currently the gold standard for unrelated donor hematopoietic cell transplantation (HCT). In Europe, patients are also matched at the HLA-DQB1 loci (10/10 match). However, there is increasing evidence that matching at HLA-DRB3/4/5 loci may help to lower transpl...

journal_title：American journal of hematology

authors： Ducreux S,Dubois V,Amokrane K,Yakoub-Agha I,Labalette M,Michallet M,Rubio MT,Kennel A,Forcade E,Lafarge X,Bulabois CE,Masson D,Daguindau E,Devys A,Moalic V,Quelvennec E,Boudifa A,Picard C,Van Endert P,de Matteis M,

更新日期：2018-05-04 00:00:00

abstract：:This analysis, using data from the bortezomib-melphalan-prednisone (VMP) arm of the Phase III VISTA study, investigated whether increased cumulative bortezomib dose could improve overall survival (OS) in transplant-ineligible patients with previously untreated multiple myeloma. Median cumulative bortezomib dose receiv...

journal_title：American journal of hematology

authors： Mateos MV,Richardson PG,Dimopoulos MA,Palumbo A,Anderson KC,Shi H,Elliott J,Dow E,van de Velde H,Niculescu L,San Miguel JF

更新日期：2015-04-01 00:00:00

abstract：:Although infectious complications represent a relevant cause of morbidity and mortality in patients with myelofibrosis (MF), little is known about their incidence, outcome and risk factors. We retrospectively evaluated a cohort of 507 MF patients, diagnosed between 1980 and 2014 in five Italian hematology centers, to ...

journal_title：American journal of hematology

authors： Polverelli N,Breccia M,Benevolo G,Martino B,Tieghi A,Latagliata R,Sabattini E,Riminucci M,Godio L,Catani L,Nicolosi M,Perricone M,Sollazzo D,Colafigli G,Campana A,Merli F,Vitolo U,Alimena G,Martinelli G,Lewis RE,V

更新日期：2017-01-01 00:00:00

abstract：:Primary systemic light-chain (AL) amyloidosis a disorder characterized by accumulation of monoclonal light chains as aggregated amyloid fibrils in tissues of multiple organs to cause organ dysfunction and death (Kyle and Gertz, Semin Hematol 1995;32:45-59; Merlini and Bellotti, N Engl J Med 2003;349:583-596). Although...

journal_title：American journal of hematology

authors： Jun HJ,Kim K,Kim SJ,Mun YC,Bang SM,Won JH,Kim CS,Lee JH,Korean Multiple Myeloma Working Party (KMMWP).

更新日期：2013-01-01 00:00:00

abstract：:Celecoxib, a specific cyclooxygenase-2 (Cox-2) inhibitor, has been shown to possess antitumor activity in a variety of cancer cells. However, the antitumor activity of celecoxib in hematopoietic tumors, especially in chronic myeloid leukemia (CML), has not been well established. This study was designed to investigate ...

journal_title：American journal of hematology

authors： Zhang GS,Liu DS,Dai CW,Li RJ

更新日期：2006-04-01 00:00:00

abstract：:In May 2005 at the 8th International Symposium on Myelodysplastic Syndromes (MDS), a consensus meeting was held on iron overload in MDS (Seymour, Hematol Oncol Clin 2005; Suppl 1:18-25). The recommendations of the 2005 consensus meeting were discussed in the context of currently available evidence at the 9th Internati...

journal_title：American journal of hematology

authors： Bennett JM,MDS Foundation's Working Group on Transfusional Iron Overload.

更新日期：2008-11-01 00:00:00

abstract：:Quinine-induced immune thrombocytopenia with hemolytic uremic syndrome (HUS) is a recently defined clinical entity. In this paper we have attempted to characterize the natural history and laboratory abnormalities typical of quinine-induced immune thrombocytopenia associated with hemolytic uremic syndrome in nine patie...

journal_title：American journal of hematology

authors： Gottschall JL,Neahring B,McFarland JG,Wu GG,Weitekamp LA,Aster RH

更新日期：1994-12-01 00:00:00

abstract：:The underlying mechanisms of reactive macrophage activation syndromes (rMAS) are not understood in detail, and there is no specific treatment. This observational study was prompted by intravenous immunoglobulin (IVIG), dramatically halting two distinct rMAS episodes in the same patient. We evaluated the potential bene...

journal_title：American journal of hematology

authors： Emmenegger U,Frey U,Reimers A,Fux C,Semela D,Cottagnoud P,Spaeth PJ,Neftel KA

更新日期：2001-09-01 00:00:00

abstract：:Hemoglobin Lyon-Bron was found in two members of a family of German ascent presenting with a moderate normocytic anemia. In this alpha 2 globin variant, the N-terminal valine of the chain was replaced by an alanine. Electrospray mass spectrometry of the alpha chain showed that, as normally, the initiator methionine wa...

journal_title：American journal of hematology

authors： Lacan P,Souillet G,Aubry M,Promé D,Richelme-David S,Kister J,Wajcman H,Francina A

更新日期：2002-03-01 00:00:00

abstract：:The above abstract from the THSNA 2016 Summit Abstract Proceedings, first published online in the American Journal of Hematology on 20 July 2016 in Wiley OnlineLibrary (www.onlinelibrary.wiley.com), and in Volume 91, Issue 9, p. E427, has been retracted by agreement between the authors, the journal Editor-in-Chief, Ca...

