Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial.

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 microg/m2) was administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on neutrophil kinetics and function. With treatment, blood neutrophil counts rose gradually to peak at 3 1/2 times baseline by day 14. At day 5 marrow ...

journal_title：American journal of hematology

authors： Dale DC,Liles WC,Llewellyn C,Price TH

更新日期：1998-01-01 00:00:00

abstract：:At sites of vascular injury, the platelet collagen receptor Glycoprotein Ia/IIa (GPIa/IIa) acts as an important mediator of platelet adhesion to fibrillar collagens. Two silent polymorphisms (807C/T and 873G/A) within the glycoprotein Ia gene have been implicated in increased risk of developing thrombosis and myocardi...

journal_title：American journal of hematology

authors： Komurcu E,Erginel-Unaltuna N

更新日期：2002-01-01 00:00:00

abstract：:Fetal calf serum (FCS) is used as a component of the media for cells grown in culture. However, the high cost of FCS has stimulated a search for a possible alternative. Approximately 10% of human platelet concentrates prepared for clinical transfusions are outdated. Sera prepared from platelet concentrates were compar...

journal_title：American journal of hematology

authors： Schwartz KA,Lu G,Trosko JE,Chang CC

更新日期：1984-07-01 00:00:00

abstract：:Some evidence has shown that platelet crossmatching is useful in multitransfused patients with hypoplastic bone marrows who are refractory to platelet therapy through alloimmunization. Several immunoglobulin binding assays other than enzyme-linked immunospecific assay (ELISA) have been studied previously. We performed...

journal_title：American journal of hematology

authors： Brubaker DB,Duke JC,Romine M

更新日期：1987-04-01 00:00:00

abstract：:Post-transfusion purpura (PTP) with severe thrombocytopenia occurred eight days after transfusion in a 28-year-old woman and responded to treatment with prednisone and plasma exchange. In contrast to nearly all previously studied cases of PTP, the patient's platelets were PlA1-positive and anti-PlA1 antibody could not...

journal_title：American journal of hematology

authors： Keimowitz RM,Collins J,Davis K,Aster RH

更新日期：1986-01-01 00:00:00

abstract：:We report a case of refractory anemia with excess blasts (RAEB) developing in a 67-year old man with a history of polycythemia vera; results of cytogenetic and immunophenotyping studies are described. In this report the clinical, cytogenetic and hematologic features of myelodysplasia complicating polycythemia vera are...

journal_title：American journal of hematology

authors： Shamdas GJ,Spier CM,List AF

更新日期：1991-05-01 00:00:00

abstract：:Hereditary spherocytosis (HS) is due to different membrane protein defects (i.e., deficiency of spectrin and ankyrin, band 3, or band 4.2). In order to gain new insight into the relationships between band 3 function and proteins associated with the cytoskeleton, we studied erythrocyte anion transport activity in HS ch...

journal_title：American journal of hematology

authors： De Franceschi L,Olivieri O,Miraglia del Giudice E,Perrotta S,Sabato V,Corrocher R,Iolascon A

更新日期：1997-07-01 00:00:00

abstract：:The introduction of Imatinib (IM) has significantly altered the treatment for CML, although only limited follow-up results are available. As failure of Interferon-alpha had been associated with poor prognosis and results of IM-treatment in this patient group may allow earlier estimation of long-term benefits for early...

journal_title：American journal of hematology

authors： Hess G,Meyer RG,Schuch B,Bechthold K,El-Kholy I,Huber C

更新日期：2008-03-01 00:00:00

abstract：:Prenatal diagnosis was carried out on a woman who had previously given birth to a son with a spontaneous mutation of C-->T transition at nt 31133 of the factor IX (F.IX) gene. The diagnosis was performed on chorionic villi sampling by the method of amplification-created restriction site (ACRS). It revealed a female fe...

journal_title：American journal of hematology

authors： Young JH,Wang JC,Gau JP,Hu HT

更新日期：1996-08-01 00:00:00

abstract：:We have developed a murine monoclonal antibody (mAb) specific for the delta chain of hemoglobin (Hb) A2 that does not cross-react with alpha, beta, or gamma chains. The mAb reacted with Hb P-Nilotic (beta delta hybrid), but not with Hb Lepore-Boston (delta beta hybrid), indicating an epitope consisting of positions 11...

journal_title：American journal of hematology

authors： Shyamala M,Kiefer CR,Moscoso H,Garver FA

更新日期：1991-11-01 00:00:00

abstract：:Duvelisib (IPI-145), an oral, dual inhibitor of phosphoinositide-3-kinase (PI3K)-δ and -γ, was evaluated in a Phase 1 study in advanced hematologic malignancies, which included expansion cohorts in relapsed/refractory (RR) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and treatment-naïve (TN) CLL...

