Acute myeloid leukemia: 2014 update on risk-stratification and management.

Abstract:

OVERVIEW:Evidence suggests that even patients aged 70 or above benefit from specific AML therapy. The fundamental decision in AML then becomes whether to recommend standard or investigational treatment. This decision must rest on the likely outcome of standard treatment. Hence we review factors that predict treatment related mortality and resistance to therapy, the latter the principal cause of failure even in patients aged 70 or above. We emphasize the limitations of prediction of resistance based only on pre-treatment factors and stress the need to incorporate post-treatment factors, for example indicators of minimal residual disease. We review various newer therapeutic options and considerations that underlie the decision to recommend allogeneic hematopoietic cell transplant.

journal_name

Am J Hematol

authors

Estey EH

doi

10.1002/ajh.23834

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1063-81

issue

11

eissn

0361-8609

issn

1096-8652

journal_volume

89

pub_type

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