journal_title：American journal of hematology

authors：

更新日期：2017-04-01 00:00:00

abstract：:Seven normal human peripheral blood cell fractions (buffy coat, mononuclear cells, non-T, T, Fc-IgM receptor-depleted T-lymphocyte, Fc-IgG receptor-depleted T-lymphocyte, and autologous rosette-forming T-cell-depleted T-lymphocyte subpopulations) treated with phytohemagglutinin (PHA) were examined for the production o...

journal_title：American journal of hematology

authors： López-Karpovitch X,Padrós-Semorile MR,Rojas R,Martínez-Sánchez L

更新日期：1985-11-01 00:00:00

abstract：:Aberrant promoter DNA methylation is a well-described mechanism of leukemogenesis within hematologic malignancies, including acute lymphoblastic leukemia (ALL). However, the importance of methylation patterns among the adolescent and young adult (AYA) ALL population has not been well established. DNA methylation of 18...

journal_title：American journal of hematology

authors： DiNardo CD,Gharibyan V,Yang H,Wei Y,Pierce S,Kantarjian HM,Garcia-Manero G,Rytting M

更新日期：2013-09-01 00:00:00

abstract：:Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)-related childhood mortality and SCD-related morbidity in high-income countries. We remain cautiously optimisti...

journal_title：American journal of hematology

authors： Chaturvedi S,DeBaun MR

更新日期：2016-01-01 00:00:00

abstract：:A 1750 base pair cDNA to human terminal deoxynucleotidyl transferase (TdT) has been cloned. This cDNA detects a dominant 2200 base pair messenger RNA species in normal and leukemic cells synthesizing the enzyme. A quantitative dot blot assay was utilized to survey a number of clinical samples from patients with TdT po...

journal_title：American journal of hematology

authors： Wolf SC,Steinherz PG,Landau NR,Silverstone AE

更新日期：1987-07-01 00:00:00

abstract：:Autoimmune hemolytic anemia is thought to be mediated via auto-antibodies produced by lymphoid B cells. This may be an idiopathic process or secondary to an underlying infection or lymphoproliferative disorder. Conventional treatment comprises immunosuppression with corticosteroids and, in some cases, splenectomy. A p...

journal_title：American journal of hematology

authors： Ramanathan S,Koutts J,Hertzberg MS

更新日期：2005-02-01 00:00:00

abstract：:Thrombocytopenia is a poor prognostic indicator in the myelodysplastic syndromes (MDS). Treatment options for patients with symptomatic thrombocytopenia are limited. Danazol, an attenuated androgen, may have some efficacy in increasing the platelet count of patients with MDS. We retrospectively reviewed 33 patients wi...

journal_title：American journal of hematology

authors： Chan G,DiVenuti G,Miller K

更新日期：2002-11-01 00:00:00

abstract：:Hb Knossos is a beta-chain variant (beta 27 Ser----Ala) that is unrecognizable by conventional separation methods but detectable by globin electrophoresis on urea-Triton X-acrylamide gels or by IEF. Hb Knossos is characterized by reduced synthesis and by interaction with beta-thalassemia, in which the double heterozyg...

journal_title：American journal of hematology

authors： Fessas P,Loukopoulos D,Kokkinou S,Papasotiriou Y,Karaklis A

更新日期：1986-02-01 00:00:00

abstract：:Since trisomy 12 is the most common chromosome abnormality found in CLL and MDM2 has been mapped to this chromosome, we examined the possible association of MDM2 in the pathogenesis of CLL. A rearrangement of the MDM2 gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Sout...

journal_title：American journal of hematology

authors： Huang YQ,Raphael B,Buchbinder A,Li JJ,Zhang WG,Friedman-Kien AE

更新日期：1994-10-01 00:00:00

abstract：:Mutation of the VHL tumor suppressor gene is a frequent genetic event in the carcinogenesis of renal-cell carcinoma (RCC). Circulating endothelial progenitor cells (EPCs) have important role in neoangiogenesis, and mobilization of these cells is induced by various growth factors including erythropoietin (EPO). With th...

journal_title：American journal of hematology

authors： Rad FH,Ulusakarya A,Gad S,Sibony M,Juin F,Richard S,Machover D,Uzan G

更新日期：2008-02-01 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) is a complex acquired coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetrical complications, sepsis, cancer, and trauma. Numerous laboratory tests are avail...

journal_title：American journal of hematology

authors： Carey MJ,Rodgers GM

更新日期：1998-09-01 00:00:00

abstract：:Leukemic cells from the peripheral blood of 52 patients with acute and chronic leukemias were incubated with 12-0-tetradecanoyl phorbol ester (TPA). Thirty-one cases of lymphocytic leukemia (18 cases of acute lymphoblastic and 13 cases of chronic lymphocytic leukemia), 13 cases of acute nonlymphoblastic (myelo or myel...

journal_title：American journal of hematology

authors： Polliack A,Leizerowitz R,Korkesh A,Gurfel D,Gamliel H,Galili U

更新日期：1982-11-01 00:00:00