journal_title：American journal of hematology

authors： O'Brien S,Patel M,Kahl BS,Horwitz SM,Foss FM,Porcu P,Jones J,Burger J,Jain N,Allen K,Faia K,Douglas M,Stern HM,Sweeney J,Kelly P,Kelly V,Flinn I

更新日期：2018-11-01 00:00:00

abstract：:The clinical features of patients with splenic marginal zone cell lymphoma (SMZCL) have rarely been reported. In the present study, immunological abnormalities, particularly hematological abnormalities, observed in SMZCL were described. Autoimmune hemolytic anemia, immune thrombocytopenia, and appearance of lupus anti...

journal_title：American journal of hematology

authors： Murakami H,Irisawa H,Saitoh T,Matsushima T,Tamura J,Sawamura M,Karasawa M,Hosomura Y,Kojima M

更新日期：1997-11-01 00:00:00

abstract：:The efficacy of the three common intra- and extragenic polymorphic sites of the factor VIII and IX genes has been examined in the Indian population, with an aim to develop a strategy that would be accurate and informative, yet economical. The approach for hemophilia A carrier detection includes tests for BclI, XbaI, a...

journal_title：American journal of hematology

authors： Shetty S,Ghosh K,Pathare A,Colah R,Badakare S,Mohanty D

更新日期：1997-04-01 00:00:00

abstract：:"PVP storage disease" is a disorder occurring in patients who have received high molecular weight polyvinylpyrrolidone (PVP), which cannot be excreted from the body. These large polymers deposit in the histiocytes and cause proliferation and infiltration of histiocytes in the reticuloendothelial system. There was usua...

journal_title：American journal of hematology

authors： Dunn P,Kuo T,Shih LY,Wang PN,Sun CF,Chang MJ

更新日期：1998-01-01 00:00:00

abstract：:We performed a laparoscopic splenectomy (LS) in 60 patients (age 9-83, 45 females) with idiopathic thrombocytopenic purpura (ITP) who did not achieve sustained remission on steroid therapy. Using a modified procedure, the mean duration of LS was 78 min (range 25-240 min) and surgery was associated with only 5% major a...

journal_title：American journal of hematology

authors： Szold A,Schwartz J,Abu-Abeid S,Bulvik S,Eldor A

更新日期：2000-01-01 00:00:00

abstract：:A significant anemia develops in Buffalo rats bearing the Morris hepatoma 7777. By indiceal measurements the red blood cells (RBCs) appear to be microcytic and hypochromic. Ferrokinetic studies demonstrate a decreased uptake of iron in the bone marrow and an increased incorporation of iron in the spleens of the tumor-...

journal_title：American journal of hematology

authors： Lamar C Jr,Greene AS,Greene WB

更新日期：1979-01-01 00:00:00

abstract：:This analysis, using data from the bortezomib-melphalan-prednisone (VMP) arm of the Phase III VISTA study, investigated whether increased cumulative bortezomib dose could improve overall survival (OS) in transplant-ineligible patients with previously untreated multiple myeloma. Median cumulative bortezomib dose receiv...

journal_title：American journal of hematology

authors： Mateos MV,Richardson PG,Dimopoulos MA,Palumbo A,Anderson KC,Shi H,Elliott J,Dow E,van de Velde H,Niculescu L,San Miguel JF

更新日期：2015-04-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is rarely complicated by chylothorax: we present a 93-year-old woman with CLL who developed recurrent pleural effusions that were ultimately found to be chylous in nature. Despite eight repeated thoracenteses, she continued to experience re-accumulation of fluid, and therefore, video...

journal_title：American journal of hematology

authors： Doerr CH,Staats BA,Markovic SN

更新日期：2002-07-01 00:00:00

abstract：:The activation pathways for the generation of enzymes involved in blood clotting, clot lysis, complement activation, and kinin generation are briefly reviewed. The interrelationship of the four systems is illustrated by the multiple functions of four key enzymes: Factor XIIa, kallikrein, plasmin, and C1 esterase. The ...

journal_title：American journal of hematology

authors： Murano G

更新日期：1978-01-01 00:00:00

abstract：:The aim of this study was to evaluate the clinical efficacy and safety of the ultrasound-guided fine needle biopsy (UG-FNB) of the spleen in a large population of patients. We collected retrospectively the findings concerning the application of UG-FNB of the spleen from eight Italian clinical centers that utilized thi...

