Abstract:
:A growing body of evidence suggests that iron overload is associated with inferior outcomes after myeloablative allogeneic hematopoietic stem cell transplantation (HSCT). However, all of those studies used surrogate markers of iron overload, especially serum ferritin, and most had a retrospective design. We conducted a prospective observational study in patients with myelodysplastic syndrome or acute leukemia undergoing myeloablative HSCT. Forty-five patients who were followed for over 1 year, with serial measurements of serum iron parameters, as well as liver and cardiac magnetic resonance imaging. There was no significant increase in ferritin, liver or cardiac iron content in the 12 months following HSCT. Although serum ferritin still appeared to have prognostic significance, as previously reported, pre-HSCT iron overload (as reflected in liver iron content) was not associated with increased mortality, relapse, or graft-versus-host disease. These results raise the possibility that the adverse prognostic impact of pre-HSCT hyperferritinemia may be related to factors independent of iron overload.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Armand P,Sainvil MM,Kim HT,Rhodes J,Cutler C,Ho VT,Koreth J,Alyea EP,Neufeld EJ,Kwong RY,Soiffer RJ,Antin JHdoi
10.1002/ajh.23188subject
Has Abstractpub_date
2012-06-01 00:00:00pages
569-72issue
6eissn
0361-8609issn
1096-8652journal_volume
87pub_type
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