Abstract:
:In some cases, bone marrow aplasia has been thought to result from immunologic abnormalities. Our patient had severe transfusion-dependent aplastic anemia, which responded to treatment with prednisone on two occasions. The exacerbations of aplastic anemia were associated with lymphocytic proliferation which on one occasion had the characteristics of T-cell chronic lymphocytic leukemia. Though he had had mild lymphoproliferation for a number of years, he ultimately died with progressive diffuse lymphoid infiltration of the bone marrow and other organs. The simultaneous occurrence of the T-cell lymphoproliferation and aplastic anemia and their simultaneous response to therapy suggests that this may be a clinical example of T-lymphocyte mediated suppression of erythropoiesis.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Bodner S,Cohen HJdoi
10.1002/ajh.2830110310subject
Has Abstractpub_date
1981-11-01 00:00:00pages
293-8issue
3eissn
0361-8609issn
1096-8652journal_volume
11pub_type
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