journal_title：American journal of hematology

authors： Civardi G,Vallisa D,Bertè R,Giorgio A,Filice C,Caremani M,Caturelli E,Pompili M,De Sio I,Buscarini E,Cavanna L

更新日期：2001-06-01 00:00:00

abstract：:The occurrence of factor VIII inhibitors in non-hemophilic patients is a rare event with a potentially lethal outcome. Despite its infrequent occurrence, the association of this inhibitor with multiple autoimmune diseases is well recognized. We report the case of a patient with the recently described autoimmune lympho...

journal_title：American journal of hematology

authors： Fang BS,Sneller MC,Straus SE,Frenkel L,Dale JK,Rick ME

更新日期：2000-07-01 00:00:00

abstract：OVERVIEW:Evidence suggests that even patients aged 70 or above benefit from specific AML therapy. The fundamental decision in AML then becomes whether to recommend standard or investigational treatment. This decision must rest on the likely outcome of standard treatment. Hence we review factors that predict treatment r...

journal_title：American journal of hematology

authors： Estey EH

更新日期：2014-11-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal stem-cell disorder in which blood cells lack complement inhibiting membrane proteins, and become susceptible to complement-mediated injury, leading to chronic intravascular hemolysis and pancytopenia. Glucocorticoids have been a mainstay of therapy. For patien...

journal_title：American journal of hematology

authors： Harrington WJ Sr,Kolodny L,Horstman LL,Jy W,Ahn YS

更新日期：1997-02-01 00:00:00

abstract：:Recombinant DNA technology and protein engineering are creating hope that we can address ongoing challenges in hemophilia care such as reducing the costs of therapy, increasing the availability to the developing world, and improving the functional properties of these proteins. Technological advances to improve the hal...

journal_title：American journal of hematology

authors： Pipe SW

更新日期：2012-05-01 00:00:00

abstract：:The roles of fibrinogen and fibronectin were contasted in the responses of human platelets to Staphylococcus aureus and collagen. Congenital afibrinogenemic (CA) platelets and washed normal platelets had delayed aggregation due to a prolonged latent phase in response to contact with the bacteria when fibrinogen was ab...

journal_title：American journal of hematology

authors： Clawson CC,White JG,Herzberg MC

更新日期：1980-01-01 00:00:00

abstract：:Eight patients with severe chronic autoimmune thrombocytopenic purpura (AITP) refractory to high-dose intravenous immunoglobulin (IVIgG) and/or oral prednisone were treated with one to three infusions of high-dose methylprednisolone (HDMP) (15 mg/kg/day). The mean platelet count before treatment was 12 +/- 10 x 10(9)/...

journal_title：American journal of hematology

authors： Godeau B,Zini JM,Schaeffer A,Bierling P

更新日期：1995-04-01 00:00:00

abstract：:Complete remission can be achieved in 60-80% of adults with diffuse aggressive non-Hodgkin's lymphoma. However, 20-40% of them will subsequently relapse. Nevertheless, formal follow-up guidelines for recurrence detection have never been advocated. We analyzed the pattern of relapse in 30 patients with intermediate- an...

journal_title：American journal of hematology

authors： Elis A,Blickstein D,Klein O,Eliav-Ronen R,Manor Y,Lishner M

更新日期：2002-01-01 00:00:00

abstract：:Despite advances in chemotherapeutic agents, the prognosis for some cancers remains extremely poor, suggesting the need for other treatment modalities. Immunotherapy appears an ideal approach because the mechanisms of tumor cell killing induced by tumor vaccines are different from those from chemotherapy. Various inve...

journal_title：American journal of hematology

authors： Dadabayev AR,Wang Z,Zhang Y,Zhang J,Robinson WR,Lim SH

更新日期：2005-09-01 00:00:00

abstract：DISEASE OVERVIEW:Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in one or more extracutaneous organs. DIAGNOSIS:The major criterion is presence of multifocal clusters of morphologically abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase...

journal_title：American journal of hematology

authors： Pardanani A

更新日期：2013-07-01 00:00:00

abstract：:Circulating thrombomodulin is a novel endothelial cell marker, which may reflect the endothelial injury. Plasma levels of thrombomodulin were quantitated by an enzyme-linked immunosorbent assay (ELISA) in patients with hematological malignancies, liver disease, diabetes mellitus, collagen disease, thrombotic disease, ...

journal_title：American journal of hematology

authors： Takahashi H,Ito S,Hanano M,Wada K,Niwano H,Seki Y,Shibata A

更新日期：1992-09-01 00:00:00