Acute promyelocytic leukaemia (M3): relapse with acute myeloblastic leukaemia (M2) and dic(5;17) (q11;p11).

Abstract:

:Secondary leukaemia following treatment of M3 acute promyelocytic leukaemia (APL) is a rare event. We describe a patient in remission following chemotherapy for APL who relapsed with M2 acute non-lymphoblastic leukaemia (ANLL). The original t(15;17) (q22;q21) chromosome translocation was lost and replaced by a clone containing a dic(5;17) (q11;p11) abnormality. Southern genomic analysis demonstrated re-arrangements of the retinoic acid receptor varies; is directly proportional to (RAR varies; is directly proportional to) and PML genes in the APL blasts at presentation but not in the M2 ANLL marrow at relapse. The significance of unbalanced 5;17 translocations as markers for therapy-related secondary leukaemia is discussed.

journal_name

Am J Hematol

authors

Hatzis T,Standen GR,Howell RT,Savill C,Wagstaff M,Scott GL

doi

10.1002/ajh.2830480108

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

40-4

issue

1

eissn

0361-8609

issn

1096-8652

journal_volume

48

pub_type

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