Hypercalcemia in idiopathic myelofibrosis: modulation of calcium and collagen homeostasis by 1,25-dihydroxyvitamin D3.

Abstract:

:A case of idiopathic myelofibrosis (IMF) presenting with hypercalcemia and hypercalcitriolemia is reported. It is proposed that ectopic production of the active vitamin D metabolite related to ongoing clonal expansion in the bone marrow accounts for the hypercalcemic state. Consistently low levels of circulating type I procollagen propeptide (PICP) and lack of progression of the bone marrow fibrosis during almost 6 months of follow-up point to an in vivo inhibition of type I collagen synthesis by 1,25-dihydroxyvitamin D3.

journal_name

Am J Hematol

authors

Voss A,Schmidt K,Hasselbalch H,Junker P

doi

10.1002/ajh.2830390316

keywords:

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

231-3

issue

3

eissn

0361-8609

issn

1096-8652

journal_volume

39

pub_type

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